Nfkb1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: Nfkb1 (nuclear factor kappa B subunit 1) Rattus norvegicus
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Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
RGD ID: 70498
Description: Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (E)-roxithromycin; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding factor KBF1; EBP-1; NF-kappaB; NF-kB; nuclear factor kappa B p105 subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP,ISO)
7H-xanthine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (EXP)
[6]-Shogaol  (ISO)
abamectin  (EXP)
acenaphthoquinone  (ISO)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
Actein  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
aluminium sulfate (anhydrous)  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphibole asbestos  (ISO)
anethole  (ISO)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
aripiprazole  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
aurantio-obtusin  (ISO)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
butyric acid  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
carboplatin  (EXP,ISO)
Cardamonin  (EXP)
carmustine  (EXP,ISO)
carvacrol  (ISO)
casticin  (ISO)
CCCP  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chrysin  (EXP)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproheptadine  (EXP)
D-glucose  (ISO)
daidzein  (ISO)
danazol  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicofol  (ISO)
dicoumarol  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (ISO)
diltiazem  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP)
enalapril  (EXP)
endosulfan  (EXP,ISO)
endrin  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl acetate  (ISO)
ethylene glycol  (EXP)
ethylisopropylamiloride  (ISO)
eugenol  (EXP,ISO)
Evodiamine  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flurbiprofen  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
gastrin-17  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside C-K  (EXP)
glafenine  (EXP)
gliotoxin  (ISO)
glucaric acid  (ISO)
glucose  (ISO)
glutathione  (ISO)
glutathione disulfide  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
guggulsterone  (EXP,ISO)
GW 501516  (ISO)
haloperidol  (EXP)
harmaline  (ISO)
heme b  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanreotide  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
leptomycin B  (ISO)
limonene  (EXP)
linalool  (ISO)
linoleic acid  (EXP)
lipoarabinomannan  (ISO)
lipoic acid  (EXP,ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
losartan  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (EXP)
maneb  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
Mecamylamine  (EXP,ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP,ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mevinphos  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
monotropein  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
myo-inositol hexakisphosphate  (ISO)
Myrtucommulone A  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naproxen  (ISO)
naringin  (EXP)
Neferine  (EXP)
neoechinulin A  (ISO)
neratinib  (ISO)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
o-anisidine  (ISO)
obeticholic acid  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (EXP,ISO)
PD123319  (EXP)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perindopril  (ISO)
permethrin  (EXP)
pevonedistat  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanil  (ISO)
propionic acid  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ritonavir  (ISO)
rocaglamide  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
salicylates  (EXP)
sarin  (EXP)
SB 203580  (ISO)
scoparone  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
succimer  (EXP,ISO)
succinic acid  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
trans-anethole  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
Tropicamide  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
WR-1065  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zingerone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to angiotensin  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IDA)
cellular response to carbohydrate stimulus  (IDA)
cellular response to cytokine stimulus  (IDA)
cellular response to diterpene  (IDA)
cellular response to dsRNA  (ISO)
cellular response to glucoside  (IDA)
cellular response to interleukin-1  (IDA,ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (IDA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to peptide  (IDA)
cellular response to tumor necrosis factor  (IDA,IEP,ISO)
cellular response to virus  (ISO)
gene expression  (ISO)
JNK cascade  (ISO)
leukocyte migration involved in inflammatory response  (IEP)
mammary gland involution  (ISO)
MAPK cascade  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of calcidiol 1-monooxygenase activity  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of gene expression  (IMP)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of miRNA metabolic process  (ISO)
positive regulation of miRNA transcription  (IMP)
positive regulation of miRNA-mediated gene silencing  (IMP)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA,IEA)
response to bacterium  (IEP)
response to copper ion  (IEP)
response to ethanol  (IEP)
response to muscle stretch  (ISO)
response to organic cyclic compound  (IDA,IEP)
response to oxidative stress  (IDA)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
system development  (IEA)

Cellular Component
cytoplasm  (IDA,IEA,ISO)
cytosol  (IDA,ISO)
mitochondrion  (ISO)
neuron projection  (IDA)
NF-kappaB complex  (ISO)
nucleoplasm  (ISO)
nucleus  (IDA,IEA,ISO,TAS)
protein-containing complex  (IDA)

References

References - curated
# Reference Title Reference Citation
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21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
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39. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
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41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
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45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
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49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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53. Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. Ramirez SH, etal., J Neurochem. 2001 Aug;78(4):874-89.
54. GOA pipeline RGD automated data pipeline
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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65. Contact of Chlamydophila pneumoniae with type II cell triggers activation of calcium-mediated NF-kappa B pathway. Wissel H, etal., Biochim Biophys Acta. 2005 Mar 22;1743(1-2):37-48.
66. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
67. microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism. Yang Q, etal., Mol Med Rep. 2014 Jun;9(6):2213-20. doi: 10.3892/mmr.2014.2068. Epub 2014 Mar 24.
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69. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
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71. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. Zhang HM, etal., Am J Physiol Cell Physiol. 2006 May;290(5):C1310-20. Epub 2005 Dec 14.
72. Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury. Zhang J, etal., PLoS One. 2019 Sep 6;14(9):e0222033. doi: 10.1371/journal.pone.0222033. eCollection 2019.
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74. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
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Additional References at PubMed
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Genomics

Candidate Gene Status
Nfkb1 is a candidate Gene for QTL Eau5
Comparative Map Data
Nfkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
NFKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,501,359 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4102,501,331 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBI
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
T2T-CHM13v2.04105,815,285 - 105,931,246 (+)NCBI
Nfkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,290,416 - 135,397,728 (-)NCBIGRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBImm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
Nfkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
NFKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0panPan3
NFKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBI
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBI
ROS_Cfam_1.0 Ensembl3224,141,192 - 24,259,887 (+)Ensembl
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBI
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBI
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBI
Nfkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBI
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,390,637 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
NFKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,589,494 - 50,711,472 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBIVero_WHO_p1.0
Nfkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,333,616 - 5,408,723 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
D2Mco50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,097,958 - 224,098,088 (+)MAPPERmRatBN7.2
Rnor_6.02240,856,230 - 240,856,359NCBIRnor6.0
Rnor_5.02259,411,018 - 259,411,147UniSTSRnor5.0
RGSC_v3.42233,177,238 - 233,177,367UniSTSRGSC3.4
Celera2216,306,923 - 216,307,052UniSTS
Cytogenetic Map2q43UniSTS
RH127857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,016,559 - 224,016,753 (+)MAPPERmRatBN7.2
Rnor_6.02240,773,866 - 240,774,059NCBIRnor6.0
Rnor_5.02259,330,723 - 259,330,916UniSTSRnor5.0
RGSC_v3.42233,091,359 - 233,091,552UniSTSRGSC3.4
Celera2216,227,195 - 216,227,388UniSTS
RH 3.4 Map21563.3UniSTS
Cytogenetic Map2q43UniSTS
PMC213488P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,053,636 - 224,053,739 (+)MAPPERmRatBN7.2
Rnor_6.02240,811,118 - 240,811,220NCBIRnor6.0
Rnor_5.02259,367,975 - 259,368,077UniSTSRnor5.0
RGSC_v3.42233,128,434 - 233,128,536UniSTSRGSC3.4
Celera2216,263,668 - 216,263,770UniSTS
Cytogenetic Map2q43UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of r