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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Manba | Rat | beta-mannosidosis | | ISO | MANBA (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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Imported Disease Annotations - CTDObject Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Manba | Rat | beta-mannosidosis | | ISO | MANBA (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | | |
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# | Reference Title | Reference Citation |
1. | Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. | Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27. |
2. | Rat ISS GO annotations from GOA human gene data--August 2006 | GOA data from the GO Consortium |
3. | Rat ISS GO annotations from MGI mouse gene data--August 2006 | MGD data from the GO Consortium |
4. | OMIM Disease Annotation Pipeline | OMIM Disease Annotation Pipeline |
5. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
6. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
7. | Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis. | Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8. |
PMID:3447593 | PMID:12477932 | PMID:15489334 | PMID:16377659 | PMID:19710420 | PMID:30552791 |
Manba (Rattus norvegicus - Norway rat) |
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MANBA (Homo sapiens - human) |
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Manba (Mus musculus - house mouse) |
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Manba (Chinchilla lanigera - long-tailed chinchilla) |
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MANBA (Pan paniscus - bonobo/pygmy chimpanzee) |
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MANBA (Canis lupus familiaris - dog) |
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Manba (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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MANBA (Sus scrofa - pig) |
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MANBA (Chlorocebus sabaeus - green monkey) |
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Manba (Heterocephalus glaber - naked mole-rat) |
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Variants in Manba
491 total Variants ![]() |
The detailed report is available here: | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer |
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | ![]() | Full Report | ![]() | CSV | ![]() | TAB | ![]() | Printer | ![]() | Gviewer |
RH129782 |
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BQ209115 |
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alimentary part of gastrointestinal system
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appendage
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circulatory system
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ectoderm
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endocrine system
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endoderm
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exocrine system
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hemolymphoid system
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hepatobiliary system
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integumental system
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mesenchyme
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mesoderm
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musculoskeletal system
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nervous system
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renal system
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reproductive system
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respiratory system
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sensory system
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visual system
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19 | 13 | 78 | 203 | 91 | 90 | 59 | 135 | 59 | 6 | 440 | 256 | 22 | 181 | 98 | 119 | 31 | 30 | 30 |
RefSeq Transcripts | NM_001031655 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
GenBank Nucleotide | AC120718 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
BC099094 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
BC111710 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000002 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
Ensembl Acc Id: | ENSRNOT00000087371 ⟹ ENSRNOP00000072765 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Ensembl Acc Id: | ENSRNOT00000160262 ⟹ ENSRNOP00000109012 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001031655 ⟹ NP_001026825 | ||||||||||||||||||||||||||||||||
RefSeq Status: | PROVISIONAL | ||||||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||||||
Position: |
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Sequence: |
Protein RefSeqs | NP_001026825 | (Get FASTA) | NCBI Sequence Viewer |
GenBank Protein | AAH99094 | (Get FASTA) | NCBI Sequence Viewer |
AAI11711 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000072765 | ||
ENSRNOP00000072765.1 | |||
GenBank Protein | Q4FZV0 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_001026825 ⟸ NM_001031655 |
- Peptide Label: | precursor |
- UniProtKB: | Q2NKP5 (UniProtKB/Swiss-Prot), Q4FZV0 (UniProtKB/Swiss-Prot), A6HVY3 (UniProtKB/TrEMBL) |
- Sequence: |
Ensembl Acc Id: | ENSRNOP00000072765 ⟸ ENSRNOT00000087371 |
Ensembl Acc Id: | ENSRNOP00000109012 ⟸ ENSRNOT00000160262 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q4FZV0-F1-model_v2 | AlphaFold | Q4FZV0 | 1-881 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13691771 | ||||||||
Promoter ID: | EPDNEW_R2296 | ||||||||
Type: | initiation region | ||||||||
Name: | Manba_1 | ||||||||
Description: | mannosidase beta | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:1305785 | AgrOrtholog |
BioCyc Gene | G2FUF-51132 | BioCyc |
Ensembl Genes | ENSRNOG00000052247 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot |
Ensembl Transcript | ENSRNOT00000087371 | ENTREZGENE |
ENSRNOT00000087371.2 | UniProtKB/Swiss-Prot | |
Gene3D-CATH | 2.60.40.10 | UniProtKB/Swiss-Prot |
Galactose-binding domain-like | UniProtKB/Swiss-Prot | |
Glycosidases | UniProtKB/Swiss-Prot | |
IMAGE_CLONE | IMAGE:7383173 | IMAGE-MGC_LOAD |
IMAGE:7458970 | IMAGE-MGC_LOAD | |
InterPro | Beta-gal/glucu_dom_sf | UniProtKB/Swiss-Prot |
Beta-mannosidase-like_N2 | UniProtKB/Swiss-Prot | |
Beta-mannosidase_GH2 | UniProtKB/Swiss-Prot | |
Beta-mannosidase_Ig | UniProtKB/Swiss-Prot | |
Galactose-bd-like_sf | UniProtKB/Swiss-Prot | |
Glyco_hydro_2_cat | UniProtKB/Swiss-Prot | |
Glycoside_hydrolase_SF | UniProtKB/Swiss-Prot | |
Ig-like_fold | UniProtKB/Swiss-Prot | |
Mannosidase_ig | UniProtKB/Swiss-Prot | |
KEGG Report | rno:310864 | UniProtKB/Swiss-Prot |
MGC_CLONE | MGC:116230 | IMAGE-MGC_LOAD |
MGC:125196 | IMAGE-MGC_LOAD | |
NCBI Gene | 310864 | ENTREZGENE |
PANTHER | BETA-MANNOSIDASE | UniProtKB/Swiss-Prot |
BETA-MANNOSIDASE | UniProtKB/Swiss-Prot | |
Pfam | Glyco_hydro_2_C | UniProtKB/Swiss-Prot |
Glyco_hydro_2_N2 | UniProtKB/Swiss-Prot | |
Ig_mannosidase | UniProtKB/Swiss-Prot | |
Mannosidase_ig | UniProtKB/Swiss-Prot | |
PhenoGen | Manba | PhenoGen |
RatGTEx | ENSRNOG00000052247 | RatGTEx |
Superfamily-SCOP | SSF49303 | UniProtKB/Swiss-Prot |
SSF49785 | UniProtKB/Swiss-Prot | |
SSF51445 | UniProtKB/Swiss-Prot | |
UniProt | A6HVY3 | ENTREZGENE, UniProtKB/TrEMBL |
MANBA_RAT | UniProtKB/Swiss-Prot | |
Q2NKP5 | ENTREZGENE | |
Q4FZV0 | ENTREZGENE | |
UniProt Secondary | Q2NKP5 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2016-02-11 | Manba | mannosidase beta | Manba | mannosidase beta A | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2016-02-10 | Manba | mannosidase beta A | Manba | mannosidase, beta A, lysosomal | Nomenclature updated to reflect human and mouse nomenclature | 1299863 | APPROVED |
2005-12-06 | Manba | mannosidase, beta A, lysosomal | Manba_predicted | mannosidase, beta A, lysosomal (predicted) | Symbol and Name updated | 1559027 | APPROVED |
2005-01-12 | Manba_predicted | mannosidase, beta A, lysosomal (predicted) | Symbol and Name status set to approved | 70820 | APPROVED |