RGD Reference Report - L-type amino acid transporter 1 expression in esophageal carcinogenesis according to WHO and Japanese classifications of intraepithelial neoplasia. - Rat Genome Database

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L-type amino acid transporter 1 expression in esophageal carcinogenesis according to WHO and Japanese classifications of intraepithelial neoplasia.

Authors: Hashimoto, Hirotsugu  Kurata, Atsushi  Kikuchi, Hiroyuki  Masuda, Yoshio  Fujita, Koji  Okuyama, Rikiya  Inoue, Shigeru  Horiuchi, Hajime  Kuroda, Masahiko 
Citation: Hashimoto H, etal., Pathol Int. 2017 May;67(5):247-255. doi: 10.1111/pin.12528. Epub 2017 Mar 29.
RGD ID: 151361286
Pubmed: PMID:28370814   (View Abstract at PubMed)
DOI: DOI:10.1111/pin.12528   (Journal Full-text)

L-type amino acid transporter 1 (LAT1) has an essential role in cell proliferation especially in neoplasms. Although immunohistochemical expression of LAT1 has been investigated in invasive esophageal carcinoma, its expression in intraepithelial neoplasia (IEN) has not been reported. Further, classification of esophageal IEN is currently different between the World Health Organization (WHO) and Japanese criteria. Therefore, in this study, immunohistochemical expressions of LAT1 along with Ki-67 were analyzed in 66 esophageal samples of endoscopic submucosal dissection. Extension of cells positive for either marker within the epithelium, along with LAT1 intensity at the base of the epithelium, was evaluated. The results among early IENs, progressed IENs, and invasive carcinoma based on both WHO and Japanese criteria were compared. It was demonstrated that Ki-67+ cells extended toward the superficial layer in IENs, which was more pronounced in progressed compared with early IENs based on both WHO and Japanese criteria. Although similar results were obtained for LAT1+ cells, LAT1+ cell extended more in invasive carcinoma than in progressed IENs according to the WHO criteria. Further, LAT1 intensity was different between early and progressed IENs based on the Japanese criteria alone. Thus, use of LAT1 immunohistochemistry and Japanese classification may be more meaningful to characterize esophageal carcinogenesis.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
SLC7A5Humanesophagitis  IEP protein:increased expression:epitheliumRGD 
Slc7a5Ratesophagitis  ISOSLC7A5 (Homo sapiens)protein:increased expression:epitheliumRGD 
Slc7a5Mouseesophagitis  ISOSLC7A5 (Homo sapiens)protein:increased expression:epitheliumRGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc7a5  (solute carrier family 7 member 5)

Genes (Mus musculus)
Slc7a5  (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)

Genes (Homo sapiens)
SLC7A5  (solute carrier family 7 member 5)


Additional Information