RGD Reference Report - Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study.

General

Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study.
Authors:	Bayraktar, N Kilic, S Bayraktar, MR Aksoy, N
Citation:	Bayraktar N, etal., J Clin Lab Anal. 2010;24(1):25-30. doi: 10.1002/jcla.20356.
RGD ID:	7247647
Pubmed:	PMID:20087949 (View Abstract at PubMed)
PMCID:	PMC6647705 (View Article at PubMed Central)
DOI:	DOI:10.1002/jcla.20356 (Journal Full-text)
It is well known that antioxidants and reactive oxygen species play an important role in carcinogenesis. In this study, we attempted to evaluate antioxidant enzyme activities and lipid peroxidation levels in cancerous bladder tissue and to determine their relationship with bacterial infection. Bacterial culture was made from all urine samples using Blood and Eosin Methylene Blue agars for checking the presence of bacterial infections. We measured thiobarbituric acid reactive substances (TBARs) and activities of xanthine oxidase (XO), superoxide dismutase (SOD), glutathione peroxidase (GSH-PX), and catalase (CAT) in cancerous tissues of 25 bladder cancer patients, in noncancerous adjacent bladder tissues of 13 out of these 25 patients, and in control bladder tissues of 15 patients with a non-neoplastic genitourinary disease. TBARs levels increased and XO, SOD, GSH-PX, and CAT activities decreased significantly in cancerous bladder tissues. TBARS, XO, and SOD levels were not significantly different between noncancerous adjacent tissue and control bladder tissue. Statistically significantly lower GSH-PX and higher CAT activities were observed in noncancerous adjacent bladder tissue compared with cancerous tissue. GSH-PX level of tumor tissue was correlated significantly with tumor grade (r=-0.425, P=0.034). Results suggested that pathway activity of free radicals were accelerated in the cancerous human bladder tissues via increased TBARs levels and decreased enzyme activities of XO, SOD, GSH-PX, and CAT, which implicated a severe exposure of cancerous tissues to oxidative stress.

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Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
urinary bladder cancer		IDA		7247647	protein:decreased activity:urinary bladder	RGD
urinary bladder cancer		ISO	XDH (Homo sapiens)	7247647; 7247647	protein:decreased activity:urinary bladder	RGD

Objects Annotated

Genes (Rattus norvegicus)

Xdh (xanthine dehydrogenase)

Genes (Mus musculus)

Xdh (xanthine dehydrogenase)

Genes (Homo sapiens)

XDH (xanthine dehydrogenase)

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Lipid peroxidation and antioxidant enzyme activities in cancerous bladder tissue and their relation with bacterial infection: a controlled clinical study.