Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) - Rat Genome Database

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Gene: Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) Mus musculus
Analyze
Symbol: Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
RGD ID: 11134
MGI Page MGI
Description: Enables calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including negative regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of cardiac muscle hypertrophy in response to stress; and positive regulation of connective tissue replacement. Acts upstream of or within several processes, including calcineurin-NFAT signaling cascade; cardiac muscle hypertrophy in response to stress; and regulation of transcription, DNA-templated. Located in several cellular components, including Z disc; cytosol; and mitochondrion. Part of calcineurin complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut gland; and jaw. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900074D19Rik; AI841391; AW413465; C; calcineurin A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; Caln; Calna; CAM-PRP catalytic subunit; CN; CnA; CNA alpha; MGC106804; PP2B alpha 1; PP2BA alpha; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393136,375,778 - 136,643,488 (+)NCBIGRCm39mm39
GRCm39 Ensembl3136,375,885 - 136,643,488 (+)Ensembl
GRCm383136,669,714 - 136,937,727 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3136,670,124 - 136,937,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv373136,333,734 - 136,598,743 (+)NCBIGRCm37mm9NCBIm37
MGSCv363136,608,157 - 136,873,166 (+)NCBImm8
Celera3143,090,942 - 143,357,512 (+)NCBICelera
Cytogenetic Map3G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2,3-Trichloropropane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-amino-2,6-dinitrotoluene  (ISO)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetazolamide  (EXP)
acrolein  (ISO)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (ISO)
aristolochic acid  (ISO)
Aroclor 1254  (EXP)
arsenous acid  (ISO)
atorvastatin calcium  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzyl acetate  (ISO)
bis(2-chloroethyl) sulfide  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
chlorendic acid  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clozapine  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (EXP,ISO)
cypermethrin  (ISO)
dexamethasone  (ISO)
diallyl disulfide  (ISO)
diarsenic trioxide  (ISO)
dimercaprol  (EXP)
diphenylmethane-4,4'-diisocyanate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
famotidine  (ISO)
fenofibrate  (EXP)
flavonoids  (ISO)
flutamide  (ISO)
formaldehyde  (ISO)
fulvestrant  (ISO)
furan  (ISO)
gamma-tocopherol  (EXP)
glyphosate  (ISO)
haloperidol  (ISO)
histamine  (ISO)
hydrogen peroxide  (EXP)
indometacin  (ISO)
irinotecan  (ISO)
lipopolysaccharide  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methotrexate  (ISO)
methylmercury chloride  (ISO)
metoprolol  (ISO)
nitric oxide  (EXP)
oxaliplatin  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perindopril  (ISO)
phenobarbital  (EXP)
pirinixic acid  (EXP)
piroxicam  (ISO)
propiconazole  (EXP)
quercetin  (ISO)
rimonabant  (EXP)
risperidone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP)
SB 431542  (ISO)
SCH 23390  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (EXP)
Soman  (ISO)
staurosporine  (EXP,ISO)
tacrolimus hydrate  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
tocopherol  (EXP)
topotecan  (ISO)
trichloroethene  (EXP,ISO)
triphenyl phosphate  (ISO)
troglitazone  (EXP)
tungsten  (EXP)
tunicamycin  (EXP)
Tylophorine  (ISO)
valproic acid  (ISO)
vinclozolin  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
brain development  (ISO)
calcineurin-mediated signaling  (IBA,ISO)
calcineurin-NFAT signaling cascade  (IBA,IDA,IGI,IMP,ISO)
calcium ion transport  (IMP)
calcium-mediated signaling  (IGI)
cardiac muscle hypertrophy in response to stress  (IGI)
cellular response to glucose stimulus  (ISO)
dephosphorylation  (IDA)
excitatory postsynaptic potential  (IGI)
G1/S transition of mitotic cell cycle  (IMP)
modulation of chemical synaptic transmission  (IMP)
multicellular organismal response to stress  (IDA)
negative regulation of chromatin binding  (IMP)
negative regulation of dendrite morphogenesis  (IMP)
negative regulation of gene expression  (IDA)
negative regulation of insulin secretion  (ISO)
negative regulation of production of miRNAs involved in gene silencing by miRNA  (IDA)
peptidyl-serine dephosphorylation  (ISO)
positive regulation of cardiac muscle hypertrophy  (IGI)
positive regulation of cardiac muscle hypertrophy in response to stress  (IDA)
positive regulation of cell adhesion  (ISO)
positive regulation of cell migration  (ISO)
positive regulation of connective tissue replacement  (IGI)
positive regulation of DNA-binding transcription factor activity  (IDA)
positive regulation of endocytosis  (IMP)
positive regulation of gene expression  (IDA)
positive regulation of transcription by RNA polymerase II  (IDA,IGI,ISO)
postsynaptic modulation of chemical synaptic transmission  (IMP)
protein dephosphorylation  (IDA,IMP,ISO)
protein import into nucleus  (IDA)
response to amphetamine  (ISO)
response to calcium ion  (ISO)
skeletal muscle fiber development  (IMP)
transition between fast and slow fiber  (IDA)

Cellular Component

References

References - curated
1. Bales JW, etal., J Neurotrauma. 2010 Jan;27(1):109-20.
2. Eastwood SL, etal., Biol Psychiatry. 2005 Apr 1;57(7):702-10. doi: 10.1016/j.biopsych.2004.12.029.
3. Gillis AM, etal., Cardiovasc Res. 2004 Dec 1;64(3):488-95.
4. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
5. Koulmann N, etal., Am J Respir Crit Care Med. 2006 Jun 23;.
6. Mansuy IM, etal., Cell 1998 Jan 9;92(1):39-49.
7. Martin LJ, etal., Toxicol Sci. 2007 Dec;100(2):474-85. doi: 10.1093/toxsci/kfm229. Epub 2007 Sep 4.
8. MGD and Homologene mouse data transfer
9. MGD data from the GO Consortium
10. MGD IEA
11. Molkentin JD, etal., Cell. 1998 Apr 17;93(2):215-28.
12. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
13. Pipeline to import KEGG annotations from KEGG into RGD
14. Pipeline to import Pathway Interaction Database annotations from NCI into RGD
15. RGD automated import pipeline
16. RGD automated import pipeline for gene-chemical interactions
17. Rodriguez A, etal., J Biol Chem. 2005 Mar 18;280(11):9980-4. Epub 2005 Jan 25.
18. Shibasaki F and McKeon F, J Cell Biol. 1995 Nov;131(3):735-43.
19. Vega RB, etal., Proc Natl Acad Sci U S A 2003 Jan 21;100(2):669-74. Epub 2003 Jan 6.
20. Wakamatsu A, etal., Physiol Rep. 2016 Mar;4(6). pii: e12679. doi: 10.14814/phy2.12679.
21. Wilkins BJ and Molkentin JD, Biochem Biophys Res Commun. 2004 Oct 1;322(4):1178-91.
22. Woolley SM, etal., J Thorac Cardiovasc Surg. 2004 Feb;127(2):376-84.
23. Wu J, etal., J Clin Invest. 2015 Nov 2;125(11):4091-106. doi: 10.1172/JCI81061. Epub 2015 Oct 5.
24. Xifro X, etal., Neurobiol Dis. 2009 Dec;36(3):461-9. Epub 2009 Sep 4.
25. Yger M and Girault JA, Front Behav Neurosci. 2011 Sep 8;5:56. doi: 10.3389/fnbeh.2011.00056. eCollection 2011.
Additional References at PubMed
PMID:1318721   PMID:1328240   PMID:2162844   PMID:2556704   PMID:2848250   PMID:7791792   PMID:8077208   PMID:8155595   PMID:8187553   PMID:8627154   PMID:8889548   PMID:9017603  
PMID:9084440   PMID:9489697   PMID:9515963   PMID:9515964   PMID:10200317   PMID:10349636   PMID:10767319   PMID:10839803   PMID:10862698   PMID:10922068   PMID:11015619   PMID:11042159  
PMID:11062266   PMID:11076861   PMID:11114196   PMID:11257222   PMID:11279073   PMID:11733061   PMID:11782539   PMID:11813252   PMID:11842093   PMID:11981809   PMID:12370307   PMID:12377773  
PMID:12414688   PMID:12477932   PMID:12520002   PMID:12574411   PMID:12617961   PMID:12660151   PMID:12773574   PMID:12808150   PMID:12809556   PMID:12851457   PMID:14610273   PMID:14656927  
PMID:14741691   PMID:14767060   PMID:15082723   PMID:15509543   PMID:15543153   PMID:15590926   PMID:15665106   PMID:15782199   PMID:15880107   PMID:16024798   PMID:16141072   PMID:16141073  
PMID:16286645   PMID:16512683   PMID:16602821   PMID:16717086   PMID:16735444   PMID:16793906   PMID:16800626   PMID:16931796   PMID:16959763   PMID:17072859   PMID:17114649   PMID:17198697  
PMID:17229811   PMID:17428973   PMID:17475677   PMID:17587059   PMID:17684059   PMID:17699657   PMID:17878357   PMID:17881460   PMID:17967808   PMID:17978097   PMID:18077674   PMID:18086917  
PMID:18199592   PMID:18287559   PMID:18544643   PMID:18586679   PMID:18639592   PMID:18676376   PMID:18815128   PMID:19075228   PMID:19129256   PMID:19138174   PMID:19188439   PMID:19203999  
PMID:19287093   PMID:19351742   PMID:19478199   PMID:19527231   PMID:19538478   PMID:19560418   PMID:19626032   PMID:19710169   PMID:19717566   PMID:19747209   PMID:19769983   PMID:19782130  
PMID:19799774   PMID:19854199   PMID:19861587   PMID:19879877   PMID:19907005   PMID:19907416   PMID:20032460   PMID:20153290   PMID:20351294   PMID:20359506   PMID:20402674   PMID:20601385  
PMID:20639889   PMID:20647544   PMID:20810903   PMID:20937869   PMID:20970476   PMID:21059644   PMID:21076497   PMID:21233454   PMID:21267068   PMID:21421818   PMID:21427212   PMID:21435446  
PMID:21540458   PMID:21622531   PMID:21677750   PMID:21689596   PMID:21690297   PMID:21873635   PMID:21986493   PMID:22060133   PMID:22164265   PMID:22239345   PMID:22495310   PMID:22560297  
PMID:22688515   PMID:22984995   PMID:23261540   PMID:23300663   PMID:23407945   PMID:23638102   PMID:23733189   PMID:23744075   PMID:23825400   PMID:23996002   PMID:24107951   PMID:24161931  
PMID:24291696   PMID:24336651   PMID:24448406   PMID:24498049   PMID:24526353   PMID:24657879   PMID:24672054   PMID:24721909   PMID:24835995   PMID:24838101   PMID:24952961   PMID:25051958  
PMID:25193101   PMID:25287476   PMID:26029823   PMID:26031702   PMID:26299309   PMID:26410627   PMID:26411342   PMID:26430214   PMID:26514267   PMID:26724383   PMID:26794871   PMID:27171192  
PMID:27301880   PMID:27307045   PMID:27507650   PMID:27889896   PMID:27892464   PMID:28062573   PMID:28671696   PMID:28706196   PMID:28826478   PMID:29444424   PMID:29457983   PMID:30068389  
PMID:30274399   PMID:30562941   PMID:30699351   PMID:30995482   PMID:31626368   PMID:31696965   PMID:32325033   PMID:32376900  


Genomics

Comparative Map Data
Ppp3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393136,375,778 - 136,643,488 (+)NCBIGRCm39mm39
GRCm39 Ensembl3136,375,885 - 136,643,488 (+)Ensembl
GRCm383136,669,714 - 136,937,727 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3136,670,124 - 136,937,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv373136,333,734 - 136,598,743 (+)NCBIGRCm37mm9NCBIm37
MGSCv363136,608,157 - 136,873,166 (+)NCBImm8
Celera3143,090,942 - 143,357,512 (+)NCBICelera
Cytogenetic Map3G3NCBI
PPP3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4101,023,409 - 101,348,278 (-)EnsemblGRCh38hg38GRCh38
GRCh384101,023,418 - 101,348,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374101,944,575 - 102,268,683 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364102,163,610 - 102,487,376 (-)NCBINCBI36hg18NCBI36
Build 344102,301,764 - 102,625,531NCBI
Celera499,241,833 - 99,567,826 (-)NCBI
Cytogenetic Map4q24NCBI
HuRef497,682,764 - 98,006,594 (-)NCBIHuRef
CHM1_14101,921,069 - 102,245,098 (-)NCBICHM1_1
Ppp3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22225,165,981 - 225,440,978 (+)NCBI
Rnor_6.0 Ensembl2241,909,832 - 242,184,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.02241,909,332 - 242,186,861 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02260,463,144 - 260,737,186 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42234,130,176 - 234,409,232 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12234,116,915 - 234,395,972 (+)NCBI
Celera2217,359,756 - 217,630,340 (+)NCBICelera
Cytogenetic Map2q43NCBI
Ppp3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554966,908,224 - 7,059,816 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554966,934,542 - 7,059,745 (+)NCBIChiLan1.0ChiLan1.0
PPP3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14104,113,512 - 104,435,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4104,113,520 - 104,435,394 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0493,447,095 - 93,770,339 (-)NCBIMhudiblu_PPA_v0panPan3
PPP3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13222,688,141 - 22,996,693 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3222,688,143 - 22,996,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3218,960,549 - 19,234,052 (+)NCBI
ROS_Cfam_1.03222,910,701 - 23,219,264 (-)NCBI
UMICH_Zoey_3.13222,888,729 - 23,197,885 (-)NCBI
UNSW_CanFamBas_1.03222,670,376 - 22,979,752 (-)NCBI
UU_Cfam_GSD_1.03216,885,817 - 17,195,548 (+)NCBI
Ppp3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530118,494,657 - 18,802,106 (+)NCBI
SpeTri2.0NW_0049365201,987,989 - 2,146,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8119,428,743 - 119,754,650 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18119,429,181 - 119,754,615 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28128,461,857 - 128,883,250 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1749,149,044 - 49,478,796 (-)NCBI
ChlSab1.1 Ensembl749,148,933 - 49,321,013 (-)Ensembl
Vero_WHO_p1.0NW_02366603727,622,035 - 27,951,191 (-)NCBI
Ppp3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248306,318,352 - 6,584,232 (+)NCBI

Position Markers
AW413465  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,937,438 - 136,937,526UniSTSGRCm38
MGSCv373136,600,402 - 136,600,490UniSTSGRCm37
Celera3143,359,173 - 143,359,261UniSTS
Cytogenetic Map3G3UniSTS
Whitehead/MRC_RH31529.65UniSTS
D3Mit146  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,841,004 - 136,841,138UniSTSGRCm38
MGSCv373136,503,968 - 136,504,102UniSTSGRCm37
Celera3143,262,341 - 143,262,473UniSTS
Cytogenetic Map3G3UniSTS
cM Map368.5UniSTS
Whitehead Genetic348.1UniSTS
Whitehead/MRC_RH31529.65UniSTS
Whitehead_YAC3 UniSTS
Ppp3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv373136,598,250 - 136,598,616UniSTSGRCm37
Celera3143,357,019 - 143,357,385UniSTS
Cytogenetic Map3G3UniSTS
cM Map3 UniSTS
AI841391  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,936,864 - 136,936,996UniSTSGRCm38
MGSCv373136,599,828 - 136,599,960UniSTSGRCm37
Celera3143,358,599 - 143,358,731UniSTS
Cytogenetic Map3G3UniSTS
Whitehead/MRC_RH31529.65UniSTS
J05479  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,935,288 - 136,935,451UniSTSGRCm38
MGSCv373136,598,252 - 136,598,415UniSTSGRCm37
Celera3143,357,021 - 143,357,184UniSTS
Cytogenetic Map3G3UniSTS
Whitehead_YAC3 UniSTS
SHGC-67255  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,935,255 - 136,935,358UniSTSGRCm38
MGSCv373136,598,219 - 136,598,322UniSTSGRCm37
Celera3143,356,988 - 143,357,091UniSTS
Cytogenetic Map3G3UniSTS
WI-16419  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,936,043 - 136,936,140UniSTSGRCm38
MGSCv373136,599,007 - 136,599,104UniSTSGRCm37
Celera3143,357,777 - 143,357,874UniSTS
Cytogenetic Map3G3UniSTS
Ppp3ca  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3G3UniSTS
cM Map3 UniSTS
PPP3CA  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm383136,935,286 - 136,935,652UniSTSGRCm38
MGSCv373136,598,250 - 136,598,616UniSTSGRCm37
Celera3143,357,019 - 143,357,385UniSTS
Cytogenetic Map3G3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301705Sles3_msystemic lupus erythmatosus suppressor 3 (mouse)Not determined337120713143647422Mouse
1301528Loco1_mlocomotor activity 1 (mouse)Not determined3133756256160039680Mouse
1301563Alcp3_malcohol preference locus 3 (mouse)Not determined3131031299160039680Mouse
1302151Lprm2_mlymphoproliferation modifier 2 (mouse)Not determined3120073096154073283Mouse
1558868Ses9_msalmonella enteritidis susceptibility 9 (mouse)Not determined3119351571153351695Mouse
1302056Orgwq4_morgan weight QTL 4 (mouse)Not determined330013439147599053Mouse
1302093Orgwq5_morgan weight QTL 5 (mouse)Not determined3107469620147599053Mouse
1301805Mors2_mmodifier of obesity related sterility 2 (mouse)Not determined3103689010137689134Mouse
1300619Cdcs1_mcytokine deficiency colitis susceptibility 1 (mouse)Not determined3110041233144041356Mouse
1300752Ap6q_malcohol preference 6 QTL (mouse)Not determined3100465596147339967Mouse
1300753Eae10_msusceptibility to experimental allergic encephalomyelitis 10 (mouse)Not determined3132030856148745542Mouse
1301381Bomb1_mbone marrow pre-B 1 (mouse)Not determined3111339594145339768Mouse
1301347Fpli_mfasting plasma insulin (mouse)Not determined3126754753160039680Mouse
1301218Letohc1_mlow ethanol consumption 1 (mouse)Not determined3126647225160039680Mouse
1301100Bdt2_mbone density traits 2 (mouse)Not determined3115030856149031023Mouse
4142178Ctrq2_mC. trachomatis resistance QTL 2 (mouse)Not determined389232660137747247Mouse
4142245Pstc1_mperiosteal circumference 1 (mouse)Not determined3126564487160039680Mouse
10043919Afpq8_mabdominal fat percent QTL 8 (mouse)Not determined3119351571153351695Mouse
10412120Ccs3_mcolon cancer susceptibility 3 (mouse)Not determined3132048775146311914Mouse
10412240Alpq6_malcohol preference QTL 6 (mouse)Not determined3121066317155066317Mouse
4142449Tgq14_mtriglyceride QTL 14 (mouse)Not determined119612825153612825Mouse
4141935Tgq15_mtriglyceride QTL 15 (mouse)Not determined119612825153612825Mouse
11039523Tbbr1_mTrypanosoma brucei brucei response 1 (mouse)3131143739160039680Mouse
27226733Tibmd6_mtibia midshaft diameter 6, 16 week (mouse)3101400000150100000Mouse
26884415Bzwq11_mbi-zygomatic width QTL 11, 16 week (mouse)3125200000137500000Mouse
27226732Tibmd3_mtibia midshaft diameter 3, 10 week (mouse)396700000148100000Mouse
26884419Bzwq6_mbi-zygomatic width QTL 6, 10 week (mouse)3100700000137500000Mouse
26884382Bzwq1_mbi-zygomatic width QTL 1, 5 week (mouse)352300000137500000Mouse
26884436Zlq3_mzygomatic length QTL 3, 10 week (mouse)33200000142700000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1436
Count of miRNA genes:671
Interacting mature miRNAs:864
Transcripts:ENSMUST00000056758, ENSMUST00000070198, ENSMUST00000124206, ENSMUST00000124777, ENSMUST00000130114, ENSMUST00000130768
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001293622 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_008913 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017319493 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030252464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036162944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC116384 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC124177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC127681 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC129775 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI835974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK053582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK076570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146387 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150393 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK166287 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177425 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177666 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK179617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181310 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189167 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191345 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197466 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202249 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK206754 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK209023 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK210527 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK213582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK218972 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC024843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC096652 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC138612 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J04134 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J05479 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S78668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000056758   ⟹   ENSMUSP00000053101
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,670,770 - 136,935,779 (+)Ensembl
RefSeq Acc Id: ENSMUST00000070198   ⟹   ENSMUSP00000071040
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,670,124 - 136,937,727 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124206
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,670,124 - 136,797,838 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124777
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,834,693 - 136,881,500 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,903,149 - 136,905,659 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130768
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,902,333 - 136,928,538 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196170
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,880,434 - 136,883,080 (+)Ensembl
RefSeq Acc Id: ENSMUST00000196603
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl3136,887,949 - 136,889,986 (+)Ensembl
RefSeq Acc Id: NM_001293622   ⟹   NP_001280551
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,375,827 - 136,643,488 (+)NCBI
GRCm383136,670,066 - 136,937,727 (+)NCBI
Celera3143,090,031 - 143,359,462 (+)NCBI
Sequence:
RefSeq Acc Id: NM_008913   ⟹   NP_032939
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,375,827 - 136,643,488 (+)NCBI
GRCm383136,670,066 - 136,937,727 (+)NCBI
MGSCv373136,333,734 - 136,598,743 (+)RGD
Celera3143,090,031 - 143,359,462 (+)NCBI
cM Map3 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_017319492   ⟹   XP_017174981
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,498,580 - 136,643,486 (+)NCBI
GRCm383136,792,819 - 136,937,727 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017319493   ⟹   XP_017174982
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,375,778 - 136,643,485 (+)NCBI
GRCm383136,669,714 - 136,937,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252462   ⟹   XP_030108322
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,375,778 - 136,643,485 (+)NCBI
GRCm383136,669,714 - 136,937,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252463   ⟹   XP_030108323
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,375,778 - 136,643,485 (+)NCBI
GRCm383136,669,714 - 136,937,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030252464   ⟹   XP_030108324
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,375,778 - 136,643,485 (+)NCBI
GRCm383136,669,714 - 136,937,724 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036162944   ⟹   XP_036018837
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm393136,495,790 - 136,643,486 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_032939   ⟸   NM_008913
- Peptide Label: isoform 1
- UniProtKB: P63328 (UniProtKB/Swiss-Prot),   B2RRX2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001280551   ⟸   NM_001293622
- Peptide Label: isoform 2
- UniProtKB: P63328 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017174982   ⟸   XM_017319493
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017174981   ⟸   XM_017319492
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_030108323   ⟸   XM_030252463
- Peptide Label: isoform X1
RefSeq Acc Id: XP_030108324   ⟸   XM_030252464
- Peptide Label: isoform X2
RefSeq Acc Id: XP_030108322   ⟸   XM_030252462
- Peptide Label: isoform X1
RefSeq Acc Id: ENSMUSP00000071040   ⟸   ENSMUST00000070198
RefSeq Acc Id: ENSMUSP00000053101   ⟸   ENSMUST00000056758
RefSeq Acc Id: XP_036018837   ⟸   XM_036162944
- Peptide Label: isoform X1
Protein Domains
SER_THR_PHOSPHATASE

Promoters
RGD ID:6834280
Promoter ID:MM_KWN:36196
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000056758,   ENSMUST00000098590,   OTTMUST00000039611,   OTTMUST00000039613,   OTTMUST00000039614
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363136,332,256 - 136,333,862 (+)MPROMDB
RGD ID:6834281
Promoter ID:MM_KWN:36198
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Lung
Transcripts:OTTMUST00000039615
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363136,496,906 - 136,498,062 (+)MPROMDB
RGD ID:6834282
Promoter ID:MM_KWN:36200
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung
Transcripts:OTTMUST00000039617,   UC008RMI.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv363136,565,161 - 136,566,362 (+)MPROMDB
RGD ID:6882450
Promoter ID:EPDNEW_M4676
Type:initiation region
Name:Ppp3ca_1
Description:Mus musculus protein phosphatase 3, catalytic subunit, alphaisoform , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4677  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383136,670,153 - 136,670,213EPDNEW
RGD ID:6882452
Promoter ID:EPDNEW_M4677
Type:initiation region
Name:Ppp3ca_2
Description:Mus musculus protein phosphatase 3, catalytic subunit, alphaisoform , transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M4676  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm383136,670,688 - 136,670,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:107164 AgrOrtholog
Ensembl Genes ENSMUSG00000028161 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000053101 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000071040 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000056758 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000070198 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  MPP_PP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PP2B UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:19055 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:107164 ENTREZGENE
NCBI Gene 19055 ENTREZGENE
PANTHER PTHR45673 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ppp3ca PhenoGen
PRINTS STPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt B2RRX2 ENTREZGENE, UniProtKB/TrEMBL
  P63328 ENTREZGENE, UniProtKB/Swiss-Prot
  Q4V9X0_MOUSE UniProtKB/TrEMBL
  Q8C649_MOUSE UniProtKB/TrEMBL
UniProt Secondary P12816 UniProtKB/Swiss-Prot
  P20652 UniProtKB/Swiss-Prot
  Q3UCU1 UniProtKB/Swiss-Prot
  Q64135 UniProtKB/Swiss-Prot