Tacr3 (tachykinin receptor 3) - Rat Genome Database

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Gene: Tacr3 (tachykinin receptor 3) Rattus norvegicus
Analyze
Symbol: Tacr3
Name: tachykinin receptor 3
RGD ID: 3810
Description: Enables tachykinin receptor activity. Involved in several processes, including conditioned place preference; positive regulation of luteinizing hormone secretion; and positive regulation of uterine smooth muscle contraction. Located in axon terminus; dendritic spine; and neuronal cell body membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; and hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: neurokinin B receptor; neuromedin K receptor; neuromedin K receptor (neurokinin B/tachikin 3); neuromedin-K receptor; NK-3 receptor; NK-3R; Nkr; Nmkr; Tac3r; tachikin receptor 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Eau5
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82225,940,497 - 226,037,756 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2225,940,444 - 226,037,756 (+)EnsemblGRCr8
mRatBN7.22223,266,536 - 223,363,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2223,266,536 - 223,363,791 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2230,969,011 - 231,055,530 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02228,868,726 - 228,955,238 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02223,733,543 - 223,820,045 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,021,152 - 240,118,971 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,021,152 - 240,118,971 (+)Ensemblrn6Rnor6.0
Rnor_5.02258,547,661 - 258,644,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42232,309,015 - 232,404,964 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2215,485,216 - 215,569,645 (+)NCBICelera
RGSC_v3.12232,295,754 - 232,391,704 (+)NCBI
Cytogenetic Map2q43NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Neurokinin-3 receptors modulate dopamine cell function and alter the effects of 6-hydroxydopamine. Bannon MJ, etal., Brain Res. 1995 Oct 9;695(1):19-24.
2. Evidence for mediation of nociception by injection of the NK-3 receptor agonist, senktide, into the dorsal periaqueductal gray of rats. Bassi GS, etal., Psychopharmacology (Berl). 2008 Dec 18.
3. Stimulation of tachykinin NK-3 receptors in the nucleus basalis magnocellularis reduces alcohol intake in rats. Ciccocioppo R, etal., Peptides. 1997;18(9):1349-55. doi: 10.1016/s0196-9781(97)00189-7.
4. Mechanism of action for reduction of ethanol intake in rats by the tachykinin NK-3 receptor agonist aminosenktide. Ciccocioppo R, etal., Pharmacol Biochem Behav. 1998 Dec;61(4):459-64. doi: 10.1016/s0091-3057(98)00090-2.
5. Estrogen-dependent regulation of neurokinin 3 receptor-mediated uterine contractility in the rat. Crane LH, etal., Biol Reprod. 2002 Nov;67(5):1480-7.
6. Localization of the neuromedin K receptor (NK3) in the central nervous system of the rat. Ding YQ, etal., J Comp Neurol. 1996 Jan 8;364(2):290-310.
7. The tachykinin receptor 3 is associated with alcohol and cocaine dependence. Foroud T, etal., Alcohol Clin Exp Res. 2008 Jun;32(6):1023-30. doi: 10.1111/j.1530-0277.2008.00663.x. Epub 2008 Apr 15.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
10. Agonist and hypertonic saline-induced trafficking of the NK3-receptors on vasopressin neurons within the paraventricular nucleus of the hypothalamus. Haley GE and Flynn FW, Am J Physiol Regul Integr Comp Physiol. 2006 May;290(5):R1242-50. Epub 2005 Dec 15.
11. Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension. Haley GE and Flynn FW, Am J Physiol Regul Integr Comp Physiol. 2008 Oct;295(4):R1158-67. Epub 2008 Jul 23.
12. Characterization of ligand-binding properties and selectivities of three rat tachykinin receptors by transfection and functional expression of their cloned cDNAs in mammalian cells. Ingi T, etal., J Pharmacol Exp Ther. 1991 Dec;259(3):968-75.
13. Trafficking of tachykinin neurokinin 3 receptor to nuclei of neurons in the paraventricular nucleus of the hypothalamus following osmotic challenge. Jensen D, etal., Neuroscience. 2008 Jul 31;155(1):308-16. Epub 2008 May 24.
14. Neurokinin 3 receptor activation potentiates the psychomotor and nucleus accumbens dopamine response to cocaine, but not its place conditioning effects. Jocham G, etal., Eur J Neurosci. 2007 Apr;25(8):2457-72.
15. Neurokinin B receptor antagonism decreases luteinising hormone pulse frequency and amplitude and delays puberty onset in the female rat. Li SY, etal., J Neuroendocrinol. 2014 Aug;26(8):521-7. doi: 10.1111/jne.12167.
16. Time-dependent changes in neurokinin(3) receptors and tachykinins during adjuvant-induced peripheral inflammation in the rat. Linden DR, etal., Neuroscience. 2000;98(4):801-11.
17. The tachykinin NH2-senktide, a selective neurokinin B receptor agonist, is a very potent inhibitor of salt appetite in the rat. Massi M, etal., Neurosci Lett. 1988 Oct 17;92(3):341-6.
18. The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration. McCarson KE and Krause JE, Neuroscience. 1995 Feb;64(3):729-39.
19. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
20. Age and species-dependent differences in the neurokinin B system in rat and human brain. Mileusnic D, etal., Neurobiol Aging. 1999 Jan-Feb;20(1):19-35.
21. Cardiovascular roles of tachykinin peptides in the nucleus tractus solitarii of rats. Nagashima A, etal., Brain Res. 1989 May 22;487(2):392-6.
22. Central pressor actions of neurokinin B: increases in neurokinin B contents in discrete nuclei in spontaneously hypertensive rats. Nagashima A, etal., Brain Res. 1989 Oct 9;499(1):198-203.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
25. Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment. Pinto FM, etal., Endocrinology. 1999 Jun;140(6):2526-32.
26. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
27. Application of taste reactivity to study the mechanism of alcohol intake inhibition by the tachykinin aminosenktide. Polidori C, etal., Peptides. 1998;19(9):1557-64. doi: 10.1016/s0196-9781(98)00112-0.
28. GOA pipeline RGD automated data pipeline
29. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
30. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
31. Kainic acid induced seizures cause a marked increase in the expression of neurokinin-3 receptor mRNA in the rat cerebellum. Roder C, etal., Neurosci Lett. 1994 Nov 7;181(1-2):158-60.
32. The third intracellular loop and carboxyl tail of neurokinin 1 and 3 receptors determine interactions with beta-arrestins. Schmidlin F, etal., Am J Physiol Cell Physiol 2003 Oct;285(4):C945-58.
33. Cloning and expression of a rat neuromedin K receptor cDNA. Shigemoto R, etal., J Biol Chem 1990 Jan 15;265(2):623-8.
34. Immunoelectron microscopic localization of NK-3 receptor in the rat spinal cord. Zerari F, etal., Neuroreport. 1997 Aug 18;8(12):2661-4. doi: 10.1097/00001756-199708180-00005.
35. Prenatal Exposure to Methamphetamine: Up-Regulation of Brain Receptor Genes. Zoubková H, etal., Front Neurosci. 2019 Aug 1;13:771. doi: 10.3389/fnins.2019.00771. eCollection 2019.
Additional References at PubMed
PMID:15121234   PMID:15537880   PMID:16025449   PMID:17197098   PMID:17437961   PMID:17522129   PMID:19224600   PMID:20709160   PMID:21045176   PMID:21166923   PMID:21697521   PMID:21939739  
PMID:22762252   PMID:22985858   PMID:23150555   PMID:23983264   PMID:24708241   PMID:25825817   PMID:26851555   PMID:30207304  


Genomics

Comparative Map Data
Tacr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82225,940,497 - 226,037,756 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2225,940,444 - 226,037,756 (+)EnsemblGRCr8
mRatBN7.22223,266,536 - 223,363,791 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2223,266,536 - 223,363,791 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2230,969,011 - 231,055,530 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02228,868,726 - 228,955,238 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02223,733,543 - 223,820,045 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02240,021,152 - 240,118,971 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,021,152 - 240,118,971 (+)Ensemblrn6Rnor6.0
Rnor_5.02258,547,661 - 258,644,112 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42232,309,015 - 232,404,964 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2215,485,216 - 215,569,645 (+)NCBICelera
RGSC_v3.12232,295,754 - 232,391,704 (+)NCBI
Cytogenetic Map2q43NCBI
TACR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384103,586,031 - 103,719,985 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4103,586,031 - 103,719,985 (-)Ensemblhg38GRCh38
GRCh374104,507,188 - 104,641,142 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364104,730,074 - 104,860,422 (-)NCBIBuild 36Build 36hg18NCBI36
Build 344104,868,228 - 104,998,577NCBI
Celera4101,809,125 - 101,939,478 (-)NCBICelera
Cytogenetic Map4q24NCBI
HuRef4100,245,509 - 100,375,866 (-)NCBIHuRef
CHM1_14104,487,252 - 104,617,580 (-)NCBICHM1_1
T2T-CHM13v2.04106,897,954 - 107,031,922 (-)NCBIT2T-CHM13v2.0
Tacr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393134,534,768 - 134,640,342 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3134,534,768 - 134,640,340 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383134,829,007 - 134,934,581 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3134,829,007 - 134,934,579 (+)Ensemblmm10GRCm38
MGSCv373134,491,971 - 134,597,545 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363134,766,394 - 134,871,959 (+)NCBIMGSCv36mm8
Celera3141,238,671 - 141,345,575 (+)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.47NCBI
Tacr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,151,668 - 5,222,624 (+)Ensembl
ChiLan1.0NW_0049554965,152,134 - 5,222,565 (+)NCBIChiLan1.0ChiLan1.0
TACR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23101,649,480 - 101,782,419 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14101,936,181 - 102,074,800 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0496,022,788 - 96,162,249 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14106,644,943 - 106,776,172 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4106,644,943 - 106,776,172 (-)EnsemblpanPan2panpan1.1
TACR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13224,812,344 - 24,888,452 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3224,812,119 - 24,907,580 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3217,136,602 - 17,213,041 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03225,029,113 - 25,105,792 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3225,028,888 - 25,106,462 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13225,048,235 - 25,126,781 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03224,791,973 - 24,868,622 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03214,994,194 - 15,070,872 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
TACR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8117,662,122 - 117,721,613 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18117,662,122 - 117,718,317 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28126,511,759 - 126,570,636 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TACR3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1751,662,248 - 51,764,058 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl751,665,147 - 51,762,390 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603730,211,968 - 30,313,605 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tacr3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248304,635,987 - 4,704,251 (+)NCBIHetGla 1.0HetGla 1.0hetGla2

Variants

.
Variants in Tacr3
799 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:48
Interacting mature miRNAs:51
Transcripts:ENSRNOT00000012473
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301408Kidm36Kidney mass QTL 360.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2190613715226808892Rat
1598813Memor9Memory QTL 92.7exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2199341726234244620Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2217139753236660713Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2211744537249053267Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
2298479Eau5Experimental allergic uveoretinitis QTL 50.0021uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)2202446871237938339Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2214226044247136170Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2211744537249053267Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2215377404237938339Rat
738013Alc15Alcohol consumption QTL 154.10.00022consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)2184165752229165752Rat
61398Bp50Blood pressure QTL 504.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2189599258234599258Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2211744537249053267Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2193452645245889826Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2211744537249053267Rat
2317885Alcrsp28Alcohol response QTL 282.10.63response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2212828222249053267Rat
1581499Esta2Estrogen-induced thymic atrophy QTL 2thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2189599258226936289Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2218414747240841241Rat
9589044Scfw1Subcutaneous fat weight QTL 15.80.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)2182171407227171407Rat
8694435Bw166Body weight QTL 16614.080.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)2182171407227171407Rat
61417Cia10Collagen induced arthritis QTL 103.4joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)2179946951224946951Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
8694383Bw158Body weight QTL 1587.690.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)2182171407227171407Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2200990457245990457Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2211744537249053267Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2221136523241305619Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
8694194Abfw1Abdominal fat weight QTL 111.70.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)2182171407227171407Rat
61366Iddm3Insulin dependent diabetes mellitus QTL 34.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2189599258234599258Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2219753301247136170Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
2300189Bmd48Bone mineral density QTL 485.80.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)2179335906224335906Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1359019Hrtrt19Heart rate QTL 192.9heart pumping trait (VT:2000009)heart rate (CMO:0000002)2219753301226277316Rat

Markers in Region
D2Rat64  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22223,265,204 - 223,265,385 (+)MAPPERmRatBN7.2
Rnor_6.02240,019,821 - 240,020,001NCBIRnor6.0
Rnor_5.02258,546,330 - 258,546,510UniSTSRnor5.0
RGSC_v3.42232,307,684 - 232,307,864UniSTSRGSC3.4
RGSC_v3.42232,307,683 - 232,307,864RGDRGSC3.4
Celera2215,483,885 - 215,484,065UniSTS
RGSC_v3.12232,294,423 - 232,294,604RGD
RH 3.4 Map21547.0RGD
RH 3.4 Map21547.0UniSTS
RH 2.0 Map21118.5RGD
SHRSP x BN Map295.4298RGD
FHH x ACI Map2110.7298RGD
Cytogenetic Map2q42-q44UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
9 9 52 126 60 54 32 18 32 4 191 91 4 105 51 77 22 14 14

Sequence


Ensembl Acc Id: ENSRNOT00000012473   ⟹   ENSRNOP00000012473
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2225,940,444 - 226,037,756 (+)Ensembl
mRatBN7.2 Ensembl2223,266,536 - 223,363,791 (+)Ensembl
Rnor_6.0 Ensembl2240,021,152 - 240,118,971 (+)Ensembl
RefSeq Acc Id: NM_017053   ⟹   NP_058749
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82225,940,497 - 226,037,756 (+)NCBI
mRatBN7.22223,266,536 - 223,363,791 (+)NCBI
Rnor_6.02240,021,152 - 240,118,971 (+)NCBI
Rnor_5.02258,547,661 - 258,644,112 (+)NCBI
RGSC_v3.42232,309,015 - 232,404,964 (+)RGD
Celera2215,485,216 - 215,569,645 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_058749 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41688 (Get FASTA)   NCBI Sequence Viewer  
  EDL82245 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000012473
  ENSRNOP00000012473.2
GenBank Protein P16177 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_058749   ⟸   NM_017053
- UniProtKB: P16177 (UniProtKB/Swiss-Prot),   A6HVV9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000012473   ⟸   ENSRNOT00000012473
Protein Domains
G-protein coupled receptors family 1 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P16177-F1-model_v2 AlphaFold P16177 1-452 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3810 AgrOrtholog
BioCyc Gene G2FUF-51147 BioCyc
Ensembl Genes ENSRNOG00000009372 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000012473 ENTREZGENE
  ENSRNOT00000012473.3 UniProtKB/Swiss-Prot
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Neurokn_rcpt UniProtKB/Swiss-Prot
  NK3_rcpt UniProtKB/Swiss-Prot
KEGG Report rno:24808 UniProtKB/Swiss-Prot
NCBI Gene 24808 ENTREZGENE
PANTHER G-PROTEIN COUPLED RECEPTOR TKR-1-RELATED UniProtKB/Swiss-Prot
  NEUROMEDIN-K RECEPTOR UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PhenoGen Tacr3 PhenoGen
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  NEUROKININ3R UniProtKB/Swiss-Prot
  NEUROKININR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009372 RatGTEx
SMART 7TM_GPCR_Srsx UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot
UniProt A6HVV9 ENTREZGENE, UniProtKB/TrEMBL
  NK3R_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Tacr3  tachykinin receptor 3    tachikin receptor 3  Name updated 1299863 APPROVED
2002-06-10 Tacr3  tachikin receptor 3      Symbol and Name status set to approved 70586 APPROVED
2000-11-11 Tac3r  Neuromedin K receptor (Neurokinin B/Tachikin 3)      Symbol and name withdrawn 61478 WITHDRAWN
2000-11-11 Tacr3  Tachikin receptor 3      Symbol and name updated 61478 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in brain and peripheral tissues 68907
gene_product member of the seven transmembrane domain superfamily of G protein coupled receptors 68907
gene_protein predicted protein consists of 452 aa residues 68907