Hrtrt19 QTL Report (Rattus norvegicus) - Rat Genome Database

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QTL: Hrtrt19 (Heart rate QTL 19) Rattus norvegicus

Symbol: Hrtrt19
Name: Heart rate QTL 19
RGD ID: 1359019
Also known as: Hr19
Trait: heart pumping trait   (VT:2000009)    
Measurement Type: heart rate   (CMO:0000002)    
LOD Score: 2.9
P Value: Not Available
Variance: Not Available
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22219,753,301 - 226,277,316RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.02236,318,496 - 243,026,643RGD_MAPPER_PIPELINERnor6.0
Rnor_5.02254,867,191 - 261,576,629RGDRnor5.0
RGSC_v3.42228,663,949 - 234,266,109RGDRGSC3.4
RGSC_v3.12228,650,690 - 234,252,848RGD
Cross Type: recombinantinbred
Strains Crossed: BXH/Ipcv HXB/Ipcv 
JBrowse: View Region in Genome Browser (JBrowse)
Model



Disease Annotations     Click to see Annotation Detail View
Bradycardia  (IAGP)
heart disease  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
Experimental Data Annotations     Click to see Annotation Detail View

Clinical Measurement
heart rate  (IDA)

Experimental Condition

Measurement Method

Vertebrate Trait

Rat Strain
BXH/Ipcv  (IEA)
HXB/Ipcv  (IEA)

References

References - curated
1. Jaworski RL, etal., Hypertension 2002 Feb;39(2 Pt 2):348-52.

Region

Genes in Region
The following Genes overlap with this region.    Full Report CSV TAB Printer Analysis Tools
RGD IDSymbolNameChrStartStopSpecies
620241Lef1lymphoid enhancer binding factor 12219666549219779815Rat
69321Hadhhydroxyacyl-CoA dehydrogenase2219787935219830335Rat
1309433Cyp2u1cytochrome P450, family 2, subfamily u, polypeptide 12219849403219866959Rat
7625966LOC102552472aminoacyl tRNA synthase complex-interacting multifunctional protein 1-like2219855905219864052Rat
1305778Sgms2sphingomyelin synthase 22219889809219967704Rat
11404996LOC108350108uncharacterized LOC1083501082219916828219934897Rat
11520544LOC108350109uncharacterized LOC1083501092219949115219959917Rat
41260335LOC120100944uncharacterized LOC1201009442219976241219979672Rat
41156518LOC120101055protein PBDC1-like2220020063220022513Rat
1308081Papss13'-phosphoadenosine 5'-phosphosulfate synthase 12220040338220114399Rat
40994666LOC120101344U1 spliceosomal RNA2220206250220206413Rat
1594188LOC680243similar to Actin-related protein 102220553641220554855Rat
1308639Dkk2dickkopf WNT signaling pathway inhibitor 22220568338220660225Rat
41268366LOC120100620uncharacterized LOC1201006202220758968220764188Rat
41214852LOC120101194U6 spliceosomal RNA2221038075221038177Rat
7738424LOC102547683uncharacterized LOC1025476832221090549221103890Rat
1563706Gimd1GIMAP family P-loop NTPase domain containing 12221103878221138559Rat
620466Aimp1aminoacyl tRNA synthetase complex-interacting multifunctional protein 12221151907221175458Rat
1307816TbckTBC1 domain containing kinase2221175749221348126Rat
41108173LOC120101311small nucleolar RNA SNORA172221294661221294790Rat
1593709Npntnephronectin2221391151221459527Rat
1590828LOC365942similar to CG5149-PA2221459266221464322Rat
7720012LOC102548236uncharacterized LOC1025482362221475058221499118Rat
1311822Gstcdglutathione S-transferase, C-terminal domain containing2221499083221591888Rat
1359136Ints12integrator complex subunit 122221591650221609497Rat
1311728Arhgef38Rho guanine nucleotide exchange factor 382221610212221739841Rat
7572082LOC102546359uncharacterized LOC1025463592221797737221800778Rat
1307965Ppa2inorganic pyrophosphatase 22221800791221878079Rat
1591740Gpbp1l2GC-rich promoter binding protein 1-like 22221964036221967326Rat
1311625Tet2tet methylcytosine dioxygenase 22221988645222072813Rat
41203961LOC120100945uncharacterized LOC1201009452222070769222082377Rat
41280602LOC120101230small nucleolar RNA SNORA702222110982222111103Rat
2323726LOC100362967ribosomal protein 10-like2222111139222111551Rat
40967376LOC120101282small nucleolar RNA SNORA172222114424222114555Rat
11437904LOC108350114glyceraldehyde-3-phosphate dehydrogenase pseudogene2222128067222141244Rat
41224173LOC120100946uncharacterized LOC1201009462222629081222668827Rat
69228Cxxc4CXXC finger protein 42222664148222689365Rat
2323572LOC100363023hypothetical LOC1003630232222787557222789283Rat
3810Tacr3tachykinin receptor 32223266536223363791Rat
41360797LOC12010062140S ribosomal protein S26-like2223598382223598776Rat
1589432LOC680644similar to Myosin regulatory light chain 2, smooth muscle isoform (Myosin RLC)2223610495223611007Rat
1307115Cenpecentromere protein E2223637035223695692Rat
1309898Bdh23-hydroxybutyrate dehydrogenase 22223702410223723076Rat
1598112Slc9b2solute carrier family 9 member B22223726982223761234Rat
1305087Slc9b1solute carrier family 9 member B12223769105223818359Rat
41364128LOC120100947uncharacterized LOC1201009472223822297223827993Rat
41037515LOC120101362small nucleolar RNA SNORA262223824846223824966Rat
1566242Cisd2CDGSH iron sulfur domain 22223828937223853768Rat
6486070LOC100912622uncharacterized LOC1009126222223858081223868546Rat
619912Ube2d3ubiquitin-conjugating enzyme E2D 32223868397223899606Rat
1305785Manbamannosidase beta2223910432224002988Rat
41194115LOC120100948uncharacterized LOC1201009482223932050223934801Rat
40993262LOC120101140U6 spliceosomal RNA2224015573224015679Rat
70498Nfkb1nuclear factor kappa B subunit 12224016214224132135Rat
41144425LOC120101106U2 spliceosomal RNA2224145615224145716Rat
1308236Slc39a8solute carrier family 39 member 82224171787224319326Rat
11462118LOC10835011660S ribosomal protein L7 pseudogene2224181434224222483Rat
1564639Bank1B-cell scaffold protein with ankyrin repeats 12224530475224800420Rat
9294131LOC10369173360S ribosomal protein L29 pseudogene2224815128224815436Rat
3382Ppp3caprotein phosphatase 3 catalytic subunit alpha2225165981225440978Rat
1588169LOC680797similar to protein kinase C and casein kinase substrate in neurons 32225474055225475975Rat
40939843LOC120100622uncharacterized LOC1201006222225885497225888436Rat
1303218Emcnendomucin2225891100225970932Rat
1561427LOC499715LRRGT000952226053474226074090Rat
41011800LOC120100949uncharacterized LOC1201009492226057178226074795Rat
2322961Ddit4lDNA-damage-inducible transcript 4-like2226128273226131044Rat
11496584LOC108350121uncharacterized LOC1083501212226205496226207736Rat

Markers in Region
The following Markers overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolExpected SizeChrStartStopSpeciesMatch
36962D2Rat631232222436573222436696Ratregion
34785D2Rat651562226102309226102471Ratregion
35064D2Rat641812223265204223265385Ratregion
35849D2Rat621732219753301219753474Ratregion
38054D2Rat1382332221166836221167075Ratregion
38852D2Rat1652492221035642221035911Ratregion
39118D2Rat1391382223490383223490532Ratregion
41462D2Rat2451252224813322224813458Ratregion
42625D2Rat3622472221122010221122274Ratregion
42627D2Rat2922482221122010221122275Ratregion
42628D2Rat2931412224786940224787090Ratregion
41066D2Rat2471632226277159226277316Ratregion
43591D2Got1942872222842003222842288Ratregion
66474D2Uia122152220360923220361140Ratregion
66531D2Mco51122223024296223024402Ratregion
1630255D2Got3551572220302444220302596Ratregion
1628117D2Got3591662224160255224160421Ratregion
1629030D2Got3601322224430206224430339Ratregion
1639714D2Got3572722224792464224792736Ratregion
1641596D2Mco501302224097958224098088Ratregion
1632674D2Got3672072220130961220131168Ratregion
1633066D2Got4112022226263171226263369Ratregion
1640426D2Got4282962222280947222281238Ratregion
1635199D2Got3581422223887815223887957Ratregion
1635371D2Got3611572224805112224805269Ratregion
1633684D2Got3561282220302464220302592Ratregion
7206044Tet21032222000938222001041Ratregion
5035598SHGC-672551062225438449225438555Ratregion
5034013RH1410271802225972027225972207Ratregion
5034327AI5018542062224318762224318968Ratregion
5034478BF415569992225329115225329214Ratregion
5026516RH1325122202221590735221590955Ratregion
5032957RH1371001612225970767225970928Ratregion
5027993J054791652225438482225438647Ratregion
5028089X586361642219778709219778873Ratregion
5025664RH1291871862220114160220114346Ratregion
5030935BF3995452112221367006221367217Ratregion
5033757RH1400091952224530943224531138Ratregion
5033809RH1402012192223862708223862927Ratregion
5025924RH1302202062219787950219788156Ratregion
5031099BF4061861982225444985225445183Ratregion
5055139RH1436281022219830486219830588Ratregion
5053139RH1424761562225303513225303669Ratregion
5059304BG3771491272221611055221611182Ratregion
5059308AI0719941822220660460220660642Ratregion
7193034PPP3CA3682225438480225438848Ratregion
5050206RH1339222072219779447219779654Ratregion
5050670RH1341902152222689023222689238Ratregion
5041770RH1290481902225440644225440834Ratregion
5043998RH1303512102225439717225439926Ratregion
5044496RH1306361822226132437226132619Ratregion
5041346RH1288042102221391277221391487Ratregion
5049586RH1335662042223828934223829138Ratregion
5040282RH1281941992219862686219862886Ratregion
5043018RH1297822042224002741224002945Ratregion
5039700RH1278571942224016559224016753Ratregion
5040800RH1284902202223897045223897265Ratregion
5072378RH1368142352223862708223862943Ratregion
5076748RH1393551572220658840220658997Ratregion
5075340RH1385381522225979779225979931Ratregion
5074854RH1382561732225298708225298881Ratregion
5078080RH1401321982222669355222669553Ratregion
5072858RH1370951872219788003219788190Ratregion
5080340RH1415232102221499933221500142Ratregion
5073374RH1373992032223861766223861969Ratregion
5072962RH1371541802223854978223855158Ratregion
5074094RH1378172182225214161225214379Ratregion
5063446BI3018031732226135539226135712Ratregion
5066832AU0481241992221603937221604136Ratregion
5066896AU0480862582224964332224964590Ratregion
5067594AU0476511402226036966226037106Ratregion
5064394BF3991981682225443476225443644Ratregion
5066070BE1167081762223887351223887527Ratregion
5064912BF3999111172222003891222004008Ratregion
5082635BE1198881952225421869225422064Ratregion
5088036Papss12152220113737220113952Ratregion
5090113AU049557992220610890220610991Ratregion
5087157BQ2091151812223931408223931589Ratregion
5085353BQ1959501882219813422219813610Ratregion
5082473BF4160752162225322033225322249Ratregion
5084574AI0139441232223715445223715568Ratregion
5085202BE0964081612219853715219853874Ratregion
5503418G338601642221607444221607608Ratregion
5504468PMC213488P11032224053636224053739Ratregion
5506123UniSTS:498418742219893918219893992Ratregion
5506839G464082182220077542220077760Ratregion
5503841Dkk21062220569176220569282Ratregion
5501536RH694315912219760126219760717Ratregion
5502707PPP3CA1112225380592225380703Ratregion
Position Markers

Flank 1: (D2Rat62)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22219,753,301 - 219,753,474 (+)MAPPER
Rnor_6.02236,318,496 - 236,318,668NCBI
Rnor_5.02254,867,191 - 254,867,363UniSTS
RGSC_v3.42228,663,949 - 228,664,122RGD
RGSC_v3.42228,663,950 - 228,664,122UniSTS
RGSC_v3.12228,650,690 - 228,650,862RGD
Celera2212,009,629 - 212,009,815UniSTS
RH 3.4 Map21548.6RGD
RH 3.4 Map21548.6UniSTS
RH 2.0 Map21101.3RGD
SHRSP x BN Map290.8698RGD
Cytogenetic Map2q34-q45UniSTS
Peak: (D2Rat63)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22222,436,573 - 222,436,696 (+)MAPPER
Rnor_6.02239,166,081 - 239,166,203NCBI
Rnor_5.02257,699,734 - 257,699,856UniSTS
RGSC_v3.42231,464,968 - 231,465,091RGD
RGSC_v3.42231,464,969 - 231,465,091UniSTS
RGSC_v3.12231,451,708 - 231,451,831RGD
Celera2214,666,794 - 214,666,916UniSTS
RH 2.0 Map21115.0RGD
SHRSP x BN Map294.3198RGD
FHH x ACI Map2106.9199RGD
Flank 2: (D2Rat247)
Rat AssemblyChrPosition (strand)Source
mRatBN7.22226,277,159 - 226,277,316 (+)MAPPER
Rnor_6.02243,026,487 - 243,026,643NCBI
Rnor_5.02261,576,473 - 261,576,629UniSTS
Celera2218,444,053 - 218,444,209UniSTS
SHRSP x BN Map297.6498RGD
SHRSP x BN Map297.6498UniSTS
Cytogenetic Map2q44UniSTS


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2185876309219753474Rat
1359031Bp275Blood pressure QTL 275arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2185876309219753474Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
2299161Iddm33Insulin dependent diabetes mellitus QTL 332.98blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2206312063220876787Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2006-04-14 Hrtrt19  Heart rate QTL 19  Hr19    Symbol updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
qtl_cross_type recombinantinbred  
qtl_general deficits in early trial bradycardia may be linked to locus for regulation of blood pressure 625381