Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Papss1 | Rat | 1,1-dichloroethene | decreases expression | ISO | Papss1 (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of PAPSS1 mRNA | CTD | PMID:26682919 | Papss1 | Rat | 1,2-dimethylhydrazine | multiple interactions | ISO | Papss1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PAPSS1 mRNA | CTD | PMID:22206623 | Papss1 | Rat | 1,2-dimethylhydrazine | decreases expression | ISO | Papss1 (Mus musculus) | 6480464 | 1 and 2-Dimethylhydrazine results in decreased expression of PAPSS1 mRNA | CTD | PMID:22206623 | Papss1 | Rat | 1,4-dithiothreitol | increases activity | ISO | PAPSS1 (Homo sapiens) | 6480464 | Dithiothreitol results in increased activity of PAPSS1 protein | CTD | PMID:15065880 | Papss1 | Rat | 1-chloro-2,4-dinitrobenzene | affects binding | ISO | PAPSS1 (Homo sapiens) | 6480464 | Dinitrochlorobenzene binds to PAPSS1 protein | CTD | PMID:32991956 | Papss1 | Rat | 17alpha-ethynylestradiol | increases expression | EXP | | 6480464 | Ethinyl Estradiol results in increased expression of PAPSS1 mRNA | CTD | PMID:17557909 | Papss1 | Rat | 17beta-estradiol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of PAPSS1 mRNA | CTD | PMID:26496021 | Papss1 | Rat | 17beta-estradiol | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | Estradiol promotes the reaction [PAPSS1 protein binds to ESR1 protein] | CTD | PMID:27156127 | Papss1 | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Papss1 (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PAPSS1 mRNA | CTD | PMID:21570461 | Papss1 | Rat | 2,3,7,8-Tetrachlorodibenzofuran | decreases expression | EXP | | 6480464 | 2 more ... | CTD | PMID:32109520 | Papss1 | Rat | 2,4,6-trinitrotoluene | affects expression | EXP | | 6480464 | Trinitrotoluene affects the expression of PAPSS1 mRNA | CTD | PMID:21346803 | Papss1 | Rat | 2,4-dinitrotoluene | affects expression | EXP | | 6480464 | 2 and 4-dinitrotoluene affects the expression of PAPSS1 mRNA | CTD | PMID:21346803 | Papss1 | Rat | 3-chloropropane-1,2-diol | decreases expression | EXP | | 6480464 | alpha-Chlorohydrin results in decreased expression of PAPSS1 protein | CTD | PMID:34915118 | Papss1 | Rat | 4,4'-diaminodiphenylmethane | increases expression | EXP | | 6480464 | 4 and 4'-diaminodiphenylmethane results in increased expression of PAPSS1 mRNA | CTD | PMID:30723492 | Papss1 | Rat | 4,4'-sulfonyldiphenol | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | bisphenol S results in increased expression of PAPSS1 protein | CTD | PMID:34186270 | Papss1 | Rat | 4-amino-2,6-dinitrotoluene | affects expression | EXP | | 6480464 | 4-amino-2 and 6-dinitrotoluene affects the expression of PAPSS1 mRNA | CTD | PMID:21346803 | Papss1 | Rat | 4-octylphenol | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | 4-octylphenol results in decreased expression of PAPSS1 mRNA | CTD | PMID:16223563 | Papss1 | Rat | acetamide | increases expression | EXP | | 6480464 | acetamide results in increased expression of PAPSS1 mRNA | CTD | PMID:31881176 | Papss1 | Rat | acrolein | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PAPSS1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PAPSS1 mRNA | CTD | PMID:32699268 | Papss1 | Rat | actinomycin D | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of and results in increased secretion of PAPSS1 protein | CTD | PMID:38460933 | Papss1 | Rat | afimoxifene | decreases response to substance | ISO | PAPSS1 (Homo sapiens) | 6480464 | PAPSS1 results in decreased susceptibility to afimoxifene | CTD | PMID:21233418 | Papss1 | Rat | aflatoxin B1 | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Aflatoxin B1 affects the expression of PAPSS1 protein | CTD | PMID:20106945 | Papss1 | Rat | alpha-pinene | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PAPSS1 mRNA and [Air Pollutants results in increased abundance of [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone]] which results in increased oxidation of PAPSS1 mRNA | CTD | PMID:32699268 | Papss1 | Rat | Aroclor 1254 | decreases expression | ISO | Papss1 (Mus musculus) | 6480464 | Chlorodiphenyl (54% Chlorine) results in decreased expression of PAPSS1 mRNA | CTD | PMID:23650126 | Papss1 | Rat | arsenic acid | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | PAPSS1 protein binds to and affects the metabolism of arsenic acid | CTD | PMID:15065880 | Papss1 | Rat | arsenite(3-) | increases methylation | ISO | PAPSS1 (Homo sapiens) | 6480464 | arsenite results in increased methylation of PAPSS1 promoter | CTD | PMID:23974009 | Papss1 | Rat | arsenite(3-) | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | arsenite inhibits the reaction [G3BP1 protein binds to PAPSS1 mRNA] | CTD | PMID:32406909 | Papss1 | Rat | arsenous acid | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Arsenic Trioxide co-treated with Ascorbic Acid] results in decreased expression of PAPSS1 mRNA | CTD | PMID:25555879 | Papss1 | Rat | arsenous acid | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PAPSS1 mRNA | CTD | PMID:25555879 | Papss1 | Rat | azoxystrobin | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | azoxystrobin results in increased expression of PAPSS1 mRNA | CTD | PMID:33512557 | Papss1 | Rat | benzo[a]pyrene | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of PAPSS1 mRNA | CTD | PMID:32234424 | Papss1 | Rat | beta-lapachone | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | beta-lapachone results in increased expression of PAPSS1 mRNA | CTD | PMID:38218311 | Papss1 | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in decreased expression of PAPSS1 mRNA | CTD | PMID:16223563 | Papss1 | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with Estradiol] results in increased expression of PAPSS1 mRNA | CTD | PMID:26496021 | Papss1 | Rat | bisphenol A | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | bisphenol A results in decreased expression of PAPSS1 protein | CTD | PMID:34186270 | Papss1 | Rat | bisphenol A | increases methylation | ISO | PAPSS1 (Homo sapiens) | 6480464 | bisphenol A results in increased methylation of PAPSS1 gene | CTD | PMID:31601247 | Papss1 | Rat | bisphenol A | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | bisphenol A results in increased expression of PAPSS1 protein | CTD | PMID:32981897 | Papss1 | Rat | bisphenol A | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | bisphenol A affects the expression of PAPSS1 mRNA | CTD | PMID:30903817 | Papss1 | Rat | bisphenol A | increases methylation | EXP | | 6480464 | bisphenol A results in increased methylation of PAPSS1 gene | CTD | PMID:28505145 | Papss1 | Rat | bisphenol A | affects expression | EXP | | 6480464 | bisphenol A affects the expression of PAPSS1 mRNA | CTD | PMID:25181051 | Papss1 | Rat | Bisphenol B | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | bisphenol B results in increased expression of PAPSS1 protein | CTD | PMID:34186270 | Papss1 | Rat | chlordecone | decreases expression | ISO | Papss1 (Mus musculus) | 6480464 | Chlordecone results in decreased expression of PAPSS1 mRNA | CTD | PMID:33711761 | Papss1 | Rat | cisplatin | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Cisplatin results in increased expression of PAPSS1 mRNA | CTD | PMID:27594783 | Papss1 | Rat | cobalt dichloride | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | cobaltous chloride results in decreased expression of PAPSS1 mRNA | CTD | PMID:19320972 | Papss1 | Rat | cobalt dichloride | decreases expression | EXP | | 6480464 | cobaltous chloride results in decreased expression of PAPSS1 mRNA | CTD | PMID:24386269 | Papss1 | Rat | copper atom | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PAPSS1 mRNA | CTD | PMID:30556269 | Papss1 | Rat | copper(0) | decreases expression | EXP | | 6480464 | Copper results in decreased expression of PAPSS1 mRNA | CTD | PMID:30556269 | Papss1 | Rat | cyclosporin A | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PAPSS1 mRNA | CTD | PMID:25562108 | Papss1 | Rat | diarsenic trioxide | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Arsenic Trioxide results in decreased expression of PAPSS1 mRNA | CTD | PMID:25555879 | Papss1 | Rat | diarsenic trioxide | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Arsenic Trioxide co-treated with Ascorbic Acid] results in decreased expression of PAPSS1 mRNA | CTD | PMID:25555879 | Papss1 | Rat | Dibutyl phosphate | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PAPSS1 mRNA | CTD | PMID:37042841 | Papss1 | Rat | dibutyl phthalate | decreases expression | ISO | Papss1 (Mus musculus) | 6480464 | Dibutyl Phthalate results in decreased expression of PAPSS1 mRNA | CTD | PMID:21266533 | Papss1 | Rat | Diisodecyl phthalate | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | diisodecyl phthalate results in decreased expression of PAPSS1 mRNA | CTD | PMID:16223563 | Papss1 | Rat | diuron | decreases expression | EXP | | 6480464 | Diuron results in decreased expression of PAPSS1 mRNA | CTD | PMID:21551480 | Papss1 | Rat | enzyme inhibitor | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of PAPSS1 protein | CTD | PMID:23301498 | Papss1 | Rat | ethanol | affects splicing | ISO | Papss1 (Mus musculus) | 6480464 | Ethanol affects the splicing of PAPSS1 mRNA | CTD | PMID:30319688 | Papss1 | Rat | flutamide | increases expression | EXP | | 6480464 | Flutamide results in increased expression of PAPSS1 mRNA | CTD | PMID:24136188 | Papss1 | Rat | folic acid | multiple interactions | ISO | Papss1 (Mus musculus) | 6480464 | [1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of PAPSS1 mRNA | CTD | PMID:22206623 | Papss1 | Rat | glafenine | increases expression | EXP | | 6480464 | Glafenine results in increased expression of PAPSS1 mRNA | CTD | PMID:24136188 | Papss1 | Rat | glycidyl methacrylate | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | glycidyl methacrylate results in increased expression of PAPSS1 protein | CTD | PMID:36641056 | Papss1 | Rat | hydrogen peroxide | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Hydrogen Peroxide affects the expression of PAPSS1 mRNA | CTD | PMID:21179406 | Papss1 | Rat | ivermectin | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of PAPSS1 protein | CTD | PMID:32959892 | Papss1 | Rat | L-1,4-dithiothreitol | increases activity | ISO | PAPSS1 (Homo sapiens) | 6480464 | Dithiothreitol results in increased activity of PAPSS1 protein | CTD | PMID:15065880 | Papss1 | Rat | L-ascorbic acid | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [arsenic trioxide co-treated with Ascorbic Acid] results in decreased expression of PAPSS1 mRNA | CTD | PMID:25555879 | Papss1 | Rat | L-ascorbic acid | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Ascorbic Acid results in decreased expression of PAPSS1 mRNA | CTD | PMID:25555879 | Papss1 | Rat | lead(0) | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Lead results in decreased expression of PAPSS1 mRNA | CTD | PMID:19921347 | Papss1 | Rat | lead(0) | affects methylation | ISO | PAPSS1 (Homo sapiens) | 6480464 | Lead affects the methylation of PAPSS1 gene | CTD | PMID:31636367 | Papss1 | Rat | lipopolysaccharide | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of PAPSS1 mRNA | CTD | PMID:35811015 | Papss1 | Rat | molybdate | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | PAPSS1 protein binds to and affects the metabolism of molybdate | CTD | PMID:15065880 | Papss1 | Rat | Nutlin-3 | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Dactinomycin co-treated with nutlin 3] results in increased expression of and results in increased secretion of PAPSS1 protein | CTD | PMID:38460933 | Papss1 | Rat | ozone | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Acrolein co-treated with methacrylaldehyde co-treated with alpha-pinene co-treated with Ozone] results in increased oxidation of PAPSS1 mRNA more ... | CTD | PMID:32699268 | Papss1 | Rat | paracetamol | affects expression | ISO | Papss1 (Mus musculus) | 6480464 | Acetaminophen affects the expression of PAPSS1 mRNA | CTD | PMID:17562736 | Papss1 | Rat | paracetamol | increases expression | EXP | | 6480464 | Acetaminophen results in increased expression of PAPSS1 mRNA | CTD | PMID:33387578 | Papss1 | Rat | paracetamol | increases expression | ISO | Papss1 (Mus musculus) | 6480464 | Acetaminophen results in increased expression of PAPSS1 mRNA | CTD | PMID:29246445 | Papss1 | Rat | paracetamol | multiple interactions | ISO | Papss1 (Mus musculus) | 6480464 | PANX1 gene mutant form inhibits the reaction [Acetaminophen results in increased expression of PAPSS1 mRNA] | CTD | PMID:29246445 | Papss1 | Rat | perchlorate | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | perchlorate binds to and results in decreased activity of PAPSS1 protein | CTD | PMID:15065880 | Papss1 | Rat | phenobarbital | increases expression | ISO | Papss1 (Mus musculus) | 6480464 | Phenobarbital results in increased expression of PAPSS1 mRNA | CTD | PMID:19270015 | Papss1 | Rat | picoxystrobin | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | picoxystrobin results in increased expression of PAPSS1 mRNA | CTD | PMID:33512557 | Papss1 | Rat | pirinixic acid | decreases expression | ISO | Papss1 (Mus musculus) | 6480464 | pirinixic acid results in decreased expression of PAPSS1 mRNA | CTD | PMID:17426115 | Papss1 | Rat | potassium chromate | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | potassium chromate(VI) results in decreased expression of PAPSS1 mRNA | CTD | PMID:22714537 | Papss1 | Rat | resveratrol | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in increased expression of PAPSS1 mRNA | CTD | PMID:23557933 | Papss1 | Rat | rotenone | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Rotenone results in increased expression of PAPSS1 mRNA | CTD | PMID:33512557 | Papss1 | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | [S-(1 and 2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in decreased expression of PAPSS1 mRNA | CTD | PMID:35811015 | Papss1 | Rat | selenic acid | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | PAPSS1 protein binds to and affects the metabolism of Selenic Acid | CTD | PMID:15065880 | Papss1 | Rat | sulforaphane | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | sulforaphane results in decreased expression of PAPSS1 mRNA | CTD | PMID:31838189 | Papss1 | Rat | sunitinib | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Sunitinib results in increased expression of PAPSS1 mRNA | CTD | PMID:31533062 | Papss1 | Rat | tert-butyl hydroperoxide | decreases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | tert-Butylhydroperoxide results in decreased expression of PAPSS1 mRNA | CTD | PMID:15336504 | Papss1 | Rat | tetrachloromethane | multiple interactions | ISO | Papss1 (Mus musculus) | 6480464 | [PANX1 protein co-treated with Carbon Tetrachloride] affects the expression of PAPSS1 mRNA | CTD | PMID:29987408 | Papss1 | Rat | thioacetamide | increases expression | EXP | | 6480464 | Thioacetamide results in increased expression of PAPSS1 mRNA | CTD | PMID:34492290 | Papss1 | Rat | titanium dioxide | decreases methylation | ISO | Papss1 (Mus musculus) | 6480464 | titanium dioxide results in decreased methylation of PAPSS1 promoter | CTD | PMID:35295148 | Papss1 | Rat | trichostatin A | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | trichostatin A affects the expression of PAPSS1 mRNA | CTD | PMID:28542535 | Papss1 | Rat | triphenyl phosphate | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PAPSS1 mRNA | CTD | PMID:37042841 | Papss1 | Rat | tris(2-butoxyethyl) phosphate | affects expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of PAPSS1 mRNA | CTD | PMID:29024780 | Papss1 | Rat | tungstate | multiple interactions | ISO | PAPSS1 (Homo sapiens) | 6480464 | PAPSS1 protein binds to and affects the metabolism of tungstate | CTD | PMID:15065880 | Papss1 | Rat | valproic acid | increases expression | ISO | Papss1 (Mus musculus) | 6480464 | Valproic Acid results in increased expression of PAPSS1 mRNA | CTD | PMID:21427059 | Papss1 | Rat | valproic acid | increases expression | ISO | PAPSS1 (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PAPSS1 mRNA | CTD | PMID:29154799 | Papss1 | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of PAPSS1 gene | CTD | PMID:31682807 | |