Qpct (glutaminyl-peptide cyclotransferase) - Rat Genome Database

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Gene: Qpct (glutaminyl-peptide cyclotransferase) Rattus norvegicus
Analyze
Symbol: Qpct
Name: glutaminyl-peptide cyclotransferase
RGD ID: 1562284
Description: Predicted to enable glutaminyl-peptide cyclotransferase activity and zinc ion binding activity. Predicted to be located in extracellular region. Orthologous to human QPCT (glutaminyl-peptide cyclotransferase); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: glutaminyl cyclase; glutaminyl-peptide cyclotransferase (glutaminyl cyclase); glutaminyl-peptide cyclotransferase-like 1; hypothetical protein LOC313837; LOC313837; Qpctl1; RGD1562284; similar to Glutaminyl-peptide cyclotransferase precursor (QC); similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase); uncharacterized protein LOC313837
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,716,824 - 21,748,895 (-)NCBIGRCr8
mRatBN7.2615,964,656 - 15,996,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,964,657 - 15,996,711 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx616,280,262 - 16,313,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0616,602,485 - 16,635,791 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0616,083,483 - 16,116,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.061,657,110 - 1,689,575 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,657,331 - 1,689,559 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,647,419 - 1,679,764 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.461,845,425 - 1,878,423 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera615,630,306 - 15,661,878 (-)NCBICelera
Cytogenetic Map6q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bexarotene  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
carbon nanotube  (ISO)
carmustine  (ISO)
choline  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
clothianidin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cyclosporin A  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
diethylstilbestrol  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
ethanol  (ISO)
fenofibrate  (EXP)
folic acid  (ISO)
gemfibrozil  (EXP)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
L-methionine  (ISO)
lead(0)  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel sulfate  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
pentanal  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (EXP,ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
quercetin  (ISO)
quinolin-8-ol  (ISO)
ritodrine  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
succimer  (ISO)
sulforaphane  (ISO)
temozolomide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
topotecan  (EXP)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Glutaminyl cyclases as novel targets for the treatment of septic arthritis. Hellvard A, etal., J Infect Dis. 2013 Mar 1;207(5):768-77. doi: 10.1093/infdis/jis729. Epub 2012 Nov 29.
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7999256   PMID:21288892   PMID:23376485   PMID:23533145   PMID:25002582  


Genomics

Comparative Map Data
Qpct
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8621,716,824 - 21,748,895 (-)NCBIGRCr8
mRatBN7.2615,964,656 - 15,996,730 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl615,964,657 - 15,996,711 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx616,280,262 - 16,313,568 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0616,602,485 - 16,635,791 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0616,083,483 - 16,116,422 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.061,657,110 - 1,689,575 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl61,657,331 - 1,689,559 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.061,647,419 - 1,679,764 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.461,845,425 - 1,878,423 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera615,630,306 - 15,661,878 (-)NCBICelera
Cytogenetic Map6q12NCBI
QPCT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38237,344,630 - 37,373,322 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl237,342,827 - 37,373,322 (+)EnsemblGRCh38hg38GRCh38
GRCh37237,571,773 - 37,600,465 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36237,425,257 - 37,453,969 (+)NCBINCBI36Build 36hg18NCBI36
Build 34237,483,519 - 37,512,115NCBI
Celera237,412,695 - 37,441,406 (+)NCBICelera
Cytogenetic Map2p22.2NCBI
HuRef237,311,579 - 37,340,390 (+)NCBIHuRef
CHM1_1237,501,200 - 37,529,906 (+)NCBICHM1_1
T2T-CHM13v2.0237,351,621 - 37,380,410 (+)NCBIT2T-CHM13v2.0
Qpct
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391779,359,335 - 79,397,807 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1779,359,335 - 79,397,807 (+)EnsemblGRCm39 Ensembl
GRCm381779,051,906 - 79,090,378 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1779,051,906 - 79,090,378 (+)EnsemblGRCm38mm10GRCm38
MGSCv371779,451,246 - 79,489,583 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361778,956,964 - 78,995,436 (+)NCBIMGSCv36mm8
MGSCv361778,307,076 - 78,344,882 (+)NCBIMGSCv36mm8
Celera1783,366,401 - 83,403,264 (+)NCBICelera
Cytogenetic Map17E3NCBI
cM Map1749.83NCBI
Qpct
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554415,138,477 - 5,168,455 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554415,138,477 - 5,168,056 (+)NCBIChiLan1.0ChiLan1.0
QPCT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21289,106,271 - 89,135,090 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A89,110,245 - 89,139,229 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A37,371,848 - 37,400,820 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A38,136,537 - 38,165,254 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A38,136,532 - 38,165,254 (+)Ensemblpanpan1.1panPan2
QPCT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11729,700,422 - 29,741,652 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1729,716,378 - 29,741,221 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1729,531,103 - 29,555,598 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01730,366,927 - 30,391,480 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1730,366,993 - 30,392,807 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11729,593,903 - 29,618,395 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01729,660,151 - 29,684,689 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01729,875,410 - 29,899,919 (+)NCBIUU_Cfam_GSD_1.0
Qpct
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629242,264,101 - 42,294,078 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936663929,363 - 959,668 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936663929,737 - 959,458 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
QPCT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3102,792,720 - 102,823,026 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13102,795,199 - 102,823,090 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23109,332,654 - 109,360,644 (-)NCBISscrofa10.2Sscrofa10.2susScr3
QPCT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11470,015,260 - 70,044,033 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1470,015,261 - 70,043,941 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604541,903,220 - 41,931,940 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Qpct
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473818,945,969 - 18,984,016 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473818,945,954 - 18,984,016 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Qpct
301 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:41
Interacting mature miRNAs:44
Transcripts:ENSRNOT00000049672
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552962Pigfal16Plasma insulin-like growth factor 1 level QTL 169.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)6141223769Rat
1549905Stresp10Stress response QTL 106.830.0066stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)6127574569Rat
10401812Kidm54Kidney mass QTL 54kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1331743Uae28Urinary albumin excretion QTL 284.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)6134235784Rat
10401800Kidm49Kidney mass QTL 49kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)61436878859368788Rat
1300164Rf15Renal function QTL 153.12renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449754641141Rat
9589129Insul24Insulin level QTL 2419.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)6141223769Rat
1578758Tcas9Tongue tumor susceptibility QTL 93.29tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)6137618905Rat
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)610894415110548006Rat
7411603Foco13Food consumption QTL 135.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6141223769Rat
1598843Cm63Cardiac mass QTL 632.6heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)6139036266Rat
738024Sach5Saccharine consumption QTL 53.90.00039consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)6143394190Rat
7411542Bw127Body weight QTL 1275.50.001body mass (VT:0001259)body weight gain (CMO:0000420)6141223769Rat
2293706Bmd20Bone mineral density QTL 204.30.0002femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)6507449719988050Rat
9589048Scfw3Subcutaneous fat weight QTL 34.570.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)6141223769Rat
2292616Ept15Estrogen-induced pituitary tumorigenesis QTL 154.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
738023Alc17Alcohol consumption QTL 173.10.003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)6127574569Rat
1354616Despr12Despair related QTL 120.0012locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)6127574569Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)615107216107351382Rat
2293709Bss23Bone structure and strength QTL 235.180.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)6142487980Rat
2293650Bss31Bone structure and strength QTL 315.050.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)6142487980Rat
7411584Foco4Food consumption QTL 44.30.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)6142838846Rat
1578665Bss16Bone structure and strength QTL 164.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)61173566972593685Rat
2300176Bmd51Bone mineral density QTL 5111.70.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)6127574569Rat
1300128Rf16Renal function QTL 163.89renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)6507449734434305Rat
1578668Bmd14Bone mineral density QTL 143.8femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)61173566972593685Rat
2301972Bp325Blood pressure QTL 3254.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)6172227641Rat
2293656Bss28Bone structure and strength QTL 286.790.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)6142487980Rat
1358190Ept1Estrogen-induced pituitary tumorigenesis QTL 14.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)6984331220338915Rat
2300190Bmd52Bone mineral density QTL 5211.20.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)6127574569Rat

Markers in Region
RH128088  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2615,964,967 - 15,965,183 (-)MAPPERmRatBN7.2
Rnor_6.061,689,048 - 1,689,263NCBIRnor6.0
Rnor_5.061,679,237 - 1,679,452UniSTSRnor5.0
RGSC_v3.461,877,742 - 1,877,957UniSTSRGSC3.4
Celera615,630,166 - 15,630,381UniSTS
Cytogenetic Map6q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 58 58 58 92 15 33
Low 15 135 136 72 62 72 32 40 142 108 130 24 24
Below cutoff 6 33 17 7 17 5 16 7

Sequence


Ensembl Acc Id: ENSRNOT00000049672   ⟹   ENSRNOP00000045568
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl615,964,657 - 15,996,711 (-)Ensembl
Rnor_6.0 Ensembl61,657,331 - 1,689,559 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079864   ⟹   ENSRNOP00000072958
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl615,964,657 - 15,996,699 (-)Ensembl
Rnor_6.0 Ensembl61,657,332 - 1,689,123 (+)Ensembl
RefSeq Acc Id: NM_001134557   ⟹   NP_001128029
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,716,824 - 21,748,895 (-)NCBI
mRatBN7.2615,964,656 - 15,996,730 (-)NCBI
Rnor_6.061,657,332 - 1,689,123 (+)NCBI
Rnor_5.061,647,419 - 1,679,764 (+)NCBI
RGSC_v3.461,845,425 - 1,878,423 (+)RGD
Celera615,630,306 - 15,661,878 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001399516   ⟹   NP_001386445
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8621,716,824 - 21,748,895 (-)NCBI
mRatBN7.2615,964,656 - 15,996,730 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001128029 (Get FASTA)   NCBI Sequence Viewer  
  NP_001386445 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC28781 (Get FASTA)   NCBI Sequence Viewer  
  EDM02796 (Get FASTA)   NCBI Sequence Viewer  
  EDM02797 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000045568.3
  ENSRNOP00000072958.1
RefSeq Acc Id: NP_001128029   ⟸   NM_001134557
- Peptide Label: isoform 2
- UniProtKB: A0A0G2K497 (UniProtKB/TrEMBL),   A6H9U1 (UniProtKB/TrEMBL),   A6H9U2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072958   ⟸   ENSRNOT00000079864
Ensembl Acc Id: ENSRNOP00000045568   ⟸   ENSRNOT00000049672
RefSeq Acc Id: NP_001386445   ⟸   NM_001399516
- Peptide Label: isoform 1
- UniProtKB: A6H9U2 (UniProtKB/TrEMBL),   D4AC85 (UniProtKB/TrEMBL)
Protein Domains
Peptidase M28

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC85-F1-model_v2 AlphaFold D4AC85 1-362 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694362
Promoter ID:EPDNEW_R4884
Type:initiation region
Name:Qpct_1
Description:glutaminyl-peptide cyclotransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.061,657,320 - 1,657,380EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1562284 AgrOrtholog
BioCyc Gene G2FUF-38498 BioCyc
BioCyc Pathway PWY-7942 [5-oxo-L-proline metabolism] BioCyc
BioCyc Pathway Image PWY-7942 BioCyc
Ensembl Genes ENSRNOG00000005705 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000049672.5 UniProtKB/TrEMBL
  ENSRNOT00000079864.2 UniProtKB/TrEMBL
Gene3D-CATH Zn peptidases UniProtKB/TrEMBL
InterPro M28_QC_like UniProtKB/TrEMBL
  Peptidase_M28 UniProtKB/TrEMBL, UniProtKB/TrEMBL
  QC/QCL UniProtKB/TrEMBL
KEGG Report rno:313837 UniProtKB/TrEMBL
NCBI Gene 313837 ENTREZGENE
PANTHER GLUTAMINYL-PEPTIDE CYCLOTRANSFERASE UniProtKB/TrEMBL
  PTHR12283 UniProtKB/TrEMBL
Pfam Peptidase_M28 UniProtKB/TrEMBL
PhenoGen Qpct PhenoGen
RatGTEx ENSRNOG00000005705 RatGTEx
Superfamily-SCOP Zn-dependent exopeptidases UniProtKB/TrEMBL
UniProt A0A0G2K497 ENTREZGENE, UniProtKB/TrEMBL
  A6H9U1 ENTREZGENE, UniProtKB/TrEMBL
  A6H9U2 ENTREZGENE, UniProtKB/TrEMBL
  D4AC85 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-18 Qpct  glutaminyl-peptide cyclotransferase  Qpctl1  glutaminyl-peptide cyclotransferase-like 1  Data merged from RGD:621086 737654 APPROVED
2013-11-25 Qpctl1  glutaminyl-peptide cyclotransferase-like 1  Qpct  glutaminyl-peptide cyclotransferase  Name and Symbol changed 629549 APPROVED
2013-11-25 Qpct  glutaminyl-peptide cyclotransferase  RGD1562284  similar to Glutaminyl-peptide cyclotransferase precursor (QC)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-11-20 Qpct  glutaminyl-peptide cyclotransferase  Qpct  glutaminyl-peptide cyclotransferase (glutaminyl cyclase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1562284  similar to Glutaminyl-peptide cyclotransferase precursor (QC)   RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-10 RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (predicted)  RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) (predicted)  Name updated 1299863 APPROVED
2006-03-10 RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (predicted)    similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) (predicted)  Name updated 1299863 APPROVED
2006-03-07 RGD1562284_predicted  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase) (predicted)  LOC313837  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC313837  similar to Glutaminyl-peptide cyclotransferase precursor (QC) (Glutaminyl-tRNA cyclotransferase) (Glutaminyl cyclase)      Symbol and Name status set to provisional 70820 PROVISIONAL
2004-09-10 Qpct  glutaminyl-peptide cyclotransferase (glutaminyl cyclase)  Qpct  glutaminyl cyclase  Name updated 1299863 APPROVED
2004-09-10 Qpct  glutaminyl-peptide cyclotransferase (glutaminyl cyclase)    glutaminyl cyclase  Name updated 1299863 APPROVED
2002-08-07 Qpct  glutaminyl cyclase      Symbol and Name status set to provisional 70820 PROVISIONAL