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Gene: PPP3CA (protein phosphatase 3 catalytic subunit alpha) Homo sapiens
Symbol: PPP3CA
Name: protein phosphatase 3 catalytic subunit alpha
Description: Exhibits several functions, including ATPase binding activity; calmodulin binding activity; and calmodulin-dependent protein phosphatase activity. Involved in several processes, including calcineurin-NFAT signaling cascade; peptidyl-serine dephosphorylation; and response to calcium ion. Localizes to several cellular components, including the calcineurin complex; dendritic spine; and nucleoplasm. Colocalizes with the cytoplasmic side of plasma membrane. Implicated in infantile or early childhood epileptic encephalopathy 1. Biomarker of focal segmental glomerulosclerosis and schizophrenia; PARTICIPATES IN interleukin-12 signaling pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; INTERACTS WITH 1,2,3-Trichloropropane; 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ACCIID; calcineurin A alpha; calmodulin-dependent calcineurin A subunit alpha isoform; CALN; CALNA; CALNA1; CAM-PRP catalytic subunit; CCN1; CNA1; IECEE; IECEE1; PPP2B; protein phosphatase 2B, catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform; protein phosphatase 3 (formerly 2b), catalytic subunit, alpha isoform (calcineurin a alpha); serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Mus musculus (house mouse) : Ppp3ca (protein phosphatase 3, catalytic subunit, alpha isoform)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Canis lupus familiaris (dog) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
Sus scrofa (pig) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Chlorocebus sabaeus (green monkey) : PPP3CA (protein phosphatase 3 catalytic subunit alpha)
Heterocephalus glaber (naked mole-rat) : Ppp3ca (protein phosphatase 3 catalytic subunit alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl4101,023,409 - 101,348,278 (-)Ensembl
GRCh384101,023,418 - 101,348,295 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh374101,944,587 - 102,268,655 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364102,163,610 - 102,487,376 (-)NCBINCBI36hg18NCBI36
Build 344102,301,764 - 102,625,531NCBI
Celera499,241,833 - 99,567,826 (-)NCBI
Cytogenetic Map4q24NCBI
HuRef497,682,764 - 98,006,594 (-)NCBIHuRef
CHM1_14101,921,069 - 102,245,098 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPP3CA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 730900
Created: 2003-12-10
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.