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Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Npnt | Rat | 1,1-dichloroethene | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | vinylidene chloride results in decreased expression of NPNT mRNA | CTD | PMID:26682919 | Npnt | Rat | 1,2-dichloroethane | increases expression | ISO | Npnt (Mus musculus) | 6480464 | ethylene dichloride results in increased expression of NPNT mRNA | CTD | PMID:28960355 | Npnt | Rat | 17beta-estradiol | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Estradiol results in decreased expression of NPNT mRNA | CTD | PMID:21185374 and PMID:31614463 | Npnt | Rat | 17beta-estradiol | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Estradiol results in increased expression of NPNT mRNA | CTD | PMID:39298647 | Npnt | Rat | 17beta-estradiol | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [Estradiol co-treated with TGFB1 protein] results in decreased expression of NPNT mRNA | CTD | PMID:30165855 | Npnt | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of NPNT mRNA | CTD | PMID:20106945 | Npnt | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Npnt (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of NPNT mRNA | CTD | PMID:26377647 and PMID:28922406 | Npnt | Rat | 2,4-dibromophenyl 2,4,5-tribromophenyl ether | affects expression | ISO | Npnt (Mus musculus) | 6480464 | 2 more ... | CTD | PMID:38648751 | Npnt | Rat | 2-palmitoylglycerol | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | 2-palmitoylglycerol results in increased expression of NPNT mRNA | CTD | PMID:37199045 | Npnt | Rat | 3,3',5-triiodo-L-thyronine | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Triiodothyronine results in increased expression of NPNT mRNA | CTD | PMID:25172293 | Npnt | Rat | 4,4'-sulfonyldiphenol | affects expression | ISO | Npnt (Mus musculus) | 6480464 | bisphenol S affects the expression of NPNT mRNA | CTD | PMID:30951980 | Npnt | Rat | 4-hydroxyphenyl retinamide | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Fenretinide results in increased expression of NPNT mRNA | CTD | PMID:28973697 | Npnt | Rat | acrylamide | decreases expression | EXP | | 6480464 | Acrylamide results in decreased expression of NPNT mRNA | CTD | PMID:28959563 | Npnt | Rat | aflatoxin B1 | decreases methylation | ISO | NPNT (Homo sapiens) | 6480464 | Aflatoxin B1 results in decreased methylation of NPNT gene | CTD | PMID:27153756 | Npnt | Rat | all-trans-retinoic acid | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Tretinoin results in increased expression of NPNT mRNA | CTD | PMID:21934132 | Npnt | Rat | all-trans-retinoic acid | multiple interactions | ISO | Npnt (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of NPNT mRNA | CTD | PMID:30951980 | Npnt | Rat | alpha-Zearalanol | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of NPNT mRNA | CTD | PMID:35163327 | Npnt | Rat | antirheumatic drug | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Antirheumatic Agents results in increased expression of NPNT mRNA | CTD | PMID:24449571 | Npnt | Rat | aristolochic acid A | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | aristolochic acid I results in decreased expression of NPNT mRNA | CTD | PMID:33212167 | Npnt | Rat | arsane | affects methylation | ISO | NPNT (Homo sapiens) | 6480464 | Arsenic affects the methylation of NPNT gene | CTD | PMID:25304211 | Npnt | Rat | arsenic atom | affects methylation | ISO | NPNT (Homo sapiens) | 6480464 | Arsenic affects the methylation of NPNT gene | CTD | PMID:25304211 | Npnt | Rat | azathioprine | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Azathioprine results in decreased expression of NPNT mRNA | CTD | PMID:22623647 | Npnt | Rat | benzo[a]pyrene | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased expression of NPNT mRNA | CTD | PMID:22316170 | Npnt | Rat | benzo[a]pyrene | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in decreased expression of NPNT mRNA | CTD | PMID:35870112 | Npnt | Rat | benzo[a]pyrene | increases methylation | ISO | NPNT (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of NPNT 3' UTR | CTD | PMID:27901495 | Npnt | Rat | benzo[a]pyrene | affects methylation | ISO | NPNT (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of NPNT promoter | CTD | PMID:27901495 | Npnt | Rat | benzo[a]pyrene | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | Benzo(a)pyrene results in decreased expression of NPNT mRNA | CTD | PMID:20713471 | Npnt | Rat | bis(2-ethylhexyl) phthalate | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Diethylhexyl Phthalate results in increased expression of NPNT mRNA | CTD | PMID:31163220 | Npnt | Rat | bisphenol A | increases expression | ISO | Npnt (Mus musculus) | 6480464 | bisphenol A results in increased expression of NPNT mRNA | CTD | PMID:30951980 and PMID:32156529 | Npnt | Rat | bisphenol F | affects expression | ISO | Npnt (Mus musculus) | 6480464 | bisphenol F affects the expression of NPNT mRNA | CTD | PMID:30951980 | Npnt | Rat | bisphenol F | multiple interactions | ISO | Npnt (Mus musculus) | 6480464 | [bisphenol F co-treated with Tretinoin] results in decreased expression of NPNT mRNA | CTD | PMID:30951980 | Npnt | Rat | cadmium dichloride | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Cadmium Chloride results in increased expression of NPNT mRNA | CTD | PMID:26314618 | Npnt | Rat | carbon nanotube | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | Nanotubes more ... | CTD | PMID:25554681 | Npnt | Rat | CGP 52608 | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to NPNT gene] | CTD | PMID:28238834 | Npnt | Rat | chlordecone | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Chlordecone results in increased expression of NPNT mRNA | CTD | PMID:33711761 | Npnt | Rat | chlorpyrifos | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | Chlorpyrifos results in decreased expression of NPNT mRNA | CTD | PMID:37019170 | Npnt | Rat | copper atom | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of NPNT mRNA | CTD | PMID:20971185 | Npnt | Rat | copper(0) | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NSC 689534 binds to Copper] which results in decreased expression of NPNT mRNA | CTD | PMID:20971185 | Npnt | Rat | copper(II) sulfate | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Copper Sulfate results in decreased expression of NPNT mRNA | CTD | PMID:19549813 | Npnt | Rat | coumestrol | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPNT mRNA | CTD | PMID:19167446 | Npnt | Rat | coumestrol | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Coumestrol results in decreased expression of NPNT mRNA | CTD | PMID:19167446 | Npnt | Rat | cyclosporin A | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of NPNT mRNA | CTD | PMID:25562108 | Npnt | Rat | dichloroacetic acid | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Dichloroacetic Acid results in increased expression of NPNT mRNA | CTD | PMID:28962523 | Npnt | Rat | dioxygen | multiple interactions | ISO | Npnt (Mus musculus) | 6480464 | [NFE2L2 protein affects the susceptibility to Oxygen] which affects the expression of NPNT mRNA | CTD | PMID:30529165 | Npnt | Rat | dorsomorphin | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Npnt | Rat | doxorubicin | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of NPNT mRNA | CTD | PMID:29803840 | Npnt | Rat | Enterolactone | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [Coumestrol co-treated with 2 and 3-bis(3'-hydroxybenzyl)butyrolactone] results in decreased expression of NPNT mRNA | CTD | PMID:19167446 | Npnt | Rat | etoposide | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Etoposide results in increased expression of NPNT mRNA | CTD | PMID:25270620 | Npnt | Rat | fentin chloride | decreases expression | EXP | | 6480464 | triphenyltin chloride results in decreased expression of NPNT mRNA | CTD | PMID:37156404 | Npnt | Rat | genistein | increases expression | ISO | Npnt (Mus musculus) | 6480464 | Genistein results in increased expression of NPNT mRNA | CTD | PMID:32186404 | Npnt | Rat | inulin | multiple interactions | ISO | Npnt (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of NPNT mRNA | CTD | PMID:36331819 | Npnt | Rat | iron dichloride | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | ferrous chloride results in increased expression of NPNT mRNA | CTD | PMID:35984750 | Npnt | Rat | ivermectin | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Ivermectin results in decreased expression of NPNT protein | CTD | PMID:32959892 | Npnt | Rat | lead diacetate | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | lead acetate results in decreased expression of NPNT mRNA | CTD | PMID:22613225 | Npnt | Rat | mercury dibromide | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | mercuric bromide results in increased expression of NPNT mRNA | CTD | PMID:26272509 | Npnt | Rat | mercury dibromide | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA | CTD | PMID:27188386 | Npnt | Rat | methylmercury chloride | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | methylmercuric chloride results in decreased expression of NPNT mRNA | CTD | PMID:23179753 | Npnt | Rat | nickel atom | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Nickel results in decreased expression of NPNT mRNA | CTD | PMID:24768652 | Npnt | Rat | ozone | multiple interactions | ISO | Npnt (Mus musculus) | 6480464 | [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of NPNT mRNA | CTD | PMID:34911549 | Npnt | Rat | panobinostat | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA | CTD | PMID:27188386 | Npnt | Rat | panobinostat | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | panobinostat results in increased expression of NPNT mRNA | CTD | PMID:26272509 | Npnt | Rat | paracetamol | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Acetaminophen results in increased expression of NPNT mRNA | CTD | PMID:22230336 | Npnt | Rat | paraquat | decreases expression | EXP | | 6480464 | Paraquat results in decreased expression of NPNT mRNA | CTD | PMID:32680482 | Npnt | Rat | perfluorooctane-1-sulfonic acid | affects expression | ISO | Npnt (Mus musculus) | 6480464 | perfluorooctane sulfonic acid affects the expression of NPNT mRNA | CTD | PMID:19429403 | Npnt | Rat | perfluorooctane-1-sulfonic acid | multiple interactions | ISO | Npnt (Mus musculus) | 6480464 | [perfluorooctane sulfonic acid co-treated with Inulin] results in increased expression of NPNT mRNA and [perfluorooctane sulfonic acid co-treated with Pectins] results in increased expression of NPNT mRNA | CTD | PMID:36331819 | Npnt | Rat | perfluorooctanoic acid | affects expression | ISO | Npnt (Mus musculus) | 6480464 | perfluorooctanoic acid affects the expression of NPNT mRNA | CTD | PMID:19429403 | Npnt | Rat | perfluorooctanoic acid | multiple interactions | EXP | | 6480464 | [Zeranol co-treated with perfluorooctanoic acid] results in decreased expression of NPNT mRNA | CTD | PMID:35163327 | Npnt | Rat | phosgene | affects expression | ISO | Npnt (Mus musculus) | 6480464 | Phosgene affects the expression of NPNT mRNA | CTD | PMID:16300373 | Npnt | Rat | pirinixic acid | increases expression | ISO | Npnt (Mus musculus) | 6480464 | pirinixic acid results in increased expression of NPNT mRNA | CTD | PMID:18301758 more ... | Npnt | Rat | potassium dichromate | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of NPNT mRNA | CTD | PMID:23608068 | Npnt | Rat | propanal | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | propionaldehyde results in decreased expression of NPNT mRNA | CTD | PMID:26079696 | Npnt | Rat | resveratrol | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [Plant Extracts co-treated with Resveratrol] results in decreased expression of NPNT mRNA | CTD | PMID:23557933 | Npnt | Rat | SB 431542 | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NOG protein co-treated with mercuric bromide co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... | CTD | PMID:27188386 | Npnt | Rat | silicon dioxide | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Silicon Dioxide analog results in decreased expression of NPNT mRNA | CTD | PMID:25895662 | Npnt | Rat | sodium arsenite | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | sodium arsenite results in decreased expression of NPNT mRNA | CTD | PMID:34032870 | Npnt | Rat | sodium arsenite | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of NPNT mRNA | CTD | PMID:35954277 | Npnt | Rat | sodium arsenite | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | sodium arsenite results in decreased expression of NPNT mRNA | CTD | PMID:37682722 | Npnt | Rat | sunitinib | decreases expression | ISO | NPNT (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of NPNT mRNA | CTD | PMID:31533062 | Npnt | Rat | titanium dioxide | increases expression | ISO | Npnt (Mus musculus) | 6480464 | titanium dioxide results in increased expression of NPNT mRNA | CTD | PMID:23557971 | Npnt | Rat | titanium dioxide | increases methylation | ISO | Npnt (Mus musculus) | 6480464 | titanium dioxide results in increased methylation of NPNT gene | CTD | PMID:35295148 | Npnt | Rat | trichostatin A | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | trichostatin A results in increased expression of NPNT mRNA | CTD | PMID:24935251 and PMID:26272509 | Npnt | Rat | trichostatin A | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA | CTD | PMID:27188386 | Npnt | Rat | triclosan | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Triclosan results in increased expression of NPNT mRNA | CTD | PMID:30510588 | Npnt | Rat | tris(2-butoxyethyl) phosphate | affects expression | ISO | NPNT (Homo sapiens) | 6480464 | tris(2-butoxyethyl) phosphate affects the expression of NPNT mRNA | CTD | PMID:29024780 | Npnt | Rat | trovafloxacin | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | trovafloxacin results in decreased expression of NPNT mRNA | CTD | PMID:35537566 | Npnt | Rat | valproic acid | increases methylation | ISO | NPNT (Homo sapiens) | 6480464 | Valproic Acid results in increased methylation of NPNT gene | CTD | PMID:29154799 | Npnt | Rat | valproic acid | decreases expression | ISO | Npnt (Mus musculus) | 6480464 | Valproic Acid results in decreased expression of NPNT mRNA | CTD | PMID:24896083 | Npnt | Rat | valproic acid | increases expression | ISO | NPNT (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of NPNT mRNA | CTD | PMID:23179753 more ... | Npnt | Rat | valproic acid | multiple interactions | ISO | NPNT (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1 and 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of NPNT mRNA | CTD | PMID:27188386 | Npnt | Rat | vinclozolin | increases methylation | EXP | | 6480464 | vinclozolin results in increased methylation of NPNT gene | CTD | PMID:31079544 | |