Enables tachykinin receptor activity. Involved in several processes, including conditioned place preference; positive regulation of luteinizing hormone secretion; and positive regulation of uterine smooth muscle contraction. Located in axon terminus; dendritic spine; and neuronal cell body membrane. Used to study hypertension. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; and hypogonadotropic hypogonadism 11 with or without anosmia. Orthologous to human TACR3 (tachykinin receptor 3); PARTICIPATES IN calcium/calcium-mediated signaling pathway; INTERACTS WITH 3,4-methylenedioxymethamphetamine; 6-propyl-2-thiouracil; ammonium chloride.
Blockade of NK3R signaling in the PVN decreases vasopressin and oxytocin release and c-Fos expression in the magnocellular neurons in response to hypotension.
Characterization of ligand-binding properties and selectivities of three rat tachykinin receptors by transfection and functional expression of their cloned cDNAs in mammalian cells.
Neurokinin 3 receptor activation potentiates the psychomotor and nucleus accumbens dopamine response to cocaine, but not its place conditioning effects.
The formalin-induced expression of tachykinin peptide and neurokinin receptor messenger RNAs in rat sensory ganglia and spinal cord is modulated by opiate preadministration.
Tachykinin receptor and neutral endopeptidase gene expression in the rat uterus: characterization and regulation in response to ovarian steroid treatment.