Manba (mannosidase beta) - Rat Genome Database

Name: Manba
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Manba (mannosidase beta) Rattus norvegicus

Analyze

Symbol:

Manba

Name:

mannosidase beta

RGD ID:

1305785

Description:

Enables beta-mannosidase activity and mannose binding activity. Predicted to be involved in glycoprotein catabolic process and oligosaccharide catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in beta-mannosidosis. Orthologous to human MANBA (mannosidase beta); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,2',4,4'-Tetrabromodiphenyl ether.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

beta-mannosidase; LOC310864; lysosomal beta A mannosidase; mannanase; mannase; mannosidase beta A; mannosidase, beta A, lysosomal; MGC116230; MGC125196

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	MANBA (mannosidase beta)	HGNC	Ensembl, HomoloGene, Inparanoid, NCBI, Panther, PhylomeDB
Mus musculus (house mouse):	Manba (mannosidase, beta A, lysosomal)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Manba (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	MANBA (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	MANBA (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Manba (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	MANBA (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	MANBA (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Manba (mannosidase beta)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	MANBA (mannosidase beta)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Manba (mannosidase, beta A, lysosomal)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	manba (mannosidase, beta A, lysosomal)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	C33G3.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	beta-Man	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	223,910,432 - 224,002,988 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	223,910,432 - 224,002,983 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	231,635,810 - 231,734,245 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	229,535,549 - 229,633,977 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	224,400,334 - 224,498,764 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	240,668,213 - 240,760,264 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	240,668,195 - 240,760,261 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	259,187,111 - 259,227,267 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	259,281,496 - 259,317,121 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	232,983,989 - 233,077,788 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	233,032,256 - 233,064,521 (+)	NCBI
Celera	2	216,118,587 - 216,213,623 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

beta-mannosidosis (ISO)

common variable immunodeficiency (ISO)

genetic disease (ISO)

Hearing Loss (ISO)

intellectual disability (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,2',4,4'-Tetrabromodiphenyl ether (EXP)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

2-hydroxypropanoic acid (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-diaminodiphenylmethane (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

amiodarone (EXP)

amitriptyline (EXP)

antirheumatic drug (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

bisphenol F (ISO)

chlordecone (ISO)

cisplatin (ISO)

clomipramine (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

cyproconazole (EXP)

DDT (EXP)

dexamethasone (ISO)

epoxiconazole (EXP,ISO)

fenthion (ISO)

fipronil (EXP)

glyphosate (EXP)

imipramine (EXP)

indometacin (ISO)

ivermectin (ISO)

ketoconazole (EXP)

lead(0) (ISO)

lead(2+) (ISO)

levofloxacin (EXP)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

paracetamol (ISO)

pirinixic acid (ISO)

prochloraz (EXP)

protein kinase inhibitor (ISO)

rac-lactic acid (ISO)

rotenone (EXP,ISO)

sodium fluoride (ISO)

tamoxifen (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

triphenyl phosphate (EXP)

triptonide (ISO)

urethane (ISO)

valdecoxib (EXP)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

glycoprotein catabolic process (IBA,ISO,ISS)

oligosaccharide catabolic process (ISO)

Cellular Component

extracellular space (ISO)

lysosomal lumen (ISO)

lysosome (IDA)

Molecular Function

beta-mannosidase activity (IBA,IDA,ISO)

hydrolase activity (ISO)

mannose binding (IDA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Rat brain contains high levels of mannose-6-phosphorylated glycoproteins including lysosomal enzymes and palmitoyl-protein thioesterase, an enzyme implicated in infantile neuronal lipofuscinosis.	Sleat DE, etal., J Biol Chem. 1996 Aug 9;271(32):19191-8.

Additional References at PubMed

PMID:3447593	PMID:12477932	PMID:15489334	PMID:16377659	PMID:19710420	PMID:30552791

Genomics

Comparative Map Data

Manba
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	223,910,432 - 224,002,988 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	223,910,432 - 224,002,983 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	231,635,810 - 231,734,245 (+)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	229,535,549 - 229,633,977 (+)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	224,400,334 - 224,498,764 (+)	NCBI	Rnor_WKY
Rnor_6.0	2	240,668,213 - 240,760,264 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	240,668,195 - 240,760,261 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	259,187,111 - 259,227,267 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Rnor_5.0	2	259,281,496 - 259,317,121 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	232,983,989 - 233,077,788 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	233,032,256 - 233,064,521 (+)	NCBI
Celera	2	216,118,587 - 216,213,623 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

MANBA
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	102,630,770 - 102,760,968 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	102,630,770 - 102,760,994 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	103,551,927 - 103,682,125 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	103,771,691 - 103,901,196 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	4	103,909,850 - 104,039,341	NCBI
Celera	4	100,851,923 - 100,981,403 (-)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI
HuRef	4	99,288,756 - 99,418,261 (-)	NCBI		HuRef
CHM1_1	4	103,528,967 - 103,658,610 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	105,944,714 - 106,074,870 (-)	NCBI		T2T-CHM13v2.0

Manba
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	135,191,367 - 135,277,165 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	135,191,372 - 135,277,165 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	135,485,611 - 135,571,404 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	135,485,611 - 135,571,404 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	135,148,575 - 135,234,368 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	135,423,055 - 135,508,791 (+)	NCBI		MGSCv36	mm8
Celera	3	141,900,054 - 141,991,576 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	62.65	NCBI

Manba
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	5,744,250 - 5,841,293 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	5,744,374 - 5,837,974 (+)	NCBI	ChiLan1.0	ChiLan1.0

MANBA
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	105,718,176 - 105,846,251 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	105,718,124 - 105,846,251 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	95,055,206 - 95,184,727 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

MANBA
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	24,052,078 - 24,167,565 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	24,038,920 - 24,167,535 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	17,856,745 - 17,971,441 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	24,271,881 - 24,386,916 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	24,271,886 - 24,386,953 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	24,251,773 - 24,404,094 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	24,031,263 - 24,147,488 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	15,715,565 - 15,830,821 (+)	NCBI		UU_Cfam_GSD_1.0

Manba
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	17,273,310 - 17,371,563 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936520	616,826 - 713,793 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936520	616,762 - 715,010 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

MANBA
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	118,251,106 - 118,361,900 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	118,251,122 - 118,361,903 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	127,225,147 - 127,302,034 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

MANBA
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	50,725,249 - 50,860,041 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	50,725,248 - 50,859,995 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	29,236,817 - 29,371,373 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Manba
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	5,254,495 - 5,330,611 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	5,254,545 - 5,329,627 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Manba
414 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	526
Count of miRNA genes:	236
Interacting mature miRNAs:	279
Transcripts:	ENSRNOT00000018202, ENSRNOT00000073629
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
1359019	Hrtrt19	Heart rate QTL 19	2.9		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	219753301	226277316	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat

Markers in Region

RH129782

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	224,002,741 - 224,002,945 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	240,760,018 - 240,760,221	NCBI	Rnor6.0
Rnor_5.0	2	259,316,875 - 259,317,078	UniSTS	Rnor5.0
RGSC_v3.4	2	233,077,542 - 233,077,745	UniSTS	RGSC3.4
Celera	2	216,213,377 - 216,213,580	UniSTS
RH 3.4 Map	2	1567.5	UniSTS
Cytogenetic Map	2	q43	UniSTS

BQ209115

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	223,931,408 - 223,931,589 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	240,688,691 - 240,688,871	NCBI	Rnor6.0
Rnor_5.0	2	259,213,897 - 259,214,077	UniSTS	Rnor5.0
RGSC_v3.4	2	233,005,906 - 233,006,086	UniSTS	RGSC3.4
Celera	2	216,140,510 - 216,140,690	UniSTS
RH 3.4 Map	2	1558.8	UniSTS
Cytogenetic Map	2	q43	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		26	47	36	18	36			10	29	11	11
Low	3	17	10	5	1	5	8	11	64	6	30		8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001031655	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC099094	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC111710	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000087371 ⟹ ENSRNOP00000072765

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	223,910,432 - 224,002,983 (+)	Ensembl
Rnor_6.0 Ensembl	2	240,668,195 - 240,760,261 (+)	Ensembl

RefSeq Acc Id:

NM_001031655 ⟹ NP_001026825

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	223,910,432 - 224,002,988 (+)	NCBI
Rnor_6.0	2	240,668,213 - 240,760,264 (+)	NCBI
Rnor_5.0	2	259,187,111 - 259,227,267 (+)	NCBI
Rnor_5.0	2	259,281,496 - 259,317,121 (+)	NCBI
RGSC_v3.4	2	232,983,989 - 233,077,788 (+)	RGD
Celera	2	216,118,587 - 216,213,623 (+)	RGD

Sequence:

show sequence

CTGCGAGCGGTCAGCATGCATCTCCACCTGCTCTTTCTGTTGGCGCTGTGCGGGGCAGGCTGTA
TGGCCGCAGGTCCCAGCTACAGCCTGAGAGGGAGCTGGCGGGTGAGCAACGGGAATAGTTCCCT
GGAGCTGCCGGCTACTGTCCCTGGCTATGTGCACAGCGCCCTGCAGCAGCACGGGCTGATCCAG
GATCCTTACTACAGATTTAATGACCTGAACTACAGATGGATTTCCTTAGATAACTGGACCTACA
GCACAGAATTTAAAATCCCCTTTAATCGCAGTGAATGGCAGAAGGTAAAGTTGATTTTTGACGG
AGTCGATACAGTTGCAGAAATCCTGTTCAATAATGTCACTATTGGGAAGACAGACAACATGTTC
ACCAGATATAGCTTTGACGTCACCAATGTGGTCAAAGACGTGAACTCCCTAAAGCTGCGGTTCC
AGTCAGCAGTGCAGTATGCTGAGTGTCAGAGCAAAGCTCACACTCAATACCGGGTGCCCCCAGA
GTGCCCCCCAGTGGAACAGAAGGGTGAATGCCACGTCAACTTCATCCGAAAGGAGCAGTGCTCC
TTCAGCTGGGACTGGGGGCCTTCCTTTCCCTCTCAAGGAATCTGGAAAGACGTTAGAATCGAAG
CCTATAACATCGCTCATCTGGATCACCTGACATTTTTGCCATTGTATGATAACACTTCTCAGGC
GTGGACTATTGAAATAGAGGCTTCTTTTGATGTTGTCAGCACAAAGCCAGTTGGTGGTCAGGTG
ACTATAGCCATCCCCGAACTGAAAACACAGCAGGCAAACCACATTGAACTTCAACATGGGCAAA
GGATTGTTAAACTCCTTGTCAAAATTAGGAAGGACGTCACCGTGGAGACCTGGTGGCCTCATGG
ACATGGGAACCAGACTGGGTACAACACGACAATTCTCTTTGCGCTGGATGGAGGCTTAAAAATT
GAAAAAGCAGCCAAGGTTTATTTCAGAACAGTGCAACTTATAGAAGAACCTATAACAGGGTCTC
CTGGTCTGAGTTTCTACTTCAAAATTAATGGGCTTCCTATATTTCTGAAAGGCTCAAACTGGAT
CCCAGCTGACTCATTCCAAGACAAAGTCACTTCTGAACTGCTGCAGCTCCTTCTCCAGTCCGCC
GTGGATGCTAACATGAACACTCTGCGCGTGTGGGGGGGTGGCATCTACGAGCAGGATGAATTCT
ATGCACTGTGTGACGAACTTGGAATAATGGTGTGGCAGGACTTCATGTTTGCCAGTGCCCTCTA
TCCAACTGAGCCAGGCTTCCTAGAGTCAGTGAGAAAAGAAGTCACTTACCAGGTCAGGAGACTG
AAGTCTCACCCCTCCGTCATCATCTGGAGTGGTAATAATGAGAATGAAGTGGCTCTCAGGGTGA
ACTGGTTCCATGTAAACCCCAGGGACCTGGGGACTTACATCAACGACTATGTGACCCTCTACGT
GAAAACCATCAGGGAGATTGTCTTATCGGAAGATAGGAGTCGTCCGTTCATTGCATCCAGCCCA
ACCAATGGGGTCAAAACCATGACGGAAGGCTGGATCTCTAAGGACCCTTATAGCACCCAGTATG
GCGACATGCATTTTTACGACTATTTCAGTGACTGCTGGGACTGGAAGGTCTTTCCAAAAGCTCG
ATTAGTGTCTGAATATGGCTACCAGTCCTGGCCTTCCTTCAGCACACTACAAAAGGTCTCTCGT
CAAGAGGACTGGTCTTACAGCAGCCGCTTCTCCCTTCATCGGCAGCATCATGGAAATGGCAACA
ATGAAATGCTTCACCAGGTACAGCTTCATTTCCAACTCCCCCAAAGGAGAGACCCAGTGCGTGC
ATTTAAAGATACCATCTACCTCACTCAGGTGATGCAGGCCCAGTGTATCAAAACAGAAACCGAG
TTCTACCTGCGCAGCCGCAGCGAGATAGTGAATGGAGAAGGCCACACCATGGGGGCACTGTACT
GGCAGCTGAATGATATCTGGCAGGCTCCTTCCTGGGCCTCTCTTGAGTACGGAGGGAAATGGAA
AATGCTTCATTACTTCGCTCAGCGTTTCTTCGCTCCGCTGCTGCCAGTCGGTTTTGAAGATGAA
GGCGTTTTTTATGTCTACGGTGTGTCAGATCTTCACAAGGACTACCCCACAAAGCTCACCGTGA
GGCTCCACCGCTGGAGCTCCCAGAAGCCTTTGTGCACCTTCGTGAGTTTGAGTGCTGTGATTAA
GGCAGGGGAGGCGATGGTTCTGTTCCAGATGCCAGTGTCTAAGCTGCTGAAGAGGTGTAAAGAA
TGCACAAGGGACACCTGTGTGGTTTCCTTTTACCTCTCAACTGACAATGAACTCTTCAGTCCAA
CCAACTACCATTTCCTGTCCTCCCTGAAGGATGCCAAAGGGATGGTCAAGGCCAACATCACTGT
CAGCATCTCTCAGAAGGGTGATCTATTTGTTTTTGATCTGAAATCGTCAACATCAGCCATCACT
CCCTTTGTTTGGTTGGATGTAGGAAGCATCCCGGGGAGATTTAGTGACAACGGCTTCCTCATGA
TTAAGAAGGAGCTCTCGGTACTGTTTTACCCATGGAAGCCCACCAGCAAGAGTGAGCTGCAGCA
GGCCTTCAGTGTCACCTCCCTGACAGATCTGTACTGAAGGGACGTGAGTTGTATTTTGGTGGAC
ACTGGGGACGAAGGCTTTCTAGAGCACGGTTGGAGGAGAGGCAGCCTGAGGTAAAGCCAAGGAC
ATATCCATGCCTGGGATCTTTGACTTCCAACTCTCCAGTCTGAACAGTGACTACTACTAATCCA
GGTGACATCCTTAGACAAGGTCTTGCCTGGGTTTTCTTGAATCTTGCAGGATTGTGGTTTTTGA
GAACTTTGTTCCACAGCTAAAACACATCCAGAAGAGTTATAACACCTGATGACCTTTTGGGGAA
CCACTAGATTGTGACATGATGATACATGTCCAACCAAATGTGGGGGTTCTGAAGTAATGTAGGC
CTTTCATAGCACCACGAATTCTACCCACTGAAGGTGAAGTGCGTGCCTACGATTGCCAGAGGAG
ATGGGAACTCAGATACTACAACAGATATTGCTTGATGGCAGCCATATTGATTATGGGTAGACAG
AGGAGGGGCCTGAATGTTGTATTTGATTACCATCTCCATGAAGGATTCCCTTTTTCATATGGTT
TGTCAATAACTCTTTTTATTTAAAGACCAAGAAAGTGATCTTTCTTTAAAAAGCAGTCTAGGTT
GATTGTGCTGGTACCTTCCTATAGTTCCGGCACTCTGGGGGCAGAGGCAGGAGGATCACAAGTT
CAAAGTTGGCCCTGACTACACTGTAGAATTTTTCACCTCTCTTGGTTCTGAGTGTTCTCGTGAG
CTTTAGGCTTAACACTGATTCTAATGAACTCTCTAATCCAAAGGTAACGAGCTACATTTAAATT
CATTGGCTCTGCTGGGGAAGTGGCAAAAAAAAATGTTAATAAGTAGCTATTTTGGGTACTGGTT
TGTGGGCTTTTGGGTACAACTTTTATACTTTTCTATATATTTTAAATTATATGAAAAAACCATA
AGGTTATGTAAATTGCATTGACAACTTGAAAGTTTATTTGCACTCTATTTAACCATTTAATAAA
CACTTCATTGCATACAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001026825	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99094	(Get FASTA)	NCBI Sequence Viewer
	AAI11711	(Get FASTA)	NCBI Sequence Viewer
	Q4FZV0	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:	NP_001026825 ⟸ NM_001031655
- Peptide Label:	precursor
- UniProtKB:	Q2NKP5 (UniProtKB/Swiss-Prot), Q4FZV0 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MHLHLLFLLALCGAGCMAAGPSYSLRGSWRVSNGNSSLELPATVPGYVHSALQQHGLIQDPYYR FNDLNYRWISLDNWTYSTEFKIPFNRSEWQKVKLIFDGVDTVAEILFNNVTIGKTDNMFTRYSF DVTNVVKDVNSLKLRFQSAVQYAECQSKAHTQYRVPPECPPVEQKGECHVNFIRKEQCSFSWDW GPSFPSQGIWKDVRIEAYNIAHLDHLTFLPLYDNTSQAWTIEIEASFDVVSTKPVGGQVTIAIP ELKTQQANHIELQHGQRIVKLLVKIRKDVTVETWWPHGHGNQTGYNTTILFALDGGLKIEKAAK VYFRTVQLIEEPITGSPGLSFYFKINGLPIFLKGSNWIPADSFQDKVTSELLQLLLQSAVDANM NTLRVWGGGIYEQDEFYALCDELGIMVWQDFMFASALYPTEPGFLESVRKEVTYQVRRLKSHPS VIIWSGNNENEVALRVNWFHVNPRDLGTYINDYVTLYVKTIREIVLSEDRSRPFIASSPTNGVK TMTEGWISKDPYSTQYGDMHFYDYFSDCWDWKVFPKARLVSEYGYQSWPSFSTLQKVSRQEDWS YSSRFSLHRQHHGNGNNEMLHQVQLHFQLPQRRDPVRAFKDTIYLTQVMQAQCIKTETEFYLRS RSEIVNGEGHTMGALYWQLNDIWQAPSWASLEYGGKWKMLHYFAQRFFAPLLPVGFEDEGVFYV YGVSDLHKDYPTKLTVRLHRWSSQKPLCTFVSLSAVIKAGEAMVLFQMPVSKLLKRCKECTRDT CVVSFYLSTDNELFSPTNYHFLSSLKDAKGMVKANITVSISQKGDLFVFDLKSSTSAITPFVWL DVGSIPGRFSDNGFLMIKKELSVLFYPWKPTSKSELQQAFSVTSLTDLY hide sequence

RefSeq Acc Id:

ENSRNOP00000072765 ⟸ ENSRNOT00000087371

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q4FZV0-F1-model_v2	AlphaFold	Q4FZV0	1-881	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691771

Promoter ID:

EPDNEW_R2296

Type:

initiation region

Name:

Manba_1

Description:

mannosidase beta

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	240,668,162 - 240,668,222	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1305785	AgrOrtholog
BioCyc Gene	G2FUF-51132	BioCyc
Ensembl Genes	ENSRNOG00000052247	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein	ENSRNOP00000072765	ENTREZGENE
	ENSRNOP00000072765.1	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000087371	ENTREZGENE
	ENSRNOT00000087371.2	UniProtKB/Swiss-Prot
Gene3D-CATH	2.60.40.10	UniProtKB/Swiss-Prot
	Galactose-binding domain-like	UniProtKB/Swiss-Prot
	Glycosidases	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7383173	IMAGE-MGC_LOAD
	IMAGE:7458970	IMAGE-MGC_LOAD
InterPro	Beta-gal/glucu_dom_sf	UniProtKB/Swiss-Prot
	Beta-mannosidase_Ig	UniProtKB/Swiss-Prot
	Galactose-bd-like_sf	UniProtKB/Swiss-Prot
	Glyco_hydro_2_cat	UniProtKB/Swiss-Prot
	Glycoside_hydrolase_SF	UniProtKB/Swiss-Prot
	Ig-like_fold	UniProtKB/Swiss-Prot
	Mannosidase_ig	UniProtKB/Swiss-Prot
KEGG Report	rno:310864	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:116230	IMAGE-MGC_LOAD
	MGC:125196	IMAGE-MGC_LOAD
NCBI Gene	310864	ENTREZGENE
PANTHER	BETA-MANNOSIDASE	UniProtKB/Swiss-Prot
	BETA-MANNOSIDASE	UniProtKB/Swiss-Prot
Pfam	Glyco_hydro_2_C	UniProtKB/Swiss-Prot
	Ig_mannosidase	UniProtKB/Swiss-Prot
	Mannosidase_ig	UniProtKB/Swiss-Prot
PhenoGen	Manba	PhenoGen
Superfamily-SCOP	SSF49303	UniProtKB/Swiss-Prot
	SSF49785	UniProtKB/Swiss-Prot
	SSF51445	UniProtKB/Swiss-Prot
UniProt	MANBA_RAT	UniProtKB/Swiss-Prot
	Q2NKP5	ENTREZGENE
	Q4FZV0	ENTREZGENE
UniProt Secondary	Q2NKP5	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-11	Manba	mannosidase beta	Manba	mannosidase beta A	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2016-02-10	Manba	mannosidase beta A	Manba	mannosidase, beta A, lysosomal	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-12-06	Manba	mannosidase, beta A, lysosomal	Manba_predicted	mannosidase, beta A, lysosomal (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Manba_predicted	mannosidase, beta A, lysosomal (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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