Npnt (nephronectin) - Rat Genome Database

Name: Npnt
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Npnt (nephronectin) Rattus norvegicus

Analyze

Symbol:

Npnt

Name:

nephronectin

RGD ID:

1593709

Description:

Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of alkaline phosphatase activity. Predicted to act upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regulation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Predicted to be located in basement membrane; extracellular region; and smooth muscle contractile fiber. Orthologous to human NPNT (nephronectin); INTERACTS WITH acrylamide; paraquat; vinclozolin.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

LOC686753; similar to nephronectin isoform a

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	NPNT (nephronectin)	HGNC	NCBI
Mus musculus (house mouse):	Npnt (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Npnt (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	NPNT (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	NPNT (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Npnt (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	NPNT (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	NPNT (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Npnt (nephronectin)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	NPNT (nephronectin)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Npnt (nephronectin)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	npnta (nephronectin a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	221,391,151 - 221,459,527 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	221,391,153 - 221,459,401 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	229,049,550 - 229,117,766 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	226,949,232 - 227,017,459 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	221,806,890 - 221,875,109 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	238,001,767 - 238,068,886 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	238,002,990 - 238,068,694 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	256,541,460 - 256,609,626 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	213,627,605 - 213,693,773 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

bilateral renal aplasia (ISS)

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',5-triiodo-L-thyronine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

acrylamide (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

azathioprine (ISO)

benzo[a]pyrene (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (ISO)

bisphenol F (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

chlordecone (ISO)

copper atom (ISO)

copper(0) (ISO)

copper(II) sulfate (ISO)

coumestrol (ISO)

cyclosporin A (ISO)

dichloroacetic acid (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

Enterolactone (ISO)

etoposide (ISO)

genistein (ISO)

ivermectin (ISO)

lead diacetate (ISO)

mercury dibromide (ISO)

methylmercury chloride (ISO)

nickel atom (ISO)

ozone (ISO)

panobinostat (ISO)

paracetamol (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phosgene (ISO)

pirinixic acid (ISO)

potassium dichromate (ISO)

propanal (ISO)

resveratrol (ISO)

SB 431542 (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

triclosan (ISO)

tris(2-butoxyethyl) phosphate (ISO)

trovafloxacin (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

branching involved in ureteric bud morphogenesis (ISO)

cell-cell adhesion mediated by integrin (ISO)

cell-matrix adhesion (ISO)

cellular response to tumor necrosis factor (ISO)

establishment of protein localization (ISO)

extracellular matrix organization (ISO)

pilomotor reflex (ISO)

positive regulation of alkaline phosphatase activity (ISO)

positive regulation of cell-substrate adhesion (ISO)

positive regulation of ERK1 and ERK2 cascade (ISO)

positive regulation of osteoblast differentiation (ISO)

positive regulation of smooth muscle contraction (ISO)

positive regulation of transcription by RNA polymerase II (ISO)

positive regulation of transforming growth factor beta receptor signaling pathway (ISO)

smooth muscle cell differentiation (ISO)

transforming growth factor beta receptor signaling pathway (ISO)

ureteric bud development (ISO)

Cellular Component

basement membrane (ISO)

collagen-containing extracellular matrix (ISO)

extracellular matrix (ISO)

extracellular region (ISO)

membrane (IEA)

smooth muscle contractile fiber (ISO)

Molecular Function

calcium ion binding (IEA)

integrin binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	GOA pipeline	RGD automated data pipeline
2.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:11470831	PMID:11546798	PMID:17537792	PMID:18757743	PMID:19199708	PMID:19342381	PMID:19944102	PMID:21335239	PMID:21689636	PMID:24006456

Genomics

Comparative Map Data

Npnt
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	2	221,391,151 - 221,459,527 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	2	221,391,153 - 221,459,401 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	2	229,049,550 - 229,117,766 (-)	NCBI	Rnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0	2	226,949,232 - 227,017,459 (-)	NCBI	Rnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0	2	221,806,890 - 221,875,109 (-)	NCBI	Rnor_WKY
Rnor_6.0	2	238,001,767 - 238,068,886 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	2	238,002,990 - 238,068,694 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	2	256,541,460 - 256,609,626 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	2	213,627,605 - 213,693,773 (-)	NCBI		Celera
Cytogenetic Map	2	q43	NCBI

NPNT
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	105,895,471 - 105,971,671 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	4	105,894,775 - 106,004,027 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	4	106,816,628 - 106,892,828 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	107,036,054 - 107,112,277 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Celera	4	104,115,729 - 104,192,091 (+)	NCBI		Celera
Cytogenetic Map	4	q24	NCBI
HuRef	4	102,551,277 - 102,627,657 (+)	NCBI		HuRef
CHM1_1	4	106,793,392 - 106,869,624 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	109,206,597 - 109,282,798 (+)	NCBI		T2T-CHM13v2.0

Npnt
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	3	132,587,506 - 132,656,052 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	3	132,587,506 - 132,656,052 (-)	Ensembl		GRCm39 Ensembl
GRCm38	3	132,881,745 - 132,950,291 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	3	132,881,745 - 132,950,291 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	3	132,545,647 - 132,613,255 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	3	132,819,989 - 132,887,597 (-)	NCBI		MGSCv36	mm8
Celera	3	139,306,540 - 139,374,486 (-)	NCBI		Celera
Cytogenetic Map	3	G3	NCBI

Npnt
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955496	3,320,946 - 3,388,694 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955496	3,321,310 - 3,388,625 (-)	NCBI	ChiLan1.0	ChiLan1.0

NPNT
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	4	108,974,971 - 109,054,671 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	108,974,971 - 109,054,671 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	4	98,365,727 - 98,445,746 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

NPNT
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	32	26,706,147 - 26,781,792 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	32	26,705,476 - 26,781,275 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	32	15,244,637 - 15,320,270 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	32	26,938,244 - 27,013,911 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	32	26,938,240 - 27,013,899 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	32	26,934,668 - 27,010,414 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	32	26,679,785 - 26,755,603 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	32	13,106,933 - 13,182,805 (-)	NCBI		UU_Cfam_GSD_1.0

Npnt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405301	14,346,316 - 14,448,517 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936814	1,095,974 - 1,165,866 (-)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936814	1,096,604 - 1,165,755 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

NPNT
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	115,779,840 - 115,861,137 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	8	115,768,963 - 115,861,170 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	124,205,423 - 124,229,272 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

NPNT
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	7	53,924,655 - 54,001,320 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	7	53,924,701 - 54,001,852 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	32,544,147 - 32,621,638 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Npnt
(Heterocephalus glaber - naked mole-rat)

Naked Mole-rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624830	2,881,638 - 2,943,586 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624830	2,881,948 - 2,943,577 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Npnt
560 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	300
Count of miRNA genes:	88
Interacting mature miRNAs:	89
Transcripts:	ENSRNOT00000072131, ENSRNOT00000073037, ENSRNOT00000075259
Prediction methods:	Microtar, Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354648	Bp239	Blood pressure QTL 239		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	66118463	226797303	Rat
724534	Uae6	Urinary albumin excretion QTL 6	10		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	2	78665619	249053267	Rat
1354622	Kidm16	Kidney mass QTL 16	3		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	2	81754530	222436696	Rat
1354649	Kidm17	Kidney mass QTL 17	2.9		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	2	81754530	227146641	Rat
1331794	Bp202	Blood pressure QTL 202	3.66819		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	141194931	223265385	Rat
1331805	Cm29	Cardiac mass QTL 29	3.50746		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	2	141194931	223265385	Rat
1641891	Alcrsp17	Alcohol response QTL 17			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	149559561	249053267	Rat
8662843	Vetf9	Vascular elastic tissue fragility QTL 9	2.05		thoracic aorta molecular composition trait (VT:0010568)	aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)	2	157142078	226277316	Rat
1358356	Srcrt1	Stress Responsive Cort QTL1	3.66		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	2	161699179	222436696	Rat
2306901	Bp337	Blood pressure QTL 337		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	164073756	227146641	Rat
1331734	Bp204	Blood pressure QTL 204	3.61192		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	168358098	223265385	Rat
2300189	Bmd48	Bone mineral density QTL 48	5.8	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	2	179335906	224335906	Rat
61417	Cia10	Collagen induced arthritis QTL 10	3.4		joint integrity trait (VT:0010548)	experimental arthritis severity measurement (CMO:0001459)	2	179946951	224946951	Rat
8694435	Bw166	Body weight QTL 166	14.08	0.001	retroperitoneal fat pad mass (VT:0010430)	retroperitoneal fat pad weight to body weight ratio (CMO:0000635)	2	182171407	227171407	Rat
9589044	Scfw1	Subcutaneous fat weight QTL 1	5.8	0.001	subcutaneous adipose mass (VT:1000472)	abdominal subcutaneous fat pad weight (CMO:0002069)	2	182171407	227171407	Rat
8694383	Bw158	Body weight QTL 158	7.69	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	2	182171407	227171407	Rat
8694194	Abfw1	Abdominal fat weight QTL 1	11.7	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	2	182171407	227171407	Rat
738013	Alc15	Alcohol consumption QTL 15	4.1	0.00022	consumption behavior trait (VT:0002069)	ethanol drink intake rate to body weight ratio (CMO:0001616)	2	184165752	229165752	Rat
1581499	Esta2	Estrogen-induced thymic atrophy QTL 2			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	2	189599258	226936289	Rat
61366	Iddm3	Insulin dependent diabetes mellitus QTL 3	4.7		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	2	189599258	234599258	Rat
61398	Bp50	Blood pressure QTL 50	4.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	2	189599258	234599258	Rat
2301408	Kidm36	Kidney mass QTL 36		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	2	190613715	226808892	Rat
2317752	Glom23	Glomerulus QTL 23	3.6		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	2	193452645	245889826	Rat
1598813	Memor9	Memory QTL 9	2.7		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	2	199341726	234244620	Rat
1598835	Anxrr18	Anxiety related response QTL 18	2.98		body movement coordination trait (VT:0005424)	number of rearing movements in an experimental apparatus (CMO:0001752)	2	200990457	245990457	Rat
2298479	Eau5	Experimental allergic uveoretinitis QTL 5		0.0021	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	2	202446871	237938339	Rat
7207490	Bss111	Bone structure and strength QTL 111	6.4		femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	2	211744537	249053267	Rat
7207482	Bss107	Bone structure and strength QTL 107	7		femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	2	211744537	249053267	Rat
7207484	Bss108	Bone structure and strength QTL 108	5.3		femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	2	211744537	249053267	Rat
1298075	Scl17	Serum cholesterol level QTL 17	3.4		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	2	211744537	249053267	Rat
1549836	Bss2	Bone structure and strength QTL 2	7.5		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	2	211744537	249053267	Rat
2317885	Alcrsp28	Alcohol response QTL 28	2.1	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	2	212828222	249053267	Rat
1300126	Bp175	Blood pressure QTL 175	3.46		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	2	214226044	247136170	Rat
2313073	Bmd75	Bone mineral density QTL 75	4.1	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	2	215377404	237938339	Rat
1331767	Hrtrt12	Heart rate QTL 12	3.373		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	218414747	240841241	Rat
1359019	Hrtrt19	Heart rate QTL 19	2.9		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	2	219753301	226277316	Rat
2293833	Kiddil8	Kidney dilation QTL 8	2.9		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat
2293844	Kiddil7	Kidney dilation QTL 7	3.5		kidney pelvis morphology trait (VT:0004194)	hydronephrosis severity score (CMO:0001208)	2	219753301	247136170	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	1	20	13	6	17	6	1	1	25	35	28	11	1
Low	2	21	44	35	2	35	7	10	49		13		7
Below cutoff		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001402176	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_001075423	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_002726041	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003753661	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006224263	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008775269	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017591400	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103852	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103853	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039103855	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH473952	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000079	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000078608 ⟹ ENSRNOP00000073239

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	221,391,165 - 221,459,333 (-)	Ensembl
Rnor_6.0 Ensembl	2	238,002,990 - 238,068,694 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000079479 ⟹ ENSRNOP00000074549

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	221,391,165 - 221,459,333 (-)	Ensembl
Rnor_6.0 Ensembl	2	238,002,990 - 238,068,694 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000090834 ⟹ ENSRNOP00000069738

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	221,391,156 - 221,459,376 (-)	Ensembl
Rnor_6.0 Ensembl	2	238,002,990 - 238,068,694 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000118889 ⟹ ENSRNOP00000077007

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	2	221,391,153 - 221,459,401 (-)	Ensembl

RefSeq Acc Id:

XM_039103852 ⟹ XP_038959780

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	221,391,151 - 221,459,527 (-)	NCBI

RefSeq Acc Id:

XM_039103853 ⟹ XP_038959781

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	221,391,151 - 221,459,526 (-)	NCBI

RefSeq Acc Id:

XM_039103854 ⟹ XP_038959782

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	221,391,151 - 221,459,527 (-)	NCBI

RefSeq Acc Id:

XM_039103855 ⟹ XP_038959783

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	2	221,391,151 - 221,459,526 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_001389105	(Get FASTA)	NCBI Sequence Viewer
	XP_038959780	(Get FASTA)	NCBI Sequence Viewer
	XP_038959781	(Get FASTA)	NCBI Sequence Viewer
	XP_038959782	(Get FASTA)	NCBI Sequence Viewer
	XP_038959783	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	EDL82225	(Get FASTA)	NCBI Sequence Viewer
	EDL82226	(Get FASTA)	NCBI Sequence Viewer
	EDL82227	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000074549 ⟸ ENSRNOT00000079479

RefSeq Acc Id:

ENSRNOP00000069738 ⟸ ENSRNOT00000090834

RefSeq Acc Id:

ENSRNOP00000073239 ⟸ ENSRNOT00000078608

RefSeq Acc Id:	XP_038959782 ⟸ XM_039103854
- Peptide Label:	isoform X3

RefSeq Acc Id:	XP_038959780 ⟸ XM_039103852
- Peptide Label:	isoform X1
- UniProtKB:	A0A0G2K500 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038959783 ⟸ XM_039103855
- Peptide Label:	isoform X4

RefSeq Acc Id:	XP_038959781 ⟸ XM_039103853
- Peptide Label:	isoform X2

RefSeq Acc Id:

ENSRNOP00000077007 ⟸ ENSRNOT00000118889

Protein Domains

EGF-like MAM

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1593709	AgrOrtholog
BioCyc Gene	G2FUF-51172	BioCyc
Ensembl Genes	ENSRNOG00000052873	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein	ENSRNOP00000069738	ENTREZGENE
	ENSRNOP00000069738.2	UniProtKB/TrEMBL
	ENSRNOP00000073239	ENTREZGENE
	ENSRNOP00000073239.2	UniProtKB/TrEMBL
	ENSRNOP00000074549.2	UniProtKB/TrEMBL
	ENSRNOP00000077007	ENTREZGENE
	ENSRNOP00000077007.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000078608	ENTREZGENE
	ENSRNOT00000078608.2	UniProtKB/TrEMBL
	ENSRNOT00000079479.2	UniProtKB/TrEMBL
	ENSRNOT00000090834	ENTREZGENE
	ENSRNOT00000090834.2	UniProtKB/TrEMBL
	ENSRNOT00000118889	ENTREZGENE
	ENSRNOT00000118889.1	UniProtKB/TrEMBL
Gene3D-CATH	2.60.120.200	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
InterPro	ConA-like_dom_sf	UniProtKB/TrEMBL
	EGF-like_Ca-bd_dom	UniProtKB/TrEMBL
	EGF-like_dom	UniProtKB/TrEMBL
	EGF-type_Asp/Asn_hydroxyl_site	UniProtKB/TrEMBL
	EGF_Ca-bd_CS	UniProtKB/TrEMBL
	Growth_fac_rcpt_cys_sf	UniProtKB/TrEMBL
	MAM_dom	UniProtKB/TrEMBL
NCBI Gene	686753	ENTREZGENE
PANTHER	NEPHRONECTIN	UniProtKB/TrEMBL
	PA14 DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
Pfam	EGF_CA	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
PhenoGen	Npnt	PhenoGen
PROSITE	ASX_HYDROXYL	UniProtKB/TrEMBL
	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM_2	UniProtKB/TrEMBL
SMART	EGF	UniProtKB/TrEMBL
	EGF_CA	UniProtKB/TrEMBL
	MAM	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	SSF49899	UniProtKB/TrEMBL
	SSF57184	UniProtKB/TrEMBL
UniProt	A0A0G2JW46_RAT	UniProtKB/TrEMBL
	A0A0G2K500	ENTREZGENE, UniProtKB/TrEMBL
	A0A0G2K8C1_RAT	UniProtKB/TrEMBL
	A0A8I5Y706_RAT	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2015-12-21	Npnt	nephronectin	LOC686753	similar to nephronectin isoform a	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-11-20	LOC686753	similar to nephronectin isoform a			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - MGI

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Imported Disease Annotations - ClinVar

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