Tet2 (tet methylcytosine dioxygenase 2) - Rat Genome Database

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Gene: Tet2 (tet methylcytosine dioxygenase 2) Rattus norvegicus
Analyze
Symbol: Tet2
Name: tet methylcytosine dioxygenase 2
RGD ID: 1311625
Description: Predicted to enable 5-methylcytosine dioxygenase activity; ferrous iron binding activity; and zinc ion binding activity. Involved in response to organic cyclic compound. Predicted to be located in chromosome. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); hematologic cancer (multiple); lung non-small cell carcinoma; and primary immunodeficiency disease. Orthologous to human TET2 (tet methylcytosine dioxygenase 2); PARTICIPATES IN DNA modification pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC310859; methylcytosine dioxygenase TET2; probable methylcytosine dioxygenase TET2; RGD1311625; similar to KIAA1546 protein; tet oncogene family member 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82224,662,654 - 224,746,819 (-)NCBIGRCr8
mRatBN7.22221,988,645 - 222,072,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,988,645 - 222,072,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02238,719,389 - 238,802,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,720,835 - 238,803,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,252,323 - 257,335,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42231,016,023 - 231,039,777 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12231,002,809 - 231,063,981 (-)NCBI
Celera2214,215,516 - 214,299,103 (-)NCBICelera
Cytogenetic Map2q43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (ISO)
17beta-estradiol  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-(hydroxymethyl)cytosine  (ISO)
5-methylcytosine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butanal  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chloroquine  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
curcumin  (ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (EXP)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
geldanamycin  (ISO)
Geniposide  (ISO)
hydrogen peroxide  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
malathion  (EXP)
methimazole  (EXP)
methylmercury chloride  (ISO)
morphine  (ISO)
N-acetyl-L-cysteine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
p-chloromercuribenzoic acid  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
permethrin  (EXP)
potassium chromate  (ISO)
propanal  (ISO)
SB 431542  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
succimer  (ISO)
sulfadimethoxine  (EXP)
tetrachloro-1,4-benzoquinone  (ISO)
tetrachlorohydroquinone  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
triptonide  (ISO)
uranium atom  (EXP)
urethane  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
chromosome  (IEA)
nucleus  (IBA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Expression Patterns for TETs, LGR5 and BMI1 in Cancer Stem-like Cells Isolated from Human Colon Cancer. Atlasy N, etal., Avicenna J Med Biotechnol. 2019 Apr-Jun;11(2):156-161.
2. Demethylation of the RB1 promoter concomitant with reactivation of TET2 and TET3 impairs gastric carcinogenesis in K19-Wnt1/C2mE transgenic mice. Cao D, etal., Life Sci. 2020 Dec 15;263:118580. doi: 10.1016/j.lfs.2020.118580. Epub 2020 Oct 12.
3. Cancer epigenetics: from mechanism to therapy. Dawson MA and Kouzarides T, Cell. 2012 Jul 6;150(1):12-27. doi: 10.1016/j.cell.2012.06.013.
4. FISH analysis for TET2 deletion in a cohort of 362 Brazilian myeloid malignancies: correlation with karyotype abnormalities. de Oliveira FM, etal., Med Oncol. 2013 Mar;30(1):483. doi: 10.1007/s12032-013-0483-1. Epub 2013 Feb 7.
5. Playing TETris with DNA modifications. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
6. LncRNA-ANRIL promotes gastric cancer progression by enhancing NF-kB signaling. Deng W, etal., Exp Biol Med (Maywood). 2019 Sep;244(12):953-959. doi: 10.1177/1535370219860207. Epub 2019 Jun 26.
7. TET2 regulates LncRNA-ANRIL expression and inhibits the growth of human gastric cancer cells. Deng W, etal., IUBMB Life. 2016 May;68(5):355-64. doi: 10.1002/iub.1490. Epub 2016 Mar 29.
8. Characteristic profiles of DNA epigenetic modifications in colon cancer and its predisposing conditions-benign adenomas and inflammatory bowel disease. Dziaman T, etal., Clin Epigenetics. 2018 May 30;10:72. doi: 10.1186/s13148-018-0505-0. eCollection 2018.
9. DNA methylation of immune checkpoints in the peripheral blood of breast and colorectal cancer patients. Elashi AA, etal., Oncoimmunology. 2018 Nov 10;8(2):e1542918. doi: 10.1080/2162402X.2018.1542918. eCollection 2019.
10. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. Loss of nuclear localization of TET2 in colorectal cancer. Huang Y, etal., Clin Epigenetics. 2016 Jan 26;8:9. doi: 10.1186/s13148-016-0176-7. eCollection 2016.
12. Trichloroethylene-induced gene expression and DNA methylation changes in B6C3F1 mouse liver. Jiang Y, etal., PLoS One. 2014 Dec 30;9(12):e116179. doi: 10.1371/journal.pone.0116179. eCollection 2014.
13. FGFR3â–³7-9 promotes tumor progression via the phosphorylation and destabilization of ten-eleven translocation-2 in human hepatocellular carcinoma. Jin Z, etal., Cell Death Dis. 2020 Oct 23;11(10):903. doi: 10.1038/s41419-020-03089-2.
14. Loss of 5-hydroxymethylcytosine and TET2 in oral squamous cell carcinoma. Jäwert F, etal., Anticancer Res. 2013 Oct;33(10):4325-8.
15. Decrease of 5-hydroxymethylcytosine in rat liver with subchronic exposure to genotoxic carcinogens riddelliine and aristolochic acid. Lian CG, etal., Mol Carcinog. 2014 Aug 23. doi: 10.1002/mc.22201.
16. Global DNA 5-Hydroxymethylcytosine and 5-Formylcytosine Contents Are Decreased in the Early Stage of Hepatocellular Carcinoma. Liu J, etal., Hepatology. 2019 Jan;69(1):196-208. doi: 10.1002/hep.30146. Epub 2018 Dec 17.
17. STAT5 and TET2 Cooperate to Regulate FOXP3-TSDR Demethylation in CD4+ T Cells of Patients with Colorectal Cancer. Ma H, etal., J Immunol Res. 2018 Jun 14;2018:6985031. doi: 10.1155/2018/6985031. eCollection 2018.
18. TET family proteins and 5-hydroxymethylcytosine in esophageal squamous cell carcinoma. Murata A, etal., Oncotarget. 2015 Sep 15;6(27):23372-82.
19. Concurrent loss of Ezh2 and Tet2 cooperates in the pathogenesis of myelodysplastic disorders. Muto T, etal., J Exp Med. 2013 Nov 18;210(12):2627-39. doi: 10.1084/jem.20131144. Epub 2013 Nov 11.
20. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
21. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
22. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
23. Comprehensive gene review and curation RGD comprehensive gene curation
24. Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. Saint-Martin C, etal., Blood. 2009 Aug 20;114(8):1628-32. doi: 10.1182/blood-2009-01-197525. Epub 2009 Jun 29.
25. Genomic Landscape of Esophageal Squamous Cell Carcinoma in a Japanese Population. Sawada G, etal., Gastroenterology. 2016 May;150(5):1171-1182. doi: 10.1053/j.gastro.2016.01.035. Epub 2016 Feb 10.
26. Ten-eleven-translocation 2 (TET2) is downregulated in myelodysplastic syndromes. Scopim-Ribeiro R, etal., Eur J Haematol. 2015 May;94(5):413-8. doi: 10.1111/ejh.12445. Epub 2014 Oct 1.
27. Loss of 5-Hydroxymethylcytosine Is an Independent Unfavorable Prognostic Factor for Esophageal Squamous Cell Carcinoma. Shi X, etal., PLoS One. 2016 Apr 6;11(4):e0153100. doi: 10.1371/journal.pone.0153100. eCollection 2016.
28. Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low-abundance mutant clones with early origins, but indicates no definite prognostic value. Smith AE, etal., Blood. 2010 Nov 11;116(19):3923-32. doi: 10.1182/blood-2010-03-274704. Epub 2010 Aug 6.
29. TET2, ASXL1 and EZH2 mutations in Chinese with myelodysplastic syndromes. Wang J, etal., Leuk Res. 2013 Mar;37(3):305-11. doi: 10.1016/j.leukres.2012.10.004. Epub 2012 Oct 23.
30. The TET2/E-cadherin/β-catenin regulatory loop confers growth and invasion in hepatocellular carcinoma cells. Yang G, etal., Exp Cell Res. 2018 Feb 15;363(2):218-226. doi: 10.1016/j.yexcr.2018.01.011. Epub 2018 Jan 10.
31. TET2 suppresses nasopharyngeal carcinoma progression by inhibiting glycolysis metabolism. Zhang X, etal., Cancer Cell Int. 2020 Aug 3;20:363. doi: 10.1186/s12935-020-01456-9. eCollection 2020.
32. Association of molecular characteristics with survival in advanced non-small cell lung cancer patients treated with checkpoint inhibitors. Zhao D, etal., Lung Cancer. 2020 Aug;146:174-181. doi: 10.1016/j.lungcan.2020.05.025. Epub 2020 May 24.
Additional References at PubMed
PMID:18288583   PMID:19372391   PMID:20639862   PMID:21057493   PMID:21723200   PMID:21723201   PMID:21778364   PMID:21803851   PMID:21817016   PMID:21873190   PMID:23222540   PMID:23353889  
PMID:24315485   PMID:35016888  


Genomics

Comparative Map Data
Tet2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82224,662,654 - 224,746,819 (-)NCBIGRCr8
mRatBN7.22221,988,645 - 222,072,813 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2221,988,645 - 222,072,534 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.02238,719,389 - 238,802,975 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2238,720,835 - 238,803,024 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02257,252,323 - 257,335,750 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42231,016,023 - 231,039,777 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12231,002,809 - 231,063,981 (-)NCBI
Celera2214,215,516 - 214,299,103 (-)NCBICelera
Cytogenetic Map2q43NCBI
TET2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384105,145,875 - 105,279,803 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4105,145,875 - 105,279,816 (+)EnsemblGRCh38hg38GRCh38
GRCh374106,067,032 - 106,200,960 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364106,287,392 - 106,383,377 (+)NCBINCBI36Build 36hg18NCBI36
Celera4103,367,233 - 103,500,234 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4101,802,173 - 101,936,091 (+)NCBIHuRef
CHM1_14106,044,130 - 106,178,054 (+)NCBICHM1_1
T2T-CHM13v2.04108,456,807 - 108,590,746 (+)NCBIT2T-CHM13v2.0
Tet2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393133,169,438 - 133,250,882 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3133,169,440 - 133,250,900 (-)EnsemblGRCm39 Ensembl
GRCm383133,463,677 - 133,545,136 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3133,463,679 - 133,545,139 (-)EnsemblGRCm38mm10GRCm38
MGSCv373133,126,641 - 133,207,354 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363133,400,983 - 133,426,624 (-)NCBIMGSCv36mm8
Celera3139,886,715 - 139,967,658 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map361.84NCBI
Tet2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554963,885,035 - 3,926,106 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554963,885,684 - 3,963,056 (-)NCBIChiLan1.0ChiLan1.0
TET2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23103,232,771 - 103,365,873 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14103,525,110 - 103,658,251 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0497,612,439 - 97,745,544 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14108,225,209 - 108,358,400 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4108,269,082 - 108,358,400 (+)Ensemblpanpan1.1panPan2
TET2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13226,021,745 - 26,145,109 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3226,059,693 - 26,143,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3215,878,947 - 16,004,016 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03226,234,028 - 26,359,107 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3226,233,933 - 26,357,310 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13226,252,220 - 26,377,230 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03225,996,769 - 26,121,941 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03213,740,508 - 13,865,760 (-)NCBIUU_Cfam_GSD_1.0
Tet2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530115,030,779 - 15,167,846 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936752440,136 - 577,615 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936752440,137 - 577,339 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TET2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8116,415,267 - 116,545,299 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18116,413,253 - 116,546,976 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28125,007,902 - 125,139,465 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TET2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1753,193,824 - 53,326,813 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl753,193,941 - 53,326,942 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603731,808,498 - 31,945,648 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tet2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248303,446,141 - 3,519,084 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248303,446,331 - 3,543,450 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Tet2
512 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:130
Count of miRNA genes:61
Interacting mature miRNAs:65
Transcripts:ENSRNOT00000046775, ENSRNOT00000071991
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat

Markers in Region
BF399911  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22222,003,891 - 222,004,008 (+)MAPPERmRatBN7.2
Rnor_6.02238,734,624 - 238,734,740NCBIRnor6.0
Rnor_5.02257,267,558 - 257,267,674UniSTSRnor5.0
RGSC_v3.42231,028,266 - 231,028,382UniSTSRGSC3.4
Celera2214,230,763 - 214,230,879UniSTS
RH 3.4 Map21554.7UniSTS
Cytogenetic Map2q43UniSTS
Tet2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22222,000,938 - 222,001,041 (+)MAPPERmRatBN7.2
Rnor_6.02238,731,671 - 238,731,773NCBIRnor6.0
Rnor_5.02257,264,605 - 257,264,707UniSTSRnor5.0
Celera2214,227,810 - 214,227,912UniSTS
Cytogenetic Map2q43UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000046775   ⟹   ENSRNOP00000048956
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2221,988,645 - 222,072,534 (-)Ensembl
Rnor_6.0 Ensembl2238,720,835 - 238,803,024 (-)Ensembl
RefSeq Acc Id: NM_001427557   ⟹   NP_001414486
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,662,654 - 224,746,186 (-)NCBI
RefSeq Acc Id: XM_006233347   ⟹   XP_006233409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,662,654 - 224,746,808 (-)NCBI
mRatBN7.22221,988,645 - 222,072,811 (-)NCBI
Rnor_6.02238,719,389 - 238,802,975 (-)NCBI
Rnor_5.02257,252,323 - 257,335,750 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008761534   ⟹   XP_008759756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,662,654 - 224,746,809 (-)NCBI
mRatBN7.22221,988,645 - 222,072,812 (-)NCBI
Rnor_6.02238,719,389 - 238,802,975 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063281965   ⟹   XP_063138035
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,662,654 - 224,746,807 (-)NCBI
RefSeq Acc Id: XM_063281966   ⟹   XP_063138036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,674,906 - 224,746,819 (-)NCBI
RefSeq Acc Id: XR_010063615
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,674,906 - 224,746,819 (-)NCBI
RefSeq Acc Id: XR_010063616
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82224,674,906 - 224,746,819 (-)NCBI
RefSeq Acc Id: XP_006233409   ⟸   XM_006233347
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_008759756   ⟸   XM_008761534
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000048956   ⟸   ENSRNOT00000046775
RefSeq Acc Id: XP_063138035   ⟸   XM_063281965
- Peptide Label: isoform X3
RefSeq Acc Id: NP_001414486   ⟸   NM_001427557
- UniProtKB: D4AC33 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138036   ⟸   XM_063281966
- Peptide Label: isoform X4
Protein Domains
Methylcytosine dioxygenase TET1-3 oxygenase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4AC33-F1-model_v2 AlphaFold D4AC33 1-1920 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691783
Promoter ID:EPDNEW_R2291
Type:multiple initiation site
Name:Tet2_1
Description:tet methylcytosine dioxygenase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02238,802,904 - 238,802,964EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311625 AgrOrtholog
BioCyc Gene G2FUF-51161 BioCyc
Ensembl Genes ENSRNOG00000023579 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000046775.6 UniProtKB/TrEMBL
InterPro 2OGFeDO_nucleic_acid_mod UniProtKB/TrEMBL
  TET1/2/3 UniProtKB/TrEMBL
  TET_oxygenase UniProtKB/TrEMBL
NCBI Gene 310859 ENTREZGENE
PANTHER METHYLCYTOSINE DIOXYGENASE TET2 UniProtKB/TrEMBL
  PTHR23358 UniProtKB/TrEMBL
Pfam Tet_JBP UniProtKB/TrEMBL
PhenoGen Tet2 PhenoGen
RatGTEx ENSRNOG00000023579 RatGTEx
SMART Tet_JBP UniProtKB/TrEMBL
UniProt D4AC33 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-10-18 Tet2  tet methylcytosine dioxygenase 2  Tet2  tet oncogene family member 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-04-23 Tet2  tet oncogene family member 2  RGD1311625  similar to KIAA1546 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1311625  similar to KIAA1546 protein   RGD1311625_predicted  similar to KIAA1546 protein (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-20 RGD1311625_predicted  similar to KIAA1546 protein (predicted)  LOC310859_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC310859_predicted  similar to KIAA1546 protein (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL