NFKB1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: NFKB1 (nuclear factor kappa B subunit 1) Homo sapiens
Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
RGD ID: 730892
Description: Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; actinin binding activity; and transcription coactivator binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to mechanical stimulus; and regulation of RNA metabolic process. Acts upstream of or within cellular response to lipopolysaccharide. Located in cytosol; mitochondrion; and nucleus. Implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency; melanoma; prostate cancer; and tropical spastic paraparesis. Biomarker of lung cancer; lung non-small cell carcinoma; pancreatic adenocarcinoma; and stomach cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: CVID12; DKFZp686C01211; DNA binding factor KBF1; DNA-binding factor KBF1; EBP-1; KBF1; MGC54151; NF-kappa-B; NF-kappa-B1; NF-kappaB; NF-kappabeta; NF-kB; NF-kB1; NFkappaB; NFKB-p105; NFKB-p50; nuclear factor kappa-B DNA binding subunit; nuclear factor NF-kappa-B p105 subunit; nuclear factor NF-kappa-B p50 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; p105; p50
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh384102,501,359 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4102,501,331 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBI
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
T2T-CHM13v2.04105,815,285 - 105,931,246 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (EXP)
(-)-epigallocatechin 3-gallate  (EXP)
(20S)-ginsenoside Rg3  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (EXP)
(E)-roxithromycin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (EXP,ISO)
(R)-mevalonic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (EXP,ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1,3-benzothiazole-2-thiol  (EXP)
1,4-dithiothreitol  (EXP,ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (ISO)
2,4-dinitrobenzenesulfonic acid  (EXP)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (ISO)
2-deoxy-D-glucose  (EXP)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (EXP)
2-methylcholine  (EXP)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
3-nitropropanoic acid  (ISO)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-aminobenzoic acid  (EXP)
4-hydroxy-17beta-estradiol  (EXP)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitrotoluene  (ISO)
4-octylphenol  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (EXP)
5-Hydroxycapric acid  (EXP)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (ISO)
7-ketocholesterol  (EXP,ISO)
7H-xanthine  (ISO)
9-cis,11-trans-octadecadienoic acid  (ISO)
9H-xanthine  (ISO)
[6]-Shogaol  (ISO)
abamectin  (ISO)
acenaphthoquinone  (EXP)
acetaldehyde  (EXP,ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (EXP,ISO)
Actein  (ISO)
actinomycin D  (EXP)
afatinib  (EXP)
aflatoxin B1  (EXP,ISO)
AH23848  (EXP)
AICA ribonucleotide  (ISO)
alachlor  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-amanitin  (ISO)
alpha-D-galactose  (ISO)
aluminium sulfate (anhydrous)  (EXP)
amiloride  (EXP)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (EXP)
amphibole asbestos  (EXP)
anethole  (EXP)
Anetholtrithion  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (EXP)
apigenin  (EXP,ISO)
aripiprazole  (EXP)
Aroclor 1254  (EXP)
arsane  (EXP,ISO)
arsenic atom  (EXP,ISO)
arsenite(3-)  (EXP)
arsenous acid  (EXP,ISO)
atrazine  (EXP,ISO)
aurantio-obtusin  (ISO)
azadirachtin A  (EXP)
B 581  (EXP)
baicalein  (EXP)
bathocuproine disulfonic acid  (EXP)
belinostat  (EXP)
benazepril  (ISO)
benomyl  (ISO)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (ISO)
beryllium sulfate  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (EXP)
beta-ionone  (ISO)
bezafibrate  (ISO)
bis(2-chloroethyl) sulfide  (EXP)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bleomycin A2  (ISO)
boric acid  (EXP)
bortezomib  (EXP)
butane-2,3-dione  (EXP)
butein  (EXP)
butyric acid  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (ISO)
cannabidiol  (EXP,ISO)
capsaicin  (EXP)
capsazepine  (ISO)
carbamazepine  (EXP)
carbaryl  (ISO)
carbon nanotube  (ISO)
carboplatin  (EXP,ISO)
Cardamonin  (ISO)
carmustine  (EXP,ISO)
carvacrol  (ISO)
casticin  (EXP)
celecoxib  (EXP)
cerium trichloride  (ISO)
chlordecone  (ISO)
chloroform  (EXP)
chloroquine  (EXP,ISO)
cholesterol  (ISO)
choline  (ISO)
chondroitin sulfate  (EXP)
chrysin  (ISO)
ciglitazone  (EXP)
cimetidine  (EXP)
ciprofibrate  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clonidine  (EXP)
clonidine (amino form)  (EXP)
clonidine (imino form)  (EXP)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
colforsin daropate hydrochloride  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) sulfate  (EXP)
coumestrol  (EXP)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (EXP)
curcumin  (EXP,ISO)
cycloheximide  (EXP)
cyclosporin A  (ISO)
cyfluthrin  (EXP)
cylindrospermopsin  (EXP)
cypermethrin  (EXP)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
danazol  (EXP)
decabromodiphenyl ether  (EXP)
deoxycholic acid  (EXP)
deoxynivalenol  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (EXP)
diazoxide  (EXP)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (ISO)
diclofenac  (EXP,ISO)
dicofol  (ISO)
dicoumarol  (EXP)
dieckol  (EXP)
dieldrin  (ISO)
dienogest  (EXP)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (ISO)
digitoxin  (EXP)
dihydroartemisinin  (ISO)
dihydroxyacetone  (EXP)
diltiazem  (EXP)
dimethylarsinic acid  (EXP,ISO)
dioscin  (ISO)
diosgenin  (EXP)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (EXP)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
endrin  (ISO)
erythromycin A  (ISO)
esculetin  (EXP)
ethanol  (EXP,ISO)
ethyl acetate  (EXP)
ethylene glycol  (ISO)
ethylisopropylamiloride  (EXP)
eugenol  (EXP,ISO)
Evodiamine  (EXP)
felodipine  (ISO)
fenofibrate  (EXP)
ferroheme b  (EXP)
Fexofenadine hydrochloride  (EXP)
fisetin  (EXP)
flurbiprofen  (ISO)
fluticasone  (EXP)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fosinopril  (ISO)
fucoidan  (EXP)
fulvestrant  (EXP)
gadolinium atom  (EXP)
gadolinium trichloride  (EXP,ISO)
galactose  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gastrin-17  (EXP)
gefitinib  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
gingerol  (ISO)
ginsenoside C-K  (ISO)
glafenine  (ISO)
gliotoxin  (EXP)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutathione  (EXP)
glutathione disulfide  (ISO)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (EXP,ISO)
guggulsterone  (EXP,ISO)
GW 501516  (ISO)
haloperidol  (ISO)
harmaline  (EXP)
heme b  (EXP)
hesperidin  (ISO)
hexadecanoic acid  (EXP,ISO)
histamine  (EXP)
Honokiol  (ISO)
hyaluronic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroxyurea  (EXP)
ibuprofen  (EXP,ISO)
indole-3-acetic acid  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
irbesartan  (ISO)
irinotecan  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isoeugenol  (EXP)
isoflurane  (ISO)
isoliquiritigenin  (ISO)
isoniazide  (ISO)
isoprenaline  (ISO)
isotretinoin  (ISO)
ivermectin  (EXP)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (ISO)
lanreotide  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leptomycin B  (EXP)
limonene  (ISO)
linalool  (EXP)
linoleic acid  (ISO)
lipoarabinomannan  (ISO)
lipoic acid  (EXP,ISO)
lipophosphoglycan  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium hydride  (ISO)
lonafarnib  (EXP)
losartan  (ISO)
luteolin  (EXP,ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (ISO)
manganese(II) chloride  (ISO)
mangiferin  (EXP)
Mecamylamine  (EXP,ISO)
Melarsoprol  (EXP)
melatonin  (ISO)
melittin  (EXP,ISO)
menadione  (EXP)
mercaptopurine  (EXP)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
metam  (ISO)
metformin  (EXP,ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (ISO)
methoctramine tetrahydrochloride  (ISO)
methotrexate  (EXP,ISO)
methyl salicylate  (EXP)
methylarsonic acid  (EXP)
methyllycaconitine  (ISO)
methylmercury chloride  (EXP)
methylmercury(1+)  (ISO)
methylseleninic acid  (EXP)
mevinphos  (ISO)
mifepristone  (EXP)
mono(2-ethylhexyl) phthalate  (ISO)
monodansylcadaverine  (ISO)
monosodium L-glutamate  (ISO)
monotropein  (ISO)
morphine  (ISO)
Muraglitazar  (ISO)
myo-inositol hexakisphosphate  (ISO)
Myrtucommulone A  (ISO)
N'-Nitrosonornicotine  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (EXP)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (ISO)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naproxen  (EXP)
naringin  (ISO)
Neferine  (ISO)
neoechinulin A  (ISO)
neratinib  (EXP)
neurotensin  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel sulfate  (EXP)
niclosamide  (EXP)
nicorandil  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (ISO)
nitroprusside  (EXP,ISO)
nonanoic acid  (ISO)
Nonylphenol  (EXP,ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
o-anisidine  (EXP)
obeticholic acid  (EXP,ISO)
Octachlorostyrene  (ISO)
okadaic acid  (EXP)
olanzapine  (ISO)
oleanolic acid  (EXP)
ozone  (EXP,ISO)
p-menthan-3-ol  (EXP)
p-tolualdehyde  (ISO)
paclitaxel  (EXP,ISO)
Paeonol  (ISO)
paracetamol  (ISO)
paraquat  (EXP,ISO)
parthenolide  (EXP,ISO)
PD123319  (ISO)
pentachlorophenol  (ISO)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
pergolide  (EXP)
perindopril  (ISO)
permethrin  (ISO)
pevonedistat  (EXP)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (EXP)
phenylarsine oxide  (EXP)
phenylbutazone  (EXP)
phenytoin  (EXP)
phloretin  (ISO)
phlorizin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperine  (EXP)
pirinixic acid  (ISO)
platycodin D  (EXP)
potassium chromate  (EXP)
progesterone  (EXP)
propanil  (ISO)
propionic acid  (EXP)
prostaglandin E2  (ISO)
protein kinase inhibitor  (EXP)
pterostilbene  (EXP)
puerarin  (ISO)
purine-6-thiol  (EXP)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
rebaudioside A  (ISO)
resveratrol  (EXP,ISO)
Rhein  (EXP)
ritonavir  (EXP)
rocaglamide  (EXP)
romidepsin  (EXP)
rotenone  (EXP,ISO)
ruthenium red  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
salicylates  (ISO)
sarin  (ISO)
SB 203580  (EXP,ISO)
scoparone  (EXP)
Se-methyl-L-selenocysteine  (ISO)
Se-methylselenocysteine  (ISO)
serpentine asbestos  (EXP)
sertraline  (EXP)
silicon dioxide  (EXP)
silver atom  (EXP,ISO)
silver(0)  (EXP,ISO)
simazine  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (ISO)
sirolimus  (EXP)
sodium arsenite  (EXP,ISO)
sodium chromate  (ISO)
sodium dodecyl sulfate  (EXP)
Sodium oleate  (EXP)
Sodium salicylate  (ISO)
Soman  (ISO)
sorafenib  (ISO)
staurosporine  (EXP)
sterigmatocystin  (ISO)
steviol  (ISO)
stevioside  (ISO)
streptozocin  (ISO)
succimer  (ISO)
succinic acid  (EXP)
sulfasalazine  (EXP,ISO)
sulforaphane  (EXP,ISO)
sulindac  (EXP)
sulindac sulfide  (EXP)
sunitinib  (EXP,ISO)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
telmisartan  (ISO)
terbutaline  (EXP)
teriflunomide  (EXP)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
Tetramethylthiourea  (EXP)
thalidomide  (EXP,ISO)
theophylline  (EXP)
thioacetamide  (ISO)
thiostrepton  (EXP)
thiram  (EXP)
Tiron  (EXP)
titanium dioxide  (EXP)
trans-anethole  (EXP)
trans-isoeugenol  (EXP)
tributylstannane  (ISO)
Tributyltin oxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
troglitazone  (EXP,ISO)
Tropicamide  (ISO)
urethane  (ISO)
ursodeoxycholic acid  (EXP,ISO)
ursolic acid  (ISO)
valproic acid  (EXP,ISO)
vanadyl sulfate  (EXP)
vancomycin  (ISO)
venom  (EXP)
vitamin E  (EXP)
vorinostat  (EXP)
wortmannin  (ISO)
WR-1065  (EXP)
xanthohumol  (EXP)
Y-27632  (EXP)
zerumbone  (EXP)
zinc atom  (EXP,ISO)
zinc dichloride  (EXP)
zinc molecular entity  (EXP)
zinc oxide  (ISO)
zinc protoporphyrin  (ISO)
zinc pyrithione  (EXP)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)
zineb  (EXP)
zingerone  (ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
cellular response to angiotensin  (IMP)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to diterpene  (ISO)
cellular response to dsRNA  (IEA,ISO)
cellular response to glucoside  (ISO)
cellular response to interleukin-1  (IEP,ISO)
cellular response to interleukin-6  (IMP)
cellular response to lipopolysaccharide  (IEA,IMP,ISO)
cellular response to mechanical stimulus  (IEP)
cellular response to nicotine  (IMP)
cellular response to organic cyclic compound  (ISO)
cellular response to peptide  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to virus  (IEA)
gene expression  (IEA)
inflammatory response  (TAS)
JNK cascade  (IEA)
leukocyte migration involved in inflammatory response  (ISO)
mammary gland involution  (IEA)
MAPK cascade  (IEA)
negative regulation of apoptotic process  (ISO,TAS)
negative regulation of calcidiol 1-monooxygenase activity  (IDA)
negative regulation of cholesterol transport  (IC)
negative regulation of cytokine production  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IDA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of protein metabolic process  (IC)
negative regulation of transcription by RNA polymerase II  (IC,IGI,IMP)
negative regulation of vitamin D biosynthetic process  (IC)
positive regulation of canonical Wnt signaling pathway  (IMP)
positive regulation of DNA-templated transcription  (IDA,IMP,NAS)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (IDA)
positive regulation of lipid storage  (IC)
positive regulation of macrophage derived foam cell differentiation  (IC)
positive regulation of miRNA metabolic process  (IMP)
positive regulation of miRNA transcription  (ISO)
positive regulation of miRNA-mediated gene silencing  (ISO)
positive regulation of transcription by RNA polymerase II  (IC,IDA,IEA,IMP)
regulation of DNA-templated transcription  (IEA)
regulation of gene expression  (IEA)
regulation of transcription by RNA polymerase II  (IBA,IEA)
regulation of type I interferon production  (IEA)
response to bacterium  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)
transcription by RNA polymerase II  (TAS)

Cellular Component


References - curated
# Reference Title Reference Citation
1. Differential requirement for NF-kappa B family members in control of helminth infection and intestinal inflammation. Artis D, etal., J Immunol. 2002 Oct 15;169(8):4481-7. doi: 10.4049/jimmunol.169.8.4481.
2. Alteration of NF-kappaB activity leads to mitochondrial apoptosis after infection with pathological prion protein. Bourteele S, etal., Cell Microbiol. 2007 Sep;9(9):2202-17. doi: 10.1111/j.1462-5822.2007.00950.x. Epub 2007 Jun 15.
3. Importance of polymorphisms in NF-kappaB1 and NF-kappaBIalpha genes for melanoma risk, clinicopathological features and tumor progression in Swedish melanoma patients. Bu H, etal., J Cancer Res Clin Oncol. 2007 Nov;133(11):859-66. Epub 2007 May 11.
4. NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice. Burkitt MD, etal., J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.
5. Signaling mediated by the NF-κB sub-units NF-κB1, NF-κB2 and c-Rel differentially regulate Helicobacter felis-induced gastric carcinogenesis in C57BL/6 mice. Burkitt MD, etal., Oncogene. 2013 Dec 12;32(50):5563-73. doi: 10.1038/onc.2013.334. Epub 2013 Aug 26.
6. Celecoxib attenuates liver steatosis and inflammation in non-alcoholic steatohepatitis induced by high-fat diet in rats. Chen J, etal., Mol Med Report. 2011 Jun 2. doi: 10.3892/mmr.2011.501.
7. The NF-kappaB p50 subunit is protective during intestinal Entamoeba histolytica infection of 129 and C57BL/6 mice. Cho KN, etal., Infect Immun. 2010 Apr;78(4):1475-81. doi: 10.1128/IAI.00669-09. Epub 2010 Jan 19.
8. Global ischemia activates nuclear factor-kappa B in forebrain neurons of rats. Clemens JA, etal., Stroke. 1997 May;28(5):1073-80; discussion 1080-1.
9. Genetic Variations in Inflammatory Response Genes and Their Association with the Risk of Prostate Cancer. Cui X, etal., Biomed Res Int. 2015;2015:674039. doi: 10.1155/2015/674039. Epub 2015 Dec 14.
10. The alternative NF-kappaB signalling pathway is a prerequisite for an appropriate immune response against lymphocytic choriomeningitis virus infection. Droebner K, etal., Viral Immunol. 2010 Jun;23(3):295-308. doi: 10.1089/vim.2009.0101.
11. The -94Ins/DelATTG polymorphism in NF¿B1 promoter modulates chronic hepatitis C and liver disease progression. Fakhir FZ, etal., Infect Genet Evol. 2016 Apr;39:141-6. doi: 10.1016/j.meegid.2016.01.023. Epub 2016 Jan 28.
12. Cytokine polymorphisms and plasma levels are associated with sleep onset insomnia in adults living with HIV/AIDS. Gay CL, etal., Brain Behav Immun. 2015 Jul;47:58-65. doi: 10.1016/j.bbi.2014.11.018. Epub 2014 Dec 20.
13. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
14. Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Gupta S, etal., Am J Physiol Heart Circ Physiol. 2005 Jul;289(1):H20-9. Epub 2005 Mar 4.
15. Polymorphisms in NFKB1 and NFKBIA Genes Modulate the Risk of Developing Prostate Cancer among Han Chinese. Han X, etal., Med Sci Monit. 2015 Jun 12;21:1707-15. doi: 10.12659/MSM.893471.
16. NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS. Harris TH, etal., J Neuroimmunol. 2010 May;222(1-2):19-28. doi: 10.1016/j.jneuroim.2009.12.009. Epub 2010 Feb 13.
17. Shared principles in NF-kappaB signaling. Hayden MS and Ghosh S, Cell. 2008 Feb 8;132(3):344-62.
18. IkappaBalpha gene promoter polymorphisms are associated with hepatocarcinogenesis in patients infected with hepatitis B virus genotype C. He Y, etal., Carcinogenesis. 2009 Nov;30(11):1916-22. doi: 10.1093/carcin/bgp226. Epub 2009 Oct 1.
19. Farnesoid X receptor agonist INT-767 attenuates liver steatosis and inflammation in rat model of nonalcoholic steatohepatitis. Hu YB, etal., Drug Des Devel Ther. 2018 Jul 16;12:2213-2221. doi: 10.2147/DDDT.S170518. eCollection 2018.
20. Reactive Oxygen Species Are Involved in the Development of Gastric Cancer and Gastric Cancer-Related Depression through ABL1-Mediated Inflammation Signaling Pathway. Huang T, etal., Oxid Med Cell Longev. 2019 Jul 15;2019:5813985. doi: 10.1155/2019/5813985. eCollection 2019.
21. Sunitinib Inhibits Breast Cancer Cell Proliferation by Inducing Apoptosis, Cell-cycle Arrest and DNA Repair While Inhibiting NF-κB Signaling Pathways. Korashy HM, etal., Anticancer Res. 2017 Sep;37(9):4899-4909. doi: 10.21873/anticanres.11899.
22. Interleukin-15 is associated with disease severity in viral bronchiolitis. Leahy TR, etal., Eur Respir J. 2016 Jan;47(1):212-22. doi: 10.1183/13993003.00642-2015. Epub 2015 Nov 5.
23. Lack of association of a functional -94ins/delATTG NFKB1 promoter polymorphism with susceptibility and clinical expression of biopsy-proven giant cell arteritis in northwest Spain. Martin J, etal., J Rheumatol. 2006 Feb;33(2):285-8.
24. Cytokine Gene Polymorphisms Associated With Symptom Clusters in Oncology Patients Undergoing Radiation Therapy. Miaskowski C, etal., J Pain Symptom Manage. 2017 Sep;54(3):305-316.e3. doi: 10.1016/j.jpainsymman.2017.05.007. Epub 2017 Aug 8.
25. Inhibition of experimental abdominal aortic aneurysm in the rat by use of decoy oligodeoxynucleotides suppressing activity of nuclear factor kappaB and ets transcription factors. Nakashima H, etal., Circulation. 2004 Jan 6;109(1):132-8. Epub 2003 Dec 8.
26. Expression Patterns of Growth and Survival Genes with Prognostic Implications in Advanced Pancreatic Cancer. Pectasides D, etal., Anticancer Res. 2016 Dec;36(12):6347-6356.
27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
30. Nuclear factor-kappaB activation leads to down-regulation of fatty acid oxidation during cardiac hypertrophy. Planavila A, etal., J Biol Chem. 2005 Apr 29;280(17):17464-71. Epub 2005 Feb 22.
31. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
32. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
33. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
34. Integrative microarray analysis of pathways dysregulated in metastatic prostate cancer. Setlur SR, etal., Cancer Res. 2007 Nov 1;67(21):10296-303. doi: 10.1158/0008-5472.CAN-07-2173.
35. NF-kappaB1 p105 suppresses lung tumorigenesis through the Tpl2 kinase but independently of its NF-kappaB function. Sun F, etal., Oncogene. 2016 May 5;35(18):2299-310. doi: 10.1038/onc.2015.299. Epub 2015 Aug 24.
36. Possible implication of NFKB1A and NKG2D genes in susceptibility to HTLV-1-associated myelopathy/tropical spastic paraparesis in Peruvian patients infected with HTLV-1. Talledo M, etal., J Med Virol. 2012 Feb;84(2):319-26. doi: 10.1002/jmv.22255.
37. The association between NFKB1-94ins/del ATTG polymorphism and non-small cell lung cancer risk in a Chinese Han population. Wang Y, etal., Int J Clin Exp Med. 2015 May 15;8(5):8153-7. eCollection 2015.
38. Dihydroartemisinin protects against alcoholic liver injury through alleviating hepatocyte steatosis in a farnesoid X receptor-dependent manner. Xu W, etal., Toxicol Appl Pharmacol. 2017 Jan 15;315:23-34. doi: 10.1016/j.taap.2016.12.001. Epub 2016 Dec 6.
39. Neuroprotective role for the p50 subunit of NF-kappaB in an experimental model of Huntington's disease. Yu Z, etal., J Mol Neurosci. 2000 Aug;15(1):31-44.
40. Garlic Oil Suppressed Nitrosodiethylamine-Induced Hepatocarcinoma in Rats by Inhibiting PI3K-AKT-NF-κB Pathway. Zhang CL, etal., Int J Biol Sci. 2015 Apr 25;11(6):643-51. doi: 10.7150/ijbs.10785. eCollection 2015.
41. Combined prognostic value of both RelA and IkappaB-alpha expression in human non-small cell lung cancer. Zhang D, etal., Ann Surg Oncol. 2007 Dec;14(12):3581-92. doi: 10.1245/s10434-007-9560-z. Epub 2007 Sep 27.
42. Genetic polymorphisms in PXR and NF-κB1 influence susceptibility to anti-tuberculosis drug-induced liver injury. Zhang J, etal., PLoS One. 2019 Sep 6;14(9):e0222033. doi: 10.1371/journal.pone.0222033. eCollection 2019.
43. Distinct patterns of intracerebral hemorrhage-induced alterations in NF-kappaB subunit, iNOS, and COX-2 expression. Zhao X, etal., J Neurochem. 2007 May;101(3):652-63. Epub 2007 Jan 23.
44. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Zheng L, etal., Biomed Pharmacother. 2018 Jan;97:481-488. doi: 10.1016/j.biopha.2017.10.153. Epub 2017 Nov 6.
Additional References at PubMed
PMID:1406630   PMID:1505523   PMID:1508666   PMID:1518839   PMID:1527859   PMID:1583734   PMID:1612589   PMID:1992489   PMID:2017258   PMID:2050119   PMID:2108863   PMID:2203531  
PMID:2234062   PMID:2497520   PMID:7494249   PMID:7651415   PMID:7690421   PMID:7692236   PMID:7694229   PMID:7729429   PMID:7739549   PMID:7742037   PMID:7788295   PMID:7800480  
PMID:7823959   PMID:7830764   PMID:7838536   PMID:7859743   PMID:7862168   PMID:7891711   PMID:7933095   PMID:7957556   PMID:7959007   PMID:8087845   PMID:8096091   PMID:8113688  
PMID:8139561   PMID:8151786   PMID:8178481   PMID:8196632   PMID:8207793   PMID:8246997   PMID:8255759   PMID:8289399   PMID:8290595   PMID:8319912   PMID:8423996   PMID:8428580  
PMID:8441377   PMID:8550813   PMID:8615004   PMID:8621941   PMID:8627654   PMID:8628291   PMID:8631829   PMID:8642313   PMID:8649779   PMID:8676466   PMID:8692272   PMID:8709193  
PMID:8717528   PMID:8724035   PMID:8746784   PMID:8790371   PMID:8798655   PMID:8814265   PMID:8825636   PMID:8834464   PMID:8870842   PMID:8887676   PMID:8997639   PMID:9094628  
PMID:9110146   PMID:9135156   PMID:9218802   PMID:9223487   PMID:9235945   PMID:9250404   PMID:9252186   PMID:9278385   PMID:9315679   PMID:9334723   PMID:9368006   PMID:9468519  
PMID:9510190   PMID:9525916   PMID:9529257   PMID:9535861   PMID:9556555   PMID:9560267   PMID:9566873   PMID:9566883   PMID:9572494   PMID:9584180   PMID:9621091   PMID:9722548  
PMID:9730685   PMID:9738011   PMID:9792375   PMID:9809067   PMID:9837938   PMID:9865693   PMID:9865694   PMID:9895331   PMID:9950430   PMID:9990852   PMID:10023675   PMID:10075655  
PMID:10207088   PMID:10225209   PMID:10235509   PMID:10357819   PMID:10362352   PMID:10384093   PMID:10393859   PMID:10400814   PMID:10426996   PMID:10446807   PMID:10469655   PMID:10480634  
PMID:10498867   PMID:10562553   PMID:10580107   PMID:10625680   PMID:10635328   PMID:10644332   PMID:10644726   PMID:10646849   PMID:10671224   PMID:10704334   PMID:10723127   PMID:10775602  
PMID:10777532   PMID:10799874   PMID:10811897   PMID:10835356   PMID:10847592   PMID:10856288   PMID:10928981   PMID:10931834   PMID:10969074   PMID:10970863   PMID:11020244   PMID:11036073  
PMID:11044099   PMID:11094166   PMID:11158290   PMID:11160671   PMID:11241736   PMID:11278695   PMID:11297557   PMID:11299302   PMID:11313474   PMID:11356851   PMID:11385624   PMID:11418662  
PMID:11425860   PMID:11468175   PMID:11511100   PMID:11522182   PMID:11526476   PMID:11579140   PMID:11590148   PMID:11607785   PMID:11696595   PMID:11704662   PMID:11739381   PMID:11756416  
PMID:11779220   PMID:11819787   PMID:11827962   PMID:11830587   PMID:11830590   PMID:11833470   PMID:11859566   PMID:11880271   PMID:11931769   PMID:11942414   PMID:11943214   PMID:11953428  
PMID:11959143   PMID:11970949   PMID:11971907   PMID:11972054   PMID:11976329   PMID:11980335   PMID:11983170   PMID:12019209   PMID:12021045   PMID:12032828   PMID:12032830   PMID:12040437  
PMID:12052823   PMID:12057007   PMID:12058256   PMID:12067898   PMID:12077118   PMID:12077347   PMID:12086956   PMID:12089148   PMID:12091382   PMID:12115625   PMID:12122011   PMID:12133438  
PMID:12135603   PMID:12145210   PMID:12150710   PMID:12150997   PMID:12166787   PMID:12167619   PMID:12173051   PMID:12181421   PMID:12195699   PMID:12198114   PMID:12203044   PMID:12230568  
PMID:12237108   PMID:12244126   PMID:12296854   PMID:12297126   PMID:12297724   PMID:12297725   PMID:12365017   PMID:12388747   PMID:12393603   PMID:12396456   PMID:12406554   PMID:12414801  
PMID:12419805   PMID:12427593   PMID:12428105   PMID:12431991   PMID:12433922   PMID:12444143   PMID:12444202   PMID:12470471   PMID:12471036   PMID:12471041   PMID:12473373   PMID:12477932  
PMID:12482504   PMID:12482669   PMID:12482991   PMID:12485413   PMID:12488445   PMID:12495677   PMID:12496256   PMID:12496485   PMID:12496486   PMID:12538487   PMID:12574335   PMID:12592338  
PMID:12594215   PMID:12594338   PMID:12604365   PMID:12606501   PMID:12606947   PMID:12618429   PMID:12620896   PMID:12623850   PMID:12637324   PMID:12644014   PMID:12646168   PMID: