PPP3CA (protein phosphatase 3 catalytic subunit alpha) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: PPP3CA (protein phosphatase 3 catalytic subunit alpha) Canis lupus familiaris
Analyze
Symbol: PPP3CA
Name: protein phosphatase 3 catalytic subunit alpha
RGD ID: 12066106
Description: ENCODES a protein that exhibits calcium-dependent protein serine/threonine phosphatase activity (ortholog); calmodulin binding (ortholog); phosphoprotein phosphatase activity (ortholog); INVOLVED IN calcineurin-NFAT signaling cascade (ortholog); calcium ion transport (ortholog); calcium-mediated signaling (ortholog); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development (ortholog); autism spectrum disorder (ortholog); beta-mannosidosis (ortholog); FOUND IN calcineurin complex (ortholog); glutamatergic synapse (ortholog); Schaffer collateral - CA1 synapse (ortholog); INTERACTS WITH mocetinostat
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: calcineurin catalytic subunit; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha); protein phosphatase 3, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13222,688,141 - 22,996,693 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3222,688,143 - 22,996,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3218,960,549 - 19,234,052 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03222,910,701 - 23,219,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13222,888,729 - 23,197,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03222,670,376 - 22,979,752 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03216,885,817 - 17,195,548 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
mocetinostat  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
calcineurin-mediated signaling  (IEA)
calcineurin-NFAT signaling cascade  (IEA,ISO)
calcium ion transport  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO)
cardiac muscle hypertrophy in response to stress  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
dendrite morphogenesis  (IEA,ISO)
dephosphorylation  (ISO)
epidermis development  (IEA)
excitatory postsynaptic potential  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IEA,ISO)
keratinocyte differentiation  (IEA)
modulation of chemical synaptic transmission  (IEA,ISO)
multicellular organismal response to stress  (IEA,ISO)
negative regulation of angiotensin-activated signaling pathway  (IEA)
negative regulation of dendrite morphogenesis  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of insulin secretion  (ISO)
negative regulation of signaling  (IEA)
peptidyl-serine dephosphorylation  (ISO)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of cardiac muscle hypertrophy in response to stress  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of connective tissue replacement  (IEA)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of endocytosis  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of glomerulus development  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of saliva secretion  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (IEA)
protein dephosphorylation  (ISO)
protein import into nucleus  (IEA,ISO)
regulation of cell proliferation involved in kidney morphogenesis  (IEA)
renal filtration  (IEA)
response to amphetamine  (ISO)
response to calcium ion  (IEA)
skeletal muscle fiber development  (IEA,ISO)
transition between fast and slow fiber  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
PPP3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13222,688,141 - 22,996,693 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3222,688,143 - 22,996,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3218,960,549 - 19,234,052 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03222,910,701 - 23,219,264 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,917 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13222,888,729 - 23,197,885 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03222,670,376 - 22,979,752 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03216,885,817 - 17,195,548 (+)NCBIUU_Cfam_GSD_1.0
PPP3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384101,023,418 - 101,347,526 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4101,023,409 - 101,348,278 (-)EnsemblGRCh38hg38GRCh38
GRCh374101,944,575 - 102,268,683 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364102,163,610 - 102,487,376 (-)NCBINCBI36Build 36hg18NCBI36
Build 344102,301,764 - 102,625,531NCBI
Celera499,241,833 - 99,567,826 (-)NCBICelera
Cytogenetic Map4q24NCBI
HuRef497,682,764 - 98,006,594 (-)NCBIHuRef
CHM1_14101,921,069 - 102,245,098 (-)NCBICHM1_1
T2T-CHM13v2.04104,338,695 - 104,662,217 (-)NCBIT2T-CHM13v2.0
Ppp3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393136,375,778 - 136,643,488 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3136,375,885 - 136,643,488 (+)EnsemblGRCm39 Ensembl
GRCm383136,669,714 - 136,937,727 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3136,670,124 - 136,937,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv373136,333,734 - 136,598,743 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363136,608,157 - 136,873,166 (+)NCBIMGSCv36mm8
Celera3143,090,942 - 143,357,512 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map363.34NCBI
Ppp3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82227,839,058 - 228,113,560 (+)NCBIGRCr8
mRatBN7.22225,165,981 - 225,440,978 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2225,165,766 - 225,438,974 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2232,923,341 - 233,194,495 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02230,823,106 - 231,094,243 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02225,687,726 - 225,958,877 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02241,909,332 - 242,186,861 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2241,909,832 - 242,184,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02260,463,144 - 260,737,186 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42234,130,176 - 234,409,232 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12234,116,915 - 234,395,972 (+)NCBI
Celera2217,359,756 - 217,630,340 (+)NCBICelera
Cytogenetic Map2q43NCBI
Ppp3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554966,908,224 - 7,059,816 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554966,934,542 - 7,059,745 (+)NCBIChiLan1.0ChiLan1.0
PPP3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2399,106,368 - 99,429,647 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1499,392,487 - 99,715,781 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0493,447,095 - 93,770,339 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14104,113,512 - 104,435,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4104,113,520 - 104,435,394 (-)Ensemblpanpan1.1panPan2
Ppp3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530118,494,657 - 18,802,106 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365201,987,045 - 2,146,540 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365201,987,989 - 2,146,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8119,428,779 - 119,753,105 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18119,429,181 - 119,754,615 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28128,461,857 - 128,883,250 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1749,149,044 - 49,478,796 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl749,148,933 - 49,321,013 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603727,622,035 - 27,951,191 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ppp3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248306,317,968 - 6,581,892 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248306,318,352 - 6,584,232 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PPP3CA
3581 total Variants

Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
6 5 5 23 22 16 6 6 6 6 33 22 12 14 10

Sequence


Ensembl Acc Id: ENSCAFT00000014940   ⟹   ENSCAFP00000013827
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3222,689,855 - 22,996,688 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000016916   ⟹   ENSCAFP00000015652
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3222,688,143 - 22,996,688 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000090037   ⟹   ENSCAFP00000063751
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3222,688,143 - 22,996,688 (-)Ensembl
Ensembl Acc Id: ENSCAFT00000092578   ⟹   ENSCAFP00000051576
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3222,689,855 - 22,996,688 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845043522   ⟹   ENSCAFP00845034096
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,917 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845043614   ⟹   ENSCAFP00845034170
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,230 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845043711   ⟹   ENSCAFP00845034246
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,228 (-)Ensembl
Ensembl Acc Id: ENSCAFT00845043828   ⟹   ENSCAFP00845034346
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,228 (-)Ensembl
RefSeq Acc Id: NM_001197096   ⟹   NP_001184025
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13222,688,143 - 22,996,581 (-)NCBI
Dog10K_Boxer_Tasha3218,960,549 - 19,234,052 (+)NCBI
ROS_Cfam_1.03222,910,703 - 23,219,083 (-)NCBI
UMICH_Zoey_3.13222,888,729 - 23,197,885 (-)NCBI
UNSW_CanFamBas_1.03222,670,376 - 22,979,752 (-)NCBI
UU_Cfam_GSD_1.03216,885,817 - 17,195,548 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038443773   ⟹   XP_038299701
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03222,910,701 - 23,219,264 (-)NCBI
RefSeq Acc Id: NP_001184025   ⟸   NM_001197096
- UniProtKB: A0A8C0P395 (UniProtKB/TrEMBL),   A0A8I3PMK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCAFP00000051576   ⟸   ENSCAFT00000092578
Ensembl Acc Id: ENSCAFP00000013827   ⟸   ENSCAFT00000014940
Ensembl Acc Id: ENSCAFP00000063751   ⟸   ENSCAFT00000090037
Ensembl Acc Id: ENSCAFP00000015652   ⟸   ENSCAFT00000016916
RefSeq Acc Id: XP_038299701   ⟸   XM_038443773
- Peptide Label: isoform X1
- UniProtKB: A0A8I3PS73 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSCAFP00845034096   ⟸   ENSCAFT00845043522
Ensembl Acc Id: ENSCAFP00845034346   ⟸   ENSCAFT00845043828
Ensembl Acc Id: ENSCAFP00845034246   ⟸   ENSCAFT00845043711
Ensembl Acc Id: ENSCAFP00845034170   ⟸   ENSCAFT00845043614
Protein Domains
Serine/threonine specific protein phosphatases

Promoters
RGD ID:13688731
Promoter ID:EPDNEW_C6800
Type:multiple initiation site
Name:PPP3CA_1
Description:protein phosphatase 3 catalytic subunit alpha
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13222,996,701 - 22,996,761EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010644 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030021274 UniProtKB/TrEMBL
  ENSCAFG00040022483 UniProtKB/TrEMBL
  ENSCAFG00845024635 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000014940.5 UniProtKB/TrEMBL
  ENSCAFT00030039102.1 UniProtKB/TrEMBL
  ENSCAFT00030039221.1 UniProtKB/TrEMBL
  ENSCAFT00030039295.1 UniProtKB/TrEMBL
  ENSCAFT00030039365.1 UniProtKB/TrEMBL
  ENSCAFT00030039541.1 UniProtKB/TrEMBL
  ENSCAFT00030039640.1 UniProtKB/TrEMBL
  ENSCAFT00030039685.1 UniProtKB/TrEMBL
  ENSCAFT00040041809.1 UniProtKB/TrEMBL
  ENSCAFT00040041833.1 UniProtKB/TrEMBL
  ENSCAFT00040041851.1 UniProtKB/TrEMBL
  ENSCAFT00040041952.1 UniProtKB/TrEMBL
  ENSCAFT00040042073.1 UniProtKB/TrEMBL
  ENSCAFT00040042115.1 UniProtKB/TrEMBL
  ENSCAFT00040042138.1 UniProtKB/TrEMBL
  ENSCAFT00845043522.1 UniProtKB/TrEMBL
  ENSCAFT00845043614 ENTREZGENE
  ENSCAFT00845043614.1 UniProtKB/TrEMBL
  ENSCAFT00845043711.1 UniProtKB/TrEMBL
  ENSCAFT00845043828.1 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  MPP_PP2B UniProtKB/TrEMBL
  PP2B UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/TrEMBL
KEGG Report cfa:403486 UniProtKB/TrEMBL
NCBI Gene PPP3CA ENTREZGENE
PANTHER PTHR45673 UniProtKB/TrEMBL
  SERINE/THREONINE-PROTEIN PHOSPHATASE 2B CATALYTIC SUBUNIT ALPHA ISOFORM UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
PRINTS STPHPHTASE UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/TrEMBL
UniProt A0A8C0NZA1_CANLF UniProtKB/TrEMBL
  A0A8C0P0G4_CANLF UniProtKB/TrEMBL
  A0A8C0P213_CANLF UniProtKB/TrEMBL
  A0A8C0P395 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0TFK7_CANLF UniProtKB/TrEMBL
  A0A8C0TFL5_CANLF UniProtKB/TrEMBL
  A0A8C0TIU4_CANLF UniProtKB/TrEMBL
  A0A8C0TLL8_CANLF UniProtKB/TrEMBL
  A0A8I3PMK3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3PS73 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I3Q531_CANLF UniProtKB/TrEMBL
  A0A8I3S4X4_CANLF UniProtKB/TrEMBL
  A0A8P0NBG3_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44918 ENTREZGENE