Predicted to enable co-receptor binding activity and receptor antagonist activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway and positive regulation of canonical Wnt signaling pathway. Predicted to be active in extracellular space. Orthologous to human DKK2 (dickkopf WNT signaling pathway inhibitor 2); PARTICIPATES IN Wnt signaling, canonical pathway; Wnt signaling pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of DKK2 mRNA], Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in increased methylation of DKK2 promoter]
[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA, celastrol inhibits the reaction [[Dextran Sulfate co-treated with Azoxymethane] results in increased expression of DKK2 mRNA]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA
Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in decreased expression of DKK2 mRNA], Ascorbic Acid inhibits the reaction [Benzo(a)pyrene results in increased methylation of DKK2 promoter]
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA
[NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DKK2 mRNA