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Gene: Sgms2 (sphingomyelin synthase 2) Rattus norvegicus

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Symbol:

Sgms2

Name:

sphingomyelin synthase 2

RGD ID:

1305778

Description:

Predicted to enable ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; and sphingomyelin synthase activity. Predicted to be involved in ceramide biosynthetic process; regulation of bone mineralization; and sphingomyelin biosynthetic process. Predicted to act upstream of or within ceramide phosphoethanolamine biosynthetic process. Located in plasma membrane. Human ortholog(s) of this gene implicated in calvarial doughnut lesions with bone fragility. Orthologous to human SGMS2 (sphingomyelin synthase 2); PARTICIPATES IN sphingolipid metabolic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC310849; phosphatidylcholine:ceramide cholinephosphotransferase 2; RGD1305778; similar to RIKEN cDNA 4933405A16; Sms2; spermatin

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SGMS2 (sphingomyelin synthase 2)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Sgms2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sgms2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SGMS2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SGMS2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sgms2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SGMS2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SGMS2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sgms2 (sphingomyelin synthase 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Sgms2 (sphingomyelin synthase 2)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SGMS2 (sphingomyelin synthase 2)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sgms2a	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sgms2b	Alliance	DIOPT (Ensembl Compara\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	sms-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OMA\|PANTHER)
Xenopus tropicalis (tropical clawed frog):	sgms2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	222,567,661 - 222,641,804 (-)	NCBI		GRCr8
mRatBN7.2	2	219,889,809 - 219,967,704 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	219,893,572 - 219,967,546 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	227,549,778 - 227,572,764 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	225,449,445 - 225,472,435 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	220,307,074 - 220,330,066 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	236,458,276 - 236,530,667 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	236,458,279 - 236,480,502 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	255,006,742 - 255,078,076 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	228,815,312 - 228,838,295 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	228,802,052 - 228,825,035 (-)	NCBI
Celera	2	212,149,475 - 212,172,550 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

3-Hydroxyacyl-CoA Dehydrogenase Deficiency (ISO)

calvarial doughnut lesions with bone fragility (ISO)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

Benzo[ghi]perylene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlorpyrifos (EXP)

chromium(6+) (ISO)

cisplatin (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dicrotophos (ISO)

dioxygen (EXP,ISO)

dorsomorphin (ISO)

entinostat (ISO)

ethyl methanesulfonate (ISO)

fenamidone (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

geldanamycin (ISO)

gentamycin (EXP)

glycidol (EXP)

indometacin (ISO)

inulin (ISO)

lipopolysaccharide (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (EXP,ISO)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

methylmercury chloride (ISO)

methylparaben (ISO)

N-methyl-4-phenylpyridinium (EXP)

nickel atom (ISO)

nickel sulfate (ISO)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

poly(I:C) (ISO)

rac-lactic acid (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

silver atom (ISO)

silver(0) (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dodecyl sulfate (ISO)

sulforaphane (ISO)

sunitinib (ISO)

testosterone (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

thiram (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

ceramide biosynthetic process (IBA,IEA,ISO)

ceramide phosphoethanolamine biosynthetic process (IEA,ISO)

lipid metabolic process (IEA)

regulation of bone mineralization (IEA,ISO,ISS)

sphingolipid metabolic process (IEA)

sphingomyelin biosynthetic process (IBA,IEA,ISO)

Cellular Component

endoplasmic reticulum membrane (IBA)

Golgi apparatus (IEA,ISO)

Golgi membrane (IBA,IEA,ISO)

membrane (IEA)

nucleoplasm (IEA,ISO)

plasma membrane (IBA,IDA,IEA,ISO)

Molecular Function

ceramide cholinephosphotransferase activity (IBA,IEA,ISO)

ceramide phosphoethanolamine synthase activity (IEA,ISO)

kinase activity (IEA)

phosphotransferase activity, for other substituted phosphate groups (IEA)

protein binding (ISO)

sphingomyelin synthase activity (IBA,IEA,ISO)

transferase activity (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

sphingolipid metabolic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Cellular localization of sphingomyelin synthase 2 in the seminiferous epithelium of adult rat testes.	Lee NP, etal., J Endocrinol. 2007 Jan;192(1):17-32.
3.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:14685263	PMID:21980337	PMID:25605874	PMID:25667419	PMID:29294205	PMID:30779713

Genomics

Comparative Map Data

Sgms2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	222,567,661 - 222,641,804 (-)	NCBI		GRCr8
mRatBN7.2	2	219,889,809 - 219,967,704 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	219,893,572 - 219,967,546 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	227,549,778 - 227,572,764 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	225,449,445 - 225,472,435 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	220,307,074 - 220,330,066 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	236,458,276 - 236,530,667 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	236,458,279 - 236,480,502 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	255,006,742 - 255,078,076 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	228,815,312 - 228,838,295 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	228,802,052 - 228,825,035 (-)	NCBI
Celera	2	212,149,475 - 212,172,550 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

SGMS2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	107,824,563 - 107,915,047 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	107,824,563 - 107,915,047 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	108,745,719 - 108,836,203 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	109,033,879 - 109,051,558 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	106,040,532 - 106,131,005 (+)	NCBI		Celera
Cytogenetic Map	4	q25	NCBI
HuRef	4	104,477,295 - 104,567,792 (+)	NCBI		HuRef
CHM1_1	4	108,722,193 - 108,812,665 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	111,126,863 - 111,217,333 (+)	NCBI		T2T-CHM13v2.0

Sgms2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	131,112,634 - 131,197,204 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	131,112,634 - 131,197,172 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	131,318,985 - 131,491,443 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	131,318,985 - 131,491,411 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	131,021,903 - 131,047,841 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	131,311,893 - 131,334,090 (-)	NCBI		MGSCv36	mm8
Celera	3	137,840,788 - 137,866,755 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	60.91	NCBI

Sgms2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	1,905,517 - 1,947,009 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	1,909,347 - 1,955,004 (-)	NCBI	ChiLan1.0	ChiLan1.0

SGMS2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	105,921,036 - 106,029,587 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	106,217,864 - 106,324,239 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	100,329,642 - 100,420,398 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	110,902,572 - 110,992,887 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	110,936,358 - 110,992,887 (+)	Ensembl	panpan1.1		panPan2

SGMS2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	28,277,195 - 28,407,761 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	28,354,116 - 28,403,734 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	13,614,373 - 13,744,831 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	28,506,826 - 28,637,140 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	28,615,734 - 28,637,123 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	28,500,149 - 28,630,561 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	28,244,646 - 28,375,083 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	11,481,938 - 11,612,641 (-)	NCBI		UU_Cfam_GSD_1.0

Sgms2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	12,714,369 - 12,756,874 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936818	683,659 - 726,174 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936818	687,695 - 726,123 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SGMS2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	114,057,603 - 114,076,154 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	114,052,726 - 114,145,946 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	122,315,213 - 122,407,118 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SGMS2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	55,752,419 - 55,843,408 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	55,753,270 - 55,838,914 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	34,378,008 - 34,468,860 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sgms2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	1,502,336 - 1,542,134 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	1,498,700 - 1,543,112 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sgms2
439 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	163
Count of miRNA genes:	126
Interacting mature miRNAs:	139
Transcripts:	ENSRNOT00000015020
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	217139753	236660713	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
1641925	Alcrsp2	Alcohol response QTL 2			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	221167075	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
8662832	Vetf7	Vascular elastic tissue fragility QTL 7	3.5		aorta elastin amount (VT:0003905)	aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)	2	81689826	221035911	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
2299161	Iddm33	Insulin dependent diabetes mellitus QTL 33	2.98		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	2	206312063	220876787	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1359019	Hrtrt19	Heart rate QTL 19	2.9		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	219753301	226277316	Rat

Markers in Region

UniSTS:498418

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	219,893,918 - 219,893,992 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	236,458,640 - 236,458,713	NCBI	Rnor6.0
Rnor_5.0	2	255,007,107 - 255,007,180	UniSTS	Rnor5.0
RGSC_v3.4	2	228,815,676 - 228,815,749	UniSTS	RGSC3.4
Celera	2	212,149,839 - 212,149,912	UniSTS
Cytogenetic Map	2	q43	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001014043	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006233311	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761501	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590934	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102450	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102451	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102452	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039102453	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281956	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063281957	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC085803	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ071571	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU840804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	KU840805	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000015020 ⟹ ENSRNOP00000015020

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	219,893,572 - 219,967,546 (-)	Ensembl
Rnor_6.0 Ensembl	2	236,458,279 - 236,480,502 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000097097 ⟹ ENSRNOP00000097001

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	219,893,572 - 219,967,546 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106830 ⟹ ENSRNOP00000080237

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	219,893,668 - 219,967,020 (-)	Ensembl

RefSeq Acc Id:

NM_001014043 ⟹ NP_001014065

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,590,807 (-)	NCBI
mRatBN7.2	2	219,893,555 - 219,916,698 (-)	NCBI
Rnor_6.0	2	236,458,276 - 236,480,502 (-)	NCBI
Rnor_5.0	2	255,006,742 - 255,078,076 (-)	NCBI
RGSC_v3.4	2	228,815,312 - 228,838,295 (-)	RGD
Celera	2	212,149,475 - 212,172,550 (-)	RGD

Sequence:

show sequence

GCCTGAGGGCCTGGGTATCTTCCTCAAAAGGAGGAGTCCATGGTGGAGAGGTTTGCTGTTGGAC
TCACCTGGCTGAGGCCTCTCCTCAGGACACTTACTCTTCCCACGGCCTTTTCTAAGGCACTGAA
GAGAACACTGGTCAGGCTGGAGGAACGCTGGCTTCCCCACTCCCTCTAGTGTCTTGGTACTTTG
GGAGATTGTCACAGGGACAAGAGGAAGAAGGGACAATACCATCCTCTGTGGGAAGGAGAACCAG
CTTCCTTGTGGTGACTACACAGCAGACCAGAAGGCCACCGTCTACGATTCATATCAGCACACAC
AGTCTATCCTAAGAGTCCATGTTGATCTTGGAAGTAGAGAGGTTTAAAAGAAGTTCCCACAGAA
ACCAAGAGCCTTACCATCTCCTTTAGCTCCGAAGGCTGGCGGACAATGGATATCATAGAGACAG
CAAAACTTGAAGGTCATTTGGAAAGTCAAACCAACAACTCTACCAACACTTACACAAGCCCCAC
TGAAGCTGTAGAAGAGGAGGACAAAAATGGCAAGGGTAAACCCAAGACCTTATCCAACGGGCTA
CGAAAGGGTGCCAAGAAATACCCGGACTACATCCAGATTTCCATGCCCAATGACTCCAGGAACA
AGCTTCCCCTAGAGTGGTGGAAAACAGGCATTGCCTTTGTGTACGCTCTCTTCAACCTTATCCT
GACAACAGTCATGATCACCGTTGTGCACGAGAGGGTCCCTCCCAAGGAACTCAGCCCTCCACTC
CCAGACAAGTTTTTTGATTACGTCGACCGGGTCAAATGGGCATTTTCTGTATCAGAAATAAATG
GGATGGTATTAGTTGGGCTATGGCTCACCCAGTGGCTCTTTCTGAGATACAAGTCAATAGTGGG
ACGCAGATTCTTCTTTATCATGGGAACTTTATACCTGTATCGCTGTATAACTATGTACGTCACT
ACGTTACCTGTGCCCGGAATGCACTTCCAGTGTGCTCCAAAGCTCAATGGAGACTCTCAGGCAA
AAATACAACGGATTCTCCGGTTGCTTTCTGGTGGTGGATTGTCCATCACGGGATCACACATCCT
GTGTGGAGACTTCCTCTTCAGCGGCCATACAGTTGTGCTGACACTTACTTACTTGTTCATCAAA
GAATATTCACCTCGTCACTTCTGGTGGTACCACTTGGTCTGCTGGCTGCTGAGCGCCGCTGGGA
TCGTCTGCATCCTCGTGGCGCACGAACACTACACGGTCGATGTCATCATTGCGTATTACATCAC
AACACGGCTGTTTTGGTGGTACCACTCCATGGCCAATGAAAAGAACTTGAAGGTCTCTTCCCAG
ACTAATTTCTTGTCTCGGGCTTGGTGGTTCCCCATCTTCTATTTTTTTGAAAAGAATGTGCAAG
GCTCCATTCCTTGCTGTTTCTCCTGGCCGCTGTCCTGGCCCCCTGGCTGCTTCAAGTCATCGTG
CAAAAAGTATTCTCGAGTCCAGAAGATCGGGGAGGATAATGAGAAGTCTACCTGAGCGGCCGAC
ACGACAGCCGCTTTTCCACCCAAAGAGTCCGTGCTGTAACCAAAGGCACAGCTTCCTATTTATT
TTCAGAGAACTGACTGGTGAAACGAAGTGGACCAAATTTTATGCAAAAGATTGGAGCAGTGAAG
TATTACCTTTCGGCTTTTTTTCTTCATTCATCCCAAGAAACATATATTTTCCTGTAGCTCTCCA
TTCAGGGAGGACAAGGCCCCAAGCTGGAGTTCTGCAGAGGCAAAAGAGAACACGCTAAGCCTCT
CCTCATCTTCCTTCACTTCCACACTCTTTCCAGATTGCTTTTTTTCCTCCCTTCAAGGTCAGAA
GAGTTTGCTAATGTTTTGAATAAAATGTCCGGATATATACAAAAAAAAAAAAAAAAAAAAAAAA
AAAA

hide sequence

RefSeq Acc Id:

XM_006233311 ⟹ XP_006233373

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,590,954 (-)	NCBI
mRatBN7.2	2	219,889,809 - 219,917,532 (-)	NCBI
Rnor_6.0	2	236,458,276 - 236,480,555 (-)	NCBI
Rnor_5.0	2	255,006,742 - 255,078,076 (-)	NCBI

Sequence:

show sequence

TGTTAGATATGTTCAGTCAATTAGGTCGGAGTGGGTAGAAACCAGCCATCCCTGCCTGAGGGCC
TGGGTATCTTCCTCAAAAGGAGGAGTCCATGGTGGAGAGGTTTGCTGTTGGACTCACCTGGCTG
AGGCCTCTCCTCAGGACACTTACTCTTCCCACGGCCTTTTCTAAGGCACTGAAGAGAACACTGG
TCAGGCTGGAGGAACGCTGGCTTCCCCACTCCCTCTAGTGTCTTGGTACTTTGGGAGATTGTCA
CAGGGACAAGAGGAAGGTGGCCGGGCTGGTGGCCTGACTCAAATGCAGCTTTCCTAAATTGGGA
ACAGCTGGGCCTTAGTGCAAGCTAGTATAAGAGTCGCCGGCTCTCCTCAGAAGTAGGAAGTGCC
TGTTCATTGGAGCCTGAGTGTGGTGGCTCTTAAAGCAAAGGTGCCCGTCCTCAGCCACGGAAGA
AGGGACAATACCATCCTCTGTGGGAAGGAGAACCAGCTTCCTTGTGGTGACTACACAGCAGACC
AGAAGGCCACCGTCTACGATTCATATCAGCACACACAGTCTATCCTAAGAGTCCATGTTGATCT
TGGAAGTAGAGAGGTTTAAAAGAAGTTCCCACAGAAACCAAGAGCCTTACCATCTCCTTTAGCT
CCGAAGGCTGGCGGACAATGGATATCATAGAGACAGCAAAACTTGAAGGTCATTTGGAAAGTCA
AACCAACAACTCTACCAACACTTACACAAGCCCCACTGAAGCTGTAGAAGAGGAGGACAAAAAT
GGCAAGGGTAAACCCAAGACCTTATCCAACGGGCTACGAAAGGGTGCCAAGAAATACCCGGACT
ACATCCAGATTTCCATGCCCAATGACTCCAGGAACAAGCTTCCCCTAGAGTGGTGGAAAACAGG
CATTGCCTTTGTGTACGCTCTCTTCAACCTTATCCTGACAACAGTCATGATCACCGTTGTGCAC
GAGAGGGTCCCTCCCAAGGAACTCAGCCCTCCACTCCCAGACAAGTTTTTTGATTACGTCGACC
GGGTCAAATGGGCATTTTCTGTATCAGAAATAAATGGGATGGTATTAGTTGGGCTATGGCTCAC
CCAGTGGCTCTTTCTGAGATACAAGTCAATAGTGGGACGCAGATTCTTCTTTATCATGGGAACT
TTATACCTGTATCGCTGTATAACTATGTACGTCACTACGTTACCTGTGCCCGGAATGCACTTCC
AGTGTGCTCCAAAGCTCAATGGAGACTCTCAGGCAAAAATACAACGGATTCTCCGGTTGCTTTC
TGGTGGTGGATTGTCCATCACGGGATCACACATCCTGTGTGGAGACTTCCTCTTCAGCGGCCAT
ACAGTTGTGCTGACACTTACTTACTTGTTCATCAAAGAATATTCACCTCGTCACTTCTGGTGGT
ACCACTTGGTCTGCTGGCTGCTGAGCGCCGCTGGGATCGTCTGCATCCTCGTGGCGCACGAACA
CTACACGGTCGATGTCATCATTGCGTATTACATCACAACACGGCTGTTTTGGTGGTACCACTCC
ATGGCCAATGAAAAGAACTTGAAGGTCTCTTCCCAGACTAATTTCTTGTCTCGGGCTTGGTGGT
TCCCCATCTTCTATTTTTTTGAAAAGAATGTGCAAGGCTCCATTCCTTGCTGTTTCTCCTGGCC
GCTGTCCTGGCCCCCTGGCTGCTTCAAGTCATCGTGCAAAAAGTATTCTCGAGTCCAGAAGATC
GGGGAGGATAATGAGAAGTCTACCTGAGCGGCCGACACGACAGCCGCTTTTCCACCCAAAGAGT
CCGTGCTGTAACCAAAGGCACAGCTTCCTATTTATTTTCAGAGAACTGACTGGTGAAACGAAGT
GGACCAAATTTTATGCAAAAGATTGGAGCAGTGAAGTATTACCTTTCGGCTTTTTTTCTTCATT
CATCCCAAGAAACATATATTTTCCTGTAGCTCTCCATTCAGGGAGGACAAGGCCCCAAGCTGGA
GTTCTGCAGAGGCAAAAGAGAACACGCTAAGCCTCTCCTCATCTTCCTTCACTTCCACACTCTT
TCCAGATTGCTTTTTTTCCTCCCTTCAAGGTCAGAAGAGTTTGCTAATGTTTTGAATAAAATGT
CCGGATATATACA

hide sequence

RefSeq Acc Id:

XM_017590934 ⟹ XP_017446423

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,641,004 (-)	NCBI
mRatBN7.2	2	219,893,561 - 219,965,883 (-)	NCBI
Rnor_6.0	2	236,458,276 - 236,530,667 (-)	NCBI

Sequence:

show sequence

CCCAGCCGCCCCGCCCCGGGCATCCTTGCTCATTTTCCACCTGCTGGGGGTCAGCTAGTGGCTG
TCTCTCCTCCCAGCCTGCTGCTCATTCATTTGCGACCCATTTTCGGGTACTTGGTGGCGGTGTT
GAAATGGCACAGGTTAAACCATAGGTTGTGCAGTGCCGCTCTGGGGGGTCAGGGTTGAAGTTCA
GGTGGTGGAGGAGAGACTGTCACTCGCTGACGAGCTGTGCACTAGACCAGCTCCAGGCTGCCCA
AGGGGACCTCTCTACCTTTGGGGTTCAGACCTGAGCCCCTTAAAGAAGGGAGACTCGGTGTGTC
AGCACAGAGAGGTGGGAGTGGACCTTACCCTGTCACAGTCTGTGGGTCCGGTGATCGTTCTGTT
TCAAAAGCAAATAGTTCAAATGTTATTTCCTGTAATCTTTTATTAATCCGCCATTCCTATATTT
TCAAGACTTGTTTATTTCTAAAATGACCTCAAAATCATGGCATGTGTTTGAAATTCTAAAGAGG
CTCAATTTTTTTGTCAGTGGGTTCGGATGGACTTTGAATCTTTCTTTAACTGTTCTTTGGTTTC
ATGATTAGCTTCATTTAACTATTCCTGAATCCTCGGTTATGTTAACCATTCCAAACGGATAAAA
ATGACATTAGAACCTCCAGGACAAACAAAAAACAAAAAACAAAAAAACCCCGAAGATTAAATAA
GGATTAATGAGGTTAGTAATTGAGGATGGAAAGTGCAAAAGTCTGAACATAAACCTCTTTCTTC
AAAGCAAACTTCAATAAATAGTAACTCTTGACACGTAAATAATAGCAAGTTCCAGTTGGCTTAG
GTAAATGCCAGTTTCCTTCTGACAGACCTGGCGGGCCCAGGTTAGCACGTGAAATACTGTTGTC
TACTCCCTTAGAGTGGGAAGGGAGGTTTTCAGGAAGTTAAACATTGCTGGTGGATACCTAAGAA
GGTTTTGTCCCCACCCAGTAAGTGTTTAAGAGACATCAAAGCAGAAGGACAGAGAAGGAGCCTG
GACTTTGCAGAAGAAGGGACAATACCATCCTCTGTGGGAAGGAGAACCAGCTTCCTTGTGGTGA
CTACACAGCAGACCAGAAGGCCACCGTCTACGATTCATATCAGCACACACAGTCTATCCTAAGA
GTCCATGTTGATCTTGGAAGTAGAGAGGTTTAAAAGAAGTTCCCACAGAAACCAAGAGCCTTAC
CATCTCCTTTAGCTCCGAAGGCTGGCGGACAATGGATATCATAGAGACAGCAAAACTTGAAGGT
CATTTGGAAAGTCAAACCAACAACTCTACCAACACTTACACAAGCCCCACTGAAGCTGTAGAAG
AGGAGGACAAAAATGGCAAGGGTAAACCCAAGACCTTATCCAACGGGCTACGAAAGGGTGCCAA
GAAATACCCGGACTACATCCAGATTTCCATGCCCAATGACTCCAGGAACAAGCTTCCCCTAGAG
TGGTGGAAAACAGGCATTGCCTTTGTGTACGCTCTCTTCAACCTTATCCTGACAACAGTCATGA
TCACCGTTGTGCACGAGAGGGTCCCTCCCAAGGAACTCAGCCCTCCACTCCCAGACAAGTTTTT
TGATTACGTCGACCGGGTCAAATGGGCATTTTCTGTATCAGAAATAAATGGGATGGTATTAGTT
GGGCTATGGCTCACCCAGTGGCTCTTTCTGAGATACAAGTCAATAGTGGGACGCAGATTCTTCT
TTATCATGGGAACTTTATACCTGTATCGCTGTATAACTATGTACGTCACTACGTTACCTGTGCC
CGGAATGCACTTCCAGTGTGCTCCAAAGCTCAATGGAGACTCTCAGGCAAAAATACAACGGATT
CTCCGGTTGCTTTCTGGTGGTGGATTGTCCATCACGGGATCACACATCCTGTGTGGAGACTTCC
TCTTCAGCGGCCATACAGTTGTGCTGACACTTACTTACTTGTTCATCAAAGAATATTCACCTCG
TCACTTCTGGTGGTACCACTTGGTCTGCTGGCTGCTGAGCGCCGCTGGGATCGTCTGCATCCTC
GTGGCGCACGAACACTACACGGTCGATGTCATCATTGCGTATTACATCACAACACGGCTGTTTT
GGTGGTACCACTCCATGGCCAATGAAAAGAACTTGAAGGTCTCTTCCCAGACTAATTTCTTGTC
TCGGGCTTGGTGGTTCCCCATCTTCTATTTTTTTGAAAAGAATGTGCAAGGCTCCATTCCTTGC
TGTTTCTCCTGGCCGCTGTCCTGGCCCCCTGGCTGCTTCAAGTCATCGTGCAAAAAGTATTCTC
GAGTCCAGAAGATCGGGGAGGATAATGAGAAGTCTACCTGAGCGGCCGACACGACAGCCGCTTT
TCCACCCAAAGAGTCCGTGCTGTAACCAAAGGCACAGCTTCCTATTTATTTTCAGAGAACTGAC
TGGTGAAACGAAGTGGACCAAATTTTATGCAAAAGATTGGAGCAGTGAAGTATTACCTTTCGGC
TTTTTTTCTTCATTCATCCCAAGAAACATATATTTTCCTGTAGCTCTCCATTCAGGGAGGACAA
GGCCCCAAGCTGGAGTTCTGCAGAGGCAAAAGAGAACACGCTAAGCCTCTCCTCATCTTCCTTC
ACTTCCACACTCTTTCCAGATTGCTTTTTTTCCTCCCTTCAAGGTCAGAAGAGTTTGCTAATGT
TTTGAATAAAATGTCCGGATATATACA

hide sequence

RefSeq Acc Id:

XM_039102450 ⟹ XP_038958378

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,641,804 (-)	NCBI
mRatBN7.2	2	219,893,561 - 219,967,704 (-)	NCBI

RefSeq Acc Id:

XM_039102451 ⟹ XP_038958379

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,641,207 (-)	NCBI
mRatBN7.2	2	219,893,561 - 219,967,058 (-)	NCBI

RefSeq Acc Id:

XM_039102452 ⟹ XP_038958380

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,628,717 (-)	NCBI
mRatBN7.2	2	219,893,561 - 219,953,833 (-)	NCBI

RefSeq Acc Id:

XM_039102453 ⟹ XP_038958381

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,602,072 (-)	NCBI
mRatBN7.2	2	219,893,561 - 219,946,906 (-)	NCBI

RefSeq Acc Id:

XM_063281956 ⟹ XP_063138026

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,641,004 (-)	NCBI

RefSeq Acc Id:

XM_063281957 ⟹ XP_063138027

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	222,567,661 - 222,590,930 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001014065	(Get FASTA)	NCBI Sequence Viewer
	XP_006233373	(Get FASTA)	NCBI Sequence Viewer
	XP_017446423	(Get FASTA)	NCBI Sequence Viewer
	XP_038958378	(Get FASTA)	NCBI Sequence Viewer
	XP_038958379	(Get FASTA)	NCBI Sequence Viewer
	XP_038958380	(Get FASTA)	NCBI Sequence Viewer
	XP_038958381	(Get FASTA)	NCBI Sequence Viewer
	XP_063138026	(Get FASTA)	NCBI Sequence Viewer
	XP_063138027	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH85803	(Get FASTA)	NCBI Sequence Viewer
	AAY84706	(Get FASTA)	NCBI Sequence Viewer
	EDL82215	(Get FASTA)	NCBI Sequence Viewer
	EDL82216	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000015020
	ENSRNOP00000015020.5
	ENSRNOP00000080237.1
	ENSRNOP00000097001.1
GenBank Protein	Q4JM44	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_001014065 ⟸ NM_001014043

- UniProtKB:

A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MDIIETAKLEGHLESQTNNSTNTYTSPTEAVEEEDKNGKGKPKTLSNGLRKGAKKYPDYIQISM
PNDSRNKLPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYVDRVKWAF
SVSEINGMVLVGLWLTQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKL
NGDSQAKIQRILRLLSGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCW
LLSAAGIVCILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYF
FEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST

hide sequence

RefSeq Acc Id:	XP_006233373 ⟸ XM_006233311
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDIIETAKLEGHLESQTNNSTNTYTSPTEAVEEEDKNGKGKPKTLSNGLRKGAKKYPDYIQISM PNDSRNKLPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYVDRVKWAF SVSEINGMVLVGLWLTQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKL NGDSQAKIQRILRLLSGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCW LLSAAGIVCILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYF FEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST hide sequence

RefSeq Acc Id:	XP_017446423 ⟸ XM_017590934
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)
- Sequence:	show sequence MDIIETAKLEGHLESQTNNSTNTYTSPTEAVEEEDKNGKGKPKTLSNGLRKGAKKYPDYIQISM PNDSRNKLPLEWWKTGIAFVYALFNLILTTVMITVVHERVPPKELSPPLPDKFFDYVDRVKWAF SVSEINGMVLVGLWLTQWLFLRYKSIVGRRFFFIMGTLYLYRCITMYVTTLPVPGMHFQCAPKL NGDSQAKIQRILRLLSGGGLSITGSHILCGDFLFSGHTVVLTLTYLFIKEYSPRHFWWYHLVCW LLSAAGIVCILVAHEHYTVDVIIAYYITTRLFWWYHSMANEKNLKVSSQTNFLSRAWWFPIFYF FEKNVQGSIPCCFSWPLSWPPGCFKSSCKKYSRVQKIGEDNEKST hide sequence

Ensembl Acc Id:

ENSRNOP00000015020 ⟸ ENSRNOT00000015020

RefSeq Acc Id:	XP_038958378 ⟸ XM_039102450
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958379 ⟸ XM_039102451
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958380 ⟸ XM_039102452
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038958381 ⟸ XM_039102453
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL), A0A8I5ZQ87 (UniProtKB/TrEMBL)

Ensembl Acc Id:

ENSRNOP00000097001 ⟸ ENSRNOT00000097097

Ensembl Acc Id:

ENSRNOP00000080237 ⟸ ENSRNOT00000106830

RefSeq Acc Id:	XP_063138026 ⟸ XM_063281956
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I5ZQ87 (UniProtKB/TrEMBL), A0A0G2JSK7 (UniProtKB/TrEMBL), A6HVS9 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063138027 ⟸ XM_063281957
- Peptide Label:	isoform X2

Protein Domains

Sphingomyelin synthase-like

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4JM44-F1-model_v2	AlphaFold	Q4JM44	1-365	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691761

Promoter ID:

EPDNEW_R2285

Type:

initiation region

Name:

Sgms2_1

Description:

sphingomyelin synthase 2

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	236,480,591 - 236,480,651	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305778	AgrOrtholog
BioCyc Gene	G2FUF-51206	BioCyc
Ensembl Genes	ENSRNOG00000011284	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000015020	ENTREZGENE
	ENSRNOT00000015020.6	UniProtKB/TrEMBL
	ENSRNOT00000097097.1	UniProtKB/TrEMBL
	ENSRNOT00000106830.1	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7111151	IMAGE-MGC_LOAD
InterPro	Sphingomyelin_synth-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sphingomyelin_synth-like_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:310849	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE	MGC:93838	IMAGE-MGC_LOAD
NCBI Gene	310849	ENTREZGENE
PANTHER	PHOSPHATIDYLCHOLINE:CERAMIDE CHOLINEPHOSPHOTRANSFERASE 2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR21290	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PAP2_C	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sgms2	PhenoGen
RatGTEx	ENSRNOG00000011284	RatGTEx
UniProt	A0A0G2JSK7	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZQ87	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I6AUC3_RAT	UniProtKB/TrEMBL
	A6HVS9	ENTREZGENE, UniProtKB/TrEMBL
	Q4JM44	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q5U2Z1	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-03-06	Sgms2	sphingomyelin synthase 2	RGD1305778	similar to RIKEN cDNA 4933405A16	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	RGD1305778	similar to RIKEN cDNA 4933405A16	RGD1305778_predicted	similar to RIKEN cDNA 4933405A16 (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-20	RGD1305778_predicted	similar to RIKEN cDNA 4933405A16 (predicted)	LOC310849_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC310849_predicted	similar to RIKEN cDNA 4933405A16 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)