PPP3CA (protein phosphatase 3 catalytic subunit alpha) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PPP3CA (protein phosphatase 3 catalytic subunit alpha) Pan paniscus
Analyze
Symbol: PPP3CA
Name: protein phosphatase 3 catalytic subunit alpha
RGD ID: 12015235
Description: ENCODES a protein that exhibits calcium-dependent protein serine/threonine phosphatase activity (ortholog); calmodulin binding (ortholog); phosphoprotein phosphatase activity (ortholog); INVOLVED IN aging (ortholog); brain development (ortholog); calcineurin-NFAT signaling cascade (ortholog); PARTICIPATES IN calcineurin signaling pathway; dopamine signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH Arthrogryposis, Cleft Palate, Craniosynostosis, and Impaired Intellectual Development (ortholog); beta-mannosidosis (ortholog); Brain Injuries (ortholog); FOUND IN calcineurin complex (ortholog); cytoplasmic side of plasma membrane (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14104,113,512 - 104,435,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4104,113,520 - 104,435,394 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0493,447,095 - 93,770,339 (-)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
brain development  (ISO)
calcineurin-mediated signaling  (IEA)
calcineurin-NFAT signaling cascade  (IEA,ISO)
calcium ion transport  (IEA,ISO)
calcium-mediated signaling  (IEA,ISO)
cardiac muscle hypertrophy in response to stress  (IEA,ISO)
cellular response to glucose stimulus  (ISO)
dendrite morphogenesis  (IEA,ISO)
dephosphorylation  (IEA,ISO)
epidermis development  (IEA)
excitatory postsynaptic potential  (IEA,ISO)
G1/S transition of mitotic cell cycle  (IEA,ISO)
keratinocyte differentiation  (IEA)
modulation of chemical synaptic transmission  (IEA,ISO)
multicellular organismal response to stress  (IEA,ISO)
negative regulation of chromatin binding  (IEA,ISO)
negative regulation of dendrite morphogenesis  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of insulin secretion  (ISO)
negative regulation of miRNA maturation  (IEA)
negative regulation of signaling  (IEA)
peptidyl-serine dephosphorylation  (IEA)
positive regulation of activated T cell proliferation  (IEA)
positive regulation of cardiac muscle hypertrophy  (IEA)
positive regulation of cardiac muscle hypertrophy in response to stress  (IEA)
positive regulation of cell adhesion  (IEA)
positive regulation of cell migration  (IEA)
positive regulation of connective tissue replacement  (IEA)
positive regulation of DNA-binding transcription factor activity  (IEA,ISO)
positive regulation of endocytosis  (IEA)
positive regulation of gene expression  (IEA)
positive regulation of glomerulus development  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of osteoclast differentiation  (IEA)
positive regulation of saliva secretion  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
postsynaptic modulation of chemical synaptic transmission  (IEA)
protein dephosphorylation  (IEA,ISO)
protein import into nucleus  (IEA,ISO)
regulation of cell proliferation involved in kidney morphogenesis  (IEA)
renal filtration  (IEA)
response to amphetamine  (ISO)
response to calcium ion  (IEA)
skeletal muscle fiber development  (IEA,ISO)
transition between fast and slow fiber  (IEA,ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PPP3CA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14104,113,512 - 104,435,954 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4104,113,520 - 104,435,394 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0493,447,095 - 93,770,339 (-)NCBIMhudiblu_PPA_v0panPan3
PPP3CA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384101,023,418 - 101,347,526 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4101,023,409 - 101,348,278 (-)EnsemblGRCh38hg38GRCh38
GRCh374101,944,575 - 102,268,683 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364102,163,610 - 102,487,376 (-)NCBINCBI36hg18NCBI36
Build 344102,301,764 - 102,625,531NCBI
Celera499,241,833 - 99,567,826 (-)NCBI
Cytogenetic Map4q24NCBI
HuRef497,682,764 - 98,006,594 (-)NCBIHuRef
CHM1_14101,921,069 - 102,245,098 (-)NCBICHM1_1
Ppp3ca
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393136,375,778 - 136,643,488 (+)NCBIGRCm39mm39
GRCm39 Ensembl3136,375,885 - 136,643,488 (+)Ensembl
GRCm383136,669,714 - 136,937,727 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3136,670,124 - 136,937,727 (+)EnsemblGRCm38mm10GRCm38
MGSCv373136,333,734 - 136,598,743 (+)NCBIGRCm37mm9NCBIm37
MGSCv363136,608,157 - 136,873,166 (+)NCBImm8
Celera3143,090,942 - 143,357,512 (+)NCBICelera
Cytogenetic Map3G3NCBI
Ppp3ca
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22225,165,981 - 225,440,978 (+)NCBImRatBN7.2
mRatBN7.2 Ensembl2225,165,766 - 225,438,974 (+)Ensembl
Rnor_6.02241,909,332 - 242,186,861 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2241,909,832 - 242,184,854 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02260,463,144 - 260,737,186 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42234,130,176 - 234,409,232 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12234,116,915 - 234,395,972 (+)NCBI
Celera2217,359,756 - 217,630,340 (+)NCBICelera
Cytogenetic Map2q43NCBI
Ppp3ca
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554966,908,224 - 7,059,816 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554966,934,542 - 7,059,745 (+)NCBIChiLan1.0ChiLan1.0
PPP3CA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13222,688,141 - 22,996,693 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3222,688,143 - 22,996,688 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3218,960,549 - 19,234,052 (+)NCBI
ROS_Cfam_1.03222,910,701 - 23,219,264 (-)NCBI
ROS_Cfam_1.0 Ensembl3222,912,571 - 23,219,917 (-)Ensembl
UMICH_Zoey_3.13222,888,729 - 23,197,885 (-)NCBI
UNSW_CanFamBas_1.03222,670,376 - 22,979,752 (-)NCBI
UU_Cfam_GSD_1.03216,885,817 - 17,195,548 (+)NCBI
Ppp3ca
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530118,494,657 - 18,802,106 (+)NCBI
SpeTri2.0NW_0049365201,987,989 - 2,146,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PPP3CA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8119,428,743 - 119,754,650 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18119,429,181 - 119,754,615 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28128,461,857 - 128,883,250 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PPP3CA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1749,149,044 - 49,478,796 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl749,148,933 - 49,321,013 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603727,622,035 - 27,951,191 (-)NCBIVero_WHO_p1.0
Ppp3ca
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248306,318,352 - 6,584,232 (+)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000062820   ⟹   ENSPPAP00000039908
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,113,520 - 104,198,827 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062822   ⟹   ENSPPAP00000039910
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,113,520 - 104,198,827 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062868   ⟹   ENSPPAP00000039955
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,115,927 - 104,435,394 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062870   ⟹   ENSPPAP00000039957
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,115,927 - 104,435,394 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062871   ⟹   ENSPPAP00000039958
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,115,927 - 104,435,394 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062889   ⟹   ENSPPAP00000039976
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,115,927 - 104,289,489 (-)Ensembl
RefSeq Acc Id: ENSPPAT00000062908   ⟹   ENSPPAP00000039995
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4104,115,927 - 104,289,489 (-)Ensembl
RefSeq Acc Id: XM_003829946   ⟹   XP_003829994
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14104,113,512 - 104,435,954 (-)NCBI
Mhudiblu_PPA_v0493,447,095 - 93,770,339 (-)NCBI
Sequence:
RefSeq Acc Id: XM_003829947   ⟹   XP_003829995
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14104,113,513 - 104,435,954 (-)NCBI
Mhudiblu_PPA_v0493,447,095 - 93,770,287 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003829994 (Get FASTA)   NCBI Sequence Viewer  
  XP_003829995 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003829995   ⟸   XM_003829947
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_003829994   ⟸   XM_003829946
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSPPAP00000039955   ⟸   ENSPPAT00000062868
RefSeq Acc Id: ENSPPAP00000039958   ⟸   ENSPPAT00000062871
RefSeq Acc Id: ENSPPAP00000039957   ⟸   ENSPPAT00000062870
RefSeq Acc Id: ENSPPAP00000039976   ⟸   ENSPPAT00000062889
RefSeq Acc Id: ENSPPAP00000039908   ⟸   ENSPPAT00000062820
RefSeq Acc Id: ENSPPAP00000039910   ⟸   ENSPPAT00000062822
RefSeq Acc Id: ENSPPAP00000039995   ⟸   ENSPPAT00000062908
Protein Domains
SER_THR_PHOSPHATASE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000042533 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000039908 UniProtKB/TrEMBL
  ENSPPAP00000039910 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000039955 ENTREZGENE, UniProtKB/TrEMBL
  ENSPPAP00000039957 UniProtKB/TrEMBL
  ENSPPAP00000039958 UniProtKB/TrEMBL
  ENSPPAP00000039976 UniProtKB/TrEMBL
  ENSPPAP00000039995 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000062820 UniProtKB/TrEMBL
  ENSPPAT00000062822 UniProtKB/TrEMBL
  ENSPPAT00000062868 UniProtKB/TrEMBL
  ENSPPAT00000062870 UniProtKB/TrEMBL
  ENSPPAT00000062871 UniProtKB/TrEMBL
  ENSPPAT00000062889 UniProtKB/TrEMBL
  ENSPPAT00000062908 UniProtKB/TrEMBL
Gene3D-CATH 3.60.21.10 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  MPP_PP2B UniProtKB/TrEMBL
  PP2B UniProtKB/TrEMBL
  Ser/Thr-sp_prot-phosphatase UniProtKB/TrEMBL
KEGG Report pps:100976987 UniProtKB/TrEMBL
NCBI Gene PPP3CA ENTREZGENE
PANTHER PTHR45673 UniProtKB/TrEMBL
Pfam Metallophos UniProtKB/TrEMBL
PRINTS STPHPHTASE UniProtKB/TrEMBL
PROSITE SER_THR_PHOSPHATASE UniProtKB/TrEMBL
SMART PP2Ac UniProtKB/TrEMBL
Superfamily-SCOP SSF56300 UniProtKB/TrEMBL
UniProt A0A2R9CD98_PANPA UniProtKB/TrEMBL
  A0A2R9CDE3_PANPA UniProtKB/TrEMBL
  A0A2R9CDF8_PANPA UniProtKB/TrEMBL
  A0A2R9CDI1_PANPA UniProtKB/TrEMBL
  A0A2R9CFW1_PANPA UniProtKB/TrEMBL
  A0A2R9CG03_PANPA UniProtKB/TrEMBL
  A0A2R9CNT6_PANPA UniProtKB/TrEMBL