Gene: Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Rattus norvegicus
Analyze
Symbol:
Ppp3ca
Name:
protein phosphatase 3 catalytic subunit alpha
Description:
Exhibits calmodulin binding activity; calmodulin-dependent protein phosphatase activity; and protein heterodimerization activity. Involved in several processes, including aging; cellular response to glucose stimulus; and negative regulation of insulin secretion. Localizes to the calcineurin complex; cytosol; and synapse. Colocalizes with the slit diaphragm. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
calcineurin subunit A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; Calna1; CAM-PRP catalytic subunit; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PPP3CB (protein phosphatase 3 catalytic subunit beta) HGNC
OrthoDB
Homo sapiens (human):
PPP3CC (protein phosphatase 3 catalytic subunit gamma) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Homo sapiens (human):
PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Danio rerio (zebrafish):
ppp3ca (protein phosphatase 3, catalytic subunit, alpha isozyme)
Alliance
DIOPT (InParanoid, OrthoFinder, OrthoInspector, PANTHER)
Danio rerio (zebrafish):
ppp3cb (protein phosphatase 3, catalytic subunit, beta isozyme)
Alliance
DIOPT (OrthoFinder, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
CMP2
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
CanA-14F
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Drosophila melanogaster (fruit fly):
Pp2B-14D
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Caenorhabditis elegans (roundworm):
tax-6
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Saccharomyces cerevisiae (baker's yeast):
CNA1
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 241,909,332 - 242,186,861 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_5.0 2 260,463,144 - 260,737,186 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 234,130,176 - 234,409,232 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 234,116,915 - 234,395,972 (+) NCBI Celera 2 217,359,756 - 217,630,340 (+) NCBI Celera Cytogenetic Map 2 q43 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development ISO RGD:730900 8554872 ClinVar Annotator: match by term: ARTHROGRYPOSIS, CLEFT PALATE, CRANIOSYNOSTOSIS, AND IMPAIRED INTELLECTUAL DEVELOPMENT ClinVar PMID:29432562 genetic disease ISO RGD:730900 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10473536 more ... Infantile or Early Childhood Epileptic Encephalopathy ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD ClinVar PMID:28942967 Infantile or Early Childhood Epileptic Encephalopathy ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD ClinVar PMID:10473536 more ... infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:28942967 infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:29432562 infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:10473536 more ... infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:25741868
Imported Annotations - CTD
Brain Injuries ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14499481 Left Ventricular Hypertrophy ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18344631 pancreatitis ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22952646 Prostatic Neoplasms ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17199135 testicular disease ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17785681 Wilson disease ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23519153 Imported Annotations - MGI
dilated cardiomyopathy ISS RGD:11134 13592920 MouseDO Imported Annotations - OMIM
Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development ISO RGD:730900 7240710 OMIM infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 7240710 OMIM
(S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA CTD PMID:25729387 1,2,3-Trichloropropane multiple interactions ISO RGD:730900 6480464 1 more ... CTD PMID:22952646 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of PPP3CA mRNA CTD PMID:20068009 17beta-estradiol decreases expression ISO RGD:730900 6480464 Estradiol results in decreased expression of PPP3CA mRNA CTD PMID:21185374 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PPP3CA mRNA CTD PMID:21215274 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11134 6480464 Tetrachlorodibenzodioxin affects the expression of PPP3CA mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PPP3CA mRNA CTD PMID:21346803 2-deoxy-D-glucose decreases response to substance ISO RGD:11134 6480464 PPP3CA protein results in decreased susceptibility to Deoxyglucose CTD PMID:10679475 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of PPP3CA mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:11134 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PPP3CA mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of PPP3CA mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression ISO RGD:730900 6480464 4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA CTD PMID:12419474 5-fluorouracil multiple interactions ISO RGD:730900 6480464 [Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNA, PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:16391804 , PMID:18927307 5-fluorouracil increases expression ISO RGD:730900 6480464 Fluorouracil results in increased expression of PPP3CA protein CTD PMID:15585135 , PMID:16803524 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PPP3CA mRNA CTD PMID:24780913 , PMID:25825206 acetazolamide increases expression ISO RGD:11134 6480464 Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 aflatoxin B1 decreases expression ISO RGD:11134 6480464 Aflatoxin B1 results in decreased expression of PPP3CA mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:730900 6480464 Aflatoxin B1 results in decreased methylation of PPP3CA gene, Aflatoxin B1 results in decreased methylation of PPP3CA intron CTD PMID:27153756 , PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:730900 6480464 Tretinoin results in decreased expression of PPP3CA mRNA CTD PMID:16140955 , PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PPP3CA mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:11134 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP3CA mRNA CTD PMID:23650126 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of PPP3CA mRNA CTD PMID:27377005 benzo[a]pyrene decreases expression ISO RGD:11134 6480464 Benzo(a)pyrene results in decreased expression of PPP3CA mRNA CTD PMID:20504355 , PMID:21715664 benzo[a]pyrene decreases expression ISO RGD:730900 6480464 Benzo(a)pyrene results in decreased expression of PPP3CA mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:730900 6480464 7 more ... CTD PMID:19150397 benzyl acetate multiple interactions ISO RGD:730900 6480464 benzyl acetate results in increased cleavage of and results in increased activity of PPP3CA protein CTD PMID:22952646 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:11134 6480464 Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] CTD PMID:16377760 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of PPP3CA mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide decreases expression ISO RGD:11134 6480464 Mustard Gas results in decreased expression of PPP3CA mRNA CTD PMID:16377760 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PPP3CA mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:11134 6480464 bisphenol A results in increased methylation of PPP3CA promoter CTD PMID:27312807 bisphenol F multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 cadmium dichloride increases expression ISO RGD:730900 6480464 Cadmium Chloride results in increased expression of PPP3CA mRNA CTD PMID:12160620 cadmium dichloride decreases expression ISO RGD:730900 6480464 Cadmium Chloride results in decreased expression of PPP3CA mRNA CTD PMID:18560533 calcitriol increases expression ISO RGD:730900 6480464 Calcitriol results in increased expression of PPP3CA mRNA CTD PMID:16002434 capsaicin multiple interactions EXP 6480464 PPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]] CTD PMID:17590514 carbamazepine decreases expression EXP 6480464 Carbamazepine results in decreased expression of PPP3CA mRNA, Carbamazepine results in decreased expression of PPP3CA protein CTD PMID:14642444 carbon nanotube decreases expression ISO RGD:11134 6480464 Nanotubes, Carbon analog results in decreased expression of PPP3CA mRNA, Nanotubes, Carbon results in decreased expression of PPP3CA mRNA CTD PMID:25554681 chlorendic acid multiple interactions ISO RGD:730900 6480464 chlorendic acid results in increased cleavage of and results in increased activity of PPP3CA protein CTD PMID:22952646 chlorpyrifos increases expression ISO RGD:11134 6480464 Chlorpyrifos results in increased expression of PPP3CA mRNA CTD PMID:20350560 cisplatin multiple interactions ISO RGD:730900 6480464 [Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA CTD PMID:21858171 clozapine multiple interactions EXP 6480464 [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein CTD PMID:16033416 clozapine increases expression EXP 6480464 Clozapine results in increased expression of PPP3CA mRNA CTD PMID:12437575 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of PPP3CA mRNA, Clozapine results in decreased expression of PPP3CA protein CTD PMID:16033416 cocaine affects expression EXP 6480464 Cocaine affects the expression of PPP3CA mRNA CTD PMID:20187946 cyclosporin A decreases activity ISO RGD:11134 6480464 Cyclosporine results in decreased activity of PPP3CA protein CTD PMID:19553475 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of PPP3CA protein CTD PMID:18344631 cypermethrin multiple interactions ISO RGD:730900 6480464 [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin CTD PMID:10898953 dexamethasone multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 dimercaprol multiple interactions ISO RGD:11134 6480464 Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] CTD PMID:16377760 dorsomorphin multiple interactions ISO RGD:730900 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:730900 6480464 Doxorubicin results in decreased expression of PPP3CA mRNA CTD PMID:29803840 entinostat decreases expression ISO RGD:730900 6480464 entinostat results in decreased expression of PPP3CA mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:730900 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA CTD PMID:27188386 ethanol multiple interactions ISO RGD:11134 6480464 ALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein] CTD PMID:19332462 ethanol affects splicing ISO RGD:11134 6480464 Ethanol affects the splicing of PPP3CA mRNA CTD PMID:30319688 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of PPP3CA mRNA CTD PMID:20655511 ethanol increases expression ISO RGD:11134 6480464 Ethanol results in increased expression of PPP3CA protein CTD PMID:19332462 fenofibrate multiple interactions ISO RGD:11134 6480464 PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA] CTD PMID:21318169 fenofibrate decreases expression ISO RGD:11134 6480464 Fenofibrate results in decreased expression of PPP3CA mRNA CTD PMID:21318169 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of PPP3CA mRNA CTD PMID:18035473 flutamide increases expression EXP 6480464 Flutamide results in increased expression of PPP3CA mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:730900 6480464 Formaldehyde results in decreased expression of PPP3CA mRNA CTD PMID:23649840 furan increases expression EXP 6480464 furan results in increased expression of PPP3CA mRNA CTD PMID:20562052 gamma-tocopherol increases expression ISO RGD:11134 6480464 Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of PPP3CA mRNA, Haloperidol results in decreased expression of PPP3CA protein CTD PMID:16033416 haloperidol multiple interactions EXP 6480464 [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein CTD PMID:16033416 indometacin multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 irinotecan decreases expression ISO RGD:730900 6480464 Irinotecan analog results in decreased expression of PPP3CA mRNA CTD PMID:18927307 irinotecan multiple interactions ISO RGD:730900 6480464 [Fluorouracil co-treated with Irinotecan] results in increased expression of PPP3CA mRNA, PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:16391804 , PMID:18927307 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of PPP3CA protein CTD PMID:15644446 methamphetamine multiple interactions EXP 6480464 SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein] CTD PMID:15644446 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of PPP3CA mRNA CTD PMID:30467583 methotrexate affects response to substance ISO RGD:730900 6480464 PPP3CA protein affects the susceptibility to Methotrexate CTD PMID:16217747 methylmercury chloride decreases expression ISO RGD:730900 6480464 methylmercuric chloride results in decreased expression of PPP3CA mRNA CTD PMID:28001369 nitric oxide decreases expression ISO RGD:11134 6480464 Nitric Oxide deficiency results in decreased expression of PPP3CA mRNA CTD PMID:15878706 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:11134 6480464 Acetaminophen affects the expression of PPP3CA mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:730900 6480464 Acetaminophen results in increased expression of PPP3CA mRNA CTD PMID:21420995 , PMID:25704631 paraquat increases expression ISO RGD:730900 6480464 Paraquat results in increased expression of PPP3CA mRNA CTD PMID:28619522 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of PPP3CA mRNA CTD PMID:20136073 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of PPP3CA protein CTD PMID:18344631 phenobarbital decreases expression ISO RGD:11134 6480464 Phenobarbital results in decreased expression of PPP3CA mRNA CTD PMID:19363144 phenobarbital affects expression ISO RGD:11134 6480464 Phenobarbital affects the expression of PPP3CA mRNA CTD PMID:23091169 pirinixic acid decreases expression ISO RGD:11134 6480464 pirinixic acid results in decreased expression of PPP3CA mRNA CTD PMID:21318169 pirinixic acid multiple interactions ISO RGD:11134 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of PPP3CA mRNA] CTD PMID:21318169 piroxicam multiple interactions ISO RGD:730900 6480464 [Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA CTD PMID:21858171 propiconazole decreases expression ISO RGD:11134 6480464 propiconazole results in decreased expression of PPP3CA mRNA CTD PMID:19363144 quercetin decreases expression ISO RGD:730900 6480464 Quercetin results in decreased expression of PPP3CA mRNA CTD PMID:21632981 quercetin multiple interactions ISO RGD:730900 6480464 Quercetin results in decreased activity of [PPP3CA protein binds to PPP3R1 protein] CTD PMID:19880376 risperidone multiple interactions EXP 6480464 [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein CTD PMID:16033416 risperidone decreases expression EXP 6480464 Risperidone results in decreased expression of PPP3CA mRNA, Risperidone results in decreased expression of PPP3CA protein CTD PMID:16033416 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO RGD:11134 6480464 Buthionine Sulfoximine results in increased expression of PPP3CA mRNA CTD PMID:15878706 SB 431542 multiple interactions ISO RGD:730900 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA CTD PMID:27188386 SCH 23390 multiple interactions EXP 6480464 SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein] CTD PMID:15644446 sodium arsenite affects methylation ISO RGD:730900 6480464 sodium arsenite affects the methylation of PPP3CA gene CTD PMID:28589171 sodium fluoride decreases expression ISO RGD:11134 6480464 Sodium Fluoride results in decreased expression of PPP3CA mRNA CTD PMID:27862939 Soman decreases expression EXP 6480464 Soman results in decreased expression of PPP3CA mRNA CTD PMID:19281266 staurosporine decreases response to substance ISO RGD:11134 6480464 PPP3CA protein results in decreased susceptibility to Staurosporine CTD PMID:10679475 staurosporine increases cleavage ISO RGD:730900 6480464 Staurosporine results in increased cleavage of PPP3CA protein CTD PMID:10898953 tacrolimus hydrate multiple interactions ISO RGD:730900 6480464 [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin CTD PMID:10898953 tacrolimus hydrate decreases activity ISO RGD:11134 6480464 Tacrolimus results in decreased activity of PPP3CA protein CTD PMID:19553475 tert-butyl hydroperoxide decreases expression ISO RGD:730900 6480464 tert-Butylhydroperoxide results in decreased expression of PPP3CA mRNA CTD PMID:12419474 thapsigargin multiple interactions ISO RGD:730900 6480464 [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin more ... CTD PMID:10898953 thapsigargin increases expression ISO RGD:730900 6480464 Thapsigargin results in increased expression of PPP3CA mRNA CTD PMID:17963750 thapsigargin increases cleavage ISO RGD:730900 6480464 Thapsigargin results in increased cleavage of PPP3CA protein CTD PMID:10898953 tocopherol increases expression ISO RGD:11134 6480464 Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA CTD PMID:25729387 trichloroethene multiple interactions ISO RGD:11134 6480464 PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of PPP3CA mRNA] CTD PMID:15363585 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of PPP3CA mRNA CTD PMID:19448997 troglitazone decreases expression ISO RGD:11134 6480464 troglitazone results in decreased expression of PPP3CA mRNA CTD PMID:28973697 tunicamycin increases expression ISO RGD:11134 6480464 Tunicamycin results in increased expression of PPP3CA mRNA CTD PMID:17127020 Tylophorine increases expression ISO RGD:730900 6480464 tylophorine analog results in increased expression of PPP3CA mRNA CTD PMID:19284764 valproic acid increases expression ISO RGD:730900 6480464 Valproic Acid results in increased expression of PPP3CA mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:730900 6480464 Valproic Acid affects the expression of PPP3CA mRNA CTD PMID:25979313 valproic acid decreases methylation ISO RGD:730900 6480464 Valproic Acid results in decreased methylation of PPP3CA gene CTD PMID:29154799 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of PPP3CA mRNA CTD PMID:19015723 zoledronic acid increases expression ISO RGD:730900 6480464 zoledronic acid results in increased expression of PPP3CA mRNA CTD PMID:24714768
Biological Process aging IEP 1580673 RGD brain development IEP 1580674 RGD calcineurin-mediated signaling IBA PANTHER:PTN000746105 , PomBase:SPBP4H10.0413792537 PMID:21873635 GO_Central calcineurin-NFAT signaling cascade ISO RGD:730900 1624291 RGD PMID:19154138 more ... calcineurin-NFAT signaling cascade ISO RGD:11134 1624291 MGI:MGI:102463 , MGI:MGI:103296 RGD MGI:MGI:1197815 more ... calcineurin-NFAT signaling cascade IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calcium ion transport ISO RGD:11134 1624291 RGD MGI:MGI:2667242 , PMID:12660151 calcium ion transport IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 calcium-mediated signaling ISO RGD:11134 1624291 MGI:MGI:3610315 RGD MGI:MGI:3850748 , PMID:19560418 cardiac muscle hypertrophy in response to stress ISO RGD:11134 1624291 MGI:MGI:103296 RGD MGI:MGI:2388546 , PMID:12370307 cardiac muscle hypertrophy in response to stress IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to drug ISO RGD:730900 1624291 RGD PMID:11005320 cellular response to drug IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 cellular response to glucose stimulus IMP 2316628 PMID:19965390 BHF-UCL dephosphorylation ISO RGD:11134 1624291 RGD MGI:MGI:2450227 more ... excitatory postsynaptic potential ISO RGD:11134 1624291 MGI:MGI:95815 RGD MGI:MGI:3708428 , PMID:17428973 excitatory postsynaptic potential IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 G1/S transition of mitotic cell cycle ISO RGD:11134 1624291 RGD MGI:MGI:2667242 , PMID:12660151 G1/S transition of mitotic cell cycle IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 modulation of chemical synaptic transmission ISO RGD:11134 1624291 RGD MGI:MGI:3531602 , PMID:15590926 multicellular organismal response to stress ISO RGD:11134 1624291 RGD MGI:MGI:2157270 , PMID:11782539 multicellular organismal response to stress IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of calcium ion-dependent exocytosis IC GO:0046676 2316628 PMID:19965390 BHF-UCL negative regulation of chromatin binding ISO RGD:11134 1624291 RGD MGI:MGI:5471880 , PMID:23407945 negative regulation of chromatin binding IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of dendrite morphogenesis ISO RGD:11134 1624291 RGD MGI:MGI:5471880 , PMID:23407945 negative regulation of dendrite morphogenesis IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 negative regulation of gene expression ISO RGD:11134 1624291 RGD MGI:MGI:5562625 , PMID:24161931 negative regulation of insulin secretion IMP 2316628 PMID:19965390 BHF-UCL negative regulation of production of miRNAs involved in gene silencing by miRNA ISO RGD:11134 1624291 RGD MGI:MGI:5562625 , PMID:24161931 negative regulation of production of miRNAs involved in gene silencing by miRNA IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 peptidyl-serine dephosphorylation ISO RGD:730900 1624291 RGD PMID:30611118 peptidyl-serine dephosphorylation IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cardiac muscle hypertrophy ISO RGD:11134 1624291 RNAcentral:URS0000021B51_10090, UniProtKB:P61296 RGD MGI:MGI:5562625 more ... positive regulation of cardiac muscle hypertrophy in response to stress ISO RGD:11134 1624291 RGD MGI:MGI:3848765 , PMID:19287093 positive regulation of cardiac muscle hypertrophy in response to stress IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell adhesion IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell adhesion ISO RGD:730900 1624291 RGD PMID:21785830 positive regulation of cell migration IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of cell migration ISO RGD:730900 1624291 RGD PMID:20422345 , PMID:21785830 positive regulation of connective tissue replacement ISO RGD:11134 1624291 RNAcentral:URS0000021B51_10090 RGD MGI:MGI:5784969 , PMID:24657879 positive regulation of connective tissue replacement IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of DNA-binding transcription factor activity ISO RGD:11134 1624291 RGD MGI:MGI:5494224 , PMID:23261540 positive regulation of DNA-binding transcription factor activity IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of endocytosis ISO RGD:11134 1624291 RGD MGI:MGI:5905268 , PMID:20032460 positive regulation of endocytosis IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of gene expression ISO RGD:11134 1624291 RGD MGI:MGI:5562625 , PMID:24161931 positive regulation of transcription by RNA polymerase II ISO RGD:730900 1624291 RGD PMID:22688515 positive regulation of transcription by RNA polymerase II IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 positive regulation of transcription by RNA polymerase II ISO RGD:11134 1624291 MGI:MGI:103296 , UniProtKB:Q60591 RGD MGI:MGI:3712617 more ... postsynaptic modulation of chemical synaptic transmission IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 postsynaptic modulation of chemical synaptic transmission ISO RGD:11134 1624291 RGD MGI:MGI:3772038 , PMID:11257222 protein dephosphorylation IDA 729536 RGD protein dephosphorylation ISO RGD:11134 1624291 RGD MGI:MGI:3850748 more ... protein dephosphorylation IDA 13507300 PMID:24018048 UniProt protein dephosphorylation ISO RGD:730900 1624291 RGD PMID:18815128 more ... protein dephosphorylation IDA 727532 RGD protein import into nucleus ISO RGD:11134 1624291 RGD MGI:MGI:2157270 , PMID:11782539 protein import into nucleus IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 response to amphetamine IEP 727362 reduced protein in brain striatum particulate fraction, unchanged in soluble fraction, of methamphetamine-treated rats RGD response to calcium ion ISO RGD:730900 1624291 RGD PMID:18815128 response to calcium ion ISS UniProtKB:Q08209 1600115 GO_REF:0000024 UniProt GO_REF:0000024 skeletal muscle fiber development ISO RGD:11134 1624291 RGD MGI:MGI:3586394 , PMID:16024798 skeletal muscle fiber development IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 transition between fast and slow fiber ISO RGD:11134 1624291 RGD MGI:MGI:5056263 , PMID:21427212 transition between fast and slow fiber IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 Cellular Component calcineurin complex IDA 729536 RGD calcineurin complex IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calcineurin complex ISO RGD:11134 1624291 RGD MGI:MGI:3760740 more ... calcineurin complex ISO RGD:730900 1624291 RGD PMID:12218175 more ... cytoplasm ISO RGD:730900 1624291 RGD PMID:19154138 , PMID:22343722 cytoplasm IBA PANTHER:PTN000746105 more ... 13792537 PMID:21873635 GO_Central cytoplasmic side of plasma membrane colocalizes_with ISO RGD:730900 1624291 RGD PMID:22343722 cytoplasmic side of plasma membrane IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 cytosol IDA 1580673 RGD cytosol IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central cytosol ISO RGD:730900 1624291 RGD GO_REF:0000052 cytosol TAS 1600115 Reactome:R-RNO-201760 Reactome Reactome:R-RNO-201760 cytosol ISO RGD:11134 1624291 RGD MGI:MGI:3760740 , PMID:12617961 dendritic spine ISO RGD:730900 1624291 RGD PMID:22343722 dendritic spine IEA UniProtKB-SubCell:SL-0284 1600115 GO_REF:0000039 UniProt GO_REF:0000039 glutamatergic synapse IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 glutamatergic synapse ISO RGD:11134 1624291 RGD MGI:MGI:3772038 , PMID:11257222 mitochondrion ISO RGD:11134 1624291 RGD MGI:MGI:3760740 , PMID:12617961 mitochondrion IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm ISO RGD:730900 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A0S2Z4C6 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:11134 1624291 RGD MGI:MGI:3760740 , PMID:12617961 sarcolemma IEA UniProtKB-SubCell:SL-0238 1600115 GO_REF:0000039 UniProt GO_REF:0000039 Schaffer collateral - CA1 synapse IEA UniProtKB:P63328 , ensembl:ENSMUSP000000531011600115 GO_REF:0000107 Ensembl GO_REF:0000107 Schaffer collateral - CA1 synapse ISO RGD:11134 1624291 RGD MGI:MGI:3772038 , PMID:11257222 slit diaphragm colocalizes_with IDA 11537650 RGD synapse IDA 1580673 RGD synapse IDA 13702322 PMID:1313851 SynGO Z disc ISO RGD:11134 1624291 RGD MGI:MGI:3530691 , PMID:15665106 Z disc IEA UniProtKB-SubCell:SL-0314 1600115 GO_REF:0000039 UniProt GO_REF:0000039 Molecular Function calcium-dependent protein serine/threonine phosphatase activity IDA 729536 RGD calmodulin binding IDA 729536 RGD calmodulin binding IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calmodulin binding ISO RGD:11134 1624291 RGD MGI:MGI:6119999 , PMID:26794871 calmodulin binding ISO RGD:730900 1624291 RGD PMID:11005320 more ... calmodulin-dependent protein phosphatase activity IDA 13507300 PMID:24018048 UniProt calmodulin-dependent protein phosphatase activity IBA FB:FBgn0011826 more ... 13792537 PMID:21873635 GO_Central calmodulin-dependent protein phosphatase activity ISO RGD:11134 1624291 RGD MGI:MGI:6119999 , PMID:26794871 calmodulin-dependent protein phosphatase activity ISS UniProtKB:Q08209 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calmodulin-dependent protein phosphatase activity ISO RGD:730900 1624291 RGD PMID:18815128 more ... cyclosporin A binding ISO RGD:730900 1624291 RGD PMID:12218175 , PMID:12357034 cyclosporin A binding IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 drug binding ISO RGD:730900 1624291 RGD PMID:11005320 enzyme binding ISO RGD:730900 1624291 RGD PMID:11005320 enzyme binding IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000037 UniProt GO_REF:0000037 phosphoprotein phosphatase activity IDA 727532 RGD phosphoprotein phosphatase activity ISO RGD:11134 1624291 RGD MGI:MGI:3586394 , PMID:16024798 protein binding ISO RGD:730900 1624291 UniProtKB:O00429 more ... RGD PMID:11114196 more ... protein binding ISO RGD:11134 1624291 UniProtKB:E9QLJ0 more ... RGD MGI:MGI:2450227 more ... protein binding IPI UniProtKB:Q8VHW5 8553314 PMID:24418105 IntAct protein binding IPI UniProtKB:P22002 8553443 PMID:19478199 IntAct protein binding IPI UniProtKB:Q99653 8554338 PMID:10593895 UniProt protein binding IPI RGD:628808 8553314 RGD protein binding IPI RGD:620103 1579942 RGD protein dimerization activity ISO RGD:730900 1624291 UniProtKB:P16298 , UniProtKB:Q08209 RGD PMID:11005320 protein serine/threonine phosphatase activity IDA 729536 RGD protein serine/threonine phosphatase activity ISO RGD:730900 1624291 RGD PMID:30611118 protein serine/threonine phosphatase activity TAS 1600115 Reactome:R-RNO-201760 Reactome Reactome:R-RNO-201760 protein-containing complex binding IDA 729536 heterodimerization RGD
Gene-Chemical Interaction Annotations
