Nfkb1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: Nfkb1 (nuclear factor kappa B subunit 1) Rattus norvegicus
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Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
RGD ID: 70498
Description: Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to cytokine stimulus; and cellular response to lipid. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Part of protein-containing complex. Used to study steatotic liver disease. Biomarker of alcoholic hepatitis; hepatocellular carcinoma; metabolic dysfunction-associated steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency 12; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding factor KBF1; EBP-1; NF-kappaB; NF-kB; nuclear factor kappa B p105 subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Eau5
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,689,745 - 226,805,897 (-)NCBIGRCr8
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-catechin  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP,ISO)
7H-xanthine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (EXP)
[6]-Shogaol  (ISO)
abamectin  (EXP)
acenaphthoquinone  (ISO)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
Actein  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (EXP)
aluminium atom  (EXP)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphibole asbestos  (ISO)
anethole  (ISO)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
aripiprazole  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
aurantio-obtusin  (ISO)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (EXP,ISO)
busulfan  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
Calphostin C  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
carboplatin  (EXP,ISO)
Cardamonin  (EXP)
carmustine  (EXP,ISO)
carteolol  (ISO)
carvacrol  (EXP,ISO)
casticin  (ISO)
CCCP  (ISO)
CEDRELONE  (ISO)
celecoxib  (ISO)
cerium  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chrysin  (EXP)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproheptadine  (EXP)
D-glucose  (ISO)
daidzein  (ISO)
danazol  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicofol  (ISO)
dicoumarol  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (ISO)
diltiazem  (ISO)
dimethyl fumarate  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioscin  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
diquat  (EXP)
disodium selenite  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
endrin  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl acetate  (ISO)
ethylene glycol  (EXP)
ethylisopropylamiloride  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
Evodiamine  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flurbiprofen  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (ISO)
FR900359  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
gastrin-17  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside C-K  (EXP)
glafenine  (EXP)
gliotoxin  (ISO)
glucaric acid  (ISO)
glucose  (ISO)
glutathione  (ISO)
glutathione disulfide  (EXP,ISO)
glyburide  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (EXP,ISO)
GW 501516  (ISO)
haloperidol  (EXP)
harmaline  (ISO)
heme b  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactulose  (EXP)
lanreotide  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leptomycin B  (ISO)
limonene  (EXP)
linalool  (ISO)
linoleic acid  (EXP)
lipoarabinomannan  (ISO)
lipoic acid  (EXP,ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
losartan  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (EXP)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (EXP,ISO)
Mecamylamine  (EXP,ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP,ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
mevinphos  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
monotropein  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
myo-inositol hexakisphosphate  (ISO)
Myrtucommulone A  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naproxen  (ISO)
naringin  (EXP)
Neferine  (EXP)
neoechinulin A  (ISO)
neratinib  (ISO)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
o-anisidine  (ISO)
obeticholic acid  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (EXP,ISO)
PD123319  (EXP)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perindopril  (ISO)
permethrin  (EXP)
pevonedistat  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
procyanidin B1  (ISO)
progesterone  (ISO)
propanil  (ISO)
propionic acid  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
purine-6-thiol  (ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ritonavir  (ISO)
rocaglamide  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
salicylates  (EXP)
Salinomycin  (ISO)
sarin  (EXP)
SB 203580  (ISO)
scoparone  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium disulfite  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
succimer  (EXP,ISO)
succinic acid  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
thalidomide  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
thymoquinone  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
trans-anethole  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
Tropicamide  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
WR-1065  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zingerone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA,ISO)
apoptotic process  (IEA)
B cell receptor signaling pathway  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cellular response to angiotensin  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IDA)
cellular response to carbohydrate stimulus  (IDA)
cellular response to cytokine stimulus  (IDA)
cellular response to diterpene  (IDA)
cellular response to dsRNA  (IEA,ISO)
cellular response to glucoside  (IDA)
cellular response to interleukin-1  (IDA,IEA,ISO)
cellular response to interleukin-17  (IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to lipopolysaccharide  (IDA,IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nicotine  (IEA,ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to peptide  (IDA)
cellular response to tumor necrosis factor  (IDA,IEA,IEP,ISO)
cellular response to virus  (IEA,ISO)
gene expression  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukocyte migration involved in inflammatory response  (IEP)
mammary gland involution  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of cytokine production  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
non-canonical NF-kappaB signal transduction  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of hyaluronan biosynthetic process  (IEA,ISO)
positive regulation of miRNA metabolic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
response to bacterium  (IEP)
response to copper ion  (IEP)
response to ethanol  (IEP)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (IDA,IEP)
response to oxidative stress  (IDA)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. Ahn JY, etal., EMBO J. 2006 May 17;25(10):2083-95. Epub 2006 Apr 27.
2. Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats. Aragno M, etal., Endocrinology 2002 Sep;143(9):3250-8.
3. Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. Artis D, etal., J Immunol. 2002 Oct 15;169(8):4481-7. doi: 10.4049/jimmunol.169.8.4481.
4. Suppression of 7,12-Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol: Role of Nuclear Factor-kappaB, Cyclooxygenase 2, and Matrix Metalloprotease 9. Banerjee S, etal., Cancer Res 2002 Sep 1;62(17):4945-54.
5. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Bourteele S, etal., Cell Microbiol. 2007 Sep;9(9):2202-17. doi: 10.1111/j.1462-5822.2007.00950.x. Epub 2007 Jun 15.
6. Importance of polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes for melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients. Bu H, etal., J Cancer Res Clin Oncol. 2007 Nov;133(11):859-66. Epub 2007 May 11.
7. NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. Burkitt MD, etal., J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.
8. Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Burkitt MD, etal., Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334. Epub 2013 Aug 26.
9. The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. Camandola S, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):53-60.
10. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Chen HW, etal., Shock. 2005 Sep;24(3):232-8.
11. Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Chen J, etal., Mol Med Report. 2011 Jun 2. doi: 10.3892/mmr.2011.501.
12. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
13. The NF-kappaB p50 subunit is protective during intestinal Entamoeba histolytica infection of 129 and C57BL/6 mice. Cho KN, etal., Infect Immun. 2010 Apr;78(4):1475-81. doi: 10.1128/IAI.00669-09. Epub 2010 Jan 19.
14. Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats. Clemens JA, etal., Stroke. 1997 May;28(5):1073-80; discussion 1080-1.
15. Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer. Cui X, etal., Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.
16. The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. Droebner K, etal., Viral Immunol. 2010 Jun;23(3):295-308. doi: 10.1089/vim.2009.0101.
17. The -94Ins/DelATTG polymorphism in NF¿B1 promoter modulates chronic hepatitis C and liver disease progression. Fakhir FZ, etal., Infect Genet Evol. 2016 Apr;39:141-6. doi: 10.1016/j.meegid.2016.01.023. Epub 2016 Jan 28.
18. Targeting cytokine expression in glial cells by cellular delivery of an NF-kappaB decoy. Fisher L, etal., J Mol Neurosci. 2007;31(3):209-19.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Nuclear factor-kappaB mediates the cell survival-promoting action of activity-dependent neurotrophic factor peptide-9. Glazner GW, etal., J Neurochem. 2000 Jul;75(1):101-8.
21. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
22. The cardiac K+ channel KCNQ1 is essential for gastric acid secretion. Grahammer F, etal., Gastroenterology. 2001 May;120(6):1363-71.
23. Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Gupta S, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H20-9. Epub 2005 Mar 4.
24. Cloning of rat Sertoli cell follicle-stimulating hormone primary response complementary deoxyribonucleic acid: regulation of TSC-22 gene expression. Hamil KG and Hall SH, Endocrinology 1994 Mar;134(3):1205-12.
25. Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese. Han X, etal., Med Sci Monit. 2015 Jun 12;21:1707-15. doi: 10.12659/MSM.893471.
26. NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS. Harris TH, etal., J Neuroimmunol. 2010 May;222(1-2):19-28. doi: 10.1016/j.jneuroim.2009.12.009. Epub 2010 Feb 13.
27. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
28. IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. He Y, etal., Carcinogenesis. 2009 Nov;30(11):1916-22. doi: 10.1093/carcin/bgp226. Epub 2009 Oct 1.
29. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
30. Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway. Huang T, etal., Oxid Med Cell Longev. 2019 Jul 15;2019:5813985. doi: 10.1155/2019/5813985. eCollection 2019.
31. Constitutive NF-kappa B activity in neurons. Kaltschmidt C, etal., Mol Cell Biol. 1994 Jun;14(6):3981-92.
32. Neuroprotective effects of the new diterpene, CBNU06 against beta-amyloid-induced toxicity through the inhibition of NF-kappaB signaling pathway in PC12 cells. Kim HS, etal., Eur J Pharmacol. 2009 Nov 10;622(1-3):25-31. doi: 10.1016/j.ejphar.2009.09.007. Epub 2009 Sep 16.
33. Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. Kim MK, etal., Exp Gerontol. 2010 Jun;45(6):419-26. doi: 10.1016/j.exger.2010.03.005. Epub 2010 Mar 6.
34. Differential expression of genes involved with apoptosis, cell cycle, connective tissue proteins, fuel substrate utilization, inflammation and mitochondrial biogenesis in copper-deficient rat hearts: implication of a role for Nfkappab1. Klaahsen D, etal., J Nutr Biochem. 2007 Apr 4;.
35. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
36. TNF-alpha increases expression of IL-6 and ICAM-1 genes through activation of NF-kappaB in osteoblast-like ROS17/2.8 cells. Kurokouchi K, etal., J Bone Miner Res. 1998 Aug;13(8):1290-9.
37. Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response. Laes JF, etal., Cytogenet Cell Genet 2001;92(1-2):130-3.
38. Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-kappaB activation and target gene expression in cultured rat astrocytes. Lee SY, etal., Neurosci Res. 2006 Oct;56(2):204-12. Epub 2006 Jul 13.
39. JANEX-1, a JAK3 inhibitor, protects pancreatic islets from cytokine toxicity through downregulation of NF-kappaB activation and the JAK/STAT pathway. Lv N, etal., Exp Cell Res. 2009 Jul 15;315(12):2064-71. doi: 10.1016/j.yexcr.2009.04.021. Epub 2009 May 3.
40. Lack of association of a functional -94ins/delATTG NFKB1 promoter polymorphism with susceptibility and clinical expression of biopsy-proven giant cell arteritis in northwest Spain. Martin J, etal., J Rheumatol. 2006 Feb;33(2):285-8.
41. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
42. Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy. Miaskowski C, etal., J Pain Symptom Manage. 2017 Sep;54(3):305-316.e3. doi: 10.1016/j.jpainsymman.2017.05.007. Epub 2017 Aug 8.
43. Hypoosmolarity influences the activity of transcription factor NF-kappaB in rat H4IIE hepatoma cells. Michalke M, etal., FEBS Lett. 2000 Jan 7;465(1):64-8.
44. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Nakashima H, etal., Circulation. 2004 Jan 6;109(1):132-8. Epub 2003 Dec 8.
45. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
46. Helicobacter pylori induces apoptosis of rat gastric parietal cells. Neu B, etal., Am J Physiol Gastrointest Liver Physiol 2002 Aug;283(2):G309-18.
47. Age-related differences in NFkappaB translocation and Bcl-2/Bax ratio caused by TNFalpha and Abeta42 promote survival in middle-age neurons and death in old neurons. Patel JR and Brewer GJ, Exp Neurol. 2008 Sep;213(1):93-100. doi: 10.1016/j.expneurol.2008.05.007. Epub 2008 May 22.
48. Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. Pectasides D, etal., Anticancer Res. 2016 Dec;36(12):6347-6356.
49. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
50. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
51. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
52. Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. Planavila A, etal., J Biol Chem. 2005 Apr 29;280(17):17464-71. Epub 2005 Feb 22.
53. Neurotrophins prevent HIV Tat-induced neuronal apoptosis via a nuclear factor-kappaB (NF-kappaB)-dependent mechanism. Ramirez SH, etal., J Neurochem. 2001 Aug;78(4):874-89.
54. GOA pipeline RGD automated data pipeline
55. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
56. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
57. Beta-amyloid and brain-derived neurotrophic factor, BDNF, up-regulate the expression of glutamate transporter GLT-1/EAAT2 via different signaling pathways utilizing transcription factor NF-kappaB. Rodriguez-Kern A, etal., Neurochem Int. 2003 Sep-Oct;43(4-5):363-70.
58. NF-kappaB mediates alphavbeta3 integrin-induced endothelial cell survival. Scatena M, etal., J Cell Biol. 1998 May 18;141(4):1083-93.
59. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Schwabe RF and Brenner DA, Am J Physiol Gastrointest Liver Physiol 2002 Jul;283(1):G204-11.
60. Mullerian inhibiting substance regulates NFkappaB signaling and growth of mammary epithelial cells in vivo. Segev DL, etal., J Biol Chem 2001 Jul 20;276(29):26799-806.
61. Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer. Setlur SR, etal., Cancer Res. 2007 Nov 1;67(21):10296-303. doi: 10.1158/0008-5472.CAN-07-2173.
62. NF-kappaB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-kappaB function. Sun F, etal., Oncogene. 2016 May 5;35(18):2299-310. doi: 10.1038/onc.2015.299. Epub 2015 Aug 24.
63. Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. Talledo M, etal., J Med Virol. 2012 Feb;84(2):319-26. doi: 10.1002/jmv.22255.
64. The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population. Wang Y, etal., Int J Clin Exp Med. 2015 May 15;8(5):8153-7. eCollection 2015.
65. Mutation analysis and association studies of nuclear factor-kappaB1 in sporadic Parkinson's disease patients. Wintermeyer P, etal., J Neural Transm 2002 Sep;109(9):1181-8.
66. Contact of Chlamydophila pneumoniae with type II cell triggers activation of calcium-mediated NF-kappa B pathway. Wissel H, etal., Biochim Biophys Acta. 2005 Mar 22;1743(1-2):37-48.
67. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
68. microRNA-21 protects against ischemia-reperfusion and hypoxia-reperfusion-induced cardiocyte apoptosis via the phosphatase and tensin homolog/Akt-dependent mechanism. Yang Q, etal., Mol Med Rep. 2014 Jun;9(6):2213-20. doi: 10.3892/mmr.2014.2068. Epub 2014 Mar 24.
69. Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease. Yu Z, etal., J Mol Neurosci. 2000 Aug;15(1):31-44.
70. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
71. Combined prognostic value of both RelA and IkappaB-alpha expression in human non-small cell lung cancer. Zhang D, etal., Ann Surg Oncol. 2007 Dec;14(12):3581-92. doi: 10.1245/s10434-007-9560-z. Epub 2007 Sep 27.
72. Induced focal adhesion kinase expression suppresses apoptosis by activating NF-kappaB signaling in intestinal epithelial cells. Zhang HM, etal., Am J Physiol Cell Physiol. 2006 May;290(5):C1310-20. Epub 2005 Dec 14.
73. Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury. Zhang J, etal., PLoS One. 2019 Sep 6;14(9):e0222033. doi: 10.1371/journal.pone.0222033. eCollection 2019.
74. Nuclear factor-kappaB activates transcription of the androgen receptor gene in Sertoli cells isolated from testes of adult rats. Zhang L, etal., Endocrinology 2004 Feb;145(2):781-9. Epub 2003 Oct 23.
75. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
76. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
Additional References at PubMed
PMID:1406630   PMID:7959007   PMID:10395695   PMID:11819787   PMID:11931770   PMID:11976687   PMID:12200125   PMID:12372417   PMID:12482991   PMID:12598934   PMID:12618484   PMID:12631115  
PMID:12832462   PMID:12857444   PMID:12885587   PMID:12937821   PMID:12958148   PMID:12970181   PMID:14568984   PMID:14581482   PMID:14592850   PMID:14643899   PMID:14654230   PMID:14698955  
PMID:14732351   PMID:14732362   PMID:14767990   PMID:14963004   PMID:14980066   PMID:14988658   PMID:15025948   PMID:15033730   PMID:15059791   PMID:15072545   PMID:15102957   PMID:15123351  
PMID:15208316   PMID:15220916   PMID:15243130   PMID:15249201   PMID:15256225   PMID:15285020   PMID:15308653   PMID:15457532   PMID:15471861   PMID:15489638   PMID:15520226   PMID:15557322  
PMID:15596562   PMID:15621209   PMID:15720830   PMID:15722352   PMID:15728238   PMID:15777848   PMID:15817708   PMID:15845452   PMID:15888549   PMID:15935092   PMID:15944286   PMID:16051721  
PMID:16079148   PMID:16081776   PMID:16133867   PMID:16181409   PMID:16183991   PMID:16234240   PMID:16283433   PMID:16297318   PMID:16316997   PMID:16322063   PMID:16343770   PMID:16386177  
PMID:16463669   PMID:16489637   PMID:16574982   PMID:16597735   PMID:16677107   PMID:16677605   PMID:16680015   PMID:16707097   PMID:16771681   PMID:16772709   PMID:16840655   PMID:16874877  
PMID:16877563   PMID:16879219   PMID:16920808   PMID:16938301   PMID:16971004   PMID:17009244   PMID:17023425   PMID:17072978   PMID:17150179   PMID:17162607   PMID:17242297   PMID:17252537  
PMID:17324121   PMID:17327451   PMID:17396235   PMID:17409305   PMID:17416599   PMID:17426251   PMID:17427960   PMID:17505309   PMID:17535306   PMID:17555089   PMID:17604059   PMID:17609505  
PMID:17659437   PMID:17664391   PMID:17699727   PMID:17822789   PMID:17825480   PMID:17828497   PMID:17907174   PMID:17941794   PMID:17959522   PMID:17971865   PMID:17997883   PMID:18032528  
PMID:18045535   PMID:18090225   PMID:18183619   PMID:18212740   PMID:18270204   PMID:18274644   PMID:18274700   PMID:18278452   PMID:18278461   PMID:18305221   PMID:18397856   PMID:18400403  
PMID:18404532   PMID:18420947   PMID:18420952   PMID:18423996   PMID:18448529   PMID:18469338   PMID:18485627   PMID:18535404   PMID:18566389   PMID:18580810   PMID:18586672   PMID:18593633  
PMID:18615578   PMID:18633731   PMID:18649423   PMID:18662246   PMID:18701451   PMID:18703515   PMID:18708911   PMID:18718911   PMID:18726687   PMID:18753141   PMID:18769055   PMID:18822207  
PMID:18926072   PMID:18938092   PMID:18975780   PMID:18976964   PMID:19026727   PMID:19060913   PMID:19071154   PMID:19074556   PMID:19084916   PMID:19088456   PMID:19111928   PMID:19162042  
PMID:19189070   PMID:19199090   PMID:19211730   PMID:19215923   PMID:19236545   PMID:19238531   PMID:19241483   PMID:19251249   PMID:19279034   PMID:19327173   PMID:19342961   PMID:19362079  
PMID:19365232   PMID:19403032   PMID:19404405   PMID:19404732   PMID:19430970   PMID:19457567   PMID:19458123   PMID:19476648   PMID:19481766   PMID:19501592   PMID:19570345   PMID:19593445  
PMID:19620074   PMID:19629561   PMID:19655406   PMID:19666510   PMID:19689083   PMID:19717152   PMID:19719951   PMID:19720604   PMID:19726347   PMID:19730128   PMID:19734906   PMID:19780028  
PMID:19781177   PMID:19875812   PMID:19878863   PMID:19881551   PMID:19901262   PMID:19909798   PMID:19918364   PMID:19922500   PMID:19950592   PMID:19951488   PMID:19955433   PMID:19959479  
PMID:20018240   PMID:20039418   PMID:20043889   PMID:20051532   PMID:20060382   PMID:20092996   PMID:20093339   PMID:20095325   PMID:20095326   PMID:20133768   PMID:20150208   PMID:20150961  
PMID:20155797   PMID:20187708   PMID:20201932   PMID:20360002   PMID:20360648   PMID:20380796   PMID:20404057   PMID:20406206   PMID:20433640   PMID:20442316   PMID:20486843   PMID:20501675  
PMID:20518312   PMID:20537956   PMID:20601888   PMID:20646530   PMID:20687137   PMID:20705587   PMID:20717930   PMID:20731656   PMID:20813690   PMID:20840869   PMID:20849956   PMID:20979835  
PMID:21038672   PMID:21069255   PMID:21072674   PMID:21131739   PMID:21134288   PMID:21141136   PMID:21141517   PMID:21143912   PMID:21162919   PMID:21179738   PMID:21184129   PMID:21186580  
PMID:21186606   PMID:21186609   PMID:21186627   PMID:21211536   PMID:21220710   PMID:21252158   PMID:21265102   PMID:21311037   PMID:21326386   PMID:21356247   PMID:21357467   PMID:21389697  
PMID:21403895   PMID:21434346   PMID:21506880   PMID:21528054   PMID:21542286   PMID:21550382   PMID:21564349   PMID:21606643   PMID:21607291   PMID:21611132   PMID:21645265   PMID:21675862  
PMID:21683791   PMID:21699906   PMID:21717513   PMID:21723926   PMID:21729740   PMID:21734649   PMID:21764057   PMID:21772666   PMID:21816109   PMID:21819443   PMID:21858029   PMID:21866632  
PMID:21892747   PMID:21893401   PMID:21982707   PMID:21988832   PMID:22001368   PMID:22005927   PMID:22011862   PMID:22017688   PMID:22057375   PMID:22086008   PMID:22159911   PMID:22174951  
PMID:22198514   PMID:22207578   PMID:22246136   PMID:22318995   PMID:22333058   PMID:22339544   PMID:22357537   PMID:22384199   PMID:22389501   PMID:22406301   PMID:22422608   PMID:22538426  
PMID:22555453   PMID:22569251   PMID:22572938   PMID:22575044   PMID:22617488   PMID:22627105   PMID:22634628   PMID:22659623   PMID:22732277   PMID:22739109   PMID:22771449   PMID:22847643  
PMID:22927965   PMID:22957038   PMID:23047940   PMID:23064013   PMID:23111737   PMID:23138875   PMID:23151725   PMID:23165960   PMID:23219970   PMID:23223967   PMID:23230847   PMID:23272499  
PMID:23318928   PMID:23402995   PMID:23493287   PMID:23564500   PMID:23566817   PMID:23570504   PMID:23574812   PMID:23695883   PMID:23725508   PMID:23729669   PMID:23751897   PMID:23770986  
PMID:23776175   PMID:23811396   PMID:23877628   PMID:23884820   PMID:23925818   PMID:23928073   PMID:23980096   PMID:23982744   PMID:23984387   PMID:24101667   PMID:24114535   PMID:24146067  
PMID:24173240   PMID:24217957   PMID:24223475   PMID:24335635   PMID:24349514   PMID:24434150   PMID:24434510   PMID:24471369   PMID:24513955   PMID:24553183   PMID:24625911   PMID:24663080  
PMID:24684441   PMID:24740410   PMID:24752868   PMID:24928011   PMID:25063066   PMID:25122164   PMID:25198883   PMID:25220584   PMID:25231849   PMID:25411248   PMID:25446875   PMID:25466668  
PMID:25510691   PMID:25567745   PMID:25575055   PMID:25609649   PMID:25681771   PMID:25706655   PMID:25740656   PMID:25800037   PMID:25958302   PMID:26165348   PMID:26187567   PMID:26208700  
PMID:26255634   PMID:26308798   PMID:26450610   PMID:26475712   PMID:26550927   PMID:26687115   PMID:26690896   PMID:26891076   PMID:26970569   PMID:26991692   PMID:27013094   PMID:27031871  
PMID:27107073   PMID:27302421   PMID:27342816   PMID:27429986   PMID:27443256   PMID:27693495   PMID:27765761   PMID:27939576   PMID:28031043   PMID:28033732   PMID:28161820   PMID:28173835  
PMID:28231612   PMID:28677772   PMID:28765874   PMID:28780681   PMID:28849713   PMID:29257252   PMID:29508184   PMID:29510084   PMID:29620141   PMID:29940243   PMID:30305579   PMID:30395883  
PMID:30548682   PMID:30561076   PMID:31372663   PMID:31451219   PMID:31638264   PMID:31816325   PMID:31841174   PMID:31856086   PMID:31939007   PMID:31939452   PMID:32049985   PMID:32259888  
PMID:32484026   PMID:32538742   PMID:32557145   PMID:33039977   PMID:34254317   PMID:35883637   PMID:36400309   PMID:37590975   PMID:37598133   PMID:37673222   PMID:37683611   PMID:37914064  
PMID:38334011  


Genomics

Comparative Map Data
Nfkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,689,745 - 226,805,897 (-)NCBIGRCr8
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
NFKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,501,359 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4102,501,330 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36Build 36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
T2T-CHM13v2.04105,815,285 - 105,931,246 (+)NCBIT2T-CHM13v2.0
Nfkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,290,416 - 135,397,422 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)EnsemblGRCm39 Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBIMGSCv36mm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
Nfkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
NFKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23100,585,471 - 100,700,918 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14100,871,776 - 100,987,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
NFKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3224,141,192 - 24,259,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBIUU_Cfam_GSD_1.0
Nfkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936520733,668 - 829,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,390,638 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
NFKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,589,494 - 50,711,472 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,333,616 - 5,408,723 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Nfkb1
654 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:135
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000036838, ENSRNOT00000040511, ENSRNOT00000068674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

Markers in Region
D2Mco50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,097,958 - 224,098,088 (+)MAPPERmRatBN7.2
Rnor_6.02240,856,230 - 240,856,359NCBIRnor6.0
Rnor_5.02259,411,018 - 259,411,147UniSTSRnor5.0
RGSC_v3.42233,177,238 - 233,177,367UniSTSRGSC3.4
Celera2216,306,923 - 216,307,052UniSTS
Cytogenetic Map2q43UniSTS
RH127857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,016,559 - 224,016,753 (+)MAPPERmRatBN7.2
Rnor_6.02240,773,866 - 240,774,059NCBIRnor6.0
Rnor_5.02259,330,723 - 259,330,916UniSTSRnor5.0
RGSC_v3.42233,091,359 - 233,091,552UniSTSRGSC3.4
Celera2216,227,195 - 216,227,388UniSTS
RH 3.4 Map21563.3UniSTS
Cytogenetic Map2q43UniSTS
PMC213488P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,053,636 - 224,053,739 (+)MAPPERmRatBN7.2
Rnor_6.02240,811,118 - 240,811,220NCBIRnor6.0
Rnor_5.02259,367,975 - 259,368,077UniSTSRnor5.0
RGSC_v3.42233,128,434 - 233,128,536UniSTSRGSC3.4
Celera2216,263,668 - 216,263,770UniSTS
Cytogenetic Map2q43UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 54 38 19 38 7 8 68 35 34 11 7
Low 3 3 3 1 3 6 7 1
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000036838   ⟹   ENSRNOP00000028944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2224,016,214 - 224,103,724 (-)Ensembl
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000109057   ⟹   ENSRNOP00000082290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
RefSeq Acc Id: NM_001276711   ⟹   NP_001263640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,462 (-)NCBI
mRatBN7.22224,016,214 - 224,131,937 (-)NCBI
Rnor_6.02240,773,520 - 240,890,053 (-)NCBI
Rnor_5.02259,330,377 - 259,444,869 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415012   ⟹   NP_001401941
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,462 (-)NCBI
mRatBN7.22224,016,214 - 224,131,937 (-)NCBI
RefSeq Acc Id: XM_006233360   ⟹   XP_006233422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
mRatBN7.22224,016,214 - 224,132,135 (-)NCBI
Rnor_6.02240,773,520 - 240,890,048 (-)NCBI
Rnor_5.02259,330,377 - 259,444,869 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282628   ⟹   XP_063138698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: XM_063282629   ⟹   XP_063138699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: XM_063282630   ⟹   XP_063138700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: NP_001263640   ⟸   NM_001276711
- Peptide Label: isoform 2
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233422   ⟸   XM_006233360
- Peptide Label: isoform X3
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000028944   ⟸   ENSRNOT00000036838
RefSeq Acc Id: ENSRNOP00000082290   ⟸   ENSRNOT00000109057
RefSeq Acc Id: NP_001401941   ⟸   NM_001415012
- Peptide Label: isoform 1
- UniProtKB: Q63369 (UniProtKB/Swiss-Prot),   F1LQH2 (UniProtKB/Swiss-Prot),   A0A9S9T974 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138700   ⟸   XM_063282630
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138699   ⟸   XM_063282629
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063138698   ⟸   XM_063282628
- Peptide Label: isoform X1
Protein Domains
Death   RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63369-F1-model_v2 AlphaFold Q63369 1-522 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70498 AgrOrtholog
BioCyc Gene G2FUF-51127 BioCyc
Ensembl Genes ENSRNOG00000023258 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036838.5 UniProtKB/TrEMBL
  ENSRNOT00000109057 ENTREZGENE
  ENSRNOT00000109057.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
  Immunoglobulins UniProtKB/Swiss-Prot
  Rel homology domain (RHD), DNA-binding domain UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_dom UniProtKB/Swiss-Prot
  IPT_NFkappaB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NF-kB_p105 UniProtKB/TrEMBL
  NF-kB_p105_DD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NF-kB_p105_RHD_N UniProtKB/Swiss-Prot
  NFkB/Dor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  RHD UniProtKB/TrEMBL
  RHD_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81736 ENTREZGENE
PANTHER PTHR24169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24169:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/Swiss-Prot
PharmGKB NFKB1 RGD
PhenoGen Nfkb1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFKBTNSCPFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023258 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP E set domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like transcription factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTP7_RAT UniProtKB/TrEMBL
  A0A9S9T974 ENTREZGENE, UniProtKB/TrEMBL
  A6HVY5_RAT UniProtKB/TrEMBL
  A6HVY6_RAT UniProtKB/TrEMBL
  A6HVY7_RAT UniProtKB/TrEMBL
  F1LQH2 ENTREZGENE
  NFKB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LQH2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Nfkb1  nuclear factor kappa B subunit 1  Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105  Nfkb1  nuclear factor of kappa light chain gene enhancer in B-cells 1, p105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Nfkb1  nuclear factor of kappa light chain gene enhancer in B-cells 1, p105    nuclear factor kappa B p105 subunit  Name updated 1299863 APPROVED
2002-06-10 Nfkb1  nuclear factor kappa B p105 subunit      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease expression level is related to breast cancer 625513
gene_disease plays a role in the inhibition of breast cancer cells 70295
gene_drugs strongly inhibited by resveratrol (trans-3,4,5-trihydroxystilbene), a polyphenolic phytoalexin, which suppresses DMBA (7,12-Dimethylbenz(a)anthracene)-induced mammary carcinogenesis 625513
gene_drugs resveratrol (trans-3,4,5-trihydroxystilbene)a polyphenolic phytoalexin a potent inhibitor, was able to down regulate expression in DMBA (7,12-dimethylbenzaanthracene) induced rat mammary carcinogenesis and ductal carcinoma, it has a chemopreventive action 625669
gene_drugs dehydroepiandrosterone (DHEA), a steroid produced by brain, affects the activation and subsequent nuclear translocation of Nfkb1 by oxidative stress 625669
gene_expression expressed at low levels in mammary glands during early lactation, increases after weaning 70295
gene_function DNA binding subunit of NFkB1 transcription factor 70295
gene_function interacts with FSH-regulated RNAs 634428
gene_other NFkB family consists of DNA binding subunit and transcriptional activators, including p65, p50, p52, and c-Rel, that share a Rel homology domain 70295
gene_process may be involved in ductal involution 70295
gene_process required for protection from TNF-alpha mediated apoptosis 625669
gene_process required for protection from TNF-alpha mediated apoptosis 628339
gene_process may regulate genes that are involved in pathophysiology of inflammation, immune response and atherosclerosis 625669
gene_process involved in regulating transcription of cytokines, chemokines, leukocyte adhesion molecules and regulators of cell proliferation and survival 625669
gene_regulation activation negatively correlates with peripartum Amh (Anti - Mullerian hormone (Mullerian inhibiting substance)) type II receptor levels 70295
gene_regulation activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625604
gene_regulation activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625669
gene_regulation inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 625669
gene_regulation inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 628339
gene_regulation in hippocampal region is activated by oxidative stress caused by streptozotocin-induced diabetes; 625669