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Gene: Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform) Mus musculus
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Symbol: Ppp3ca
Name: protein phosphatase 3, catalytic subunit, alpha isoform
Description: Exhibits calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; regulation of RNA metabolic process; and regulation of muscle adaptation. Localizes to several cellular components, including the Schaffer collateral - CA1 synapse; Z disc; and calcineurin complex. Predicted to colocalize with the cytoplasmic side of plasma membrane and slit diaphragm. Used to study dilated cardiomyopathy. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Is expressed in several structures, including adrenal gland; central nervous system; genitourinary system; gut gland; and liver. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2-deoxy-D-glucose; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 2900074D19Rik; AI841391; AW413465; calcineurin A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; Caln; Calna; CAM-PRP catalytic subunit; CN; CnA; CNA alpha; MGC106804; PP2B alpha 1; PP2BA alpha; serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Orthologs:
Homo sapiens (human) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Canis lupus familiaris (dog) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
Sus scrofa (pig) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Chlorocebus sabaeus (African green monkey) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Heterocephalus glaber (naked mole-rat) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl3136,670,124 - 136,937,727 (+)Ensembl
GRCm383136,669,714 - 136,937,727 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv373136,333,734 - 136,598,743 (+)NCBIGRCm37mm9NCBIm37
MGSCv363136,608,157 - 136,873,166 (+)NCBImm8
Celera3143,090,031 - 143,359,462 (+)NCBICelera
Cytogenetic Map3G3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
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References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
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Additional Information

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More on Ppp3ca
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 11134
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-02-11
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.