RGD Reference Report - Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer. - Rat Genome Database

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Prognostic significance of amino-acid transporter expression (LAT1, ASCT2, and xCT) in surgically resected tongue cancer.

Authors: Toyoda, M  Kaira, K  Ohshima, Y  Ishioka, N S  Shino, M  Sakakura, K  Takayasu, Y  Takahashi, K  Tominaga, H  Oriuchi, N  Nagamori, S  Kanai, Y  Oyama, T  Chikamatsu, K 
Citation: Toyoda M, etal., Br J Cancer. 2014 May 13;110(10):2506-13. doi: 10.1038/bjc.2014.178. Epub 2014 Apr 24.
RGD ID: 151361157
Pubmed: PMID:24762957   (View Abstract at PubMed)
PMCID: PMC4021522   (View Article at PubMed Central)
DOI: DOI:10.1038/bjc.2014.178   (Journal Full-text)


BACKGROUND: Amino-acid transporters are necessary for the tumour cell growth and survival, and have a crucial role in the development and invasiveness of cancer cells. But, it remains unclear about the prognostic significance of L-type amino-acid transporter 1 (LAT1), system ASC amino-acid transporter-2 (ASCT2), and xCT expression in patients with tongue cancer. We conducted the clinicopathological study to investigate the protein expression of these amino-acid transporters in tongue cancer.
METHODS: Eighty-five patients with surgically resected tongue cancer were evaluated. Tumour sections were stained by immunohistochemistry for LAT1, ASCT2, xCT, 4F2hc/CD98hc (4F2hc), Ki-67, and microvessel density (MVD) determined by CD34, and p53.
RESULTS: L-type amino-acid transporter 1 and 4F2hc were highly expressed in 61% (52 out of 85) and 45% (38 out of 47), respectively. ASC amino-acid transporter-2 and xCT were positively expressed in 59% (50 out of 85) and 21% (18 out of 85), respectively. The expression of both LAT1 and ASCT2 was significantly associated with disease staging, lymph-node metastasis, lymphatic permeation, 4F2hc expression and cell proliferation (Ki-67). xCT expression indicated a significant association with advanced stage and tumour factor. By univariate analysis, disease staging, lymphatic permeation, vascular invasion, LAT1, ASCT2, 4F2hc, and Ki-67 had a significant relationship with overall survival. Multivariate analysis confirmed that LAT1 was an independent prognostic factor for predicting poor prognosis.
CONCLUSIONS: L-type amino-acid transporter 1 and ASCT2 can serve as a significant prognostic factor for predicting worse outcome after surgical treatment and may have an important role in the development and aggressiveness of tongue cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Objects Annotated

Genes (Rattus norvegicus)
Slc1a5  (solute carrier family 1 member 5)
Slc3a2  (solute carrier family 3 member 2)
Slc7a11  (solute carrier family 7 member 11)
Slc7a5  (solute carrier family 7 member 5)

Genes (Mus musculus)
Slc1a5  (solute carrier family 1 (neutral amino acid transporter), member 5)
Slc3a2  (solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2)
Slc7a11  (solute carrier family 7 (cationic amino acid transporter, y+ system), member 11)
Slc7a5  (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)

Genes (Homo sapiens)
SLC1A5  (solute carrier family 1 member 5)
SLC3A2  (solute carrier family 3 member 2)
SLC7A11  (solute carrier family 7 member 11)
SLC7A5  (solute carrier family 7 member 5)


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