Nfkb1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: Nfkb1 (nuclear factor kappa B subunit 1) Rattus norvegicus
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Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
RGD ID: 70498
Description: Enables heat shock protein binding activity; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; cellular response to cytokine stimulus; and cellular response to diterpene. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Part of protein-containing complex. Used to study steatotic liver disease. Biomarker of alcoholic hepatitis; hepatocellular carcinoma; metabolic dysfunction-associated steatohepatitis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency 12; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1); PARTICIPATES IN pro-inflammatory cytokine mediated pathway; adenosine signaling pathway; ceramide signaling pathway; INTERACTS WITH (+)-catechin; (+)-taxifolin; (20S)-ginsenoside Rg3.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding factor KBF1; EBP-1; NF-kappaB; NF-kB; NFKB-p50; nuclear factor kappa B p105 subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; p50
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,689,745 - 226,805,897 (-)NCBIGRCr8
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-beta-thujone  (ISO)
(+)-catechin  (EXP)
(+)-taxifolin  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (EXP)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(E)-roxithromycin  (EXP)
(R)-adrenaline  (EXP)
(R)-camphor  (ISO)
(R)-linalyl acetate  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (ISO)
1,8-cineole  (ISO)
1-bromopropane  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5'-triiodo-L-thyronine  (EXP)
3,3',5-triiodo-L-thyronine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (EXP)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (EXP,ISO)
5-Hydroxycapric acid  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (EXP)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP,ISO)
7H-xanthine  (EXP)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (EXP)
[6]-Shogaol  (ISO)
abamectin  (EXP)
abexinostat  (ISO)
acenaphthoquinone  (ISO)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP)
Actein  (ISO)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (EXP,ISO)
AH23848  (ISO)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (EXP)
aluminium atom  (EXP)
aluminium sulfate (anhydrous)  (ISO)
aluminium(0)  (EXP)
amiloride  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
ammonium hexachloroplatinate  (ISO)
amphibole asbestos  (ISO)
anethole  (EXP,ISO)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (EXP,ISO)
aripiprazole  (ISO)
Aroclor 1254  (ISO)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
atrazine  (EXP,ISO)
aurantio-obtusin  (ISO)
azadirachtin A  (ISO)
Azoxymethane  (EXP)
B 581  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (EXP)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
berberine  (EXP)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (ISO)
bezafibrate  (ISO)
bilirubin IXalpha  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisdemethoxycurcumin  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
bleomycin A2  (EXP,ISO)
Boldine  (EXP)
boric acid  (ISO)
bortezomib  (EXP,ISO)
busulfan  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
butyric acid  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
calcitriol  (ISO)
Calphostin C  (ISO)
camphor  (ISO)
cannabidiol  (ISO)
capsaicin  (ISO)
capsazepine  (ISO)
carbamazepine  (ISO)
carbaryl  (ISO)
carbon nanotube  (EXP)
carboplatin  (EXP,ISO)
Cardamonin  (EXP)
carmustine  (EXP,ISO)
carrageenan  (EXP)
carteolol  (ISO)
carvacrol  (EXP,ISO)
casticin  (ISO)
CCCP  (ISO)
CEDRELONE  (ISO)
celecoxib  (ISO)
ceric oxide  (ISO)
cerium  (ISO)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroform  (ISO)
chloroquine  (ISO)
chlorpyrifos  (ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (ISO)
chrysin  (EXP)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (EXP)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corilagin  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (EXP,ISO)
cyproheptadine  (EXP)
D-glucose  (ISO)
daidzein  (ISO)
danazol  (ISO)
DDE  (ISO)
DDT  (ISO)
decabromodiphenyl ether  (ISO)
DENSPM  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (ISO)
diazepam  (ISO)
diazoxide  (ISO)
dibenziodolium  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (EXP,ISO)
dicofol  (ISO)
dicoumarol  (ISO)
dieckol  (ISO)
dieldrin  (EXP)
dienogest  (ISO)
diethyldithiocarbamic acid  (EXP)
diethylstilbestrol  (ISO)
digitoxin  (ISO)
dihydroartemisinin  (EXP)
dihydroxyacetone  (ISO)
diltiazem  (ISO)
dimethyl fumarate  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioscin  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
diphenyl diselenide  (EXP)
diquat  (EXP)
disodium selenite  (EXP)
disulfiram  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (EXP,ISO)
enalapril  (EXP)
endosulfan  (EXP,ISO)
endrin  (ISO)
erythromycin A  (ISO)
esculetin  (ISO)
ethanol  (EXP,ISO)
ethyl acetate  (ISO)
ethylene glycol  (EXP)
ethylisopropylamiloride  (ISO)
etoposide  (ISO)
eugenol  (EXP,ISO)
Evodiamine  (ISO)
famotidine  (ISO)
felodipine  (ISO)
fenofibrate  (ISO)
ferric oxide  (ISO)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flurbiprofen  (ISO)
fluticasone  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
fosinopril  (ISO)
FR900359  (ISO)
fucoidan  (ISO)
fulvestrant  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (EXP,ISO)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (EXP)
gastrin-17  (ISO)
gefitinib  (ISO)
genistein  (ISO)
gentamycin  (EXP)
geraniol  (EXP)
gingerol  (ISO)
ginsenoside C-K  (EXP)
glafenine  (EXP)
gliotoxin  (ISO)
glucaric acid  (ISO)
glucose  (ISO)
glutathione  (ISO)
glutathione disulfide  (EXP,ISO)
glyburide  (EXP)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
gold atom  (ISO)
gold(0)  (ISO)
guggulsterone  (EXP,ISO)
GW 501516  (ISO)
haloperidol  (EXP)
harmaline  (ISO)
heme b  (ISO)
hesperidin  (EXP)
hexadecanoic acid  (EXP,ISO)
histamine  (ISO)
Honokiol  (ISO)
hyaluronic acid  (ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
imidacloprid  (EXP)
indole-3-acetic acid  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isoeugenol  (ISO)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoniazide  (EXP)
isoprenaline  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lactulose  (EXP)
lanreotide  (EXP)
lead diacetate  (EXP)
lead(0)  (EXP,ISO)
leptomycin B  (ISO)
limonene  (EXP)
linalool  (ISO)
linalyl acetate  (ISO)
linoleic acid  (EXP)
lipoarabinomannan  (ISO)
lipoic acid  (EXP,ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (ISO)
losartan  (EXP,ISO)
luteolin  (EXP,ISO)
LY294002  (ISO)
lycopene  (EXP)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (EXP,ISO)
Mecamylamine  (EXP,ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methamphetamine  (ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP,ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methyllycaconitine  (EXP)
methylmercury chloride  (ISO)
methylmercury(1+)  (EXP)
methylseleninic acid  (ISO)
mevalonic acid  (ISO)
mevinphos  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
monotropein  (ISO)
morphine  (EXP)
Muraglitazar  (EXP)
myo-inositol hexakisphosphate  (ISO)
Myrtucommulone A  (ISO)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naproxen  (ISO)
naringin  (EXP)
Neferine  (EXP)
neoechinulin A  (ISO)
neratinib  (ISO)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (EXP)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nitric oxide  (ISO)
nitroprusside  (EXP,ISO)
nonanoic acid  (ISO)
Nonylphenol  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (EXP)
o-anisidine  (ISO)
obeticholic acid  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
oleanolic acid  (ISO)
omacetaxine mepesuccinate  (ISO)
oxaliplatin  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (EXP,ISO)
PD123319  (EXP)
pentachlorophenol  (ISO)
Pentoxifylline  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perindopril  (ISO)
permethrin  (EXP)
pevonedistat  (ISO)
PF-3758309  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenytoin  (ISO)
PhIP  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
pifithrin-alpha hydrobromide  (ISO)
piperine  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium chromate  (ISO)
prednisone  (ISO)
procyanidin B1  (ISO)
progesterone  (ISO)
propanil  (ISO)
propionic acid  (ISO)
prostaglandin E2  (ISO)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (EXP)
purine-6-thiol  (ISO)
pyrethrins  (ISO)
Pyridostigmine bromide  (EXP)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
raloxifene  (EXP)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ritonavir  (ISO)
rocaglamide  (ISO)
romidepsin  (ISO)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
rutin  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
S-nitroso-N-acetyl-D-penicillamine  (EXP)
sabinene  (ISO)
salicylates  (EXP)
Salinomycin  (ISO)
sarin  (EXP)
SB 203580  (ISO)
scoparone  (ISO)
scutellarin  (ISO)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP,ISO)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium disulfite  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (EXP,ISO)
Soman  (EXP)
sorafenib  (ISO)
spathulenol  (ISO)
staurosporine  (ISO)
sterigmatocystin  (EXP)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (EXP,ISO)
succimer  (EXP,ISO)
succinic acid  (ISO)
sulfasalazine  (EXP,ISO)
sulforaphane  (ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (ISO)
tectorigenin  (ISO)
telmisartan  (ISO)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
thalidomide  (EXP,ISO)
theophylline  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
thiram  (ISO)
thymoquinone  (EXP)
Tiron  (ISO)
titanium dioxide  (ISO)
trans-anethole  (EXP,ISO)
trans-isoeugenol  (ISO)
tributylstannane  (EXP)
Tributyltin oxide  (ISO)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP,ISO)
Tropicamide  (EXP)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
vanadyl sulfate  (ISO)
vancomycin  (ISO)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (ISO)
WR-1065  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zineb  (ISO)
zingerone  (EXP)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antibacterial innate immune response  (IEA,ISO)
apoptotic process  (IEA)
B cell receptor signaling pathway  (IEA,ISO)
canonical NF-kappaB signal transduction  (IEA,ISO)
cellular response to angiotensin  (IEA,ISO)
cellular response to brain-derived neurotrophic factor stimulus  (IDA)
cellular response to carbohydrate stimulus  (IDA)
cellular response to cytokine stimulus  (IDA)
cellular response to diterpene  (IDA)
cellular response to dsRNA  (IEA,ISO)
cellular response to glucoside  (IDA)
cellular response to interleukin-1  (IDA,IEA,ISO)
cellular response to interleukin-17  (IEA,ISO)
cellular response to interleukin-6  (IEA,ISO)
cellular response to lipopolysaccharide  (IDA,IEA,ISO)
cellular response to mechanical stimulus  (IEA,ISO)
cellular response to nicotine  (IEA,ISO)
cellular response to peptide  (IDA)
cellular response to tumor necrosis factor  (IDA,IEA,IEP,ISO)
cellular response to virus  (IEA,ISO)
gene expression  (IEA,ISO)
JNK cascade  (IEA,ISO)
mammary gland involution  (IEA,ISO)
MAPK cascade  (ISO)
negative regulation of apoptotic process  (IMP)
negative regulation of calcidiol 1-monooxygenase activity  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of cytokine production involved in inflammatory response  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
non-canonical NF-kappaB signal transduction  (IEA,ISO)
obsolete cellular response to organic cyclic compound  (IDA)
positive regulation of canonical Wnt signaling pathway  (IEA,ISO)
positive regulation of cholesterol efflux  (IEA,ISO)
positive regulation of DNA-templated transcription  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of hyaluronan biosynthetic process  (IEA,ISO)
positive regulation of lipid storage  (IEA,ISO)
positive regulation of macrophage derived foam cell differentiation  (IEA,ISO)
positive regulation of miRNA metabolic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription initiation by RNA polymerase II  (IEA,ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (ISO)
response to bacterium  (IEP)
response to copper ion  (IEP)
response to ethanol  (IEP)
response to muscle stretch  (IEA,ISO)
response to oxidative stress  (IDA)
response to xenobiotic stimulus  (IEP)
signal transduction  (IEA)
signal transduction involved in regulation of gene expression  (ISO)

Cellular Component

References

References - curated
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PMID:20518312   PMID:20537956   PMID:20601888   PMID:20646530   PMID:20687137   PMID:20705587   PMID:20717930   PMID:20731656   PMID:20813690   PMID:20840869   PMID:20849956   PMID:20979835  
PMID:21038672   PMID:21069255   PMID:21072674   PMID:21131739   PMID:21134288   PMID:21141136   PMID:21141517   PMID:21143912   PMID:21162919   PMID:21179738   PMID:21184129   PMID:21186580  
PMID:21186606   PMID:21186609   PMID:21186627   PMID:21211536   PMID:21220710   PMID:21252158   PMID:21265102   PMID:21311037   PMID:21326386   PMID:21356247   PMID:21357467   PMID:21389697  
PMID:21403895   PMID:21434346   PMID:21506880   PMID:21528054   PMID:21542286   PMID:21550382   PMID:21564349   PMID:21606643   PMID:21607291   PMID:21611132   PMID:21645265   PMID:21675862  
PMID:21683791   PMID:21699906   PMID:21717513   PMID:21723926   PMID:21729740   PMID:21734649   PMID:21764057   PMID:21772666   PMID:21816109   PMID:21819443   PMID:21858029   PMID:21866632  
PMID:21892747   PMID:21893401   PMID:21982707   PMID:21988832   PMID:22001368   PMID:22005927   PMID:22011862   PMID:22017688   PMID:22057375   PMID:22086008   PMID:22159911   PMID:22174951  
PMID:22198514   PMID:22207578   PMID:22246136   PMID:22318995   PMID:22333058   PMID:22339544   PMID:22357537   PMID:22384199   PMID:22389501   PMID:22406301   PMID:22422608   PMID:22538426  
PMID:22555453   PMID:22569251   PMID:22572938   PMID:22575044   PMID:22617488   PMID:22627105   PMID:22634628   PMID:22659623   PMID:22732277   PMID:22739109   PMID:22771449   PMID:22847643  
PMID:22927965   PMID:22957038   PMID:23047940   PMID:23064013   PMID:23111737   PMID:23138875   PMID:23151725   PMID:23165960   PMID:23219970   PMID:23223967   PMID:23230847   PMID:23272499  
PMID:23318928   PMID:23402995   PMID:23493287   PMID:23564500   PMID:23566817   PMID:23570504   PMID:23574812   PMID:23695883   PMID:23725508   PMID:23729669   PMID:23751897   PMID:23770986  
PMID:23776175   PMID:23811396   PMID:23877628   PMID:23884820   PMID:23925818   PMID:23928073   PMID:23980096   PMID:23982744   PMID:23984387   PMID:24101667   PMID:24114535   PMID:24146067  
PMID:24173240   PMID:24217957   PMID:24223475   PMID:24335635   PMID:24349514   PMID:24434150   PMID:24434510   PMID:24471369   PMID:24513955   PMID:24553183   PMID:24625911   PMID:24663080  
PMID:24684441   PMID:24740410   PMID:24752868   PMID:24928011   PMID:25063066   PMID:25122164   PMID:25198883   PMID:25220584   PMID:25231849   PMID:25411248   PMID:25446875   PMID:25466668  
PMID:25510691   PMID:25567745   PMID:25575055   PMID:25609649   PMID:25681771   PMID:25706655   PMID:25740656   PMID:25800037   PMID:25958302   PMID:26165348   PMID:26187567   PMID:26208700  
PMID:26255634   PMID:26308798   PMID:26450610   PMID:26475712   PMID:26550927   PMID:26687115   PMID:26690896   PMID:26891076   PMID:26970569   PMID:26991692   PMID:27013094   PMID:27031871  
PMID:27107073   PMID:27302421   PMID:27342816   PMID:27429986   PMID:27443256   PMID:27693495   PMID:27765761   PMID:27939576   PMID:28031043   PMID:28033732   PMID:28161820   PMID:28173835  
PMID:28231612   PMID:28677772   PMID:28765874   PMID:28780681   PMID:28849713   PMID:29257252   PMID:29508184   PMID:29510084   PMID:29620141   PMID:29940243   PMID:30305579   PMID:30395883  
PMID:30548682   PMID:30561076   PMID:31372663   PMID:31451219   PMID:31638264   PMID:31816325   PMID:31841174   PMID:31856086   PMID:31939007   PMID:31939452   PMID:32049985   PMID:32259888  
PMID:32484026   PMID:32538742   PMID:32557145   PMID:33039977   PMID:34254317   PMID:35883637   PMID:36400309   PMID:37590975   PMID:37598133   PMID:37673222   PMID:37683611   PMID:37801786  
PMID:37914064   PMID:38302679   PMID:38334011   PMID:38466011   PMID:38788361   PMID:38850784  


Genomics

Comparative Map Data
Nfkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,689,745 - 226,805,897 (-)NCBIGRCr8
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
NFKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,501,359 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4102,501,330 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36Build 36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
T2T-CHM13v2.04105,815,285 - 105,931,246 (+)NCBIT2T-CHM13v2.0
Nfkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,290,416 - 135,397,422 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)EnsemblGRCm39 Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBIMGSCv36mm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
Nfkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
NFKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23100,585,471 - 100,700,918 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14100,871,776 - 100,987,238 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
NFKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3224,141,192 - 24,259,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBIUU_Cfam_GSD_1.0
Nfkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936520733,668 - 829,435 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,390,638 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
NFKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,589,494 - 50,711,472 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,333,616 - 5,408,723 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:135
Interacting mature miRNAs:164
Transcripts:ENSRNOT00000036838, ENSRNOT00000040511, ENSRNOT00000068674
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
631563Hcuc3Hepatic copper content QTL 33.87liver copper amount (VT:0003065)liver copper weight to liver dry weight ratio (CMO:0001512)2212145502231732847Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2184482291229482291Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2202029709236904960Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2186850607231850607Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2192287802237287802Rat
1302789Stl26Serum triglyceride level QTL 263.10.0035blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)2206613059226891081Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2188565047233565047Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2192287802229609668Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2184856304229856304Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2184856304229856304Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2182635347227635347Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2184856304229856304Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166372086229820014Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2184856304229856304Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2192287802237287802Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2182024327227024327Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2159440760228950743Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221270493228950743Rat

Markers in Region
D2Mco50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,097,958 - 224,098,088 (+)MAPPERmRatBN7.2
Rnor_6.02240,856,230 - 240,856,359NCBIRnor6.0
Rnor_5.02259,411,018 - 259,411,147UniSTSRnor5.0
RGSC_v3.42233,177,238 - 233,177,367UniSTSRGSC3.4
Celera2216,306,923 - 216,307,052UniSTS
Cytogenetic Map2q43UniSTS
RH127857  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,016,559 - 224,016,753 (+)MAPPERmRatBN7.2
Rnor_6.02240,773,866 - 240,774,059NCBIRnor6.0
Rnor_5.02259,330,723 - 259,330,916UniSTSRnor5.0
RGSC_v3.42233,091,359 - 233,091,552UniSTSRGSC3.4
Celera2216,227,195 - 216,227,388UniSTS
RH 3.4 Map21563.3UniSTS
Cytogenetic Map2q43UniSTS
PMC213488P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,053,636 - 224,053,739 (+)MAPPERmRatBN7.2
Rnor_6.02240,811,118 - 240,811,220NCBIRnor6.0
Rnor_5.02259,367,975 - 259,368,077UniSTSRnor5.0
RGSC_v3.42233,128,434 - 233,128,536UniSTSRGSC3.4
Celera2216,263,668 - 216,263,770UniSTS
Cytogenetic Map2q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000036838   ⟹   ENSRNOP00000028944
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2224,016,214 - 224,103,724 (-)Ensembl
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000109057   ⟹   ENSRNOP00000082290
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
RefSeq Acc Id: NM_001276711   ⟹   NP_001263640
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,462 (-)NCBI
mRatBN7.22224,016,214 - 224,131,937 (-)NCBI
Rnor_6.02240,773,520 - 240,890,053 (-)NCBI
Rnor_5.02259,330,377 - 259,444,869 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001415012   ⟹   NP_001401941
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,462 (-)NCBI
mRatBN7.22224,016,214 - 224,131,937 (-)NCBI
RefSeq Acc Id: XM_006233360   ⟹   XP_006233422
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
mRatBN7.22224,016,214 - 224,132,135 (-)NCBI
Rnor_6.02240,773,520 - 240,890,048 (-)NCBI
Rnor_5.02259,330,377 - 259,444,869 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063282628   ⟹   XP_063138698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: XM_063282629   ⟹   XP_063138699
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: XM_063282630   ⟹   XP_063138700
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,689,745 - 226,805,897 (-)NCBI
RefSeq Acc Id: NP_001263640   ⟸   NM_001276711
- Peptide Label: isoform 2
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233422   ⟸   XM_006233360
- Peptide Label: isoform X3
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000028944   ⟸   ENSRNOT00000036838
Ensembl Acc Id: ENSRNOP00000082290   ⟸   ENSRNOT00000109057
RefSeq Acc Id: NP_001401941   ⟸   NM_001415012
- Peptide Label: isoform 1
- UniProtKB: Q63369 (UniProtKB/Swiss-Prot),   F1LQH2 (UniProtKB/Swiss-Prot),   A0A9S9T974 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138700   ⟸   XM_063282630
- Peptide Label: isoform X4
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138699   ⟸   XM_063282629
- Peptide Label: isoform X2
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138698   ⟸   XM_063282628
- Peptide Label: isoform X1
- UniProtKB: A0A9S9T974 (UniProtKB/TrEMBL)
Protein Domains
Death   RHD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63369-F1-model_v2 AlphaFold Q63369 1-522 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70498 AgrOrtholog
BioCyc Gene G2FUF-51127 BioCyc
Ensembl Genes ENSRNOG00000023258 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000036838.5 UniProtKB/TrEMBL
  ENSRNOT00000109057.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
  Immunoglobulins UniProtKB/Swiss-Prot
  Rel homology domain (RHD), DNA-binding domain UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_E-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_dom UniProtKB/Swiss-Prot
  IPT_NFkappaB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT_TIG_rcpt UniProtKB/TrEMBL
  NF-kB_p105 UniProtKB/TrEMBL
  NF-kB_p105_DD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NF-kB_p105_RHD_N UniProtKB/Swiss-Prot
  NFkB/Dor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
  RHD UniProtKB/TrEMBL
  RHD_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/Swiss-Prot
  RHD_DNA_bind_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 81736 ENTREZGENE
PANTHER PTHR24169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR24169:SF9 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Ank UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ank_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Death UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD UniProtKB/TrEMBL
  RHD_dimer UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/Swiss-Prot
PharmGKB NFKB1 RGD
PhenoGen Nfkb1 PhenoGen
PRINTS ANKYRIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  NFKBTNSCPFCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ANK_REPEAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REL_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  REL_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000023258 RatGTEx
SMART ANK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IPT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP E set domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  p53-like transcription factors UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47986 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48403 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZTP7_RAT UniProtKB/TrEMBL
  A0A9S9T974 ENTREZGENE, UniProtKB/TrEMBL
  A6HVY5_RAT UniProtKB/TrEMBL
  A6HVY6_RAT UniProtKB/TrEMBL
  A6HVY7_RAT UniProtKB/TrEMBL
  F1LQH2 ENTREZGENE
  NFKB1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary F1LQH2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-05-04 Nfkb1  nuclear factor kappa B subunit 1  Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-24 Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1  Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-31 Nfkb1  nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105  Nfkb1  nuclear factor of kappa light chain gene enhancer in B-cells 1, p105  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-12-14 Nfkb1  nuclear factor of kappa light chain gene enhancer in B-cells 1, p105    nuclear factor kappa B p105 subunit  Name updated 1299863 APPROVED
2002-06-10 Nfkb1  nuclear factor kappa B p105 subunit      Symbol and Name status set to provisional 70585 PROVISIONAL

RGD Curation Notes
Note Type Note Reference
gene_disease expression level is related to breast cancer 625513
gene_disease plays a role in the inhibition of breast cancer cells 70295
gene_drugs strongly inhibited by resveratrol (trans-3,4,5-trihydroxystilbene), a polyphenolic phytoalexin, which suppresses DMBA (7,12-Dimethylbenz(a)anthracene)-induced mammary carcinogenesis 625513
gene_drugs resveratrol (trans-3,4,5-trihydroxystilbene)a polyphenolic phytoalexin a potent inhibitor, was able to down regulate expression in DMBA (7,12-dimethylbenzaanthracene) induced rat mammary carcinogenesis and ductal carcinoma, it has a chemopreventive action 625669
gene_drugs dehydroepiandrosterone (DHEA), a steroid produced by brain, affects the activation and subsequent nuclear translocation of Nfkb1 by oxidative stress 625669
gene_expression expressed at low levels in mammary glands during early lactation, increases after weaning 70295
gene_function DNA binding subunit of NFkB1 transcription factor 70295
gene_function interacts with FSH-regulated RNAs 634428
gene_other NFkB family consists of DNA binding subunit and transcriptional activators, including p65, p50, p52, and c-Rel, that share a Rel homology domain 70295
gene_process may be involved in ductal involution 70295
gene_process required for protection from TNF-alpha mediated apoptosis 625669
gene_process required for protection from TNF-alpha mediated apoptosis 628339
gene_process may regulate genes that are involved in pathophysiology of inflammation, immune response and atherosclerosis 625669
gene_process involved in regulating transcription of cytokines, chemokines, leukocyte adhesion molecules and regulators of cell proliferation and survival 625669
gene_regulation activation negatively correlates with peripartum Amh (Anti - Mullerian hormone (Mullerian inhibiting substance)) type II receptor levels 70295
gene_regulation activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625604
gene_regulation activity is downregulated by NOS inhibitor causing inhibition of apoptosis induced by helicobacter pylori in gastric parietal cells 625669
gene_regulation inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 625669
gene_regulation inhibition of glycogen synthase kinase-3 (GSK-3) downregulates transcription induced by TNF-alpha 628339
gene_regulation in hippocampal region is activated by oxidative stress caused by streptozotocin-induced diabetes; 625669