Manba (mannosidase beta) - Rat Genome Database

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Gene: Manba (mannosidase beta) Rattus norvegicus
Analyze
Symbol: Manba
Name: mannosidase beta
RGD ID: 1305785
Description: Enables D-mannose binding activity and beta-mannosidase activity. Predicted to be involved in glycoprotein catabolic process and oligosaccharide catabolic process. Predicted to be located in extracellular space. Predicted to be active in lysosomal lumen. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: beta-mannosidase; LOC310864; lysosomal beta A mannosidase; mannanase; mannase; mannosidase beta A; mannosidase, beta A, lysosomal; MGC116230; MGC125196
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,583,968 - 226,676,520 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2226,583,917 - 226,676,517 (+)EnsemblGRCr8
mRatBN7.22223,910,432 - 224,002,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2223,910,432 - 224,002,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2231,635,810 - 231,734,245 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,535,549 - 229,633,977 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,400,334 - 224,498,764 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,668,213 - 240,760,264 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,668,195 - 240,760,261 (+)Ensemblrn6Rnor6.0
Rnor_5.02259,281,496 - 259,317,121 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02259,187,111 - 259,227,267 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42232,983,989 - 233,077,788 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2216,118,587 - 216,213,623 (+)NCBICelera
RGSC_v3.12233,032,256 - 233,064,521 (+)NCBI
Cytogenetic Map2q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3',4,4',5-Pentachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amiodarone  (EXP)
amitriptyline  (EXP)
antirheumatic drug  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
bisphenol F  (ISO)
chlordecone  (ISO)
cisplatin  (ISO)
clomipramine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
cyproconazole  (EXP)
DDT  (EXP)
dexamethasone  (ISO)
Dibutyl phosphate  (ISO)
epoxiconazole  (EXP,ISO)
fenthion  (ISO)
fipronil  (EXP)
glyphosate  (EXP)
GSK-J4  (ISO)
imipramine  (EXP)
indometacin  (ISO)
ivermectin  (ISO)
ketoconazole  (EXP)
lead(0)  (ISO)
levofloxacin  (EXP)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
paracetamol  (ISO)
pirinixic acid  (ISO)
prochloraz  (EXP)
protein kinase inhibitor  (ISO)
rac-lactic acid  (ISO)
rotenone  (EXP,ISO)
sodium fluoride  (ISO)
tamoxifen  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
triphenyl phosphate  (EXP,ISO)
triptonide  (ISO)
urethane  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.
Additional References at PubMed
PMID:3447593   PMID:12477932   PMID:15489334   PMID:16377659   PMID:19710420   PMID:30552791  


Genomics

Comparative Map Data
Manba
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82226,583,968 - 226,676,520 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2226,583,917 - 226,676,517 (+)EnsemblGRCr8
mRatBN7.22223,910,432 - 224,002,988 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2223,910,432 - 224,002,983 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2231,635,810 - 231,734,245 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02229,535,549 - 229,633,977 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02224,400,334 - 224,498,764 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,668,213 - 240,760,264 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,668,195 - 240,760,261 (+)Ensemblrn6Rnor6.0
Rnor_5.02259,281,496 - 259,317,121 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.02259,187,111 - 259,227,267 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42232,983,989 - 233,077,788 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2216,118,587 - 216,213,623 (+)NCBICelera
RGSC_v3.12233,032,256 - 233,064,521 (+)NCBI
Cytogenetic Map2q43NCBI
MANBA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,630,770 - 102,760,968 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4102,630,770 - 102,760,994 (-)Ensemblhg38GRCh38
GRCh374103,551,927 - 103,682,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,771,691 - 103,901,196 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344103,909,850 - 104,039,341NCBI
Celera4100,851,923 - 100,981,403 (-)NCBICelera
Cytogenetic Map4q24NCBI
HuRef499,288,756 - 99,418,261 (-)NCBIHuRef
CHM1_14103,528,967 - 103,658,610 (-)NCBICHM1_1
T2T-CHM13v2.04105,944,714 - 106,074,870 (-)NCBIT2T-CHM13v2.0
Manba
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,191,367 - 135,277,165 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,191,372 - 135,277,165 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383135,485,611 - 135,571,404 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,485,611 - 135,571,404 (+)Ensemblmm10GRCm38
MGSCv373135,148,575 - 135,234,368 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363135,423,055 - 135,508,791 (+)NCBIMGSCv36mm8
Celera3141,900,054 - 141,991,576 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.65NCBI
Manba
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,744,250 - 5,841,293 (+)Ensembl
ChiLan1.0NW_0049554965,744,374 - 5,837,974 (+)NCBIChiLan1.0ChiLan1.0
MANBA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23100,715,092 - 100,844,606 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14101,001,618 - 101,131,136 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0495,055,206 - 95,184,727 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14105,718,176 - 105,846,251 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,718,124 - 105,846,251 (-)EnsemblpanPan2panpan1.1
MANBA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13224,052,078 - 24,167,565 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3224,038,920 - 24,167,535 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3217,856,745 - 17,971,441 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03224,271,881 - 24,386,916 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3224,271,886 - 24,386,953 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13224,251,773 - 24,404,094 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03224,031,263 - 24,147,488 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03215,715,565 - 15,830,821 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Manba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,273,310 - 17,371,563 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936520616,826 - 713,793 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936520616,762 - 715,010 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MANBA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,251,106 - 118,361,903 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18118,251,122 - 118,361,903 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,225,147 - 127,302,034 (+)NCBISscrofa10.2Sscrofa10.2susScr3
MANBA
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,725,249 - 50,860,041 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl750,725,248 - 50,859,995 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603729,236,817 - 29,371,373 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Manba
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,254,495 - 5,330,611 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248305,254,545 - 5,329,627 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Manba
491 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:526
Count of miRNA genes:236
Interacting mature miRNAs:279
Transcripts:ENSRNOT00000018202, ENSRNOT00000073629
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
7411555Bw132Body weight QTL 1320.001body mass (VT:0001259)body weight gain (CMO:0000420)2223389739249053267Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
9587428Epfw6Epididymal fat weight QTL 67.470.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)2223389739249053267Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat

Markers in Region
RH129782  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22224,002,741 - 224,002,945 (+)MAPPERmRatBN7.2
Rnor_6.02240,760,018 - 240,760,221NCBIRnor6.0
Rnor_5.02259,316,875 - 259,317,078UniSTSRnor5.0
RGSC_v3.42233,077,542 - 233,077,745UniSTSRGSC3.4
Celera2216,213,377 - 216,213,580UniSTS
RH 3.4 Map21567.5UniSTS
Cytogenetic Map2q43UniSTS
BQ209115  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22223,931,408 - 223,931,589 (+)MAPPERmRatBN7.2
Rnor_6.02240,688,691 - 240,688,871NCBIRnor6.0
Rnor_5.02259,213,897 - 259,214,077UniSTSRnor5.0
RGSC_v3.42233,005,906 - 233,006,086UniSTSRGSC3.4
Celera2216,140,510 - 216,140,690UniSTS
RH 3.4 Map21558.8UniSTS
Cytogenetic Map2q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 13 78 203 91 90 59 135 59 6 440 256 22 181 98 119 31 30 30

Sequence


Ensembl Acc Id: ENSRNOT00000087371   ⟹   ENSRNOP00000072765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2226,583,917 - 226,676,517 (+)Ensembl
mRatBN7.2 Ensembl2223,910,432 - 224,002,983 (+)Ensembl
Rnor_6.0 Ensembl2240,668,195 - 240,760,261 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000160262   ⟹   ENSRNOP00000109012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2226,583,917 - 226,676,517 (+)Ensembl
RefSeq Acc Id: NM_001031655   ⟹   NP_001026825
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82226,583,968 - 226,676,520 (+)NCBI
mRatBN7.22223,910,432 - 224,002,988 (+)NCBI
Rnor_6.02240,668,213 - 240,760,264 (+)NCBI
Rnor_5.02259,187,111 - 259,227,267 (+)NCBI
Rnor_5.02259,281,496 - 259,317,121 (+)NCBI
RGSC_v3.42232,983,989 - 233,077,788 (+)RGD
Celera2216,118,587 - 216,213,623 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001026825 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99094 (Get FASTA)   NCBI Sequence Viewer  
  AAI11711 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072765
  ENSRNOP00000072765.1
GenBank Protein Q4FZV0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001026825   ⟸   NM_001031655
- Peptide Label: precursor
- UniProtKB: Q2NKP5 (UniProtKB/Swiss-Prot),   Q4FZV0 (UniProtKB/Swiss-Prot),   A6HVY3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072765   ⟸   ENSRNOT00000087371
Ensembl Acc Id: ENSRNOP00000109012   ⟸   ENSRNOT00000160262
Protein Domains
Beta-mannosidase Ig-fold   Beta-mannosidase-like galactose-binding   Glycoside hydrolase family 2 catalytic

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4FZV0-F1-model_v2 AlphaFold Q4FZV0 1-881 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691771
Promoter ID:EPDNEW_R2296
Type:initiation region
Name:Manba_1
Description:mannosidase beta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02240,668,162 - 240,668,222EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1305785 AgrOrtholog
BioCyc Gene G2FUF-51132 BioCyc
Ensembl Genes ENSRNOG00000052247 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000087371 ENTREZGENE
  ENSRNOT00000087371.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
  Galactose-binding domain-like UniProtKB/Swiss-Prot
  Glycosidases UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7383173 IMAGE-MGC_LOAD
  IMAGE:7458970 IMAGE-MGC_LOAD
InterPro Beta-gal/glucu_dom_sf UniProtKB/Swiss-Prot
  Beta-mannosidase-like_N2 UniProtKB/Swiss-Prot
  Beta-mannosidase_GH2 UniProtKB/Swiss-Prot
  Beta-mannosidase_Ig UniProtKB/Swiss-Prot
  Galactose-bd-like_sf UniProtKB/Swiss-Prot
  Glyco_hydro_2_cat UniProtKB/Swiss-Prot
  Glycoside_hydrolase_SF UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Mannosidase_ig UniProtKB/Swiss-Prot
KEGG Report rno:310864 UniProtKB/Swiss-Prot
MGC_CLONE MGC:116230 IMAGE-MGC_LOAD
  MGC:125196 IMAGE-MGC_LOAD
NCBI Gene 310864 ENTREZGENE
PANTHER BETA-MANNOSIDASE UniProtKB/Swiss-Prot
  BETA-MANNOSIDASE UniProtKB/Swiss-Prot
Pfam Glyco_hydro_2_C UniProtKB/Swiss-Prot
  Glyco_hydro_2_N2 UniProtKB/Swiss-Prot
  Ig_mannosidase UniProtKB/Swiss-Prot
  Mannosidase_ig UniProtKB/Swiss-Prot
PhenoGen Manba PhenoGen
RatGTEx ENSRNOG00000052247 RatGTEx
Superfamily-SCOP SSF49303 UniProtKB/Swiss-Prot
  SSF49785 UniProtKB/Swiss-Prot
  SSF51445 UniProtKB/Swiss-Prot
UniProt A6HVY3 ENTREZGENE, UniProtKB/TrEMBL
  MANBA_RAT UniProtKB/Swiss-Prot
  Q2NKP5 ENTREZGENE
  Q4FZV0 ENTREZGENE
UniProt Secondary Q2NKP5 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-11 Manba  mannosidase beta  Manba  mannosidase beta A  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-02-10 Manba  mannosidase beta A  Manba  mannosidase, beta A, lysosomal  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Manba  mannosidase, beta A, lysosomal  Manba_predicted  mannosidase, beta A, lysosomal (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Manba_predicted  mannosidase, beta A, lysosomal (predicted)      Symbol and Name status set to approved 70820 APPROVED