Nfkb1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: Nfkb1 (nuclear factor kappa B subunit 1) Rattus norvegicus
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Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
RGD ID: 70498
Description: Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to cytokine stimulus; and cellular response to diterpene. Acts upstream of or within cellular response to cytokine stimulus. Part of protein-containing complex. Used to study steatotic liver disease. Biomarker of alcoholic hepatitis; hepatocellular carcinoma; metabolic dysfunction-associated steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including HTLV-1-associated myelopathy/tropical spastic paraparesis; carcinoma (multiple); common variable immunodeficiency 12; melanoma; and prostate cancer. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding factor KBF1; EBP-1; NF-kappaB; NF-kB; NFKB-p50; nuclear factor kappa B p105 subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; p50
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,689,745 - 226,805,897 (-)NCBIGRCr8
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Nfkb1Ratalcoholic hepatitis treatmentIEP 15036816 RGD 
Nfkb1Ratatrophic gastritis severityISONfkb1 (Mus musculus)40902973associated with Helicobacter InfectionsRGD 
Nfkb1Ratbreast cancer treatmentISONFKB1 (Homo sapiens)13506729DNA:SNPs and haplotype: :multipleRGD 
Nfkb1RatCerebral Hemorrhage  IDA 2302394protein:increased activity:striatumRGD 
Nfkb1RatCerebral Toxoplasmosis severityISONfkb1 (Mus musculus)40902838 RGD 
Nfkb1RatChemical and Drug Induced Liver Injury susceptibilityISONFKB1 (Homo sapiens)40902984associated with tuberculosis more ...RGD 
Nfkb1RatChemical and Drug Induced Liver Injury treatmentIEP 15090820 RGD 
Nfkb1RatChronic Hepatitis C disease_progressionISONFKB1 (Homo sapiens)11572306DNA:insertion:promoter: -94insATTG (rs28362491) (human)RGD 
Nfkb1Ratcolorectal cancer  ISONfkb1 (Mus musculus)40902978associated with Experimental ColitisRGD 
Nfkb1Ratdepressive disorder  ISONfkb1 (Mus musculus)126908003protein:increased phosphorylation:hippocampus (mouse)RGD 
Nfkb1RatEntamoebiasis severityISONfkb1 (Mus musculus)40902842 RGD 
Nfkb1Rathepatocellular carcinoma disease_progressionISONFKB1 (Homo sapiens)40400751associated with Chronic Hepatitis B and DNA:insertion/deletion:3'utr: -94ins/delATTG (rs28720239) (human)RGD 
Nfkb1Rathepatocellular carcinoma treatmentIEP 152177911 RGD 
Nfkb1RatHTLV-1-associated myelopathy/tropical spastic paraparesis susceptibilityISONFKB1 (Homo sapiens)39018559DNA:SNP:5'utr: (rs3138045) (human)RGD 
Nfkb1RatHuntington's disease severityISONfkb1 (Mus musculus)10045663 RGD 
Nfkb1RatIntestinal Helminthiasis disease_progressionISONfkb1 (Mus musculus)40902988 RGD 
Nfkb1Ratlung cancer exacerbatesISONfkb1 (Mus musculus)11535492 RGD 
Nfkb1Ratlung cancer disease_progressionISONFKB1 (Homo sapiens)11535492 RGD 
Nfkb1Ratlung non-small cell carcinoma  ISONFKB1 (Homo sapiens)13793391protein:increased expression:nucleusRGD 
Nfkb1Ratlung non-small cell carcinoma susceptibilityISONFKB1 (Homo sapiens)13793390DNA:polymorphism:rs28362491(human)RGD 
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Original Reference(s)
Nfkb1Ratbeta-mannosidosis  ISONFKB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Beta-D-mannosidosisClinVarPMID:12468273 more ...
Nfkb1Ratcommon variable immunodeficiency  ISONFKB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Common variable immunodeficiencyClinVarPMID:16199547 more ...
Nfkb1Ratcommon variable immunodeficiency 12  ISONFKB1 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:11583829 more ...
Nfkb1Ratgenetic disease  ISONFKB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inborn genetic diseasesClinVarPMID:25741868 more ...
Nfkb1RatHigh Myopia  ISONFKB1 (Homo sapiens)8554872ClinVar Annotator: match by term: High myopiaClinVarPMID:28492532
Nfkb1Ratprimary ciliary dyskinesia 3  ISONFKB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Primary ciliary dyskinesia 3ClinVar 
Nfkb1Ratprimary immunodeficiency disease  ISONFKB1 (Homo sapiens)8554872ClinVar Annotator: match by term: Inherited Immunodeficiency DiseasesClinVarPMID:25741868 more ...
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Nfkb1Ratacute kidney failure  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29286200
Nfkb1Ratadenocarcinoma  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19028472
Nfkb1Ratbrain ischemia  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:18628779
Nfkb1RatColonic Neoplasms  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19028472 and PMID:20715105
Nfkb1Ratcommon variable immunodeficiency  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Nfkb1Ratend stage renal disease  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19420110
Nfkb1RatHeat Stroke  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24039931
Nfkb1RatHyperoxaluria  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:16284884
Nfkb1Ratliver disease  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: therapeuticCTDPMID:15743782
Nfkb1RatNeoplastic Cell Transformation  ISONFKB1 (Homo sapiens)11554173CTD more ...CTDPMID:20516118 and PMID:28823542
Nfkb1Ratovarian cyst  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21239663
Nfkb1Ratprimary biliary cholangitis  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:21399635
Nfkb1Rattype 2 diabetes mellitus  ISONFKB1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:17107852
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Nfkb1Ratcommon variable immunodeficiency 12  ISONFKB1 (Homo sapiens)7240710 OMIM 

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Nfkb1Rat(+)-artemisinin multiple interactionsISONFKB1 (Homo sapiens)6480464artemisinin inhibits the reaction [15-hydroxy-5 more ...CTDPMID:18463201 and PMID:23355332
Nfkb1Rat(+)-beta-thujone multiple interactionsISONFKB1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNACTDPMID:38000518
Nfkb1Rat(+)-catechin multiple interactionsEXP 6480464Catechin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]CTDPMID:35337893
Nfkb1Rat(+)-taxifolin multiple interactionsEXP 6480464taxifolin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]CTDPMID:35187747
Nfkb1Rat(-)-epigallocatechin 3-gallate multiple interactionsISONFKB1 (Homo sapiens)6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of NFKB1 mRNA and epigallocatechin gallate inhibits the reaction [Particulate Matter results in increased expression of NFKB1 protein]CTDPMID:22079256 and PMID:31252129
Nfkb1Rat(20S)-ginsenoside Rg3 multiple interactionsEXP 6480464[ginsenoside Rg3 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] which results in increased activity of NFKB1 proteinCTDPMID:14534150
Nfkb1Rat(20S)-ginsenoside Rg3 increases activityEXP 6480464ginsenoside Rg3 results in increased activity of NFKB1 proteinCTDPMID:14534150
Nfkb1Rat(5Z,8Z,11Z,13E)-15-HETE increases activityISONFKB1 (Homo sapiens)648046415-hydroxy-5 more ...CTDPMID:25600587
Nfkb1Rat(5Z,8Z,11Z,13E)-15-HETE affects localizationISONFKB1 (Homo sapiens)648046415-hydroxy-5 more ...CTDPMID:23355332
Nfkb1Rat(5Z,8Z,11Z,13E)-15-HETE multiple interactionsISONFKB1 (Homo sapiens)6480464artemisinin inhibits the reaction [15-hydroxy-5 more ...CTDPMID:23355332
Nfkb1Rat(E)-roxithromycin multiple interactionsEXP 6480464Roxithromycin inhibits the reaction [Diethylnitrosamine results in increased activity of [NFKB1 protein binds to RELA protein]]CTDPMID:16061884
Nfkb1Rat(R)-adrenaline multiple interactionsEXP 6480464Epinephrine promotes the reaction [[Xanthine co-treated with XDH protein] results in increased activity of [RELA protein binds to NFKB1 protein]] and Epinephrine results in increased activity of [RELA protein binds to NFKB1 protein]CTDPMID:19135123
Nfkb1Rat(R)-camphor multiple interactionsISONFKB1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNACTDPMID:38000518
Nfkb1Rat(R)-linalyl acetate multiple interactionsISONFKB1 (Homo sapiens)6480464[beta-thujone co-treated with linalyl acetate co-treated with sabinene co-treated with linalool co-treated with Camphor co-treated with myrcene co-treated with Eucalyptol co-treated with caryophyllene co-treated with spathulenol] results in increased expression of NFKB1 mRNACTDPMID:38000518
Nfkb1Rat(R)-lipoic acid multiple interactionsISONFKB1 (Homo sapiens)6480464Thioctic Acid inhibits the reaction [Zinc deficiency affects the localization of NFKB1 protein]CTDPMID:21600978
Nfkb1Rat(R)-lipoic acid multiple interactionsEXP 6480464[Thioctic Acid co-treated with Propylthiouracil] results in decreased expression of NFKB1 mRNACTDPMID:31068541
Nfkb1Rat(R)-noradrenaline multiple interactionsISONFKB1 (Homo sapiens)6480464Acetylcysteine inhibits the reaction [Norepinephrine affects the localization of NFKB1 protein] more ...CTDPMID:16782692 and PMID:23114885
Nfkb1Rat(R)-noradrenaline affects localizationISONFKB1 (Homo sapiens)6480464Norepinephrine affects the localization of NFKB1 proteinCTDPMID:23114885
Nfkb1Rat(R,R,R)-alpha-tocopherol multiple interactionsEXP 6480464alpha-Tocopherol inhibits the reaction [Hexachlorocyclohexane results in increased activity of NFKB1 protein] more ...CTDPMID:15025948 and PMID:16135673
Nfkb1Rat(R,R,R)-alpha-tocopherol multiple interactionsISONFKB1 (Homo sapiens)6480464alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [NFKB1 protein binds to NFKB1 protein]] and alpha-Tocopherol inhibits the reaction [Galactosamine results in increased activity of [RELA protein binds to NFKB1 protein]]CTDPMID:17936189

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Biological Process
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Nfkb1Ratantibacterial innate immune response involved_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratantibacterial innate immune response involved_inISONFKB1 (Homo sapiens)1624291 PMID:20406817RGDPMID:20406817
Nfkb1Ratapoptotic process involved_inIEAUniProtKB-KW:KW-00531600115GO_REF:0000043UniProtGO_REF:0000043
Nfkb1RatB cell receptor signaling pathway involved_inISONfkb1 (Mus musculus)1624291 PMID:17367755RGDPMID:17367755
Nfkb1RatB cell receptor signaling pathway involved_inIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcanonical NF-kappaB signal transduction involved_inISONFKB1 (Homo sapiens) and UniProtKB:P19838-PRO_00000303111624291 PMID:23811396RGDPMID:23811396
Nfkb1Ratcanonical NF-kappaB signal transduction involved_inISONFKB1 (Homo sapiens)1624291 PMID:34721373RGDPMID:34721373
Nfkb1Ratcanonical NF-kappaB signal transduction involved_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcellular response to angiotensin involved_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcellular response to angiotensin involved_inISONFKB1 (Homo sapiens)1624291 PMID:22357537RGDPMID:22357537
Nfkb1Ratcellular response to brain-derived neurotrophic factor stimulus  IDA 10045822 RGD 
Nfkb1Ratcellular response to carbohydrate stimulus  IDA 100458564-hydroxy-2 and 3-nonenal RGD 
Nfkb1Ratcellular response to cytokine stimulus acts_upstream_of_or_withinIDA 10402041PMID:19414010MGI 
Nfkb1Ratcellular response to diterpene  IDA 1004566019-hydroxy-1alpha more ...RGD 
Nfkb1Ratcellular response to dsRNA acts_upstream_of_or_withinISONfkb1 (Mus musculus)1624291MGI:1857225 PMID:24114535RGDPMID:24114535
Nfkb1Ratcellular response to dsRNA acts_upstream_of_or_withinIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcellular response to glucoside  IDA 10045666 RGD 
Nfkb1Ratcellular response to interleukin-1  IDA 10045667 RGD 
Nfkb1Ratcellular response to interleukin-17 involved_inIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcellular response to interleukin-17 involved_inISONfkb1 (Mus musculus)1624291 PMID:31164412RGDPMID:31164412
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Cellular Component
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Nfkb1Ratchromatin is_active_inISONFKB1 (Homo sapiens)1624291 PMID:8413223RGDPMID:8413223
Nfkb1Ratchromatin is_active_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcytoplasm located_inISONFKB1 (Homo sapiens)1624291UniProtKB:P24001-1 more ...RGDPMID:11819787 and PMID:23729669
Nfkb1Ratcytoplasm located_inIEAInterPro:IPR0004511600115GO_REF:0000002InterProGO_REF:0000002
Nfkb1Ratcytoplasm located_inIEAUniProtKB-KW:KW-09631600115GO_REF:0000043UniProtGO_REF:0000043
Nfkb1Ratcytoplasm located_inISONfkb1 (Mus musculus)1624291 PMID:20060382RGDPMID:20060382
Nfkb1Ratcytoplasm located_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcytoplasm located_inIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcytoplasm located_inIEAUniProtKB-SubCell:SL-00861600115GO_REF:0000044UniProtGO_REF:0000044
Nfkb1Ratcytosol located_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratcytosol located_inISONfkb1 (Mus musculus)1624291 PMID:11931770RGDPMID:11931770
Nfkb1Ratcytosol located_inISONFKB1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Nfkb1Ratcytosol located_inIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1RatI-kappaB/NF-kappaB complex part_ofISONFKB1 (Homo sapiens)1624291UniProtKB:P25963 and PMID:16938301RGDPMID:16938301
Nfkb1RatI-kappaB/NF-kappaB complex part_ofIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratmitochondrion located_inIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratmitochondrion located_inISONFKB1 (Homo sapiens) more ...1624291 RGDGO_REF:0000052
Nfkb1RatNF-kappaB p50/p65 complex part_ofIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1RatNF-kappaB p50/p65 complex part_ofIBAMGI:97312 and PANTHER:PTN0027928691600115GO_REF:0000033GO_CentralGO_REF:0000033
Nfkb1RatNF-kappaB p50/p65 complex part_ofISONfkb1 (Mus musculus)1624291 PMID:2001591RGDPMID:2001591
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Molecular Function
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Nfkb1Ratactinin binding enablesIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratactinin binding enablesISONFKB1 (Homo sapiens)1624291UniProtKB:O43707 and PMID:25411248RGDPMID:25411248
Nfkb1Ratchromatin binding enablesIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1Ratchromatin binding enablesISONfkb1 (Mus musculus)1624291 PMID:20442316 more ...RGDPMID:20442316 more ...
Nfkb1RatDNA binding enablesIDA 10402041PMID:19414010MGI 
Nfkb1RatDNA binding enablesISONfkb1 (Mus musculus)1624291 PMID:10395695 more ...RGDPMID:10395695 more ...
Nfkb1RatDNA binding enablesIEAInterPro:IPR011539 and InterPro:IPR0370591600115GO_REF:0000002InterProGO_REF:0000002
Nfkb1RatDNA binding enablesIEAUniProtKB:P25799 and ensembl:ENSMUSP000000298121600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1RatDNA binding enablesIEAUniProtKB-KW:KW-02381600115GO_REF:0000043UniProtGO_REF:0000043
Nfkb1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISONFKB1 (Homo sapiens)1624291 PMID:1406630 more ...RGDPMID:1406630 more ...
Nfkb1RatDNA-binding transcription activator activity, RNA polymerase II-specific enablesISONFKB1 (Homo sapiens) and UniProtKB:P19838-PRO_00000303111624291 PMID:23811396RGDPMID:23811396
Nfkb1RatDNA-binding transcription factor activity  TAS 625669 RGD 
Nfkb1RatDNA-binding transcription factor activity enablesIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1RatDNA-binding transcription factor activity enablesISONFKB1 (Homo sapiens)1624291 PMID:17426251 and PMID:8413223RGDPMID:17426251 and PMID:8413223
Nfkb1RatDNA-binding transcription factor activity enablesIEAInterPro:IPR000451 more ...1600115GO_REF:0000002InterProGO_REF:0000002
Nfkb1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesISONFKB1 (Homo sapiens)1624291 PMID:17426251 and PMID:26801246RGDPMID:17426251 and PMID:26801246
Nfkb1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIEAUniProtKB:P19838 and ensembl:ENSP000002265741600115GO_REF:0000107EnsemblGO_REF:0000107
Nfkb1RatDNA-binding transcription factor activity, RNA polymerase II-specific enablesIBAFB:FBgn0011274 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Nfkb1RatDNA-binding transcription repressor activity, RNA polymerase II-specific enablesISONFKB1 (Homo sapiens)1624291 PMID:24434510RGDPMID:24434510
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RGD Manual Annotations


  

Imported Annotations - SMPDB

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Nfkb1Ratadenosine signaling pathway  ISONFKB1 (Homo sapiens)10402751 SMPDBSMP:00320
Nfkb1Ratadenosine signaling pathway  ISONFKB1 (Homo sapiens)10402751 SMPDBSMP:00321

Imported Annotations - KEGG (archival)

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Nfkb1Ratacute myeloid leukemia pathway  IEA 6907045 KEGGrno:05221
Nfkb1Ratapoptotic cell death pathway  IEA 6907045 KEGGrno:04210
Nfkb1RatB cell receptor signaling pathway  IEA 6907045 KEGGrno:04662
Nfkb1Ratceramide signaling pathway  IEA 6907045 KEGGrno:05212
Nfkb1RatChagas disease pathway  IEA 6907045 KEGGrno:05142
Nfkb1Ratchemokine mediated signaling pathway  IEA 6907045 KEGGrno:04062
Nfkb1Ratchronic myeloid leukemia pathway  IEA 6907045 KEGGrno:05220
Nfkb1RatEntamoebiasis pathway  IEA 6907045 KEGGrno:05146
Nfkb1Rathepatitis C pathway  IEA 6907045 KEGGrno:05160
Nfkb1Ratinfluenza A pathway  IEA 6907045 KEGGrno:05164
Nfkb1RatLeishmaniasis pathway  IEA 6907045 KEGGrno:05140
Nfkb1Ratmeasles pathway  IEA 6907045 KEGGrno:05162
Nfkb1Ratmitogen activated protein kinase signaling pathway   IEA 6907045 KEGGrno:04010
Nfkb1Ratneurotrophic factor signaling pathway  IEA 6907045 KEGGrno:04722
Nfkb1RatNOD-like receptor signaling pathway  IEA 6907045 KEGGrno:04621
Nfkb1Ratpancreatic cancer pathway   IEA 6907045 KEGGrno:05212
Nfkb1Ratprostate cancer pathway   IEA 6907045 KEGGrno:05215
Nfkb1RatRetinoic acid-inducible gene (RIG) I-like receptor signaling pathway  IEA 6907045 KEGGrno:04622
Nfkb1Ratsmall cell lung carcinoma pathway  IEA 6907045 KEGGrno:05222
Nfkb1RatT cell receptor signaling pathway  IEA 6907045 KEGGrno:04660
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Reference Title
Reference Citation
1. Nuclear Akt associates with PKC-phosphorylated Ebp1, preventing DNA fragmentation by inhibition of caspase-activated DNase. Ahn JY, etal., EMBO J. 2006 May 17;25(10):2083-95. Epub 2006 Apr 27.
2. Dehydroepiandrosterone modulates nuclear factor-kappaB activation in hippocampus of diabetic rats. Aragno M, etal., Endocrinology 2002 Sep;143(9):3250-8.
3. Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. Artis D, etal., J Immunol. 2002 Oct 15;169(8):4481-7. doi: 10.4049/jimmunol.169.8.4481.
4. Suppression of 7,12-Dimethylbenz(a)anthracene-induced Mammary Carcinogenesis in Rats by Resveratrol: Role of Nuclear Factor-kappaB, Cyclooxygenase 2, and Matrix Metalloprotease 9. Banerjee S, etal., Cancer Res 2002 Sep 1;62(17):4945-54.
5. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Bourteele S, etal., Cell Microbiol. 2007 Sep;9(9):2202-17. doi: 10.1111/j.1462-5822.2007.00950.x. Epub 2007 Jun 15.
6. Importance of polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes for melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients. Bu H, etal., J Cancer Res Clin Oncol. 2007 Nov;133(11):859-66. Epub 2007 May 11.
7. NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. Burkitt MD, etal., J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.
8. Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Burkitt MD, etal., Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334. Epub 2013 Aug 26.
9. The lipid peroxidation product 4-hydroxy-2,3-nonenal inhibits constitutive and inducible activity of nuclear factor kappa B in neurons. Camandola S, etal., Brain Res Mol Brain Res. 2000 Dec 28;85(1-2):53-60.
10. In vivo heat shock protein assembles with septic liver NF-kappaB/I-kappaB complex regulating NF-kappaB activity. Chen HW, etal., Shock. 2005 Sep;24(3):232-8.
11. Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Chen J, etal., Mol Med Report. 2011 Jun 2. doi: 10.3892/mmr.2011.501.
12. Synergistic activation of NF-kappaB by tumor necrosis factor alpha and gamma interferon via enhanced I kappaB alpha degradation and de novo I kappaBbeta degradation. Cheshire JL and Baldwin AS Jr, Mol Cell Biol. 1997 Nov;17(11):6746-54.
13. The NF-kappaB p50 subunit is protective during intestinal Entamoeba histolytica infection of 129 and C57BL/6 mice. Cho KN, etal., Infect Immun. 2010 Apr;78(4):1475-81. doi: 10.1128/IAI.00669-09. Epub 2010 Jan 19.
14. Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats. Clemens JA, etal., Stroke. 1997 May;28(5):1073-80; discussion 1080-1.
15. Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer. Cui X, etal., Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.
16. The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. Droebner K, etal., Viral Immunol. 2010 Jun;23(3):295-308. doi: 10.1089/vim.2009.0101.
17. The -94Ins/DelATTG polymorphism in NF¿B1 promoter modulates chronic hepatitis C and liver disease progression. Fakhir FZ, etal., Infect Genet Evol. 2016 Apr;39:141-6. doi: 10.1016/j.meegid.2016.01.023. Epub 2016 Jan 28.
18. Targeting cytokine expression in glial cells by cellular delivery of an NF-kappaB decoy. Fisher L, etal., J Mol Neurosci. 2007;31(3):209-19.
19. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
20. Nuclear factor-kappaB mediates the cell survival-promoting action of activity-dependent neurotrophic factor peptide-9. Glazner GW, etal., J Neurochem. 2000 Jul;75(1):101-8.
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PMID:1406630   PMID:7959007   PMID:10395695   PMID:11819787   PMID:11931770   PMID:11976687   PMID:12200125   PMID:12372417   PMID:12482991   PMID:12598934   PMID:12618484   PMID:12631115  
PMID:12832462   PMID:12857444   PMID:12885587   PMID:12937821   PMID:12958148   PMID:12970181   PMID:14568984   PMID:14581482   PMID:14592850   PMID:14643899   PMID:14654230   PMID:14698955  
PMID:14732351   PMID:14732362   PMID:14767990   PMID:14963004   PMID:14980066   PMID:14988658   PMID:15025948   PMID:15033730   PMID:15059791   PMID:15072545   PMID:15102957   PMID:15123351  
PMID:15208316   PMID:15220916   PMID:15243130   PMID:15249201   PMID:15256225   PMID:15285020   PMID:15308653   PMID:15457532   PMID:15471861   PMID:15489638   PMID:15520226   PMID:15557322  
PMID:15596562   PMID:15621209   PMID:15720830   PMID:15722352   PMID:15728238   PMID:15777848   PMID:15817708   PMID:15845452   PMID:15888549   PMID:15935092   PMID:15944286   PMID:16051721  
PMID:16079148   PMID:16081776   PMID:16133867   PMID:16181409   PMID:16183991   PMID:16234240   PMID:16283433   PMID:16297318   PMID:16316997   PMID:16322063   PMID:16343770   PMID:16386177  
PMID:16463669   PMID:16489637   PMID:16574982   PMID:16597735   PMID:16677107   PMID:16677605   PMID:16680015   PMID:16707097   PMID:16771681   PMID:16772709   PMID:16840655   PMID:16874877  
PMID:16877563   PMID:16879219   PMID:16920808   PMID:16938301   PMID:16971004   PMID:17009244   PMID:17023425   PMID:17072978   PMID:17150179   PMID:17162607   PMID:17242297   PMID:17252537  
PMID:17324121   PMID:17327451   PMID:17396235   PMID:17409305   PMID:17416599   PMID:17426251   PMID:17427960   PMID:17505309   PMID:17535306   PMID:17555089   PMID:17604059   PMID:17609505  
PMID:17659437   PMID:17664391   PMID:17699727   PMID:17822789   PMID:17825480   PMID:17828497   PMID:17907174   PMID:17941794   PMID:17959522   PMID:17971865   PMID:17997883   PMID:18032528  
1 to 10 of 40 rows



Nfkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,689,745 - 226,805,897 (-)NCBIGRCr8
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
NFKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,501,359 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4102,501,330 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36Build 36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
T2T-CHM13v2.04105,815,285 - 105,931,246 (+)NCBIT2T-CHM13v2.0
Nfkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,290,416 - 135,397,422 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)EnsemblGRCm39 Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBIMGSCv36mm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
Nfkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
NFKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23100,585,471 - 100,700,918 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14100,871,776 - 100,987,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
NFKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3224,141,192 - 24,259,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBIUU_Cfam_GSD_1.0
Nfkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936520733,668 - 829,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,390,638 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
NFKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,589,494 - 50,711,472 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,333,616 - 5,408,723 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

.

.
Variants in Nfkb1
784 total Variants

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:135
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000036838, ENSRNOT00000040511, ENSRNOT00000068674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 38 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat

1 to 10 of 38 rows
D2Mco50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,097,958 - 224,098,088 (+)MAPPERmRatBN7.2
Rnor_6.02240,856,230 - 240,856,359NCBIRnor6.0
Rnor_5.02259,411,018 - 259,411,147UniSTSRnor5.0
RGSC_v3.42233,177,238 - 233,177,367UniSTSRGSC3.4
Celera2216,306,923 - 216,307,052UniSTS
Cytogenetic Map2q43UniSTS
RH127857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,016,559 - 224,016,753 (+)MAPPERmRatBN7.2
Rnor_6.02240,773,866 - 240,774,059NCBIRnor6.0
Rnor_5.02259,330,723 - 259,330,916UniSTSRnor5.0
RGSC_v3.42233,091,359 - 233,091,552UniSTSRGSC3.4
Celera2216,227,195 - 216,227,388UniSTS
RH 3.4 Map21563.3UniSTS
Cytogenetic Map2q43UniSTS
PMC213488P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,053,636 - 224,053,739 (+)MAPPERmRatBN7.2
Rnor_6.02240,811,118 - 240,811,220NCBIRnor6.0
Rnor_5.02259,367,975 - 259,368,077UniSTSRnor5.0
RGSC_v3.42233,128,434 - 233,128,536UniSTSRGSC3.4
Celera2216,263,668 - 216,263,770UniSTS
Cytogenetic Map2q43UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000036838   ⟹   ENSRNOP00000028944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2224,016,214 - 224,103,724 (-)Ensembl
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109057   ⟹   ENSRNOP00000082290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
RefSeq Acc Id: NM_001276711   ⟹   NP_001263640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,462 (-)NCBI
mRatBN7.22224,016,214 - 224,131,937 (-)NCBI
Rnor_6.02240,773,520 - 240,890,053 (-)NCBI
Rnor_5.02259,330,377 - 259,444,869 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415012   ⟹   NP_001401941
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,462 (-)NCBI
mRatBN7.22224,016,214 - 224,131,937 (-)NCBI
RefSeq Acc Id: XM_006233360   ⟹   XP_006233422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
mRatBN7.22224,016,214 - 224,132,135 (-)NCBI
Rnor_6.02240,773,520 - 240,890,048 (-)NCBI
Rnor_5.02259,330,377 - 259,444,869 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282628   ⟹   XP_063138698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: XM_063282629   ⟹   XP_063138699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: XM_063282630   ⟹   XP_063138700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: NP_001263640   ⟸   NM_001276711
- Peptide Label: isoform 2
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233422   ⟸   XM_006233360
- Peptide Label: isoform X3
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028944   ⟸   ENSRNOT00000036838
Ensembl Acc Id: ENSRNOP00000082290   ⟸   ENSRNOT00000109057
RefSeq Acc Id: NP_001401941   ⟸   NM_001415012
- Peptide Label: isoform 1
- UniProtKB: Q63369 (UniProtKB/Swiss-Prot),   F1LQH2 (UniProtKB/Swiss-Prot),   A0A9S9T974 (UniProtKB/TrEMBL)
Death   RHD

Name Modeler Protein Id AA Range Protein Structure
AF-Q63369-F1-model_v2 AlphaFold Q63369 1-522 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen



1 to 40 of 57 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-51127 BioCyc
Ensembl Genes ENSRNOG00000023258 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000036838 ENTREZGENE
  ENSRNOT00000109057 ENTREZGENE
  ENSRNOT00000127625 ENTREZGENE
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot
  1.25.40.20 UniProtKB/Swiss-Prot
  Immunoglobulins UniProtKB/Swiss-Prot
  Rel homology domain (RHD), DNA-binding domain UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot
  Death_domain UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_E-set UniProtKB/Swiss-Prot
  IPT_dom UniProtKB/Swiss-Prot
  IPT_NFkappaB UniProtKB/Swiss-Prot
  NF-kB_p105_DD UniProtKB/Swiss-Prot
  NF-kB_p105_RHD_N UniProtKB/Swiss-Prot
  NFkB/Dor UniProtKB/Swiss-Prot
  p53-like_TF_DNA-bd_sf UniProtKB/Swiss-Prot
  RHD_CS UniProtKB/Swiss-Prot
  RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 81736 ENTREZGENE
PANTHER PTHR24169 UniProtKB/Swiss-Prot
  PTHR24169:SF9 UniProtKB/Swiss-Prot
Pfam Ank UniProtKB/Swiss-Prot
  Ank_2 UniProtKB/Swiss-Prot
  Death UniProtKB/Swiss-Prot
  RHD_dimer UniProtKB/Swiss-Prot
  RHD_DNA_bind UniProtKB/Swiss-Prot
PharmGKB NFKB1 RGD
PhenoGen Nfkb1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot
  NFKBTNSCPFCT UniProtKB/Swiss-Prot
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  REL_1 UniProtKB/Swiss-Prot
1 to 40 of 57 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Nfkb1  nuclear factor kappa B subunit 1  Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105  Nfkb1  nuclear factor of kappa light chain gene enhancer in B-cells 1, p105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Nfkb1  nuclear factor of kappa light chain gene enhancer in B-cells 1, p105    nuclear factor kappa B p105 subunit  Name updated 1299863 APPROVED
2002-06-10 Nfkb1  nuclear factor kappa B p105 subunit      Symbol and Name status set to provisional 70585 PROVISIONAL

Note Type Note Reference
gene_disease expression level is related to breast cancer 625513
gene_disease plays a role in the inhibition of breast cancer cells 70295
gene_drugs strongly inhibited by resveratrol (trans-3,4,5-trihydroxystilbene), a polyphenolic phytoalexin, which suppresses DMBA (7,12-Dimethylbenz(a)anthracene)-induced mammary carcinogenesis 625513
gene_drugs resveratrol (trans-3,4,5-trihydroxystilbene)a polyphenolic phytoalexin a potent inhibitor, was able to down regulate expression in DMBA (7,12-dimethylbenzaanthracene) induced rat mammary carcinogenesis and ductal carcinoma, it has a chemopreventive action 625669
gene_drugs dehydroepiandrosterone (DHEA), a steroid produced by brain, affects the activation and subsequent nuclear translocation of Nfkb1 by oxidative stress 625669
gene_expression expressed at low levels in mammary glands during early lactation, increases after weaning 70295
gene_function DNA binding subunit of NFkB1 transcription factor 70295
gene_function interacts with FSH-regulated RNAs 634428
gene_other NFkB family consists of DNA binding subunit and transcriptional activators, including p65, p50, p52, and c-Rel, that share a Rel homology domain 70295
gene_process may be involved in ductal involution 70295
gene_process required for protection from TNF-alpha mediated apoptosis 625669
gene_process required for protection from TNF-alpha mediated apoptosis 628339
gene_process may regulate genes that are involved in pathophysiology of inflammation, immune response and atherosclerosis 625669
gene_process involved in regulating transcription of cytokines, chemokines, leukocyte adhesion molecules and regulators of cell proliferation and survival 625669
gene_regulation activation negatively correlates with peripartum Amh (Anti - Mullerian hormone (Mullerian inhibiting substance)) type II receptor levels 70295
gene_regulation activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625604
gene_regulation activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625669
gene_regulation inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 625669
gene_regulation inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 628339
gene_regulation in hippocampal region is activated by oxidative stress caused by streptozotocin-induced diabetes; 625669