Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) - Rat Genome Database

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Gene: Nfkb1 (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105) Mus musculus
Symbol: Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
RGD ID: 730893
Description: Enables several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; identical protein binding activity; and transcription coregulator activity. Involved in several processes, including B cell receptor signaling pathway; JNK cascade; and regulation of gene expression. Acts upstream of or within several processes, including cellular response to dsRNA; cellular response to tumor necrosis factor; and regulation of gene expression. Located in cytosol. Is active in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in several diseases, including carcinoma (multiple); common variable immunodeficiency 12; melanoma; prostate cancer; and tropical spastic paraparesis. Orthologous to human NFKB1 (nuclear factor kappa B subunit 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: DNA-binding factor KBF1; EBP-1; NF kappaB1; NF-k; NF-kappa-B1 p84/NF-kappa-B1 p98; NF-kappaB; NF-kappaB p50; NF-kappaB1; NF-KB1; nuclear factor kappaB p50; nuclear factor NF-kappa-B p105 subunit; nuclear factor of kappa light chain gene enhancer in B-cells 1, p105; nuclear factor of kappa light polypeptide gene enhancer in B-cells 1, p105; nuclear factor-kappaB p50; p105; p5; p50; p50 subunit of NF kappaB; p50 subunit of NF-kappaB; p50/p1; p50/p105
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm393135,290,416 - 135,397,728 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3135,290,416 - 135,397,308 (-)EnsemblGRCm39 Ensembl
GRCm383135,584,655 - 135,691,969 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3135,584,655 - 135,691,547 (-)EnsemblGRCm38mm10GRCm38
MGSCv373135,247,619 - 135,354,511 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363135,522,085 - 135,628,727 (-)NCBIMGSCv36mm8
Celera3142,004,849 - 142,111,759 (-)NCBICelera
Cytogenetic Map3G3NCBI
cM Map362.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-artemisinin  (ISO)
(+)-taxifolin  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
(20S)-ginsenoside Rg3  (ISO)
(5Z,8Z,11Z,13E)-15-HETE  (ISO)
(E)-roxithromycin  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (ISO)
(R)-mevalonic acid  (ISO)
(R)-noradrenaline  (ISO)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-nicotine  (EXP,ISO)
1'-acetoxychavicol acetate  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1,3-benzothiazole-2-thiol  (ISO)
1,4-dithiothreitol  (EXP,ISO)
1-bromopropane  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (EXP,ISO)
1-fluoro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (ISO)
1-nitropyrene  (ISO)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-D  (EXP)
2,4-dinitrobenzenesulfonic acid  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dinitrotoluene  (ISO)
2-acetamidofluorene  (EXP,ISO)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-aminopurine  (EXP)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methylcholine  (ISO)
3,3',5'-triiodo-L-thyronine  (ISO)
3,3',5'-triiodothyronine  (ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-nitropropanoic acid  (EXP)
3-phenylprop-2-enal  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-aminobenzoic acid  (ISO)
4-hydroxy-17beta-estradiol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitrotoluene  (EXP)
4-octylphenol  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-fluorouracil  (ISO)
5-Hydroxycapric acid  (ISO)
6-propyl-2-thiouracil  (ISO)
6alpha-methylprednisolone  (ISO)
7,12-dimethyltetraphene  (EXP)
7-ketocholesterol  (ISO)
7H-xanthine  (ISO)
9-cis,11-trans-octadecadienoic acid  (EXP)
9H-xanthine  (ISO)
[6]-Shogaol  (EXP)
abamectin  (ISO)
acenaphthoquinone  (ISO)
acetaldehyde  (ISO)
acetylsalicylic acid  (EXP,ISO)
acrolein  (ISO)
Actein  (EXP)
actinomycin D  (ISO)
afatinib  (ISO)
aflatoxin B1  (ISO)
AH23848  (ISO)
AICA ribonucleotide  (EXP)
alachlor  (EXP)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-amanitin  (EXP)
alpha-D-galactose  (EXP,ISO)
alpha-pinene  (ISO)
aluminium sulfate (anhydrous)  (ISO)
amiloride  (ISO)
ammonium chloride  (ISO)
ammonium hexachloroplatinate  (ISO)
amphibole asbestos  (ISO)
anethole  (ISO)
Anetholtrithion  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antirheumatic drug  (ISO)
apigenin  (ISO)
aripiprazole  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
atrazine  (ISO)
aurantio-obtusin  (EXP)
azadirachtin A  (ISO)
B 581  (ISO)
baicalein  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benazepril  (ISO)
benomyl  (EXP)
benzene  (EXP,ISO)
benzo[a]pyrene  (EXP,ISO)
benzylpenicillin  (EXP)
berberine  (ISO)
beryllium sulfate  (EXP)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-ionone  (EXP)
bezafibrate  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP)
bleomycin A2  (EXP,ISO)
boric acid  (ISO)
bortezomib  (ISO)
butane-2,3-dione  (ISO)
butein  (ISO)
butyric acid  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
capsazepine  (EXP)
carbamazepine  (ISO)
carbaryl  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
Cardamonin  (ISO)
carmustine  (EXP,ISO)
carvacrol  (EXP)
casticin  (ISO)
celecoxib  (ISO)
cerium trichloride  (EXP)
chlordecone  (EXP)
chloroform  (ISO)
chloroquine  (EXP,ISO)
cholesterol  (EXP)
choline  (EXP)
chondroitin sulfate  (ISO)
chrysin  (ISO)
ciglitazone  (ISO)
cimetidine  (ISO)
ciprofibrate  (EXP)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clonidine  (ISO)
clonidine (amino form)  (ISO)
clonidine (imino form)  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (EXP)
colforsin daropate hydrochloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
coumestrol  (ISO)
crocidolite asbestos  (EXP,ISO)
crotonaldehyde  (ISO)
curcumin  (EXP,ISO)
cycloheximide  (EXP,ISO)
cyclosporin A  (EXP)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproheptadine  (ISO)
D-glucose  (EXP,ISO)
daidzein  (EXP)
danazol  (ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (EXP)
dexamethasone  (ISO)
dextran sulfate  (EXP,ISO)
diarsenic trioxide  (EXP,ISO)
diazepam  (ISO)
diazoxide  (ISO)
dibenziodolium  (EXP,ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dicofol  (EXP)
dicoumarol  (ISO)
dieckol  (ISO)
dieldrin  (ISO)
dienogest  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP)
digitoxin  (ISO)
dihydroartemisinin  (ISO)
dihydroxyacetone  (ISO)
diltiazem  (ISO)
dimethylarsinic acid  (ISO)
dioscin  (EXP)
diosgenin  (ISO)
dioxygen  (EXP,ISO)
disodium selenite  (ISO)
disulfiram  (ISO)
dorsomorphin  (EXP)
doxorubicin  (ISO)
emodin  (ISO)
enalapril  (ISO)
endosulfan  (EXP,ISO)
endrin  (EXP)
erythromycin A  (EXP)
esculetin  (ISO)
ethanol  (ISO)
ethyl acetate  (ISO)
ethylene glycol  (ISO)
ethylisopropylamiloride  (ISO)
eugenol  (ISO)
Evodiamine  (ISO)
felodipine  (EXP)
fenofibrate  (ISO)
ferric oxide  (EXP)
ferroheme b  (ISO)
Fexofenadine hydrochloride  (ISO)
fisetin  (ISO)
flurbiprofen  (EXP)
fluticasone  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (ISO)
fosinopril  (EXP)
fucoidan  (ISO)
fulvestrant  (ISO)
gadolinium atom  (ISO)
gadolinium trichloride  (ISO)
galactose  (EXP,ISO)
gamma-hexachlorocyclohexane  (ISO)
gastrin-17  (ISO)
gefitinib  (ISO)
genistein  (EXP,ISO)
gentamycin  (ISO)
geraniol  (ISO)
gingerol  (EXP)
ginsenoside C-K  (ISO)
glafenine  (ISO)
gliotoxin  (ISO)
glucaric acid  (EXP)
glucose  (EXP,ISO)
glutathione  (ISO)
glutathione disulfide  (EXP,ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glycyrrhizinic acid  (EXP)
glyphosate  (ISO)
guggulsterone  (ISO)
GW 501516  (EXP)
haloperidol  (ISO)
harmaline  (ISO)
heme b  (ISO)
hesperidin  (ISO)
hexadecanoic acid  (ISO)
histamine  (ISO)
Honokiol  (EXP)
hyaluronic acid  (EXP,ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (EXP,ISO)
hydroxyurea  (ISO)
ibuprofen  (EXP,ISO)
indole-3-acetic acid  (ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
irbesartan  (EXP)
irinotecan  (EXP,ISO)
iron(2+) sulfate (anhydrous)  (EXP,ISO)
iron(III) nitrilotriacetate  (ISO)
isoeugenol  (ISO)
isoflurane  (ISO)
isoliquiritigenin  (EXP)
isoniazide  (ISO)
isoprenaline  (EXP,ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
L-1,4-dithiothreitol  (EXP,ISO)
L-ascorbic acid  (EXP,ISO)
L-methionine  (EXP)
lanreotide  (ISO)
lead diacetate  (ISO)
lead(0)  (ISO)
lead(2+)  (ISO)
leptomycin B  (ISO)
limonene  (ISO)
linalool  (ISO)
linoleic acid  (ISO)
lipoarabinomannan  (EXP)
lipoic acid  (ISO)
lipophosphoglycan  (ISO)
lipopolysaccharide  (EXP,ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
lonafarnib  (ISO)
losartan  (EXP,ISO)
luteolin  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
maneb  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
Mecamylamine  (ISO)
Melarsoprol  (ISO)
melatonin  (EXP,ISO)
melittin  (EXP,ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury dichloride  (ISO)
mercury(0)  (ISO)
metam  (EXP)
metformin  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (ISO)
methidathion  (EXP)
methoctramine tetrahydrochloride  (ISO)
methotrexate  (ISO)
methyl salicylate  (ISO)
methylarsonic acid  (ISO)
methyllycaconitine  (ISO)
methylmercury chloride  (ISO)
methylmercury(1+)  (ISO)
methylseleninic acid  (ISO)
mevinphos  (ISO)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (EXP)
monodansylcadaverine  (EXP)
monosodium L-glutamate  (EXP)
monotropein  (EXP)
morphine  (ISO)
Muraglitazar  (ISO)
myo-inositol hexakisphosphate  (EXP)
Myrtucommulone A  (EXP)
N'-Nitrosonornicotine  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-tosyl-L-phenylalanyl chloromethyl ketone  (EXP,ISO)
naproxen  (ISO)
naringin  (ISO)
Neferine  (ISO)
neoechinulin A  (EXP)
neratinib  (ISO)
neurotensin  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicorandil  (ISO)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (ISO)
nitric oxide  (EXP)
nitroprusside  (EXP,ISO)
nonanoic acid  (EXP)
Nonylphenol  (EXP,ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
o-anisidine  (ISO)
obeticholic acid  (ISO)
Octachlorostyrene  (EXP)
okadaic acid  (ISO)
olanzapine  (EXP)
oleanolic acid  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tolualdehyde  (EXP)
paclitaxel  (EXP,ISO)
Paeonol  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
parthenolide  (ISO)
PD123319  (ISO)
pentachlorophenol  (EXP)
Pentoxifylline  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
pergolide  (ISO)
perindopril  (EXP)
permethrin  (ISO)
pevonedistat  (ISO)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylarsine oxide  (ISO)
phenylbutazone  (ISO)
phenytoin  (ISO)
phloretin  (EXP)
phlorizin  (EXP)
phorbol 13-acetate 12-myristate  (EXP,ISO)
piperine  (ISO)
pirinixic acid  (EXP)
platycodin D  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
propanil  (EXP)
propionic acid  (ISO)
prostaglandin E2  (EXP)
protein kinase inhibitor  (ISO)
pterostilbene  (ISO)
puerarin  (ISO)
purine-6-thiol  (ISO)
Pyridostigmine bromide  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
raloxifene  (ISO)
rebaudioside A  (EXP)
resveratrol  (EXP,ISO)
Rhein  (ISO)
ritonavir  (ISO)
rocaglamide  (ISO)
romidepsin  (ISO)
rotenone  (ISO)
ruthenium red  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
salicylates  (ISO)
sarin  (ISO)
SB 203580  (EXP,ISO)
scoparone  (ISO)
Se-methyl-L-selenocysteine  (EXP)
Se-methylselenocysteine  (EXP)
serpentine asbestos  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
simazine  (EXP)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (ISO)
sodium arsenite  (EXP,ISO)
sodium chromate  (EXP)
sodium disulfite  (ISO)
sodium dodecyl sulfate  (ISO)
Sodium oleate  (ISO)
Sodium salicylate  (EXP,ISO)
Soman  (ISO)
sorafenib  (EXP)
staurosporine  (ISO)
sterigmatocystin  (ISO)
steviol  (EXP)
stevioside  (EXP)
streptozocin  (ISO)
succimer  (EXP,ISO)
succinic acid  (ISO)
sulfasalazine  (ISO)
sulforaphane  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tacrolimus hydrate  (EXP)
tamoxifen  (ISO)
telmisartan  (EXP)
terbutaline  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (EXP,ISO)
testosterone  (EXP)
tetrachloromethane  (EXP,ISO)
Tetramethylthiourea  (ISO)
thalidomide  (ISO)
theophylline  (ISO)
thioacetamide  (ISO)
thiostrepton  (ISO)
thiram  (ISO)
Tiron  (ISO)
titanium dioxide  (ISO)
trans-anethole  (ISO)
trans-isoeugenol  (ISO)
tributylstannane  (ISO)
Tributyltin oxide  (EXP)
trichloroethene  (EXP,ISO)
trichostatin A  (ISO)
troglitazone  (ISO)
Tropicamide  (ISO)
urethane  (EXP)
ursodeoxycholic acid  (ISO)
ursolic acid  (EXP)
valproic acid  (EXP,ISO)
vanadyl sulfate  (ISO)
vancomycin  (EXP)
venom  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
wortmannin  (EXP)
WR-1065  (ISO)
xanthohumol  (ISO)
Y-27632  (ISO)
zerumbone  (ISO)
zinc atom  (ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (EXP)
zinc protoporphyrin  (EXP)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (ISO)
zineb  (ISO)
zingerone  (ISO)
ziram  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
B cell receptor signaling pathway  (IDA)
cellular response to angiotensin  (ISO)
cellular response to brain-derived neurotrophic factor stimulus  (ISO)
cellular response to carbohydrate stimulus  (ISO)
cellular response to cytokine stimulus  (ISO)
cellular response to diterpene  (ISO)
cellular response to dsRNA  (IMP)
cellular response to glucoside  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to interleukin-17  (IDA)
cellular response to interleukin-6  (ISO)
cellular response to lipopolysaccharide  (IDA,ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to peptide  (ISO)
cellular response to tumor necrosis factor  (IDA,ISO)
cellular response to virus  (IMP)
gene expression  (IMP)
JNK cascade  (IMP)
leukocyte migration involved in inflammatory response  (ISO)
lymph node development  (TAS)
mammary gland involution  (IDA)
MAPK cascade  (IMP)
negative regulation of apoptotic process  (ISO)
negative regulation of calcidiol 1-monooxygenase activity  (ISO)
negative regulation of cytokine production  (IMP)
negative regulation of DNA-templated transcription  (IDA)
negative regulation of gene expression  (ISO)
negative regulation of inflammatory response  (IMP)
negative regulation of interleukin-12 production  (IDA)
negative regulation of transcription by RNA polymerase II  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of DNA-templated transcription  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of hyaluronan biosynthetic process  (ISO)
positive regulation of miRNA metabolic process  (ISO)
positive regulation of miRNA transcription  (ISO)
positive regulation of miRNA-mediated gene silencing  (ISO)
positive regulation of transcription by RNA polymerase II  (IDA,IMP,ISO)
positive regulation of transcription initiation by RNA polymerase II  (IMP)
regulation of DNA-templated transcription  (IEA)
regulation of transcription by RNA polymerase II  (IBA)
response to bacterium  (ISO)
response to copper ion  (ISO)
response to ethanol  (ISO)
response to muscle stretch  (IDA)
response to organic cyclic compound  (ISO)
response to oxidative stress  (ISO)
response to xenobiotic stimulus  (ISO)
signal transduction  (IEA)

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal B cell activation  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal bone marrow cavity morphology  (IAGP)
abnormal bone marrow cell morphology/development  (IAGP)
abnormal bone structure  (IAGP)
abnormal calcium ion homeostasis  (IAGP)
abnormal CD4-positive, alpha-beta T cell physiology  (IAGP)
abnormal class switch recombination  (IAGP)
abnormal cochlear inner hair cell morphology  (IAGP)
abnormal colon morphology  (IAGP)
abnormal cornea morphology  (IEA)
abnormal craniofacial morphology  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell differentiation  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal humoral immune response  (IAGP)
abnormal immune system organ morphology  (IAGP)
abnormal immune system physiology  (IAGP)
abnormal inflammatory response  (IAGP)
abnormal inguinal lymph node morphology  (IAGP)
abnormal long bone epiphyseal plate morphology  (IAGP)
abnormal long bone morphology  (IAGP)
abnormal lymph organ size  (IAGP)
abnormal lymphocyte physiology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal osteoclast differentiation  (IAGP)
abnormal Peyer's patch follicle morphology  (IAGP)
abnormal Peyer's patch germinal center morphology  (IAGP)
abnormal Peyer's patch T cell area morphology  (IAGP)
abnormal professional antigen presenting cell physiology  (IAGP)
abnormal skin condition  (IEA)
abnormal spleen morphology  (IAGP)
abnormal thymus cortex morphology  (IAGP)
abnormal thymus medulla morphology  (IAGP)
absent inguinal lymph nodes  (IAGP)
absent lymph nodes  (IAGP)
absent spleen white pulp  (IAGP)
arrested B cell differentiation  (IAGP)
cecum inflammation  (IAGP)
cochlear ganglion degeneration  (IAGP)
decreased B cell number  (IAGP)
decreased B cell proliferation  (IAGP)
decreased B-1 B cell number  (IEA)
decreased B-1a cell number  (IEA)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased CD8-positive, naive alpha-beta T cell number  (IEA)
decreased central memory CD4-positive, alpha-beta T cell number  (IEA)
decreased circulating amylase level  (IEA)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-2 level  (IAGP)
decreased circulating sodium level  (IEA)
decreased cochlear nerve compound action potential  (IAGP)
decreased dendritic cell number  (IAGP)
decreased double-positive T cell number  (IAGP)
decreased effector memory CD4-positive, alpha-beta T cell number  (IEA)
decreased erythrocyte cell number  (IAGP)
decreased IgA level  (IAGP)
decreased IgE level  (IAGP)
decreased IgG level  (IEA)
decreased IgG1 level  (IAGP)
decreased IgG3 level  (IAGP)
decreased IgM level  (IAGP)
decreased immunoglobulin level  (IAGP)
decreased interleukin-1 beta secretion  (IEA)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-2 secretion  (IAGP)
decreased interleukin-4 secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased lean body mass  (IEA)
decreased length of long bones  (IAGP)
decreased marginal zone B cell number  (IAGP)
decreased mature B cell number  (IAGP)
decreased mean corpuscular hemoglobin concentration  (IEA)
decreased memory T cell number  (IAGP)
decreased myeloid dendritic cell number  (IAGP)
decreased NK cell number  (IAGP)
decreased NK T cell number  (IAGP)
decreased osteoclast cell number  (IAGP)
decreased Peyer's patch number  (IAGP)
decreased regulatory T cell number  (IAGP)
decreased respiratory quotient  (IAGP)
decreased single-positive T cell number  (IAGP)
decreased susceptibility to autoimmune diabetes  (IAGP)
decreased susceptibility to Picornaviridae infection induced morbidity/mortality  (IAGP)
decreased T cell number  (IAGP)
decreased T cell proliferation  (IAGP)
decreased thermal nociceptive threshold  (IEA)
decreased tumor necrosis factor secretion  (IAGP)
diarrhea  (IAGP)
enlarged lymph nodes  (IAGP)
enlarged spleen  (IAGP)
extramedullary hematopoiesis  (IAGP)
failure of tooth eruption  (IAGP)
impaired humoral immune response  (IEA)
increased apoptosis  (IAGP)
increased B cell proliferation  (IAGP)
increased central memory CD8 positive, alpha-beta T cell number  (IEA)
increased circulating alkaline phosphatase level  (IAGP)
increased circulating free fatty acids level  (IEA)
increased granulocyte number  (IAGP)
increased IgE level  (IAGP)
increased IgG1 level  (IAGP)
increased immunoglobulin level  (IAGP)
increased leukocyte cell number  (IAGP)
increased macrophage cell number  (IAGP)
increased susceptibility to age-related hearing loss  (IAGP)
increased susceptibility to bacterial infection  (IAGP)
increased susceptibility to bacterial infection induced morbidity/mortality  (IAGP)
increased susceptibility to induced colitis  (IEA)
increased susceptibility to noise-induced hearing loss  (IAGP)
increased thermal nociceptive threshold  (IEA)
increased transitional stage B cell number  (IAGP)
large intestinal inflammation  (IAGP)
lethargy  (IAGP)
liver inflammation  (IAGP)
lung inflammation  (IAGP)
lymphoid hyperplasia  (IAGP)
myeloid hyperplasia  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IAGP)
osteopetrosis  (IAGP)
peritoneal inflammation  (IAGP)
postnatal growth retardation  (IAGP)
postnatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, incomplete penetrance  (IAGP)
rough coat  (IAGP)
small inguinal lymph nodes  (IAGP)
small Peyer's patches  (IAGP)
thin epidermis  (IAGP)
thymus hypoplasia  (IAGP)
tooth impaction  (IAGP)

References - curated
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21. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
22. MGDs mouse GO annotations MGD data from the GO Consortium
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27. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
28. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
29. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
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31. Mouse MP Annotation Import Pipeline RGD automated import pipeline
32. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
33. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
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Additional References at PubMed
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