NFKB1 (nuclear factor kappa B subunit 1) - Rat Genome Database

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Gene: NFKB1 (nuclear factor kappa B subunit 1) Canis lupus familiaris
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Symbol: NFKB1
Name: nuclear factor kappa B subunit 1
RGD ID: 12360894
Description: ENCODES a protein that exhibits actinin binding (ortholog); chromatin binding (ortholog); DNA binding (ortholog); INVOLVED IN cellular response to angiotensin (ortholog); cellular response to brain-derived neurotrophic factor stimulus (ortholog); cellular response to carbohydrate stimulus (ortholog); PARTICIPATES IN adenosine signaling pathway; ceramide signaling pathway; erythropoietin signaling pathway; ASSOCIATED WITH acute kidney failure (ortholog); adenocarcinoma (ortholog); alcoholic hepatitis (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); mitochondrion (ortholog)
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBI
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBI
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBI
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBI
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to angiotensin  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to diterpene  (ISO)
cellular response to dsRNA  (ISO)
cellular response to glucoside  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to peptide  (ISO)
cellular response to tumor necrosis factor  (ISO)
cellular response to virus  (ISO)
JNK cascade  (ISO)
leukocyte migration involved in inflammatory response  (ISO)
MAPK cascade  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of calcidiol 1-monooxygenase activity  (ISO)
negative regulation of cytokine production  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (ISO)
negative regulation of interleukin-12 production  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO,ISS)
negative regulation of transcription, DNA-templated  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of gene silencing by miRNA  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of miRNA metabolic process  (ISO)
positive regulation of pri-miRNA transcription by RNA polymerase II  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of transcription, DNA-templated  (ISS)
regulation of transcription by RNA polymerase II  (IBA)
response to bacterium  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to muscle stretch  (ISO)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

References
Additional References at PubMed
PMID:16125763   PMID:22194879   PMID:23337362   PMID:23600687   PMID:23786670   PMID:25312048   PMID:25770673   PMID:26549149   PMID:30562372   PMID:33081802  


Genomics

Comparative Map Data
NFKB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13223,948,598 - 24,040,704 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBI
ROS_Cfam_1.03224,141,129 - 24,259,888 (+)NCBI
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBI
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBI
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBI
NFKB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4102,501,331 - 102,617,302 (+)EnsemblGRCh38hg38GRCh38
GRCh384102,501,266 - 102,617,302 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374103,422,516 - 103,538,459 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364103,641,518 - 103,757,507 (+)NCBINCBI36hg18NCBI36
Build 344103,779,672 - 103,895,661NCBI
Celera4100,721,743 - 100,837,727 (+)NCBI
Cytogenetic Map4q24NCBI
HuRef499,158,873 - 99,274,686 (+)NCBIHuRef
CHM1_14103,398,776 - 103,514,779 (+)NCBICHM1_1
Nfkb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393135,290,416 - 135,397,728 (-)NCBIGRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBImm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
Nfkb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22224,016,214 - 224,132,135 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl2224,016,214 - 224,110,404 (-)Ensembl
Rnor_6.02240,773,520 - 240,890,053 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2240,773,456 - 240,866,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02259,330,377 - 259,444,869 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42233,091,013 - 233,187,501 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12233,077,759 - 233,097,514 (-)NCBI
Celera2216,226,849 - 216,340,494 (-)NCBICelera
Cytogenetic Map2q43NCBI
Nfkb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554965,842,600 - 5,927,885 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554965,842,734 - 5,950,995 (-)NCBIChiLan1.0ChiLan1.0
NFKB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14105,589,062 - 105,704,098 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4105,589,062 - 105,704,098 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0494,925,048 - 95,040,849 (+)NCBIMhudiblu_PPA_v0panPan3
Nfkb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530117,390,298 - 17,507,111 (-)NCBI
SpeTri2.0NW_004936520733,760 - 850,563 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
NFKB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8118,390,637 - 118,506,691 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.18118,391,010 - 118,478,927 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28127,365,561 - 127,368,964 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap8q23-q27NCBI
NFKB1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1750,589,494 - 50,711,472 (+)NCBI
ChlSab1.1 Ensembl750,589,856 - 50,711,498 (+)Ensembl
Vero_WHO_p1.0NW_02366603729,099,578 - 29,223,078 (+)NCBI
Nfkb1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248305,334,273 - 5,430,887 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 11 6 6 6 10 6
Low 5 11 6 6 6 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017092   ⟹   ENSCAFP00000015815
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3223,948,598 - 24,040,703 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078055   ⟹   ENSCAFP00000058939
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3223,951,116 - 24,040,703 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000081993   ⟹   ENSCAFP00000056706
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3223,945,822 - 24,040,703 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000092066   ⟹   ENSCAFP00000046887
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl3223,942,954 - 24,040,703 (+)Ensembl
RefSeq Acc Id: NM_001003344   ⟹   NP_001003344
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.13223,948,598 - 24,040,704 (+)NCBI
Dog10K_Boxer_Tasha3217,983,225 - 18,101,473 (-)NCBI
ROS_Cfam_1.03224,141,192 - 24,259,888 (+)NCBI
UMICH_Zoey_3.13224,122,163 - 24,239,736 (+)NCBI
UNSW_CanFamBas_1.03223,900,676 - 24,019,275 (+)NCBI
UU_Cfam_GSD_1.03215,842,831 - 15,961,478 (-)NCBI
Sequence:
RefSeq Acc Id: XM_038443782   ⟹   XP_038299710
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03224,141,129 - 24,259,669 (+)NCBI
RefSeq Acc Id: XM_038443783   ⟹   XP_038299711
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.03224,170,615 - 24,259,669 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001003344 (Get FASTA)   NCBI Sequence Viewer  
  XP_038299710 (Get FASTA)   NCBI Sequence Viewer  
  XP_038299711 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ABC86232 (Get FASTA)   NCBI Sequence Viewer  
  BAD27479 (Get FASTA)   NCBI Sequence Viewer  
  Q6F3J0 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001003344   ⟸   NM_001003344
- UniProtKB: Q6F3J0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSCAFP00000058939   ⟸   ENSCAFT00000078055
RefSeq Acc Id: ENSCAFP00000056706   ⟸   ENSCAFT00000081993
RefSeq Acc Id: ENSCAFP00000046887   ⟸   ENSCAFT00000092066
RefSeq Acc Id: ENSCAFP00000015815   ⟸   ENSCAFT00000017092
RefSeq Acc Id: XP_038299710   ⟸   XM_038443782
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038299711   ⟸   XM_038443783
- Peptide Label: isoform X2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010730 Ensembl, ENTREZGENE
Ensembl Protein ENSCAFP00000015815 ENTREZGENE
Ensembl Transcript ENSCAFT00000017092 ENTREZGENE
NCBI Gene NFKB1 ENTREZGENE
UniProt Q6F3J0 ENTREZGENE
VGNC ID VGNC:43780 ENTREZGENE