NFKB1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: NFKB1 (nuclear factor kappa B subunit 1) Pan paniscus
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Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
RGD ID: 11684867
Description: ENCODES a protein that exhibits double-stranded DNA binding (ortholog); enzyme binding (ortholog); heat shock protein binding (ortholog); INVOLVED IN B cell receptor signaling pathway (ortholog); cellular response to brain-derived neurotrophic factor stimulus (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); alcoholic hepatitis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); neuron projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: nuclear factor NF-kappa-B p105 subunit
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
B cell receptor signaling pathway  (ISO)
cellular response to angiotensin  (IEA)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to diterpene  (ISO)
cellular response to dsRNA  (IEA,ISO)
cellular response to glucoside  (ISO)
cellular response to interleukin-1  (IEA,ISO)
cellular response to interleukin-17  (ISO)
cellular response to interleukin-6  (IEA)
cellular response to lipopolysaccharide  (IEA,ISO)
cellular response to mechanical stimulus  (IEA)
cellular response to nicotine  (IEA)
cellular response to organic cyclic compound  (ISO)
cellular response to peptide  (ISO)
cellular response to tumor necrosis factor  (IEA,ISO)
cellular response to virus  (IEA)
gene expression  (IEA)
JNK cascade  (IEA)
leukocyte migration involved in inflammatory response  (ISO)
mammary gland involution  (IEA)
MAPK cascade  (IEA)
negative regulation of apoptotic process  (ISO)
negative regulation of calcidiol 1-monooxygenase activity  (IEA)
negative regulation of cytokine production  (IEA)
negative regulation of DNA-templated transcription  (IEA,ISO)
negative regulation of gene expression  (IEA)
negative regulation of inflammatory response  (IEA,ISO)
negative regulation of interleukin-12 production  (IEA,ISO)
negative regulation of macromolecule metabolic process  (IEA)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of canonical Wnt signaling pathway  (IEA)
positive regulation of DNA-templated transcription  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (IEA)
positive regulation of miRNA metabolic process  (IEA)
positive regulation of miRNA transcription  (ISO)
positive regulation of miRNA-mediated gene silencing  (ISO)
positive regulation of transcription by RNA polymerase II  (IEA,ISO)
positive regulation of transcription initiation by RNA polymerase II  (ISO)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IEA)
response to bacterium  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to muscle stretch  (IEA,ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

References

Genomics

Comparative Map Data
NFKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
NFKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384102,501,359 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl4102,501,330 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36Build 36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBICelera
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
T2T-CHM13v2.04105,815,285 - 105,931,246 (+)NCBIT2T-CHM13v2.0
Nfkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,290,416 - 135,397,728 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)EnsemblGRCm39 Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBIMGSCv36mm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
Nfkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2231,747,515 - 231,862,426 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02229,647,247 - 229,762,154 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02224,512,036 - 224,626,946 (-)NCBIRnor_WKY
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
Nfkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
NFKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3224,141,192 - 24,259,887 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBIUU_Cfam_GSD_1.0
Nfkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936520733,668 - 829,435 (-)EnsemblSpeTri2.0
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,390,638 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
NFKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,589,494 - 50,711,472 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Nfkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248305,333,616 - 5,408,723 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSPPAT00000040660   ⟹   ENSPPAP00000017939
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000040673   ⟹   ENSPPAP00000017952
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensembl
RefSeq Acc Id: XM_003829955   ⟹   XP_003830003
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14105,589,062 - 105,704,098 (+)NCBI
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008955333   ⟹   XP_008953581
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14105,589,062 - 105,704,098 (+)NCBI
Mhudiblu_PPA_v0494,925,429 - 95,040,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_024928587   ⟹   XP_024784355
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14105,598,252 - 105,704,098 (+)NCBI
Mhudiblu_PPA_v0494,935,035 - 95,040,849 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034958948   ⟹   XP_034814839
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0494,935,034 - 95,040,849 (+)NCBI
Protein Sequences
Protein RefSeqs XP_003830003 (Get FASTA)   NCBI Sequence Viewer  
  XP_008953581 (Get FASTA)   NCBI Sequence Viewer  
  XP_024784355 (Get FASTA)   NCBI Sequence Viewer  
  XP_034814839 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003830003   ⟸   XM_003829955
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_008953581   ⟸   XM_008955333
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_024784355   ⟸   XM_024928587
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034814839   ⟸   XM_034958948
- Peptide Label: isoform X1
RefSeq Acc Id: ENSPPAP00000017939   ⟸   ENSPPAT00000040660
RefSeq Acc Id: ENSPPAP00000017952   ⟸   ENSPPAT00000040673
Protein Domains
RHD


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000032087 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000017939.1 UniProtKB/TrEMBL
  ENSPPAP00000017952.1 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000040660.1 UniProtKB/TrEMBL
  ENSPPAT00000040673.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/TrEMBL
  1.25.40.20 UniProtKB/TrEMBL
  2.60.40.10 UniProtKB/TrEMBL
  2.60.40.340 UniProtKB/TrEMBL
InterPro Ankyrin_rpt UniProtKB/TrEMBL
  Ankyrin_rpt-contain_sf UniProtKB/TrEMBL
  DEATH-like_dom_sf UniProtKB/TrEMBL
  Death_domain UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_E-set UniProtKB/TrEMBL
  IPT_dom UniProtKB/TrEMBL
  IPT_NFkappaB UniProtKB/TrEMBL
  NF-kB_p105 UniProtKB/TrEMBL
  NFkB/Dor UniProtKB/TrEMBL
  p53-like_TF_DNA-bd UniProtKB/TrEMBL
  RHD_CS UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind_dom UniProtKB/TrEMBL
  RHD_DNA_bind_dom_sf UniProtKB/TrEMBL
KEGG Report pps:100979341 UniProtKB/TrEMBL
NCBI Gene NFKB1 ENTREZGENE
PANTHER PTHR24169 UniProtKB/TrEMBL
  PTHR24169:SF9 UniProtKB/TrEMBL
Pfam Ank_2 UniProtKB/TrEMBL
  Death UniProtKB/TrEMBL
  RHD_dimer UniProtKB/TrEMBL
  RHD_DNA_bind UniProtKB/TrEMBL
PRINTS ANKYRIN UniProtKB/TrEMBL
  NFKBTNSCPFCT UniProtKB/TrEMBL
PROSITE ANK_REPEAT UniProtKB/TrEMBL
  REL_1 UniProtKB/TrEMBL
  REL_2 UniProtKB/TrEMBL
SMART ANK UniProtKB/TrEMBL
  DEATH UniProtKB/TrEMBL
  IPT UniProtKB/TrEMBL
Superfamily-SCOP SSF47986 UniProtKB/TrEMBL
  SSF48403 UniProtKB/TrEMBL
  SSF49417 UniProtKB/TrEMBL
  SSF81296 UniProtKB/TrEMBL
UniProt A0A2R9AKQ2_PANPA UniProtKB/TrEMBL
  A0A2R9AST7_PANPA UniProtKB/TrEMBL