Nfkb1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: Nfkb1 (nuclear factor kappa B subunit 1) Rattus norvegicus
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
RGD ID: 70498
Description: Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and regulation of gene expression. Acts upstream of or within cellular response to cytokine stimulus. Located in cytosol; neuron projection; and nucleus. Part of protein-containing complex. Used to study fatty liver disease. Biomarker of alcoholic hepatitis; non-alcoholic steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH (20S)-ginsenoside Rg3; (E)-roxithromycin; (R)-adrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: DNA-binding factor KBF1; EBP-1; NF-kappaB; NF-kB; nuclear factor kappa B p105 subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R)-lipoic acid  (EXP,ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5'-triiodothyronine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-Hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP,ISO)
7H-xanthine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (EXP)
[6]-Shogaol  (ISO)
acenaphthoquinone  (ISO)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
Actein  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiloride  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphibole asbestos  (ISO)
anethole  (ISO)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
aripiprazole  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (EXP,ISO)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
butyric acid  (EXP)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
carboplatin  (EXP,ISO)
carmustine  (EXP,ISO)
carvacrol  (ISO)
casticin  (ISO)
celecoxib  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chrysin  (EXP)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproheptadine  (EXP)
D-glucose  (ISO)
daidzein  (ISO)
danazol  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicofol  (ISO)
dicoumarol  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (ISO)
diltiazem  (ISO)
dimethylarsinic acid  (EXP,ISO)
dioscin  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP)
enalapril  (EXP)
endosulfan  (EXP,ISO)
endrin  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl acetate  (ISO)
ethylene glycol  (EXP)
ethylisopropylamiloride  (ISO)
eugenol  (EXP,ISO)
Evodiamine  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flurbiprofen  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (ISO)
fucoidan  (ISO)
gadolinium trichloride  (EXP)
galactose  (ISO)
gamma-hexachlorocyclohexane  (EXP)
gastrin-17  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside C-K  (EXP)
glafenine  (EXP)
gliotoxin  (ISO)
glucaric acid  (ISO)
glucose  (ISO)
glutathione  (ISO)
glutathione disulfide  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
guggulsterone  (EXP,ISO)
GW 501516  (ISO)
haloperidol  (EXP)
harmaline  (ISO)
heme b  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lanreotide  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP)
lead(2+)  (EXP)
leptomycin B  (ISO)
limonene  (EXP)
linalool  (ISO)
linoleic acid  (EXP)
lipoarabinomannan  (ISO)
lipoic acid  (EXP,ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
losartan  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (EXP)
maneb  (ISO)
manganese(II) chloride  (EXP)
mangiferin  (ISO)
Mecamylamine  (EXP,ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP,ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mevinphos  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
monotropein  (ISO)
morphine  (EXP)
myo-inositol hexakisphosphate  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naproxen  (ISO)
naringin  (EXP)
Neferine  (EXP)
neoechinulin A  (ISO)
neratinib  (ISO)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nitroprusside  (ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
o-anisidine  (ISO)
obeticholic acid  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (EXP,ISO)
PD123319  (EXP)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perindopril  (ISO)
permethrin  (EXP)
pevonedistat  (ISO)
phenethyl caffeate  (ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanil  (ISO)
propionic acid  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ritonavir  (ISO)
rocaglamide  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
salicylates  (EXP)
sarin  (EXP)
SB 203580  (ISO)
scoparone  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP)
succimer  (EXP,ISO)
succinic acid  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thalidomide  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
trans-anethole  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (EXP,ISO)
Tropicamide  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
WR-1065  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zingerone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to angiotensin  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IDA)
cellular response to carbohydrate stimulus  (IDA)
cellular response to cytokine stimulus  (IDA)
cellular response to diterpene  (IDA)
cellular response to dsRNA  (IEA,ISO)
cellular response to glucoside  (IDA)
cellular response to interleukin-1  (IDA,IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to lipopolysaccharide  (IDA,IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nicotine  (IEA,ISO)
cellular response to organic cyclic compound  (IDA)
cellular response to peptide  (IDA)
cellular response to tumor necrosis factor  (IDA,IEA,IEP,ISO)
cellular response to virus  (IEA,ISO)
JNK cascade  (IEA,ISO)
leukocyte migration involved in inflammatory response  (IEP)
MAPK cascade  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of calcidiol 1-monooxygenase activity  (IEA,ISO)
negative regulation of cytokine production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of gene expression  (IMP)
positive regulation of gene silencing by miRNA  (IMP)
positive regulation of hyaluronan biosynthetic process  (IEA,ISO)
positive regulation of miRNA metabolic process  (IEA,ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription, DNA-templated  (ISO,ISS)
regulation of transcription by RNA polymerase II  (IBA)
response to bacterium  (IEP)
response to copper ion  (IEP)
response to ethanol  (IEP)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (IDA,IEP)
response to oxidative stress  (IDA)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)

Cellular Component
cytoplasm  (IDA,ISO)
cytosol  (IDA,IEA,ISO)
mitochondrion  (IEA,ISO)
neuron projection  (IDA)
NF-kappaB complex  (ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IDA,IEA,ISO,TAS)
protein-containing complex  (IDA)


References - curated
1. Ahn JY, etal., EMBO J. 2006 May 17;25(10):2083-95. Epub 2006 Apr 27.
2. Aragno M, etal., Endocrinology 2002 Sep;143(9):3250-8.
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4. Banerjee S, etal., Cancer Res 2002 Sep 1;62(17):4945-54.
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Additional References at PubMed
PMID:1406630   PMID:7959007   PMID:10395695   PMID:11819787   PMID:11931770   PMID:11976687   PMID:12200125   PMID:12372417   PMID:12482991   PMID:12598934   PMID:12618484   PMID:12631115  
PMID:12832462   PMID:12857444   PMID:12885587   PMID:12937821   PMID:12958148   PMID:12970181   PMID:14568984   PMID:14581482   PMID:14592850   PMID:14643899   PMID:14654230   PMID:14698955  
PMID:14732351   PMID:14732362   PMID:14767990   PMID:14963004   PMID:14980066   PMID:14988658   PMID:15025948   PMID:15033730   PMID:15059791   PMID:15072545   PMID:15102957   PMID:15123351  
PMID:15208316   PMID:15220916   PMID:15243130   PMID:15249201   PMID:15256225   PMID:15285020   PMID:15308653   PMID:15457532   PMID:15471861   PMID:15489638   PMID:15520226   PMID:15557322  
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PMID:16079148   PMID:16081776   PMID:16133867   PMID:16181409   PMID:16183991   PMID:16234240   PMID:16283433   PMID:16297318   PMID:16316997   PMID:16322063   PMID:16343770   PMID:16386177  
PMID:16463669   PMID:16489637   PMID:16574982   PMID:16597735   PMID:16677107   PMID:16677605   PMID:16680015   PMID:16707097   PMID:16771681   PMID:16772709   PMID:16840655   PMID:16874877  
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PMID:18045535   PMID:18090225   PMID:18183619   PMID:18212740   PMID:18270204   PMID:18274644   PMID:18274700   PMID:18278452   PMID:18278461   PMID:18305221   PMID:18397856   PMID:18400403  
PMID:18404532   PMID:18420947   PMID:18420952   PMID:18423996   PMID:18448529   PMID:18469338   PMID:18485627   PMID:18535404   PMID:18566389   PMID:18580810   PMID:18586672   PMID:18593633  
PMID:18615578   PMID:18633731   PMID:18649423   PMID:18662246   PMID:18701451   PMID:18703515   PMID:18708911   PMID:18718911   PMID:18726687   PMID:18753141   PMID:18769055   PMID:18822207  
PMID:18926072   PMID:18938092   PMID:18975780   PMID:18976964   PMID:19026727   PMID:19060913   PMID:19071154   PMID:19074556   PMID:19084916   PMID:19088456   PMID:19111928   PMID:19162042  
PMID:19189070   PMID:19199090   PMID:19211730   PMID:19215923   PMID:19236545   PMID:19238531   PMID:19241483   PMID:19251249   PMID:19279034   PMID:19327173   PMID:19342961   PMID:19362079  
PMID:19365232   PMID:19403032   PMID:19404405   PMID:19404732   PMID:19430970   PMID:19457567   PMID:19458123   PMID:19476648   PMID:19481766   PMID:19501592   PMID:19570345   PMID:19593445  
PMID:19620074   PMID:19629561   PMID:19655406   PMID:19666510   PMID:19689083   PMID:19717152   PMID:19719951   PMID:19720604   PMID:19726347   PMID:19730128   PMID:19734906   PMID:19780028  
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PMID:20518312   PMID:20537956   PMID:20601888   PMID:20646530   PMID:20687137   PMID:20705587   PMID:20717930   PMID:20731656   PMID:20813690   PMID:20840869   PMID:20849956   PMID:20979835  
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PMID:21683791   PMID:21699906   PMID:21717513   PMID:21723926   PMID:21729740   PMID:21734649   PMID:21764057   PMID:21772666   PMID:21816109   PMID:21819443   PMID:21858029   PMID:21866632  
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PMID:22198514   PMID:22207578   PMID:22246136   PMID:22318995   PMID:22333058   PMID:22339544   PMID:22357537   PMID:22384199   PMID:22389501   PMID:22406301   PMID:22422608   PMID:22538426  
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PMID:23776175   PMID:23811396   PMID:23877628   PMID:23884820   PMID:23925818   PMID:23928073   PMID:23980096   PMID:23982744   PMID:23984387   PMID:24101667   PMID:24114535   PMID:24146067  
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PMID:32259888   PMID:32484026   PMID:32538742   PMID:32557145  


Candidate Gene Status
Nfkb1 is a candidate Gene for QTL Eau5
Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl4102,501,331 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh384102,501,266 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBI
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393135,290,416 - 135,397,728 (-)NCBIGRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBImm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0panPan3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBI
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBI
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBI
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBI
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBI
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBI
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl8118,390,637 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1750,589,494 - 50,711,472 (+)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBIVero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,097,958 - 224,098,088 (+)MAPPERmRatBN7.2
Rnor_6.02240,856,230 - 240,856,359NCBIRnor6.0
Rnor_5.02259,411,018 - 259,411,147UniSTSRnor5.0
RGSC_v3.42233,177,238 - 233,177,367UniSTSRGSC3.4
Celera2216,306,923 - 216,307,052UniSTS
Cytogenetic Map2q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,016,559 - 224,016,753 (+)MAPPERmRatBN7.2
Rnor_6.02240,773,866 - 240,774,059NCBIRnor6.0
Rnor_5.02259,330,723 - 259,330,916UniSTSRnor5.0
RGSC_v3.42233,091,359 - 233,091,552UniSTSRGSC3.4
Celera2216,227,195 - 216,227,388UniSTS
RH 3.4 Map21563.3UniSTS
Cytogenetic Map2q43UniSTS
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,053,636 - 224,053,739 (+)MAPPERmRatBN7.2
Rnor_6.02240,811,118 - 240,811,220NCBIRnor6.0
Rnor_5.02259,367,975 - 259,368,077UniSTSRnor5.0
RGSC_v3.42233,128,434 - 233,128,536UniSTSRGSC3.4
Celera2216,263,668 - 216,263,770UniSTS
Cytogenetic Map2q43UniSTS

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:135
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000036838, ENSRNOT00000040511, ENSRNOT00000068674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 3 43 54 38 19 38 7 8 68 35 34 11 7
Low 3 3 3 1 3 6 7 1
Below cutoff