Slc7a5 (solute carrier family 7 member 5)

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Gene: Slc7a5 (solute carrier family 7 member 5) Rattus norvegicus

Analyze

Symbol:

Slc7a5

Name:

solute carrier family 7 member 5

RGD ID:

620639

Description:

Exhibits amino acid transmembrane transporter activity. Involved in amino acid import across plasma membrane. Localizes to basal plasma membrane and external side of apical plasma membrane. Orthologous to human SLC7A5 (solute carrier family 7 member 5); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

4F2 LC; 4F2 light chain; 4F2LC; E16; integral membrane protein E16; L-type amino acid transporter 1; large neutral amino acids transporter small subunit 1; LAT-1; solute carrier family 7 (amino acid transporter light chain, L system), member 5; solute carrier family 7 (cationic amino acid transporter, y+ system), member 5; TA1; TA1/LAT-1/CD98 light chain region; tumor-associated protein 1

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC7A5 (solute carrier family 7 member 5)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Slc7a5 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Slc7a5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC7A5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC7A5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc7a5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC7A5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	SLC7A5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc7a5 (solute carrier family 7 member 5)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	SLC7A5P2 (solute carrier family 7 member 5 pseudogene 2)	HGNC	PhylomeDB
Alliance orthologs ³
Mus musculus (house mouse):	Slc7a5 (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Homo sapiens (human):	SLC7A5 (solute carrier family 7 member 5)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	slc7a5 (solute carrier family 7 member 5)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG1607	Alliance	DIOPT (OMA\|OrthoFinder\|PANTHER\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	MUP1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aat-1	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Caenorhabditis elegans (roundworm):	aat-3	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER)
Drosophila melanogaster (fruit fly):	JhI-21	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	aat-4	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Caenorhabditis elegans (roundworm):	aat-9	Alliance	DIOPT (Ensembl Compara\|OMA\|PANTHER)
Saccharomyces cerevisiae (baker's yeast):	MUP3	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	19	54,693,959 - 54,722,563 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,693,959 - 54,722,563 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	65,412,970 - 65,441,647 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,120,728 - 52,149,332 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	52,125,608 - 52,154,213 (-)	NCBI
Celera	19	49,180,586 - 49,208,780 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

16Q24.3 Microdeletion Syndrome (ISO)

allergic contact dermatitis (ISO)

autism spectrum disorder (ISS)

Lung Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-chloro-2,4-dinitrobenzene (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (EXP,ISO)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,2',5,5'-tetrachlorobiphenyl (EXP,ISO)

2,3',4,4',5-Pentachlorobiphenyl (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

3,3',4,4',5-pentachlorobiphenyl (EXP,ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4-(ethoxymethylene)-2-phenyloxazol-5-one (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

actinomycin D (ISO)

afimoxifene (ISO)

aflatoxin B1 (ISO)

aflatoxin B2 (ISO)

all-trans-retinoic acid (ISO)

AM-251 (ISO)

ammonium chloride (EXP)

arsane (ISO)

arsenic atom (ISO)

atrazine (ISO)

benzene (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

beta-naphthoflavone (ISO)

bexarotene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

Bisphenol B (ISO)

bortezomib (ISO)

butan-1-ol (ISO)

cadmium dichloride (ISO)

carbamazepine (ISO)

carbon nanotube (ISO)

carbonyl sulfide (EXP)

cefaloridine (EXP)

chloroacetaldehyde (ISO)

chloropicrin (ISO)

chloroprene (ISO)

cholesterol (ISO)

chrysene (ISO)

cidofovir anhydrous (ISO)

cisplatin (ISO)

clobetasol (ISO)

clodronic acid (ISO)

clofibrate (ISO)

cobalt dichloride (EXP,ISO)

coumestrol (ISO)

crocidolite asbestos (ISO)

cycloheximide (ISO)

cyclosporin A (EXP,ISO)

daidzein (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

dicrotophos (ISO)

diethylstilbestrol (ISO)

dioxygen (ISO)

disodium selenite (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

endosulfan (EXP)

Enterolactone (ISO)

entinostat (ISO)

estrone (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

etoposide (ISO)

fenofibrate (ISO)

flavonoids (EXP)

flutamide (EXP)

folic acid (ISO)

fulvestrant (ISO)

furan (EXP)

gabapentin (ISO)

genistein (ISO)

hexane (EXP)

hydrogen peroxide (ISO)

ibuprofen (ISO)

ifosfamide (ISO)

Indeno[1,2,3-cd]pyrene (ISO)

indometacin (EXP,ISO)

isoniazide (ISO)

isotretinoin (ISO)

leflunomide (ISO)

mercury atom (ISO)

mercury dibromide (ISO)

mercury dichloride (EXP)

mercury(0) (ISO)

mestranol (ISO)

metformin (EXP)

methamphetamine (EXP)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

mitoxantrone (ISO)

N-acetyl-beta-D-glucosamine (ISO)

N-acetyl-D-glucosamine (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

nickel atom (ISO)

nickel dichloride (ISO)

nickel sulfate (ISO)

nicotine (ISO)

ochratoxin A (ISO)

oxaliplatin (EXP,ISO)

p-chloromercuribenzoic acid (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

PCB138 (EXP,ISO)

perfluorononanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

piperonyl butoxide (EXP)

pirinixic acid (ISO)

piroxicam (ISO)

potassium bromate (ISO)

progesterone (ISO)

quercetin (ISO)

raloxifene (ISO)

resveratrol (ISO)

riddelliine (EXP)

rotenone (EXP)

SB 431542 (ISO)

selenium atom (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

tamoxifen (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (ISO)

tetraphene (ISO)

thapsigargin (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

topotecan (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (EXP)

tunicamycin (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

zearalenone (ISO)

zidovudine (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

amino acid import across plasma membrane (IMP,ISO)

L-amino acid transport (ISO)

L-leucine import across plasma membrane (ISO)

L-tryptophan transmembrane transport (ISO,ISS)

leucine import across plasma membrane (ISO)

negative regulation of gene expression (ISO)

neutral amino acid transport (ISS)

phenylalanine transport (ISO)

positive regulation of interferon-gamma production (ISO)

positive regulation of interleukin-17 production (ISO)

positive regulation of interleukin-4 production (ISO)

thyroid hormone transport (ISO)

xenobiotic transport (ISO)

Cellular Component

amino acid transport complex (ISO,ISS)

apical plasma membrane (IDA,ISO)

basal plasma membrane (IDA)

basolateral plasma membrane (IDA)

cytosol (IEA,ISO)

external side of apical plasma membrane (IDA)

integral component of membrane (ISO,ISS)

intracellular membrane-bounded organelle (ISO)

lysosomal membrane (IEA)

microvillus membrane (ISO)

plasma membrane (ISO,ISS)

Molecular Function

amino acid transmembrane transporter activity (IMP,ISO,ISS)

aromatic amino acid transmembrane transporter activity (ISO)

L-amino acid transmembrane transporter activity (IBA,ISO)

L-leucine transmembrane transporter activity (ISO,ISS)

L-tryptophan transmembrane transporter activity (ISO,ISS)

neutral amino acid transmembrane transporter activity (ISO)

peptide antigen binding (ISS)

protein binding (ISO)

thyroid hormone transmembrane transporter activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

amiloride pharmacodynamics pathway (ISO)

bendroflumethiazide pharmacodynamics pathway (ISO)

bumetanide pharmacodynamics pathway (ISO)

chlorothiazide pharmacodynamics pathway (ISO)

chlorthalidone pharmacodynamics pathway (ISO)

cystinuria pathway (ISO)

eplerenone pharmacodynamics pathway (ISO)

etacrynic acid pharmacodynamics pathway (ISO)

furosemide pharmacodynamics pathway (ISO)

Hartnup disease pathway (ISO)

hydrochlorothiazide pharmacodynamics pathway (ISO)

hydroflumethiazide pharmacodynamics pathway (ISO)

iminoglycinuria pathway (ISO)

lysinuric protein intolerance pathway (ISO)

metolazone pharmacodynamics pathway (ISO)

nicotinamide adenine dinucleotide metabolic pathway (ISO)

spironolactone pharmacodynamics pathway (ISO)

torasemide pharmacodynamics pathway (ISO)

triamterene pharmacodynamics pathway (ISO)

trichlormethiazide pharmacodynamics pathway (ISO)

References

References - curated


1.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA data from the GO Consortium
3.	Kanai Y, etal., J Biol Chem 1998 Sep 11;273(37):23629-32.
4.	Lee KE and Kang YS, J Biomed Sci. 2017 May 10;24(1):28. doi: 10.1186/s12929-017-0336-x.
5.	Matsuo H, etal., Neuroreport. 2000 Nov 9;11(16):3507-11. doi: 10.1097/00001756-200011090-00021.
6.	MGD data from the GO Consortium
7.	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	Nikiforov A, etal., Crit Rev Biochem Mol Biol. 2015;50(4):284-97. doi: 10.3109/10409238.2015.1028612. Epub 2015 Apr 2.
9.	Pipeline to import SMPDB annotations from SMPDB into RGD
10.	RGD automated data pipeline
11.	RGD automated import pipeline for gene-chemical interactions
12.	Roberts LM, etal., Neuroscience. 2008 Aug 13;155(2):423-38. Epub 2008 Jun 13.
13.	Sang J, etal., Cancer Res 1995 Mar 1;55(5):1152-9.

Additional References at PubMed

PMID:15659399	PMID:17762180	PMID:19946888	PMID:20458337	PMID:24016666	PMID:25002582	PMID:25998567	PMID:29688723	PMID:30867591

Genomics

Comparative Map Data

Slc7a5
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rnor_6.0	19	54,693,959 - 54,722,563 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	54,693,959 - 54,722,563 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	19	65,412,970 - 65,441,647 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	19	52,120,728 - 52,149,332 (-)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	19	52,125,608 - 52,154,213 (-)	NCBI
Celera	19	49,180,586 - 49,208,780 (-)	NCBI		Celera
Cytogenetic Map	19	q12	NCBI

SLC7A5
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	16	87,830,023 - 87,869,507 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	16	87,830,022 - 87,869,507 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	16	87,863,629 - 87,903,100 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	86,421,130 - 86,460,601 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	16	86,421,130 - 86,460,601	NCBI
Celera	16	72,160,934 - 72,200,417 (-)	NCBI
Cytogenetic Map	16	q24.2	NCBI
HuRef	16	73,604,119 - 73,643,626 (-)	NCBI		HuRef
CHM1_1	16	89,274,981 - 89,314,543 (-)	NCBI		CHM1_1

Slc7a5
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	122,607,885 - 122,634,425 (-)	NCBI	GRCm39		mm39
GRCm38	8	121,881,146 - 121,907,686 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	121,881,150 - 121,907,694 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	8	124,405,046 - 124,431,586 (-)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	8	121,952,557 - 121,979,440 (-)	NCBI			mm8
MGSCv36	8	124,767,240 - 124,802,593 (-)	NCBI			mm8
Celera	8	126,102,885 - 126,145,803 (-)	NCBI		Celera
Cytogenetic Map	8	E1	NCBI
cM Map	8	70.8	NCBI

Slc7a5
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955541	2,103,384 - 2,130,310 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955541	2,103,437 - 2,129,668 (-)	NCBI	ChiLan1.0	ChiLan1.0

SLC7A5
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	16	87,827,058 - 87,854,154 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
Mhudiblu_PPA_v0	16	68,512,407 - 68,552,763 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

SLC7A5
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	5	65,313,105 - 65,343,858 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	5	65,313,105 - 65,343,858 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Slc7a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936641	1,513,110 - 1,538,955 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC7A5
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	1,545,940 - 1,574,288 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	6	1,545,940 - 1,574,298 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

SLC7A5
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1 Ensembl	5	73,229,951 - 73,269,754 (-)	Ensembl
ChlSab1.1	5	73,229,953 - 73,269,801 (-)	NCBI

Slc7a5
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624746	1,325,368 - 1,349,616 (+)	NCBI

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
724566	Uae12	Urinary albumin excretion QTL 12	5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	2432963	62275575	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	6506761	60220581	Rat
1578764	Stresp19	Stress response QTL 19	3.6	0.001	blood renin amount (VT:0003349)	plasma renin activity level (CMO:0000116)	19	18993982	62275575	Rat
7411549	Bw130	Body weight QTL 130	5	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	19	19177495	62275575	Rat
2298478	Eau8	Experimental allergic uveoretinitis QTL 8		0.0163	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	19	21407787	62275575	Rat
61350	Bp32	Blood pressure QTL 32		0.012	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	19	24818257	62275575	Rat
724546	Kidm3	Kidney mass QTL 3	3.1		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	19	32994392	62275575	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	19	37916799	60220451	Rat
1358200	Insglur2	Insulin/glucose ratio QTL 2	4.1		blood glucose amount (VT:0000188)	serum insulin level (CMO:0000358)	19	37916799	60220451	Rat
5135224	Leukc1	Leukocyte quantity QTL 1			eosinophil quantity (VT:0002602)	blood eosinophil count (CMO:0000033)	19	48830712	60220581	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	789
Count of miRNA genes:	299
Interacting mature miRNAs:	383
Transcripts:	ENSRNOT00000025784
Prediction methods:	Microtar, Miranda
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	24	32	26	17	26			74	18	37	2
Low		19	25	15	2	15	7	9		17	4	9	7
Below cutoff							1	2					1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_017353	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AAHX01099018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB015432	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC109048	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF329652	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473972	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U00995	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000025784 ⟹ ENSRNOP00000025784

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	19	54,693,959 - 54,722,563 (-)	Ensembl

RefSeq Acc Id:

NM_017353 ⟹ NP_059049

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	54,693,959 - 54,722,563 (-)	NCBI
Rnor_5.0	19	65,412,970 - 65,441,647 (-)	NCBI
RGSC_v3.4	19	52,120,728 - 52,149,332 (-)	RGD
Celera	19	49,180,586 - 49,208,780 (-)	RGD

Sequence:

show sequence

CGCGGAGAGCGGCTCGGCCGCGCGCACGCCGGGTATCCAGGCCGAGCCGGGAACGTCGAGAGCA
TGGCGGTCGCGGGCGCAAAGCGGCGCGCGGTTGCGGCCCCCGCGACGACGGCGGCGGAGGAGGA
GCGGCAGGCGCGGGAGAAGATGCTGGAGGCGCGGCGCGGGGACGGCGCGGACCCCGAGGGCGAA
GGCGTGACCCTGCAGCGCAATATCACACTGATCAATGGTGTGGCCATCATAGTGGGCACCATCA
TCGGTTCGGGCATCTTCGTGACGCCCACCGGCGTGCTCAAGGAAGCCGGCTCGCCCGGACTGTC
GCTTGTGGTGTGGGCTGTGTGCGGCGTCTTCTCCATCGTGGGCGCACTGTGCTACGCGGAGCTG
GGCACTACCATCTCAAAGTCAGGCGGCGACTATGCCTACATGCTAGAGGTCTACGGCTCGCTGC
CCGCCTTCCTCAAGCTCTGGATCGAGCTGCTCATCATTCGGCCCTCCTCACAGTACATCGTGGC
GCTGGTCTTCGCCACATACCTGCTCAAGCCGGTCTTCCCCACTTGTCCCGTGCCCGAGGAGGCT
GCCAAGCTCGTGGCCTGCCTCTGCGTGCTACTACTCACGGCTGTGAACTGCTACAGTGTGAAGG
CTGCTACCCGTGTGCAGGATGCCTTTGCGGCTGCCAAACTGCTGGCCCTGGCCCTCATCATCCT
GCTCGGCTTCATCCAGATGGGAAAGGACATAGGACAAGGGGATGCATCCAACCTGCACCAGAAG
TTGTCCTTTGAAGGCACCAATCTGGACGTGGGGAACATTGTGTTGGCATTGTACAGTGGCCTCT
TCGCCTACGGAGGATGGAACTATCTGAATTTTGTCACGGAGGAGATGATCAACCCCTACAGGAA
CCTCCCCCTGGCCATCATCATCTCCTTGCCCATTGTCACCCTGGTCTATGTGCTGACGAACCTG
GCCTACTTCACTACCCTGTCTACCAACCAGATGCTGACATCTGAAGCCGTGGCTGTGGATTTTG
GGAACTACCACCTGGGAGTCATGTCCTGGATCATTCCTGTCTTCGTGGGCTTGTCCTGCTTCGG
CTCTGTCAATGGGTCTCTGTTCACGTCCTCAAGACTGTTCTTCGTGGGATCCAGGGAGGGCCAC
CTGCCTTCCATCCTCTCCATGATCCACCCACAGCTTCTGACACCGGTGCCATCACTGGTGTTCA
CGTGTGTCATGACCCTGATGTACGCCTTCTCCAGAGACATCTTCTCCATCATCAACTTCTTCAG
CTTCTTCAACTGGCTGTGTGTGGCCCTGGCCATCATCGGCATGATGTGGCTCCGCTTTAAGAAG
CCTGAGCTGGAGCGTCCCATCAAGGTGAATCTGGCCCTCCCAGTGTTCTTTATCCTGGCCTGCC
TCTTCCTCATCGCCGTGTCCTTCTGGAAGACACCCCTGGAGTGCGGCATTGGCTTCGCCATCAT
CCTCAGCGGGCTGCCTGTCTACTTCTTTGGTGTGTGGTGGAAAAACAAGCCCAAATGGATCCTG
CAGGTCATCTTCTCCGTGACCGTGCTCTGCCAGAAGCTGATGCAGGTGGTTCCTCAGGAGACTT
AGCCACGTGTCCTGGGTGCCGCGGGAGAGTGCACTGTGACTGCTTCCAGACAACTCACCTTTGG
AAAAGCAGCGTCCAGGCCCGTCATCCCCACAGCTCCAGTGAGCACCACTAACTATCTTAACACC
ATCCGCTGTCCCTCAAAGGTCAGGTGTCCACAGTGGCCGTGAAAGAAACCTGGTACGAATTTGG
TCCCAGATGGTGACCATCCATGCATACATAGCAGCCACTGTGAGGTGTGCTGTGGCCTGAGGCC
TGGTCTTTCTGACTTTGGGGACTGCCACATCTGGGCTTTCTCCTCTATGATTTTTTGTTTTGTT
TTTGTAGCGTTCATTTGGGTCAAGTTTACACTACCGAGATGATTATTTTTTGACAAAACAGGGT
AGCAAAGAGCAGGAGATGGTGTGGCCGGACAGTCCGGCTCTGAGTGGGAACTGCAGGCCACAGC
TCTTCTCCGACTGTTGTTCGTTCAGTAGCACATTGTGGCTGGAGGGGACCACATCACTGTCACC
AAGTCAGAACTACTGAGACTCAAACATCACCTTTTCCACTGTGGACTTGCACTGACAAACGGAC
GATGAATGTGCTAGCTTGGGTTTGAGTTTTCTGGGTCTGTCCTAGAGATGAAACCCCAACCTGA
CCCACGAGGCAGAGCTCTACTGTGGGTCATTTGTTCCATTGTAAATGCAGAGCTCCGGTCTGAC
CACTCTGAAGTCCTGGTGATTCCCCTTCCCCTGGCTCCAAATGAAAGACCTCTGCAGCCATAAC
CCTAGTGGCACCTGGCCACCAACTGTCAACTGCGGGGCCATGTGCTCCTGTGCACACAAGCTGG
CTCTACACATTCAAGGGGCACTGCTCTGGGTCTTACTCCCTGTCCCACCCCAGCTCTCCTAGAA
CCAGACCGGCACCATGGGGCTCCACCACACACCTCTGTCCACCTCCATAATTCCTGAGACTGCT
AGCAGCTCTCTGTCAAGTCACCACCGTCCCCCCTCAGCCCCCCGGGCCACTGTTCAAAAGAATA
GGCACCAACTACCCTTCTGCTCTCTGCCACCTGTGTGACGTGACCACTCCAGCTCCCTGAGCGT
GAAAACTGCTGGCTACGTGCTGCTGTCCCTCCTGTGTGGGACCAGTCTGTTCCGGGGAGACGGT
TGAGTCCAGCAGCACATCCACTGAAGCAGCTGATCTGACTGAAGGACTTGAGGGCATGAGAATC
CCCCGCTGGCCCTTCCATTGCCTCAGAGCTGGCCTCCCTGAGGGGGTGTCAACTGGAGTGTCTA
CTGTGAAGCTCTTACATAGTGGCACCCTGATATCTCCTGGGGTTCCCTTGTGTTGGGGTGAGGA
GGCAGAGGTCAAGGTCAGAGTGCCCCTAGAAGGCTCTCCAGAGATGTGAACTCAGGTCCCCAGA
CACAAGCCTGGGTTCAAAGGGCAGGGCAAGTCTTGGTCCACGTTCATGGTGCTGACCCAGGCCC
TCTGAGAAGGCCCTGTCATTCCTATTCTGATGTCCTGAGGACGCCCATCTGTAGGTTTTTGGTT
TTAAATCAAGCCACAGCCACAGTCATTTGGCCCAATGCTTTGCATTGTGTTGTCCTAACACATC
ACTGCCCTGTGGAACCCCCCTGCCTGGCCCTTTTCAGTGGTCAGTGTCCAGTGCTGGGTACGGT
GTGTTCCCACCACACTGGGTCCACCTGCTGTGCCACTGGACTTAGTGCTGTGGTTGTAATGTCT
TTTACTATTGTATTAATGACTAGTCTGTTACATTAGACTGGGGGTGGGGTGCAAGGGTCTGCTG
GTTTGTGAGGCTTTTTGATTGGGGGGGTGGTTTGTTTTTTTTTTTTAAAGCTATTGGAGTTCT

hide sequence

Protein Sequences


Protein RefSeqs	NP_059049	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA74411	(Get FASTA)	NCBI Sequence Viewer
	AAK16501	(Get FASTA)	NCBI Sequence Viewer
	BAA33035	(Get FASTA)	NCBI Sequence Viewer
	EDL92732	(Get FASTA)	NCBI Sequence Viewer
	Q63016	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_059049 ⟸ NM_017353

- UniProtKB:

Q63016 (UniProtKB/Swiss-Prot)

- Sequence:

show sequence

MAVAGAKRRAVAAPATTAAEEERQAREKMLEARRGDGADPEGEGVTLQRNITLINGVAIIVGTI
IGSGIFVTPTGVLKEAGSPGLSLVVWAVCGVFSIVGALCYAELGTTISKSGGDYAYMLEVYGSL
PAFLKLWIELLIIRPSSQYIVALVFATYLLKPVFPTCPVPEEAAKLVACLCVLLLTAVNCYSVK
AATRVQDAFAAAKLLALALIILLGFIQMGKDIGQGDASNLHQKLSFEGTNLDVGNIVLALYSGL
FAYGGWNYLNFVTEEMINPYRNLPLAIIISLPIVTLVYVLTNLAYFTTLSTNQMLTSEAVAVDF
GNYHLGVMSWIIPVFVGLSCFGSVNGSLFTSSRLFFVGSREGHLPSILSMIHPQLLTPVPSLVF
TCVMTLMYAFSRDIFSIINFFSFFNWLCVALAIIGMMWLRFKKPELERPIKVNLALPVFFILAC
LFLIAVSFWKTPLECGIGFAIILSGLPVYFFGVWWKNKPKWILQVIFSVTVLCQKLMQVVPQET

hide sequence

RefSeq Acc Id:

ENSRNOP00000025784 ⟸ ENSRNOT00000025784

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13701201

Promoter ID:

EPDNEW_R11723

Type:

single initiation site

Name:

Slc7a5_1

Description:

solute carrier family 7 member 5

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	54,722,580 - 54,722,640	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:620639	AgrOrtholog
Ensembl Genes	ENSRNOG00000018824	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000025784	ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000025784	ENTREZGENE, UniProtKB/Swiss-Prot
InterPro	AA/rel_permease1	UniProtKB/Swiss-Prot
	L_AA_transporter	UniProtKB/Swiss-Prot
KEGG Report	rno:50719	UniProtKB/Swiss-Prot
NCBI Gene	50719	ENTREZGENE
Pfam	AA_permease_2	UniProtKB/Swiss-Prot
PhenoGen	Slc7a5	PhenoGen
TIGRFAMs	2A0308	UniProtKB/Swiss-Prot
UniGene	Rn.32261	ENTREZGENE
UniProt	LAT1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary	Q9QWL4	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc7a5	solute carrier family 7 member 5	Slc7a5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-01	Slc7a5	solute carrier family 7 (amino acid transporter light chain, L system), member 5	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Slc7a5	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5		tumor-associated protein 1	Name updated	1299863	APPROVED
2004-09-10	Slc7a5	tumor-associated protein 1	TA1		Symbol and Name updated	1299863	APPROVED
2002-08-07	TA1	tumor-associated protein 1			Symbol and Name status set to provisional	70820	PROVISIONAL

RGD Curation Notes

Note Type	Note	Reference
gene_domains	contains multiple hydrophobic transmembrane domains	634202
gene_expression	expressed in the normal adult rat tissues including testes, brain, ovary, spleen, mammary gland, and uterus; differentially expressed between hepatoma cells and normal liver	634202
gene_process	human cDNA is associated with lymphocyte activation	634202

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Imported Annotations - SMPDB