RGD Reference Report - Hypouricemic effect of the methanol extract from Prunus mume fruit in mice. - Rat Genome Database

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Hypouricemic effect of the methanol extract from Prunus mume fruit in mice.

Authors: Yi, LT  Li, J  Su, DX  Dong, JF  Li, CF 
Citation: Yi LT, etal., Pharm Biol. 2012 Nov;50(11):1423-7. doi: 10.3109/13880209.2012.683115. Epub 2012 Sep 11.
RGD ID: 7247638
Pubmed: PMID:22856880   (View Abstract at PubMed)
DOI: DOI:10.3109/13880209.2012.683115   (Journal Full-text)

CONTEXT: The fruit of the Prunus mume Sieb. et Zucc (Rosaceae) is used as a health food or medicinal material in traditional herb medicine for a long time in Eastern Asian countries. OBJECTIVE: Our present study investigated the hypouricemic effect of the methanol extract from P. mume fruit (MPMF) in mice with potassium oxonate-induced hyperuremia. MATERIALS AND METHODS: Effect of MPMF (35, 70 and 140 mg/kg, p.o.) administrated for 7 days on the serum, liver, urinary uric acid levels and liver xanthine oxidase (XO) activity were assessed in mice. RESULTS: Hyperuricemic mice induced by potassium oxonate demonstrated an elevation in serum and liver uric acid levels (11.0 mg/dL and 0.52 mg/g tissue) and a reduction in urinary uric acid levels (49.9 mg/dL). Oral administration of 140 mg/kg MPMF for 7 days reversed the abnormalities in serum, liver and urinary uric acid levels (7.1 mg/dL, 0.37 mg/g tissue and 69.7 mg/dL, respectively). In addition, 70 and 140 mg/kg MPMF (3.1 and 2.9 nmol/min per mg protein) inhibited liver XO activity compared with hyperuricemic mice (3.9 nmol/min per mg protein). DISCUSSION AND CONCLUSION: The results indicated that the beneficial hypouricaemic effect of MPMF may be mediated, at least in part, by inhibiting XO activity in the liver. Our study suggests that P. mume and its extracts may have a considerable potential for development as an anti-gout agent for clinical application.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
XDHHumanhyperuricemia treatmentISOXdh (Mus musculus) RGD 
XdhRathyperuricemia treatmentISOXdh (Mus musculus) RGD 
XdhMousehyperuricemia treatmentIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Xdh  (xanthine dehydrogenase)

Genes (Mus musculus)
Xdh  (xanthine dehydrogenase)

Genes (Homo sapiens)
XDH  (xanthine dehydrogenase)


Additional Information