RGD Reference Report - L-type amino-acid transporter 1 expression predicts the response to preoperative hyperthermo-chemoradiotherapy for advanced rectal cancer. - Rat Genome Database

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L-type amino-acid transporter 1 expression predicts the response to preoperative hyperthermo-chemoradiotherapy for advanced rectal cancer.

Authors: Ebara, Takeshi  Kaira, Kyoichi  Saito, Jun-Ichi  Shioya, Mariko  Asao, Takayuki  Takahashi, Takeo  Sakurai, Hideyuki  Kanai, Yoshikatsu  Kuwano, Hiroyuki  Nakano, Takashi 
Citation: Ebara T, etal., Anticancer Res. 2010 Oct;30(10):4223-7.
RGD ID: 151361202
Pubmed: PMID:21036745   (View Abstract at PubMed)


AIM: To evaluate whether expression of L-type amino acid transporter 1 (LAT1) in pretreatment rectal cancer biopsies is predictive of tumour response to neoadjuvant hyperthermo-chemoradiotherapy (HCRT).
PATIENTS AND METHODS: Forty-four patients with rectal adenocarcinoma who received neoadjuvant HCRT were investigated. LAT1 expression was immunohistochemically evaluated using pretreatment biopsies. The operation was performed after 2-3 months following HCRT and each resected specimen was graded by the histological criteria of the Japanese Classification of Colorectal Carcinoma.
RESULTS: A positive LAT1 expression was recognized in 50.0% (22/44) of patients. Resected specimens were divided into 2 groups according to the histological grading criteria: good response (n=29) and poor response (n=15). LAT1-negative tumours had an 81.8% probability of good response and 18.2% probability of poor response. LAT1 expression showed marginally significant association with response to HCRT (p=0.05).
CONCLUSION: LAT1 may be a useful predictive marker of response to HCRT in rectal cancer.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
rectum adenocarcinoma treatmentIEP 151361202 RGD 
rectum adenocarcinoma treatmentISOSLC7A5 (Homo sapiens)151361202; 151361202 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Slc7a5  (solute carrier family 7 member 5)

Genes (Mus musculus)
Slc7a5  (solute carrier family 7 (cationic amino acid transporter, y+ system), member 5)

Genes (Homo sapiens)
SLC7A5  (solute carrier family 7 member 5)


Additional Information