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Gene: Slc9b1 (solute carrier family 9 member B1) Rattus norvegicus

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Symbol:

Slc9b1

Name:

solute carrier family 9 member B1

RGD ID:

1305087

Description:

Predicted to be involved in flagellated sperm motility and regulation of intracellular pH. Predicted to be located in sperm principal piece. Orthologous to human SLC9B1 (solute carrier family 9 member B1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; acrylamide; bisphenol A.

Type:

protein-coding (Ensembl: pseudogene)

RefSeq Status:

VALIDATED

Previously known as:

LOC365946; Na+/H+ exchanger domain containing 1; Na+/H+ exchanger domain containing 2; Nhedc1; Nhedc2; RGD1305087; similar to RIKEN cDNA 4933425K02; sodium/hydrogen exchanger 9B1; solute carrier family 9, subfamily B (cation proton antiporter 2), member 1; solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC9B1 (solute carrier family 9 member B1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Mus musculus (house mouse):	Slc9b1 (solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc9b1 (solute carrier family 9 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC9B1 (solute carrier family 9 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC9B1 (solute carrier family 9 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc9b1 (solute carrier family 9 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC9B1 (solute carrier family 9 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC9B1 (solute carrier family 9 member B1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Slc9b1 (solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SLC9B1 (solute carrier family 9 member B1)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	si:dkey-162b23.4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F41E7.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Drosophila melanogaster (fruit fly):	Nha1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Drosophila melanogaster (fruit fly):	Nha2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F41E7.2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	F57G8.5	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	slc9b2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	226,442,892 - 226,502,966 (+)	NCBI		GRCr8
mRatBN7.2	2	223,769,105 - 223,818,359 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	223,769,105 - 223,818,179 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	231,494,639 - 231,543,764 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	229,394,375 - 229,443,501 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	224,259,152 - 224,308,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	240,527,120 - 240,581,616 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	240,527,130 - 240,576,179 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	259,048,088 - 259,097,137 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	232,849,203 - 232,891,958 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	232,785,756 - 232,878,518 (+)	NCBI
Celera	2	215,981,853 - 216,030,452 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Slc9b1	Rat	beta-mannosidosis		ISO	RGD:1605279	8554872	ClinVar Annotator: match by term: Beta-D-mannosidosis	ClinVar	PMID:12468273\|PMID:28492532\|PMID:28942967\|PMID:29432562\|PMID:30455226\|PMID:30951195\|PMID:9384606
Slc9b1	Rat	genetic disease		ISO	RGD:1605279	8554872	ClinVar Annotator: match by term: Inborn genetic diseases	ClinVar	PMID:25741868\|PMID:28492532
Slc9b1	Rat	Wolfram syndrome 2		ISO	RGD:1605279	8554872	ClinVar Annotator: match by term: CISD2-related condition \| ClinVar Annotator: match by term: Wolfram syndrome more ...	ClinVar	PMID:10739754\|PMID:17846994\|PMID:25056293\|PMID:25741868\|PMID:28492532

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Slc9b1	Rat	atrial fibrillation		ISO	RGD:1605279	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:29892015\|PMID:30061737

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Slc9b1	Rat	1,2-dimethylhydrazine	decreases expression	ISO	RGD:1312910	6480464	1,2-Dimethylhydrazine results in decreased expression of SLC9B1 mRNA	CTD	PMID:22206623
Slc9b1	Rat	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of SLC9B1 mRNA	CTD	PMID:33387578
Slc9b1	Rat	4,4'-sulfonyldiphenol	decreases expression	ISO	RGD:1605279	6480464	bisphenol S results in decreased expression of SLC9B1 mRNA	CTD	PMID:27685785
Slc9b1	Rat	acrylamide	decreases expression	EXP		6480464	Acrylamide results in decreased expression of SLC9B1 mRNA	CTD	PMID:28959563
Slc9b1	Rat	aflatoxin B1	decreases methylation	ISO	RGD:1605279	6480464	Aflatoxin B1 results in decreased methylation of SLC9B1 gene	CTD	PMID:27153756
Slc9b1	Rat	benzo[a]pyrene	increases methylation	ISO	RGD:1605279	6480464	Benzo(a)pyrene results in increased methylation of SLC9B1 5' UTR; Benzo(a)pyrene results in increased methylation of more ...	CTD	PMID:27901495
Slc9b1	Rat	benzo[e]pyrene	increases methylation	ISO	RGD:1605279	6480464	benzo(e)pyrene results in increased methylation of SLC9B1 intron	CTD	PMID:30157460
Slc9b1	Rat	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of SLC9B1 mRNA	CTD	PMID:25181051
Slc9b1	Rat	bisphenol A	decreases methylation	ISO	RGD:1605279	6480464	bisphenol A results in decreased methylation of SLC9B1 gene	CTD	PMID:31601247
Slc9b1	Rat	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of SLC9B1 gene	CTD	PMID:28505145
Slc9b1	Rat	bisphenol A	decreases expression	ISO	RGD:1605279	6480464	bisphenol A results in decreased expression of SLC9B1 mRNA	CTD	PMID:27685785
Slc9b1	Rat	cadmium dichloride	decreases expression	ISO	RGD:1605279	6480464	Cadmium Chloride results in decreased expression of SLC9B1 mRNA	CTD	PMID:38382870
Slc9b1	Rat	dioxygen	increases expression	ISO	RGD:1605279	6480464	Oxygen deficiency results in increased expression of SLC9B1 mRNA	CTD	PMID:26516004
Slc9b1	Rat	methapyrilene	increases methylation	ISO	RGD:1605279	6480464	Methapyrilene results in increased methylation of SLC9B1 intron	CTD	PMID:30157460
Slc9b1	Rat	methoxychlor	affects methylation	EXP		6480464	Methoxychlor affects the methylation of SLC9B1 gene	CTD	PMID:35440735
Slc9b1	Rat	paracetamol	increases expression	ISO	RGD:1605279	6480464	Acetaminophen results in increased expression of SLC9B1 mRNA	CTD	PMID:26690555
Slc9b1	Rat	permethrin	increases expression	ISO	RGD:1605279	6480464	Permethrin results in increased expression of SLC9B1 mRNA	CTD	PMID:37047231
Slc9b1	Rat	pirinixic acid	multiple interactions	ISO	RGD:1312910	6480464	[pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ...	CTD	PMID:19710929
Slc9b1	Rat	pirinixic acid	increases expression	ISO	RGD:1312910	6480464	pirinixic acid results in increased expression of SLC9B1 mRNA	CTD	PMID:20813756
Slc9b1	Rat	trichloroethene	decreases expression	EXP		6480464	Trichloroethylene results in decreased expression of SLC9B1 mRNA	CTD	PMID:33387578

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Slc9b1	Rat	flagellated sperm motility	involved_in	ISO	RGD:1312910	1624291	PMID:20036903, PMID:27010853	RGD	PMID:20036903\|PMID:27010853
Slc9b1	Rat	regulation of intracellular pH	involved_in	ISO	RGD:1312910	1624291	PMID:20036903	RGD	PMID:20036903

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Slc9b1	Rat	sperm principal piece	located_in	ISO	RGD:1312910	1624291	PMID:20036903	RGD	PMID:20036903

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	GOA pipeline	RGD automated data pipeline
3.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

PMID:12477932	PMID:20036903	PMID:27010853

Slc9b1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	2	226,442,892 - 226,502,966 (+)	NCBI		GRCr8
mRatBN7.2	2	223,769,105 - 223,818,359 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	223,769,105 - 223,818,179 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	231,494,639 - 231,543,764 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	2	229,394,375 - 229,443,501 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	2	224,259,152 - 224,308,281 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	2	240,527,120 - 240,581,616 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	240,527,130 - 240,576,179 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	259,048,088 - 259,097,137 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	2	232,849,203 - 232,891,958 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	2	232,785,756 - 232,878,518 (+)	NCBI
Celera	2	215,981,853 - 216,030,452 (+)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

SLC9B1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	102,885,049 - 103,019,705 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	102,885,048 - 103,019,719 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	103,806,206 - 103,940,862 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	104,025,643 - 104,160,325 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	101,105,822 - 101,237,997 (-)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI
HuRef	4	99,542,386 - 99,674,649 (-)	NCBI		HuRef
CHM1_1	4	103,782,676 - 103,917,369 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	4	106,199,371 - 106,331,591 (-)	NCBI		T2T-CHM13v2.0

Slc9b1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	135,053,754 - 135,103,588 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	135,053,790 - 135,103,588 (+)	Ensembl		GRCm39 Ensembl
GRCm38	3	135,347,993 - 135,397,827 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	135,348,029 - 135,397,827 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	135,011,001 - 135,060,791 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	135,285,445 - 135,330,469 (+)	NCBI		MGSCv36	mm8
Celera	3	141,762,353 - 141,812,176 (+)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI
cM Map	3	62.55	NCBI

Slc9b1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	5,601,578 - 5,641,594 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	5,586,836 - 5,637,550 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC9B1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	100,957,869 - 101,101,525 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	101,239,766 - 101,388,083 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	95,324,597 - 95,475,599 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	105,987,123 - 106,100,119 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	105,971,131 - 106,071,773 (-)	Ensembl	panpan1.1		panPan2

SLC9B1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	24,292,961 - 24,352,795 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	24,272,035 - 24,352,715 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	17,671,009 - 17,730,793 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	24,512,870 - 24,572,676 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	24,491,739 - 24,572,600 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	24,530,079 - 24,589,801 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	24,273,332 - 24,332,907 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	15,529,630 - 15,589,435 (+)	NCBI		UU_Cfam_GSD_1.0

Slc9b1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	17,028,688 - 17,123,018 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936520	411,811 - 466,280 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936520	405,239 - 466,280 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC9B1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	118,052,500 - 118,155,396 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	118,052,091 - 118,134,685 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	127,025,802 - 127,109,925 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC9B1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	51,011,569 - 51,125,675 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
Vero_WHO_p1.0	NW_023666037	29,521,693 - 29,637,229 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants in Slc9b1
1136 total Variants

Predicted Target Of

	Summary Value
Count of predictions:	54
Count of miRNA genes:	50
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000031348
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
8693697	Alc36	Alcohol consumption QTL 36	2	0.592	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	217139753	236660713	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
10755499	Bp389	Blood pressure QTL 389	2.61		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	2	18960362	228801039	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
7411555	Bw132	Body weight QTL 132		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	2	223389739	249053267	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
8693622	Alc26	Alcohol consumption QTL 26	2.4	0.667	drinking behavior trait (VT:0001422)	calculated ethanol drink intake rate (CMO:0001615)	2	221136523	241305619	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
9587428	Epfw6	Epididymal fat weight QTL 6	7.47	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	2	223389739	249053267	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1359019	Hrtrt19	Heart rate QTL 19	2.9		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	219753301	226277316	Rat

RH133566

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	2	223,828,934 - 223,829,138 (+)	MAPPER	mRatBN7.2
Rnor_6.0	2	240,586,752 - 240,586,955	NCBI	Rnor6.0
Rnor_5.0	2	259,106,751 - 259,106,954	UniSTS	Rnor5.0
RGSC_v3.4	2	232,902,531 - 232,902,734	UniSTS	RGSC3.4
Celera	2	216,041,025 - 216,041,228	UniSTS
RH 3.4 Map	2	1567.3	UniSTS
Cytogenetic Map	2	q43	UniSTS

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	24	109	40	38	9	25	9	6	143	72	89	45	60	29


RefSeq Transcripts	NM_001173973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591000	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282297	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282298	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282300	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063282302	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_010063634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC120718	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC158723	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000002	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000031348 ⟹ ENSRNOP00000029131

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	2	240,527,130 - 240,576,179 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000095000

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	223,769,105 - 223,818,179 (+)	Ensembl

RefSeq Acc Id:

NM_001173973 ⟹ NP_001167444

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,442,892 - 226,491,941 (+)	NCBI
mRatBN7.2	2	223,769,105 - 223,818,359 (+)	NCBI
Rnor_6.0	2	240,527,130 - 240,576,179 (+)	NCBI
Rnor_5.0	2	259,048,088 - 259,097,137 (+)	NCBI
Celera	2	215,981,853 - 216,030,452 (+)	NCBI

Sequence:

show sequence

GCCCTTCTGCTTCCGGTAAATTCCAGCCCAGTTTCTGTCCTTGGCTCTCCTGCCATCCCTGCGCGAGACGACGGTTGCTGGGTCTCTGGGAGGTCCTTGCTTATTTAGAAAGAAGAGAGAGAGAGAGA
GATTTACATCAAGACTGACAAAATTAACCCACTGGGCAGATGCTATTTATACCAATAGTGAATTCGGAGAGATGAACCTTCACGTGCGCCTGTAATTGCAGATGTGTTCCAGGATTGGTTTGTGATTT
CCAGAAGGCTCTCATTCCTTCCCCCAACCCGCTCCCCTCATCAGGATTCCTCTTGGCTTATCCCAGCGGACAAGCACTTAACACCAATGCGGCTTAAGGATTAAGGACTGTAATTGCTCACACAGCGT
GACAGACACTGCACTCGGGGGTTCTGACGATGCTTTATGGTGGCGCTATTATTGGGATAACTGTCATAAAAGCTTGTCACCTTTAGGTTTTAAAGTTCCCTGCTGAAGACTGCAAACCAACTCCTGAA
AGATGAGCGAGTCCAACATAGAAGTAGACAAGAAGGATGATCATCTCCAATCATCTATAACTGATCAGGCTCCTGAAGAACCAGAACCGAAGGTACCACAAATGAAAGAATCAAAAATGAAGGAAACA
CAAACGACCAAAATAGAAACAGAGGAATGGGAAAGAGAACACAGCAGTACAAGTAGTTTCTGTCCTCCACAGGGAACAGTAAATAAAACAATTACCGATGGAGTTACACTCATTGTATTATGGATTCT
ACTCTGGGCCCTTATAGGTCAAGAAGTTCTCCCTGGTGGAAATTTGTTTGGGCTTGTAGTTATTTTTTACAGTGCTTTTCTTGGGGGCAAAATTATAGAAGTCATTAGAATTCCTGTAGTACCTCCCC
TCCCACCTCTTCTTGGGATGTTACTGGCTGGTTTCACCATCAGGAACGTTCCGATTCTTTACAAATTTGTCCATATTCCTACCTCATGGTCTTCAGCTTTAAGAAACACTGCCCTTACTATTATCCTA
ATACGAGCTGGGCTTGGACTGGACCCACAGGCTTTGAAGCATCTGAAGGGAGTTTGTCTGAGATTGTCCTTCGGTCCATGCCTCCTAGAGGCGTGTTCAGCTGCTCTTTTCTCCCACTTCATTATGAA
CTTTCCTTGGCAATGGGGGTTCCTATTAGGTTTTGTTCTAGGTGCTGTCTCTCCTGCTGTTGTCGTTCCCAACATGCTGCTGTTGCAAGAGAACGGATATGGTGTTGAGAAGGGCATTCCAACCTTAC
TAGTGGCTGCTAGCAGTATGGATGACATCGTGGCCATCACTGGATTCAACACATTCTTGAGCATAGTCTTTTCTTCGGGTAGTGTAATTAGCAATATCCTATCATCTTTGCGGGATGTTCTTATTGGC
GTGCTGGTAGGAGTTGTTATGGGAATTTTTGTTCAGTATTTTCCAAGTAGAGATCAGGAGAGACTTACACAGAGGCGAGCCTTCCTAGTTCTGAGTATGTGTGTTTCTGCTGTCTTAGGCTGTCAGCA
CATTGGCTTACACGGATCTGGAGGACTGGTGACACTAGTGCTGTCCTTCATGGCAGCAAAACGATGGGCTGAAGAGAAGGTTGGAGTCCAAAAACTTGTTGCAAACACATGGAATATTTTTCAGCCGC
TTCTTTTTGGCTTAGTTGGAACAGAAGTGTCTGTTGAATCTCTTGAATCGAAAACTATTGGCATGTGCATTGCTACCCTGTGTTTGGCACTGCTTGTTCGAATCTTAGCCACTTTCGTGCTGATGTCT
TTTGCTAACTTTCGTTTTATGGAGAAAGTATTTATTGCTTTATCATGGATCCCTAAAGCTACAGTCCAGGCTGTCTTGGGCCCTCTAGCTCTAGAAACAGCAAGGGTCATGGCACCCCACTTGGAAGG
ATATTCAAGGAATGTGATGACAGTGGCCTTTCTAGCAATCCTGATTACAGCTCCAAATGGAGCCCTCATCATTGGCATACTGGGACCCAAAGTACTTGATCATAGTGAGGAGACATTCCCTTTAAAAG
TGGAGCTTTCAAACTTTCATAATTAAAAGTTTGCTATTACCACCTGCTTTGTCTAATGAATTATCTCACATGACGGGAAAAAAAAAAACCATCACAGTACAAAAGTTTAAAGACTGTTCATAAAACCC
AGGATTCACTAAATGCACAATTTCTCTGCAAGGCTTTCCTCCGGTTCAAAGTGAATTTAATAAAAATAGTTAACTACA

hide sequence

RefSeq Acc Id:

XM_063282297 ⟹ XP_063138367

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,442,991 - 226,491,777 (+)	NCBI

RefSeq Acc Id:

XM_063282298 ⟹ XP_063138368

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,442,893 - 226,491,777 (+)	NCBI

RefSeq Acc Id:

XM_063282300 ⟹ XP_063138370

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,442,991 - 226,502,966 (+)	NCBI

RefSeq Acc Id:

XM_063282301 ⟹ XP_063138371

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,450,541 - 226,491,777 (+)	NCBI

RefSeq Acc Id:

XM_063282302 ⟹ XP_063138372

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,442,991 - 226,487,920 (+)	NCBI

RefSeq Acc Id:

XR_010063634

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	2	226,442,991 - 226,502,966 (+)	NCBI


Protein RefSeqs	NP_001167444	(Get FASTA)	NCBI Sequence Viewer
	XP_063138367	(Get FASTA)	NCBI Sequence Viewer
	XP_063138368	(Get FASTA)	NCBI Sequence Viewer
	XP_063138370	(Get FASTA)	NCBI Sequence Viewer
	XP_063138371	(Get FASTA)	NCBI Sequence Viewer
	XP_063138372	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAI58724	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000110456

RefSeq Acc Id:

NP_001167444 ⟸ NM_001173973

- UniProtKB:

F1LPN2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSESNIEVDKKDDHLQSSITDQAPEEPEPKVPQMKESKMKETQTTKIETEEWEREHSSTSSFCPPQGTVNKTITDGVTLIVLWILLWALIGQEVLPGGNLFGLVVIFYSAFLGGKIIEVIRIPVVPPL
PPLLGMLLAGFTIRNVPILYKFVHIPTSWSSALRNTALTIILIRAGLGLDPQALKHLKGVCLRLSFGPCLLEACSAALFSHFIMNFPWQWGFLLGFVLGAVSPAVVVPNMLLLQENGYGVEKGIPTLL
VAASSMDDIVAITGFNTFLSIVFSSGSVISNILSSLRDVLIGVLVGVVMGIFVQYFPSRDQERLTQRRAFLVLSMCVSAVLGCQHIGLHGSGGLVTLVLSFMAAKRWAEEKVGVQKLVANTWNIFQPL
LFGLVGTEVSVESLESKTIGMCIATLCLALLVRILATFVLMSFANFRFMEKVFIALSWIPKATVQAVLGPLALETARVMAPHLEGYSRNVMTVAFLAILITAPNGALIIGILGPKVLDHSEETFPLKV
ELSNFHN

hide sequence

Ensembl Acc Id:

ENSRNOP00000029131 ⟸ ENSRNOT00000031348

RefSeq Acc Id:	XP_063138368 ⟸ XM_063282298
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_063138370 ⟸ XM_063282300
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_063138367 ⟸ XM_063282297
- Peptide Label:	isoform X1

Protein Domains

Cation/H+ exchanger transmembrane

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-F1LPN2-F1-model_v2	AlphaFold	F1LPN2	1-519	view protein structure

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

RGD ID:

13691768

Promoter ID:

EPDNEW_R2293

Type:

initiation region

Name:

Slc9b1_1

Description:

solute carrier family 9 member B1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	2	240,527,159 - 240,527,219	EPDNEW

Database	Acc Id	Source(s)
BioCyc Gene	G2FUF-51141	BioCyc
Ensembl Genes	ENSRNOG00000042985	Ensembl
	ENSRNOG00000069829	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000095000	ENTREZGENE
IMAGE_CLONE	IMAGE:9090632	IMAGE-MGC_LOAD
InterPro	Cation/H_exchanger	UniProtKB/TrEMBL
	CPA1_transporter	UniProtKB/TrEMBL
MGC_CLONE	MGC:187872	IMAGE-MGC_LOAD
NCBI Gene	365946	ENTREZGENE
PANTHER	PTHR31102	UniProtKB/TrEMBL
	SLC9B1-LIKE PROTEIN SLC9B1P1-RELATED	UniProtKB/TrEMBL
Pfam	Na_H_Exchanger	UniProtKB/TrEMBL
PhenoGen	Slc9b1	PhenoGen
RatGTEx	ENSRNOG00000042985	RatGTEx
	ENSRNOG00000069829	RatGTEx
UniProt	A6HVW8	ENTREZGENE, UniProtKB/TrEMBL
	B0BN84	ENTREZGENE, UniProtKB/TrEMBL
	F1LPN2	ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-24	Slc9b1	solute carrier family 9 member B1	Slc9b1	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-10-16	Slc9b1	solute carrier family 9, subfamily B (NHA1, cation proton antiporter 1), member 1	Slc9b1	solute carrier family 9, subfamily B (cation proton antiporter 2), member 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-08-16	Slc9b1	solute carrier family 9, subfamily B (cation proton antiporter 2), member 1	Nhedc1	Na+/H+ exchanger domain containing 1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2011-05-31	Nhedc1	Na+/H+ exchanger domain containing 1	Nhedc2	Na+/H+ exchanger domain containing 2	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2008-03-06	Nhedc2	Na+/H+ exchanger domain containing 2	RGD1305087_predicted	similar to RIKEN cDNA 4933425K02 (predicted)	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2005-01-20	RGD1305087_predicted	similar to RIKEN cDNA 4933425K02 (predicted)	LOC365946_predicted		Symbol and Name status set to approved	1331353	APPROVED
2005-01-12	LOC365946_predicted	similar to RIKEN cDNA 4933425K02 (predicted)			Symbol and Name status set to provisional	70820	PROVISIONAL

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InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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