Gene: Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Rattus norvegicus
Analyze
Symbol:
Ppp3ca
Name:
protein phosphatase 3 catalytic subunit alpha
Description:
Exhibits calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including cellular response to glucose stimulus; negative regulation of insulin secretion; and response to amphetamine. Localizes to calcineurin complex; cytosol; and synapse. Colocalizes with slit diaphragm. Biomarker of kidney disease. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
calcineurin subunit A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; Calna1; CAM-PRP catalytic subunit; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isoform; protein phosphatase 3, catalytic subunit, alpha isozyme; protein phosphatase-2Ba; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) HGNC
EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, Panther, PhylomeDB
Mus musculus (house mouse):
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) HGNC
EggNOG, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
PPP3CA (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ppp3ca (protein phosphatase 3 catalytic subunit alpha) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
PPP3CB (protein phosphatase 3 catalytic subunit beta) HGNC
OrthoDB
Homo sapiens (human):
PPP3CC (protein phosphatase 3 catalytic subunit gamma) HGNC
OrthoDB
Alliance orthologs 3
Mus musculus (house mouse):
Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Homo sapiens (human):
PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Danio rerio (zebrafish):
ppp3cb (protein phosphatase 3, catalytic subunit, beta isozyme)
Alliance
DIOPT (PANTHER|OrthoInspector|PhylomeDB|InParanoid)
Saccharomyces cerevisiae (baker's yeast):
CMP2
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
CanA-14F
Alliance
DIOPT (PANTHER|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Drosophila melanogaster (fruit fly):
Pp2B-14D
Alliance
DIOPT (PANTHER|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Caenorhabditis elegans (roundworm):
tax-6
Alliance
DIOPT (PANTHER|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):
CNA1
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 2 241,909,332 - 242,186,861 (+) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 2 241,909,832 - 242,184,854 (+) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 2 260,463,144 - 260,737,186 (+) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 2 234,130,176 - 234,409,232 (+) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 2 234,116,915 - 234,395,972 (+) NCBI Celera 2 217,359,756 - 217,630,340 (+) NCBI Celera Cytogenetic Map 2 q43 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
Imported Annotations - ClinVar
Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development ISO RGD:730900 8554872 ClinVar Annotator: match by term: ARTHROGRYPOSIS, CLEFT PALATE, CRANIOSYNOSTOSIS, AND IMPAIRED INTELLECTUAL DEVELOPMENT ClinVar PMID:29432562 epilepsy ISO RGD:730900 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:25741868 , PMID:28942967 genetic disease ISO RGD:730900 8554872 ClinVar Annotator: match by term: Inborn genetic diseases ClinVar PMID:10473536 more ... infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:28942967 infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, infantile or early childhood 1 ClinVar PMID:25741868 , PMID:28942967 infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, infantile or early childhood 1 ClinVar infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:29432562 infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:10473536 more ... infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: EPILEPTIC ENCEPHALOPATHY, INFANTILE OR EARLY CHILDHOOD, 1 ClinVar PMID:25741868 infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 8554872 ClinVar Annotator: match by term: Epileptic encephalopathy, infantile or early childhood 1 ClinVar PMID:25741868 , PMID:32238909 visual epilepsy ISO RGD:730900 8554872 ClinVar Annotator: match by term: Seizures ClinVar PMID:25741868 , PMID:28942967
Imported Annotations - CTD
Brain Injuries ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:14499481 Left Ventricular Hypertrophy ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:18344631 lung adenocarcinoma ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:27158780 pancreatitis ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:22952646 Prostatic Neoplasms ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17199135 testicular disease ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:17785681 Wilson disease ISO RGD:730900 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:23519153 Imported Annotations - MGI
dilated cardiomyopathy ISS RGD:11134 13592920 MouseDO Imported Annotations - OMIM
Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development ISO RGD:730900 7240710 OMIM infantile or early childhood epileptic encephalopathy 1 ISO RGD:730900 7240710 OMIM
1,2,3-Trichloropropane multiple interactions ISO RGD:730900 6480464 1 more ... CTD PMID:22952646 17beta-estradiol decreases expression EXP 6480464 Estradiol results in decreased expression of PPP3CA mRNA CTD PMID:20068009 17beta-estradiol decreases expression ISO RGD:730900 6480464 Estradiol results in decreased expression of PPP3CA mRNA CTD PMID:21185374 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of PPP3CA mRNA CTD PMID:21215274 , PMID:32109520 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:11134 6480464 Tetrachlorodibenzodioxin affects the expression of PPP3CA mRNA CTD PMID:21570461 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of PPP3CA mRNA CTD PMID:21346803 2-deoxy-D-glucose decreases response to substance ISO RGD:11134 6480464 PPP3CA protein results in decreased susceptibility to Deoxyglucose CTD PMID:10679475 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 3H-1,2-dithiole-3-thione decreases expression EXP 6480464 1, 2-dithiol-3-thione results in decreased expression of PPP3CA mRNA CTD PMID:19162173 4,4'-diaminodiphenylmethane increases expression ISO RGD:11134 6480464 4, 4'-diaminodiphenylmethane results in increased expression of PPP3CA mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 4-amino-2,6-dinitrotoluene affects expression EXP 6480464 4-amino-2, 6-dinitrotoluene affects the expression of PPP3CA mRNA CTD PMID:21346803 4-hydroxynon-2-enal decreases expression ISO RGD:730900 6480464 4-hydroxy-2-nonenal results in decreased expression of PPP3CA mRNA CTD PMID:12419474 5-fluorouracil multiple interactions ISO RGD:730900 6480464 [Fluorouracil co-treated with irinotecan] results in increased expression of PPP3CA mRNA, PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with irinotecan analog] CTD PMID:16391804 , PMID:18927307 5-fluorouracil increases expression ISO RGD:730900 6480464 Fluorouracil results in increased expression of PPP3CA protein CTD PMID:15585135 , PMID:16803524 6-propyl-2-thiouracil decreases expression EXP 6480464 Propylthiouracil results in decreased expression of PPP3CA mRNA CTD PMID:24780913 , PMID:25825206 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of PPP3CA mRNA CTD PMID:31881176 acetazolamide increases expression ISO RGD:11134 6480464 Acetazolamide results in increased expression of PPP3CA mRNA CTD PMID:19274763 aflatoxin B1 decreases expression ISO RGD:11134 6480464 Aflatoxin B1 results in decreased expression of PPP3CA mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO RGD:730900 6480464 Aflatoxin B1 results in decreased methylation of PPP3CA gene, Aflatoxin B1 results in decreased methylation of PPP3CA intron CTD PMID:27153756 , PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:730900 6480464 Tretinoin results in decreased expression of PPP3CA mRNA CTD PMID:16140955 , PMID:21934132 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of PPP3CA mRNA CTD PMID:16483693 Aroclor 1254 decreases expression ISO RGD:11134 6480464 Chlorodiphenyl (54% Chlorine) results in decreased expression of PPP3CA mRNA CTD PMID:23650126 arsenous acid increases expression ISO RGD:730900 6480464 Arsenic Trioxide results in increased expression of PPP3CA mRNA CTD PMID:17963750 arsenous acid decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PPP3CA mRNA CTD PMID:29223816 atorvastatin calcium increases expression EXP 6480464 Atorvastatin results in increased expression of PPP3CA mRNA CTD PMID:27377005 benzo[a]pyrene decreases expression ISO RGD:11134 6480464 Benzo(a)pyrene results in decreased expression of PPP3CA mRNA CTD PMID:20504355 , PMID:21715664 benzo[a]pyrene decreases expression ISO RGD:730900 6480464 Benzo(a)pyrene results in decreased expression of PPP3CA mRNA CTD PMID:20064835 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:730900 6480464 7 more ... CTD PMID:19150397 benzyl acetate multiple interactions ISO RGD:730900 6480464 benzyl acetate results in increased cleavage of and results in increased activity of PPP3CA protein CTD PMID:22952646 bis(2-chloroethyl) sulfide multiple interactions ISO RGD:11134 6480464 Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] CTD PMID:16377760 bis(2-chloroethyl) sulfide affects expression EXP 6480464 Mustard Gas affects the expression of PPP3CA mRNA CTD PMID:15651846 bis(2-chloroethyl) sulfide decreases expression ISO RGD:11134 6480464 Mustard Gas results in decreased expression of PPP3CA mRNA CTD PMID:16377760 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of PPP3CA mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:11134 6480464 bisphenol A results in increased methylation of PPP3CA promoter CTD PMID:27312807 bisphenol F multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 cadmium dichloride increases expression ISO RGD:730900 6480464 Cadmium Chloride results in increased expression of PPP3CA mRNA CTD PMID:12160620 cadmium dichloride multiple interactions EXP 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PPP3CA mRNA CTD PMID:31077537 cadmium dichloride decreases expression EXP 6480464 Cadmium Chloride results in decreased expression of PPP3CA mRNA CTD PMID:31077537 cadmium dichloride decreases expression ISO RGD:730900 6480464 Cadmium Chloride results in decreased expression of PPP3CA mRNA CTD PMID:18560533 calcitriol increases expression ISO RGD:730900 6480464 Calcitriol results in increased expression of PPP3CA mRNA CTD PMID:16002434 capsaicin multiple interactions EXP 6480464 PPP3CA protein affects the reaction [mustard oil inhibits the reaction [Capsaicin results in increased secretion of CALCA protein]] CTD PMID:17590514 carbamazepine decreases expression EXP 6480464 Carbamazepine results in decreased expression of PPP3CA mRNA, Carbamazepine results in decreased expression of PPP3CA protein CTD PMID:14642444 carbon nanotube decreases expression ISO RGD:11134 6480464 Nanotubes, Carbon analog results in decreased expression of PPP3CA mRNA, Nanotubes, Carbon results in decreased expression of PPP3CA mRNA CTD PMID:25554681 chlorendic acid multiple interactions ISO RGD:730900 6480464 chlorendic acid results in increased cleavage of and results in increased activity of PPP3CA protein CTD PMID:22952646 chlorpyrifos increases expression ISO RGD:11134 6480464 Chlorpyrifos results in increased expression of PPP3CA mRNA CTD PMID:20350560 cisplatin multiple interactions ISO RGD:730900 6480464 [Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA CTD PMID:21858171 clozapine multiple interactions EXP 6480464 [Clozapine binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein CTD PMID:16033416 clozapine increases expression EXP 6480464 Clozapine results in increased expression of PPP3CA mRNA CTD PMID:12437575 clozapine decreases expression EXP 6480464 Clozapine results in decreased expression of PPP3CA mRNA, Clozapine results in decreased expression of PPP3CA protein CTD PMID:16033416 cocaine affects expression EXP 6480464 Cocaine affects the expression of PPP3CA mRNA CTD PMID:20187946 cyclosporin A decreases activity ISO RGD:11134 6480464 Cyclosporine results in decreased activity of PPP3CA protein CTD PMID:19553475 , PMID:32220932 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of PPP3CA protein CTD PMID:18344631 cypermethrin multiple interactions ISO RGD:730900 6480464 [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin CTD PMID:10898953 dexamethasone multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 diallyl disulfide multiple interactions EXP 6480464 [Cadmium Chloride co-treated with diallyl disulfide] results in decreased expression of PPP3CA mRNA CTD PMID:31077537 diarsenic trioxide increases expression ISO RGD:730900 6480464 Arsenic Trioxide results in increased expression of PPP3CA mRNA CTD PMID:17963750 diarsenic trioxide decreases expression EXP 6480464 Arsenic Trioxide results in decreased expression of PPP3CA mRNA CTD PMID:29223816 dimercaprol multiple interactions ISO RGD:11134 6480464 Dimercaprol inhibits the reaction [Mustard Gas results in decreased expression of PPP3CA mRNA] CTD PMID:16377760 diphenylmethane-4,4'-diisocyanate multiple interactions ISO RGD:11134 6480464 [[4 more ... CTD PMID:31609387 diphenylmethane-4,4'-diisocyanate increases expression ISO RGD:11134 6480464 4, 4'-diphenylmethane diisocyanate results in increased expression of PPP3CA mRNA CTD PMID:31609387 dorsomorphin multiple interactions ISO RGD:730900 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA CTD PMID:27188386 doxorubicin decreases expression ISO RGD:730900 6480464 Doxorubicin results in decreased expression of PPP3CA mRNA CTD PMID:29803840 entinostat decreases expression ISO RGD:730900 6480464 entinostat results in decreased expression of PPP3CA mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:730900 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA CTD PMID:27188386 ethanol multiple interactions ISO RGD:11134 6480464 ALDH2 protein inhibits the reaction [Ethanol results in increased expression of PPP3CA protein] CTD PMID:19332462 ethanol affects splicing ISO RGD:11134 6480464 Ethanol affects the splicing of PPP3CA mRNA CTD PMID:30319688 ethanol decreases expression EXP 6480464 Ethanol results in decreased expression of PPP3CA mRNA CTD PMID:20655511 ethanol increases expression ISO RGD:11134 6480464 Ethanol results in increased expression of PPP3CA protein CTD PMID:19332462 famotidine decreases expression EXP 6480464 Famotidine results in decreased expression of PPP3CA protein CTD PMID:30310171 fenofibrate multiple interactions ISO RGD:11134 6480464 PPARA protein affects the reaction [Fenofibrate results in decreased expression of PPP3CA mRNA] CTD PMID:21318169 fenofibrate decreases expression ISO RGD:11134 6480464 Fenofibrate results in decreased expression of PPP3CA mRNA CTD PMID:21318169 flavonoids increases expression EXP 6480464 Flavonoids results in increased expression of PPP3CA mRNA CTD PMID:18035473 flutamide increases expression EXP 6480464 Flutamide results in increased expression of PPP3CA mRNA CTD PMID:24136188 formaldehyde decreases expression ISO RGD:730900 6480464 Formaldehyde results in decreased expression of PPP3CA mRNA CTD PMID:23649840 furan increases expression EXP 6480464 furan results in increased expression of PPP3CA mRNA CTD PMID:20562052 gamma-tocopherol increases expression ISO RGD:11134 6480464 Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 haloperidol decreases expression EXP 6480464 Haloperidol results in decreased expression of PPP3CA mRNA, Haloperidol results in decreased expression of PPP3CA protein CTD PMID:16033416 haloperidol multiple interactions EXP 6480464 [Haloperidol binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein CTD PMID:16033416 histamine increases expression EXP 6480464 Histamine results in increased expression of PPP3CA protein CTD PMID:30310171 hydrogen peroxide multiple interactions ISO RGD:11134 6480464 [Hydrogen Peroxide co-treated with N-(oxo-5 more ... CTD PMID:31494107 indometacin multiple interactions ISO RGD:730900 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PPP3CA mRNA, [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of PPP3CA mRNA CTD PMID:28628672 irinotecan decreases expression ISO RGD:730900 6480464 Irinotecan analog results in decreased expression of PPP3CA mRNA CTD PMID:18927307 irinotecan multiple interactions ISO RGD:730900 6480464 [Fluorouracil co-treated with Irinotecan] results in increased expression of PPP3CA mRNA, PPP3CA protein affects the susceptibility to [Fluorouracil co-treated with Irinotecan analog] CTD PMID:16391804 , PMID:18927307 lipopolysaccharide increases expression EXP 6480464 Lipopolysaccharides results in increased expression of PPP3CA protein CTD PMID:31714667 lipopolysaccharide multiple interactions EXP 6480464 Honghua extract, Carthamus tinctorius inhibits the reaction [Lipopolysaccharides results in increased expression of PPP3CA protein] CTD PMID:31714667 methamphetamine increases expression EXP 6480464 Methamphetamine results in increased expression of PPP3CA protein CTD PMID:15644446 methamphetamine multiple interactions EXP 6480464 SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein] CTD PMID:15644446 methapyrilene decreases expression EXP 6480464 Methapyrilene results in decreased expression of PPP3CA mRNA CTD PMID:30467583 methotrexate affects response to substance ISO RGD:730900 6480464 PPP3CA protein affects the susceptibility to Methotrexate CTD PMID:16217747 methylmercury chloride decreases expression ISO RGD:730900 6480464 methylmercuric chloride results in decreased expression of PPP3CA mRNA CTD PMID:28001369 metoprolol decreases expression EXP 6480464 Metoprolol results in decreased expression of PPP3CA protein CTD PMID:30310171 nitric oxide decreases expression ISO RGD:11134 6480464 Nitric Oxide deficiency results in decreased expression of PPP3CA mRNA CTD PMID:15878706 oxaliplatin multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA CTD PMID:25729387 paracetamol affects expression ISO RGD:11134 6480464 Acetaminophen affects the expression of PPP3CA mRNA CTD PMID:17562736 paracetamol increases expression ISO RGD:730900 6480464 Acetaminophen results in increased expression of PPP3CA mRNA CTD PMID:21420995 , PMID:25704631 paraquat increases expression ISO RGD:730900 6480464 Paraquat results in increased expression of PPP3CA mRNA CTD PMID:28619522 perfluorooctane-1-sulfonic acid increases expression EXP 6480464 perfluorooctane sulfonic acid results in increased expression of PPP3CA mRNA CTD PMID:20136073 perindopril decreases expression EXP 6480464 Perindopril results in decreased expression of PPP3CA protein CTD PMID:18344631 phenobarbital decreases expression ISO RGD:11134 6480464 Phenobarbital results in decreased expression of PPP3CA mRNA CTD PMID:19363144 phenobarbital affects expression ISO RGD:11134 6480464 Phenobarbital affects the expression of PPP3CA mRNA CTD PMID:23091169 pirinixic acid decreases expression ISO RGD:11134 6480464 pirinixic acid results in decreased expression of PPP3CA mRNA CTD PMID:21318169 pirinixic acid multiple interactions ISO RGD:11134 6480464 PPARA protein affects the reaction [pirinixic acid results in decreased expression of PPP3CA mRNA] CTD PMID:21318169 piroxicam multiple interactions ISO RGD:730900 6480464 [Piroxicam co-treated with Cisplatin] results in decreased expression of PPP3CA mRNA CTD PMID:21858171 propiconazole decreases expression ISO RGD:11134 6480464 propiconazole results in decreased expression of PPP3CA mRNA CTD PMID:19363144 quercetin decreases expression ISO RGD:730900 6480464 Quercetin results in decreased expression of PPP3CA mRNA CTD PMID:21632981 quercetin multiple interactions ISO RGD:730900 6480464 Quercetin results in decreased activity of [PPP3CA protein binds to PPP3R1 protein] CTD PMID:19880376 risperidone multiple interactions EXP 6480464 [Risperidone binds to and results in decreased activity of DRD2 protein] which results in increased expression of PPP3CA protein CTD PMID:16033416 risperidone decreases expression EXP 6480464 Risperidone results in decreased expression of PPP3CA mRNA, Risperidone results in decreased expression of PPP3CA protein CTD PMID:16033416 S-butyl-DL-homocysteine (S,R)-sulfoximine increases expression ISO RGD:11134 6480464 Buthionine Sulfoximine results in increased expression of PPP3CA mRNA CTD PMID:15878706 SB 431542 multiple interactions ISO RGD:730900 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PPP3CA mRNA CTD PMID:27188386 SCH 23390 multiple interactions EXP 6480464 SCH 23390 inhibits the reaction [Methamphetamine results in increased expression of PPP3CA protein] CTD PMID:15644446 sodium arsenite affects methylation ISO RGD:730900 6480464 sodium arsenite affects the methylation of PPP3CA gene CTD PMID:28589171 sodium fluoride decreases expression ISO RGD:11134 6480464 Sodium Fluoride results in decreased expression of PPP3CA mRNA CTD PMID:27862939 Soman decreases expression EXP 6480464 Soman results in decreased expression of PPP3CA mRNA CTD PMID:19281266 staurosporine decreases response to substance ISO RGD:11134 6480464 PPP3CA protein results in decreased susceptibility to Staurosporine CTD PMID:10679475 staurosporine increases cleavage ISO RGD:730900 6480464 Staurosporine results in increased cleavage of PPP3CA protein CTD PMID:10898953 tacrolimus hydrate multiple interactions ISO RGD:730900 6480464 [Tacrolimus results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin CTD PMID:10898953 tacrolimus hydrate decreases activity ISO RGD:11134 6480464 Tacrolimus results in decreased activity of PPP3CA protein CTD PMID:19553475 tert-butyl hydroperoxide decreases expression ISO RGD:730900 6480464 tert-Butylhydroperoxide results in decreased expression of PPP3CA mRNA CTD PMID:12419474 thapsigargin multiple interactions ISO RGD:730900 6480464 [cypermethrin results in decreased activity of PPP3CA protein] which results in decreased susceptibility to Thapsigargin more ... CTD PMID:10898953 thapsigargin increases expression ISO RGD:730900 6480464 Thapsigargin results in increased expression of PPP3CA mRNA CTD PMID:17963750 thapsigargin increases cleavage ISO RGD:730900 6480464 Thapsigargin results in increased cleavage of PPP3CA protein CTD PMID:10898953 tocopherol increases expression ISO RGD:11134 6480464 Tocopherols results in increased expression of PPP3CA mRNA CTD PMID:17654050 topotecan multiple interactions EXP 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of PPP3CA mRNA CTD PMID:25729387 trichloroethene multiple interactions ISO RGD:11134 6480464 PPARA protein inhibits the reaction [Trichloroethylene results in decreased expression of PPP3CA mRNA] CTD PMID:15363585 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of PPP3CA mRNA CTD PMID:19448997 triphenyl phosphate increases expression EXP 6480464 triphenyl phosphate results in increased expression of PPP3CA mRNA CTD PMID:30589522 troglitazone decreases expression ISO RGD:11134 6480464 troglitazone results in decreased expression of PPP3CA mRNA CTD PMID:28973697 tungsten decreases expression ISO RGD:11134 6480464 Tungsten results in decreased expression of PPP3CA mRNA CTD PMID:30912803 tunicamycin increases expression ISO RGD:11134 6480464 Tunicamycin results in increased expression of PPP3CA mRNA CTD PMID:17127020 Tylophorine increases expression ISO RGD:730900 6480464 tylophorine analog results in increased expression of PPP3CA mRNA CTD PMID:19284764 valproic acid increases expression ISO RGD:730900 6480464 Valproic Acid results in increased expression of PPP3CA mRNA CTD PMID:23179753 valproic acid affects expression ISO RGD:730900 6480464 Valproic Acid affects the expression of PPP3CA mRNA CTD PMID:25979313 valproic acid decreases methylation ISO RGD:730900 6480464 Valproic Acid results in decreased methylation of PPP3CA gene CTD PMID:29154799 vinclozolin affects expression EXP 6480464 vinclozolin affects the expression of PPP3CA mRNA CTD PMID:19015723 zoledronic acid increases expression ISO RGD:730900 6480464 zoledronic acid results in increased expression of PPP3CA mRNA CTD PMID:24714768
Biological Process aging IEP 1580673 RGD brain development IEP 1580674 RGD calcineurin-mediated signaling IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calcineurin-NFAT signaling cascade ISO RGD:730900 1624291 (PMID:15955804), (PMID:19154138), (PMID:22343722), (PMID:22688515), (PMID:23468591), (PMID:26248042) RGD PMID:15955804 more ... calcineurin-NFAT signaling cascade ISO RGD:11134 1624291 MGI:MGI:102463 more ... RGD MGI:MGI:1197815 more ... calcineurin-NFAT signaling cascade IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calcium ion transport ISO RGD:11134 1624291 (MGI:MGI:2667242, PMID:12660151) RGD MGI:MGI:2667242 , PMID:12660151 calcium-mediated signaling ISO RGD:11134 1624291 MGI:MGI:3610315 (MGI:MGI:3850748 , PMID:19560418) RGD MGI:MGI:3850748 , PMID:19560418 cardiac muscle hypertrophy in response to stress ISO RGD:11134 1624291 MGI:MGI:103296 (MGI:MGI:2388546 , PMID:12370307) RGD MGI:MGI:2388546 , PMID:12370307 cellular response to drug ISO RGD:730900 1624291 (PMID:11005320) RGD PMID:11005320 cellular response to glucose stimulus IMP 2316628 PMID:19965390 BHF-UCL dephosphorylation ISO RGD:11134 1624291 (MGI:MGI:2450227 more ... RGD MGI:MGI:2450227 more ... excitatory postsynaptic potential ISO RGD:11134 1624291 MGI:MGI:95815 (MGI:MGI:3708428 , PMID:17428973) RGD MGI:MGI:3708428 , PMID:17428973 G1/S transition of mitotic cell cycle ISO RGD:11134 1624291 (MGI:MGI:2667242, PMID:12660151) RGD MGI:MGI:2667242 , PMID:12660151 modulation of chemical synaptic transmission ISO RGD:11134 1624291 (MGI:MGI:3531602, PMID:15590926) RGD MGI:MGI:3531602 , PMID:15590926 multicellular organismal response to stress ISO RGD:11134 1624291 (MGI:MGI:2157270, PMID:11782539) RGD MGI:MGI:2157270 , PMID:11782539 negative regulation of calcium ion-dependent exocytosis IC GO:0046676 2316628 PMID:19965390 BHF-UCL negative regulation of chromatin binding ISO RGD:11134 1624291 (MGI:MGI:5471880, PMID:23407945) RGD MGI:MGI:5471880 , PMID:23407945 negative regulation of dendrite morphogenesis ISO RGD:11134 1624291 (MGI:MGI:5471880, PMID:23407945) RGD MGI:MGI:5471880 , PMID:23407945 negative regulation of gene expression ISO RGD:11134 1624291 (MGI:MGI:5562625, PMID:24161931) RGD MGI:MGI:5562625 , PMID:24161931 negative regulation of insulin secretion IMP 2316628 PMID:19965390 BHF-UCL negative regulation of production of miRNAs involved in gene silencing by miRNA ISO RGD:11134 1624291 (MGI:MGI:5562625, PMID:24161931) RGD MGI:MGI:5562625 , PMID:24161931 peptidyl-serine dephosphorylation ISO RGD:730900 1624291 (PMID:30611118) RGD PMID:30611118 positive regulation of cardiac muscle hypertrophy ISO RGD:11134 1624291 RNAcentral:URS0000021B51_10090 more ... RGD MGI:MGI:5562625 more ... positive regulation of cardiac muscle hypertrophy in response to stress ISO RGD:11134 1624291 (MGI:MGI:3848765, PMID:19287093) RGD MGI:MGI:3848765 , PMID:19287093 positive regulation of cell adhesion ISO RGD:730900 1624291 (PMID:21785830) RGD PMID:21785830 positive regulation of cell migration ISO RGD:730900 1624291 (PMID:20422345), (PMID:21785830) RGD PMID:20422345 , PMID:21785830 positive regulation of connective tissue replacement ISO RGD:11134 1624291 RNAcentral:URS0000021B51_10090 (MGI:MGI:5784969, PMID:24657879) RGD MGI:MGI:5784969 , PMID:24657879 positive regulation of DNA-binding transcription factor activity ISO RGD:11134 1624291 (MGI:MGI:5494224, PMID:23261540) RGD MGI:MGI:5494224 , PMID:23261540 positive regulation of endocytosis ISO RGD:11134 1624291 (MGI:MGI:5905268, PMID:20032460) RGD MGI:MGI:5905268 , PMID:20032460 positive regulation of gene expression ISO RGD:11134 1624291 (MGI:MGI:5562625, PMID:24161931) RGD MGI:MGI:5562625 , PMID:24161931 positive regulation of transcription by RNA polymerase II ISO RGD:730900 1624291 (PMID:22688515) RGD PMID:22688515 positive regulation of transcription by RNA polymerase II ISO RGD:11134 1624291 MGI:MGI:103296 more ... RGD MGI:MGI:3712617 more ... postsynaptic modulation of chemical synaptic transmission ISO RGD:11134 1624291 (MGI:MGI:3772038, PMID:11257222) RGD MGI:MGI:3772038 , PMID:11257222 protein dephosphorylation IDA 729536 ; 727532 RGD protein dephosphorylation ISO RGD:11134 1624291 (MGI:MGI:3850748 more ... RGD MGI:MGI:3850748 more ... protein dephosphorylation IDA 13507300 PMID:24018048 UniProt protein dephosphorylation ISO RGD:730900 1624291 (PMID:18815128), (PMID:19154138), (PMID:23468591) RGD PMID:18815128 more ... protein import into nucleus ISO RGD:11134 1624291 (MGI:MGI:2157270, PMID:11782539) RGD MGI:MGI:2157270 , PMID:11782539 response to amphetamine IEP 727362 reduced protein in brain striatum particulate fraction, unchanged in soluble fraction, of methamphetamine-treated rats RGD response to calcium ion ISO RGD:730900 1624291 (PMID:18815128) RGD PMID:18815128 response to calcium ion ISS UniProtKB:Q08209 1600115 GO_REF:0000024 UniProt GO_REF:0000024 skeletal muscle fiber development ISO RGD:11134 1624291 (MGI:MGI:3586394, PMID:16024798) RGD MGI:MGI:3586394 , PMID:16024798 transition between fast and slow fiber ISO RGD:11134 1624291 (MGI:MGI:5056263, PMID:21427212) RGD MGI:MGI:5056263 , PMID:21427212 Cellular Component calcineurin complex IDA 729536 RGD calcineurin complex IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calcineurin complex ISO RGD:11134 1624291 (MGI:MGI:3760740 more ... RGD MGI:MGI:3760740 more ... calcineurin complex ISO RGD:730900 1624291 (PMID:12218175), (PMID:12357034), (PMID:22343722), (PMID:22688515), (PMID:23468591), (PMID:27974827) RGD PMID:12218175 more ... cytoplasm ISO RGD:730900 1624291 (PMID:15955804), (PMID:19154138), (PMID:22343722) RGD PMID:15955804 more ... cytoplasm IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central cytoplasmic side of plasma membrane colocalizes_with ISO RGD:730900 1624291 (PMID:22343722) RGD PMID:22343722 cytosol IDA 1580673 RGD cytosol IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central cytosol ISO RGD:730900 1624291 RGD GO_REF:0000052 cytosol TAS 1600115 Reactome:R-RNO-201760 Reactome Reactome:R-RNO-201760 cytosol ISO RGD:11134 1624291 (MGI:MGI:3760740, PMID:12617961) RGD MGI:MGI:3760740 , PMID:12617961 dendritic spine ISO RGD:730900 1624291 (PMID:22343722) RGD PMID:22343722 glutamatergic synapse ISO RGD:11134 1624291 (MGI:MGI:3772038, PMID:11257222) RGD MGI:MGI:3772038 , PMID:11257222 mitochondrion ISO RGD:11134 1624291 (MGI:MGI:3760740, PMID:12617961) RGD MGI:MGI:3760740 , PMID:12617961 nucleoplasm ISO RGD:730900 1624291 RGD GO_REF:0000052 nucleoplasm IEA UniProtKB:Q08209 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleoplasm IEA UniProtKB:A0A0S2Z4C6 , ensembl:ENSP000003783231600115 GO_REF:0000107 Ensembl GO_REF:0000107 nucleus ISO RGD:11134 1624291 (MGI:MGI:3760740, PMID:12617961) RGD MGI:MGI:3760740 , PMID:12617961 plasma membrane ISO RGD:730900 1624291 (PMID:15955804) RGD PMID:15955804 sarcolemma IEA UniProtKB-SubCell:SL-0238 1600115 GO_REF:0000044 UniProt GO_REF:0000044 Schaffer collateral - CA1 synapse ISO RGD:11134 1624291 (MGI:MGI:3772038, PMID:11257222) RGD MGI:MGI:3772038 , PMID:11257222 slit diaphragm colocalizes_with IDA 11537650 RGD synapse IDA 1580673 RGD synapse IDA 13702322 PMID:1313851 SynGO Z disc ISO RGD:11134 1624291 (MGI:MGI:3530691, PMID:15665106) RGD MGI:MGI:3530691 , PMID:15665106 Molecular Function ATPase binding ISO RGD:730900 1624291 UniProtKB:P23634 (PMID:15955804) RGD PMID:15955804 calcium-dependent protein serine/threonine phosphatase activity IDA 729536 RGD calmodulin binding IDA 729536 RGD calmodulin binding IBA MGI:MGI:107164 more ... 13792537 PMID:21873635 GO_Central calmodulin binding ISO RGD:11134 1624291 (MGI:MGI:6119999, PMID:26794871) RGD MGI:MGI:6119999 , PMID:26794871 calmodulin binding ISO RGD:730900 1624291 (PMID:11005320), (PMID:18384083), (PMID:19404396) RGD PMID:11005320 more ... calmodulin-dependent protein phosphatase activity IDA 13507300 PMID:24018048 UniProt calmodulin-dependent protein phosphatase activity IBA FB:FBgn0011826 more ... 13792537 PMID:21873635 GO_Central calmodulin-dependent protein phosphatase activity ISO RGD:11134 1624291 (MGI:MGI:6119999, PMID:26794871) RGD MGI:MGI:6119999 , PMID:26794871 calmodulin-dependent protein phosphatase activity ISS UniProtKB:Q08209 1600115 GO_REF:0000024 UniProt GO_REF:0000024 calmodulin-dependent protein phosphatase activity ISO RGD:730900 1624291 (PMID:18815128), (PMID:19154138), (PMID:23468591) RGD PMID:18815128 more ... cyclosporin A binding ISO RGD:730900 1624291 (PMID:12218175), (PMID:12357034) RGD PMID:12218175 , PMID:12357034 drug binding ISO RGD:730900 1624291 (PMID:11005320) RGD PMID:11005320 enzyme binding ISO RGD:730900 1624291 (PMID:11005320) RGD PMID:11005320 metal ion binding IEA UniProtKB-KW:KW-0479 1600115 GO_REF:0000043 UniProt GO_REF:0000043 phosphoprotein phosphatase activity IDA 727532 RGD phosphoprotein phosphatase activity ISO RGD:11134 1624291 (MGI:MGI:3586394, PMID:16024798) RGD MGI:MGI:3586394 , PMID:16024798 protein binding IPI RGD:620103 1579942 RGD protein binding ISO RGD:11134 1624291 PR:P10417 more ... RGD MGI:MGI:2450227 more ... protein binding ISO RGD:730900 1624291 UniProtKB:A0A494C014 more ... RGD PMID:11114196 more ... protein binding IPI UniProtKB:Q8VHW5 8553314 PMID:24418105 IntAct protein binding IPI UniProtKB:P22002 8553443 PMID:19478199 IntAct protein binding IPI UniProtKB:Q99653 8554338 PMID:10593895 UniProt protein binding IPI RGD:628808 8553314 RGD protein dimerization activity ISO RGD:730900 1624291 UniProtKB:P16298 , UniProtKB:Q08209 (PMID:11005320) RGD PMID:11005320 protein serine/threonine phosphatase activity IDA 729536 RGD protein serine/threonine phosphatase activity ISO RGD:730900 1624291 (PMID:30611118) RGD PMID:30611118 protein serine/threonine phosphatase activity TAS 1600115 Reactome:R-RNO-201760 Reactome Reactome:R-RNO-201760 protein-containing complex binding IDA 729536 heterodimerization RGD
Gene-Chemical Interaction Annotations
