RGD Reference Report - NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS. - Rat Genome Database

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NF-kappaB1 contributes to T cell-mediated control of Toxoplasma gondii in the CNS.

Authors: Harris, Tajie H  Wilson, Emma H  Tait, Elia D  Buckley, Marie  Shapira, Sagi  Caamano, Jorge  Artis, David  Hunter, Christopher A 
Citation: Harris TH, etal., J Neuroimmunol. 2010 May;222(1-2):19-28. doi: 10.1016/j.jneuroim.2009.12.009. Epub 2010 Feb 13.
RGD ID: 40902838
Pubmed: PMID:20156658   (View Abstract at PubMed)
PMCID: PMC2860689   (View Article at PubMed Central)
DOI: DOI:10.1016/j.jneuroim.2009.12.009   (Journal Full-text)

In this study, the role of NF-kappaB1 was examined during toxoplasmosis. While wildtype BALB/c mice generated protective responses, NF-kappaB1(-/-) mice developed Toxoplasmic encephalitis, characterized by increased parasite burden and necrosis in the brain. Susceptibility was primarily associated with a local decrease in the number of CD8(+) T cells and IFN-gamma production, while accessory cell function appeared intact in NF-kappaB1(-/-) mice. Consistent with these findings, T cell transfer studies revealed that NF-kappaB1(-/-) T cells provided SCID mice less protection than wildtype T cells. These results demonstrate an intrinsic role for NF-kappaB1 in T cell-mediated immunity to Toxoplasmagondii.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
Cerebral Toxoplasmosis severityISONfkb1 (Mus musculus)40902838; 40902838 RGD 
Cerebral Toxoplasmosis severityIMP 40902838 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Nfkb1  (nuclear factor kappa B subunit 1)

Genes (Mus musculus)
Nfkb1  (nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105)

Genes (Homo sapiens)
NFKB1  (nuclear factor kappa B subunit 1)

Additional Information