Ppa2 (inorganic pyrophosphatase 2) - Rat Genome Database

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Gene: Ppa2 (inorganic pyrophosphatase 2) Rattus norvegicus
Analyze
Symbol: Ppa2
Name: inorganic pyrophosphatase 2
RGD ID: 1307965
Description: Predicted to enable inorganic diphosphate phosphatase activity and protein serine/threonine phosphatase activity. Predicted to be involved in diphosphate metabolic process; phosphate-containing compound metabolic process; and regulation of mitochondrial membrane potential. Predicted to be active in mitochondrion and synapse. Orthologous to human PPA2 (inorganic pyrophosphatase 2); PARTICIPATES IN oxidative phosphorylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: inorganic pyrophosphatase 2, mitochondrial; LOC310856; pyrophosphatase (inorganic) 2; RGD1307965; similar to RIKEN cDNA 1110013G13
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82224,472,738 - 224,552,101 (+)NCBIGRCr8
mRatBN7.22221,800,791 - 221,878,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,800,842 - 221,878,081 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2229,461,773 - 229,539,167 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02227,361,447 - 227,438,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02222,219,128 - 222,296,526 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02238,528,978 - 238,606,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,529,074 - 238,606,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,064,070 - 257,142,749 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42230,821,181 - 230,899,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12230,804,342 - 230,886,273 (+)NCBI
Celera2214,028,271 - 214,105,492 (+)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrotoluene  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
acetamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
dibutyl phthalate  (EXP,ISO)
dicrotophos  (ISO)
diethylstilbestrol  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenthion  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glyphosate  (ISO)
hydrogen peroxide  (ISO)
inulin  (ISO)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nefazodone  (EXP)
nimesulide  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
quercetin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
sodium arsenite  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
topotecan  (EXP)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
mitochondrion  (IBA,ISO)
synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:14651853   PMID:16129705   PMID:18614015   PMID:23376485   PMID:27523597   PMID:27523598  


Genomics

Comparative Map Data
Ppa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82224,472,738 - 224,552,101 (+)NCBIGRCr8
mRatBN7.22221,800,791 - 221,878,079 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,800,842 - 221,878,081 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2229,461,773 - 229,539,167 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02227,361,447 - 227,438,841 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02222,219,128 - 222,296,526 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02238,528,978 - 238,606,903 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,529,074 - 238,606,905 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,064,070 - 257,142,749 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42230,821,181 - 230,899,533 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12230,804,342 - 230,886,273 (+)NCBI
Celera2214,028,271 - 214,105,492 (+)NCBICelera
Cytogenetic Map2q43NCBI
PPA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384105,369,077 - 105,474,070 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4105,369,077 - 105,474,067 (-)EnsemblGRCh38hg38GRCh38
GRCh374106,290,234 - 106,395,227 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364106,509,683 - 106,614,676 (-)NCBINCBI36Build 36hg18NCBI36
Celera4103,589,454 - 103,694,416 (-)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4102,024,958 - 102,129,944 (-)NCBIHuRef
CHM1_14106,267,094 - 106,372,082 (-)NCBICHM1_1
T2T-CHM13v2.04108,679,986 - 108,784,941 (-)NCBIT2T-CHM13v2.0
Ppa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,015,842 - 133,083,996 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,015,871 - 133,083,996 (+)EnsemblGRCm39 Ensembl
GRCm383133,310,059 - 133,378,235 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,310,110 - 133,378,235 (+)EnsemblGRCm38mm10GRCm38
MGSCv373132,973,080 - 133,041,033 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,247,422 - 133,315,375 (+)NCBIMGSCv36mm8
MGSCv363133,791,006 - 133,858,976 (+)NCBIMGSCv36mm8
Celera3139,733,738 - 139,801,669 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.71NCBI
Ppa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554963,775,170 - 3,831,502 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554963,765,038 - 3,831,312 (+)NCBIChiLan1.0ChiLan1.0
PPA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23103,457,322 - 103,561,350 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14103,749,703 - 103,853,764 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0497,836,518 - 97,941,041 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14108,449,806 - 108,553,709 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4108,449,806 - 108,553,709 (-)Ensemblpanpan1.1panPan2
PPA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13226,233,932 - 26,314,999 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3226,233,965 - 26,314,975 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3215,710,523 - 15,791,919 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03226,444,703 - 26,526,297 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3226,442,974 - 26,526,363 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13226,462,248 - 26,543,261 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03226,207,432 - 26,288,704 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03213,573,872 - 13,654,916 (+)NCBIUU_Cfam_GSD_1.0
Ppa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530114,870,215 - 14,942,836 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936752279,604 - 353,522 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936752279,541 - 352,201 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8116,249,573 - 116,334,013 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18116,249,531 - 116,333,847 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28124,773,985 - 124,923,790 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1753,410,304 - 53,516,775 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603732,027,773 - 32,134,366 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248303,310,333 - 3,381,816 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248303,310,346 - 3,381,703 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Ppa2
410 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:23
Count of miRNA genes:22
Interacting mature miRNAs:23
Transcripts:ENSRNOT00000016195
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016195   ⟹   ENSRNOP00000016195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2221,800,842 - 221,878,081 (+)Ensembl
Rnor_6.0 Ensembl2238,529,074 - 238,606,905 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000076152
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2238,604,952 - 238,606,901 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108835   ⟹   ENSRNOP00000093452
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2221,800,842 - 221,870,874 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109670   ⟹   ENSRNOP00000084906
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2221,801,335 - 221,878,079 (+)Ensembl
RefSeq Acc Id: NM_001135871   ⟹   NP_001129343
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,474,873 - 224,552,101 (+)NCBI
mRatBN7.22221,800,850 - 221,878,079 (+)NCBI
Rnor_6.02238,529,072 - 238,606,903 (+)NCBI
Rnor_5.02257,064,070 - 257,142,749 (+)NCBI
RGSC_v3.42230,821,181 - 230,899,533 (+)RGD
Celera2214,028,271 - 214,105,492 (+)RGD
Sequence:
RefSeq Acc Id: XM_006233327   ⟹   XP_006233389
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,472,738 - 224,552,101 (+)NCBI
mRatBN7.22221,800,791 - 221,878,079 (+)NCBI
Rnor_6.02238,528,978 - 238,606,903 (+)NCBI
Rnor_5.02257,064,070 - 257,142,749 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039102462   ⟹   XP_038958390
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,474,901 - 224,552,101 (+)NCBI
mRatBN7.22221,800,875 - 221,878,079 (+)NCBI
RefSeq Acc Id: XM_063281963   ⟹   XP_063138033
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,474,906 - 224,552,101 (+)NCBI
RefSeq Acc Id: NP_001129343   ⟸   NM_001135871
- UniProtKB: A6HVU8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006233389   ⟸   XM_006233327
- Peptide Label: isoform X1
- UniProtKB: D4A830 (UniProtKB/TrEMBL),   A6HVU8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000016195   ⟸   ENSRNOT00000016195
RefSeq Acc Id: XP_038958390   ⟸   XM_039102462
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZZ13 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000093452   ⟸   ENSRNOT00000108835
Ensembl Acc Id: ENSRNOP00000084906   ⟸   ENSRNOT00000109670
RefSeq Acc Id: XP_063138033   ⟸   XM_063281963
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A830-F1-model_v2 AlphaFold D4A830 1-304 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691766
Promoter ID:EPDNEW_R2290
Type:initiation region
Name:Ppa2_1
Description:pyrophosphatase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02238,529,064 - 238,529,124EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1307965 AgrOrtholog
BioCyc Gene G2FUF-51163 BioCyc
Ensembl Genes ENSRNOG00000012091 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016195.6 UniProtKB/TrEMBL
  ENSRNOT00000108835.1 UniProtKB/TrEMBL
  ENSRNOT00000109670.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.80.10 UniProtKB/TrEMBL
InterPro Pyrophosphatase UniProtKB/TrEMBL
  Pyrophosphatase_sf UniProtKB/TrEMBL
NCBI Gene 310856 ENTREZGENE
PANTHER INORGANIC PYROPHOSPHATASE 2, MITOCHONDRIAL UniProtKB/TrEMBL
  Pyrophosphatase UniProtKB/TrEMBL
Pfam Pyrophosphatase UniProtKB/TrEMBL
PhenoGen Ppa2 PhenoGen
PROSITE PPASE UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012091 RatGTEx
Superfamily-SCOP Pyrophosphatase UniProtKB/TrEMBL
UniProt A0A8I5ZZ13 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AK43_RAT UniProtKB/TrEMBL
  A6HVU8 ENTREZGENE, UniProtKB/TrEMBL
  D4A830 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-09 Ppa2  inorganic pyrophosphatase 2  Ppa2  pyrophosphatase (inorganic) 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Ppa2  pyrophosphatase (inorganic) 2   Ppa2_predicted  pyrophosphatase (inorganic) 2 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-30 Ppa2_predicted  pyrophosphatase (inorganic) 2 (predicted)  RGD1307965_predicted  similar to RIKEN cDNA 1110013G13 (predicted)  Symbol and Name updated 1299863 APPROVED
2005-01-20 RGD1307965_predicted  similar to RIKEN cDNA 1110013G13 (predicted)  LOC310856_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310856_predicted  similar to RIKEN cDNA 1110013G13 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL