Eps8 (EGFR pathway substrate 8, signaling adaptor) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Eps8 (EGFR pathway substrate 8, signaling adaptor) Rattus norvegicus
Analyze
Symbol: Eps8
Name: EGFR pathway substrate 8, signaling adaptor (Ensembl:epidermal growth factor receptor pathway substrate 8)
RGD ID: 1310590
Description: Predicted to enable actin binding activity and small GTPase binding activity. Predicted to be involved in several processes, including actin filament organization; barbed-end actin filament capping; and small GTPase-mediated signal transduction. Predicted to act upstream of or within several processes, including adult locomotory behavior; behavioral response to ethanol; and cellular response to leukemia inhibitory factor. Is active in glutamatergic synapse and postsynaptic density. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 102. Orthologous to human EPS8 (EGFR pathway substrate 8, signaling adaptor); PARTICIPATES IN platelet-derived growth factor signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: epidermal growth factor receptor kinase substrate 8; epidermal growth factor receptor pathway substrate 8; LOC312812
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,119,497 - 172,291,670 (-)NCBIGRCr8
mRatBN7.24170,388,378 - 170,486,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,388,378 - 170,486,873 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,680,716 - 176,779,656 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,465,042 - 172,563,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,085,423 - 171,184,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,475,155 - 171,645,620 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,475,567 - 171,591,882 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,732,277 - 235,903,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,601,291 - 174,672,247 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,848,196 - 174,917,371 (-)NCBI
Celera4158,967,950 - 159,084,908 (-)NCBICelera
Cytogenetic Map4q44NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
acrolein  (ISO)
acrylamide  (ISO)
afimoxifene  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
Aroclor 1254  (ISO)
atrazine  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
capecitabine  (ISO)
CGP 52608  (ISO)
chromium(6+)  (ISO)
clothianidin  (ISO)
colforsin daropate hydrochloride  (ISO)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibutyl phthalate  (ISO)
disodium selenite  (ISO)
doxifluridine  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
folic acid  (ISO)
fonofos  (ISO)
formaldehyde  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
indole-3-methanol  (EXP)
indometacin  (ISO)
isoprenaline  (ISO)
ivermectin  (ISO)
leflunomide  (ISO)
methyl methanesulfonate  (ISO)
methylseleninic acid  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-4-phenylpyridinium  (ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parathion  (ISO)
permethrin  (EXP)
phenobarbital  (ISO)
pirinixic acid  (ISO)
potassium chromate  (ISO)
quercetin  (ISO)
resveratrol  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
terbufos  (ISO)
tetrachloromethane  (ISO)
thapsigargin  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
trichostatin A  (ISO)
triptonide  (ISO)
tungsten  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function
actin binding  (IBA,IEA,ISO,ISS)
protein binding  (ISO)
small GTPase binding  (IEA,ISO,ISS)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Postsynaptic enrichment of Eps8 at dendritic shaft synapses of unipolar brush cells in rat cerebellum. Sekerková G, etal., Neuroscience. 2007 Mar 2;145(1):116-29. doi: 10.1016/j.neuroscience.2006.11.061. Epub 2007 Jan 16.
Additional References at PubMed
PMID:11487543   PMID:11524436   PMID:15558031   PMID:17018287   PMID:17115031   PMID:19056867   PMID:19190083   PMID:19208628   PMID:19293393   PMID:19528316   PMID:20439489   PMID:20532239  
PMID:21236676   PMID:21835647   PMID:22114352   PMID:23314863   PMID:23376485   PMID:23392693   PMID:23533145   PMID:23918390   PMID:24741995   PMID:25159326   PMID:26252776   PMID:27450093  


Genomics

Comparative Map Data
Eps8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84172,119,497 - 172,291,670 (-)NCBIGRCr8
mRatBN7.24170,388,378 - 170,486,873 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4170,388,378 - 170,486,873 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx4176,680,716 - 176,779,656 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04172,465,042 - 172,563,994 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04171,085,423 - 171,184,375 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.04171,475,155 - 171,645,620 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4171,475,567 - 171,591,882 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04235,732,277 - 235,903,027 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.44174,601,291 - 174,672,247 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.14174,848,196 - 174,917,371 (-)NCBI
Celera4158,967,950 - 159,084,908 (-)NCBICelera
Cytogenetic Map4q44NCBI
EPS8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381215,620,134 - 15,789,388 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1215,620,134 - 15,882,329 (-)EnsemblGRCh38hg38GRCh38
GRCh371215,773,068 - 15,942,322 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361215,664,342 - 15,833,601 (-)NCBINCBI36Build 36hg18NCBI36
Build 341215,664,342 - 15,833,601NCBI
Celera1220,917,962 - 21,087,395 (-)NCBICelera
Cytogenetic Map12p12.3NCBI
HuRef1215,542,405 - 15,711,684 (-)NCBIHuRef
CHM1_11215,739,030 - 15,908,465 (-)NCBICHM1_1
T2T-CHM13v2.01215,497,359 - 15,666,619 (-)NCBIT2T-CHM13v2.0
Eps8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm396137,454,242 - 137,626,262 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl6137,454,243 - 137,631,874 (-)EnsemblGRCm39 Ensembl
GRCm386137,477,245 - 137,649,397 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl6137,477,245 - 137,654,876 (-)EnsemblGRCm38mm10GRCm38
MGSCv376137,425,766 - 137,597,641 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv366137,441,441 - 137,613,316 (-)NCBIMGSCv36mm8
MGSCv366137,872,768 - 137,987,281 (-)NCBIMGSCv36mm8
Celera6140,541,302 - 140,657,063 (-)NCBICelera
Cytogenetic Map6G1NCBI
cM Map666.78NCBI
Eps8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541312,266,371 - 12,386,088 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541312,267,701 - 12,386,088 (-)NCBIChiLan1.0ChiLan1.0
EPS8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21021,063,405 - 21,262,151 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11221,060,141 - 21,255,181 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01215,617,536 - 15,788,537 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11216,013,270 - 16,184,203 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1216,013,276 - 16,076,117 (-)Ensemblpanpan1.1panPan2
EPS8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12730,893,884 - 31,070,401 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2730,893,713 - 31,069,770 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2715,378,134 - 15,554,665 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02731,213,204 - 31,391,094 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2731,213,046 - 31,391,090 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12731,212,841 - 31,279,922 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02731,058,974 - 31,235,537 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02715,100,205 - 15,276,688 (-)NCBIUU_Cfam_GSD_1.0
Eps8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494592,057,948 - 92,223,689 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365871,785,303 - 1,951,332 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365871,785,721 - 1,951,474 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EPS8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl556,817,606 - 57,005,113 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1556,817,445 - 57,005,117 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2560,303,025 - 60,409,561 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EPS8
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11115,522,761 - 15,691,343 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1115,522,616 - 15,691,133 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606919,609,645 - 19,778,199 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Eps8
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475222,295,413 - 22,426,717 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475222,250,988 - 22,424,957 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Eps8
959 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:25
Count of miRNA genes:21
Interacting mature miRNAs:25
Transcripts:ENSRNOT00000009328
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
7411558Bw133Body weight QTL 13313.840.001body mass (VT:0001259)body weight gain (CMO:0000420)4125590636170590636Rat
1549827Scl46Serum cholesterol level QTL 463.5blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)4132396220177396220Rat
724558Plsm2Polydactyly-luxate syndrome (PLS) morphotypes QTL 20.0003hindlimb integrity trait (VT:0010563)hind foot phalanges count (CMO:0001949)4132422778177422778Rat
2303623Vencon2Ventilatory control QTL 23.8respiration trait (VT:0001943)minute ventilation (CMO:0000132)4135204660180204660Rat
1578674Bmd12Bone mineral density QTL 123.8femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)4135699135180699135Rat
2293659Bmd35Bone mineral density QTL 354.50.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)4137755016181392681Rat
61362Oia2Oil induced arthritis QTL 20.001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1298524Oia8Oil induced arthritis QTL 8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4138503169173369699Rat
1331738Bp209Blood pressure QTL 2092.979arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)4138503169179293946Rat
6478718Anxrr34Anxiety related response QTL 340.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478748Anxrr42Anxiety related response QTL 420.28008locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
6478754Anxrr43Anxiety related response QTL 430.14035locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4144639524182687754Rat
6478693Anxrr32Anxiety related response QTL 320.00092locomotor behavior trait (VT:0001392)measurement of voluntary locomotion into, out of or within a discrete space in an experimental apparatus (CMO:0000957)4144639524182687754Rat
6478700Anxrr33Anxiety related response QTL 330.00896locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4144639524182687754Rat
10401796Kidm48Kidney mass QTL 48kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)4145568712182687754Rat
634342Cia24Collagen induced arthritis QTL 244.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)4146565735175236377Rat
10053718Scort25Serum corticosterone level QTL 252.150.0097blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)4155561574182687754Rat
1300109Rf13Renal function QTL 133.91renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)4157710145182687754Rat

Markers in Region
D4Rat277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,524,245 - 170,524,470 (+)MAPPERmRatBN7.2
Rnor_6.04171,609,331 - 171,609,555NCBIRnor6.0
Rnor_5.04235,867,733 - 235,867,957UniSTSRnor5.0
RGSC_v3.44174,739,724 - 174,739,949RGDRGSC3.4
RGSC_v3.44174,739,725 - 174,739,949UniSTSRGSC3.4
RGSC_v3.14174,984,848 - 174,985,073RGD
Celera4159,101,240 - 159,101,452UniSTS
SHRSP x BN Map491.8799RGD
SHRSP x BN Map491.8799UniSTS
Cytogenetic Map4q44UniSTS
BF406009  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,388,878 - 170,389,076 (+)MAPPERmRatBN7.2
Rnor_6.04171,475,656 - 171,475,853NCBIRnor6.0
Rnor_5.04235,732,778 - 235,732,975UniSTSRnor5.0
RGSC_v3.44174,601,797 - 174,601,994UniSTSRGSC3.4
Celera4158,968,451 - 158,968,648UniSTS
Cytogenetic Map4q44UniSTS
RH139755  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,388,439 - 170,388,659 (+)MAPPERmRatBN7.2
Rnor_6.04171,475,217 - 171,475,436NCBIRnor6.0
Rnor_5.04235,732,339 - 235,732,558UniSTSRnor5.0
RGSC_v3.44174,601,358 - 174,601,577UniSTSRGSC3.4
Celera4158,968,012 - 158,968,231UniSTS
RH 3.4 Map41027.1UniSTS
Cytogenetic Map4q44UniSTS
RH141106  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24170,389,898 - 170,390,088 (+)MAPPERmRatBN7.2
Rnor_6.04171,476,676 - 171,476,865NCBIRnor6.0
Rnor_5.04235,733,798 - 235,733,987UniSTSRnor5.0
RGSC_v3.44174,602,817 - 174,603,006UniSTSRGSC3.4
Celera4158,969,471 - 158,969,660UniSTS
Cytogenetic Map4q44UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 24 6 9 50 31 31 11
Low 19 50 40 10 40 8 11 24 4 10 8
Below cutoff 1 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001376935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_001072957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006225117 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006237583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763452 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602886 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017602887 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286158 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063286164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_232499 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000009328   ⟹   ENSRNOP00000009328
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl4170,388,378 - 170,486,873 (-)Ensembl
Rnor_6.0 Ensembl4171,475,567 - 171,591,882 (-)Ensembl
RefSeq Acc Id: NM_001376935   ⟹   NP_001363864
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,497 - 172,218,160 (-)NCBI
mRatBN7.24170,388,378 - 170,486,873 (-)NCBI
RefSeq Acc Id: XM_063286158   ⟹   XP_063142228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,291,342 (-)NCBI
RefSeq Acc Id: XM_063286159   ⟹   XP_063142229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,255,216 (-)NCBI
RefSeq Acc Id: XM_063286160   ⟹   XP_063142230
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,291,342 (-)NCBI
RefSeq Acc Id: XM_063286161   ⟹   XP_063142231
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,255,216 (-)NCBI
RefSeq Acc Id: XM_063286162   ⟹   XP_063142232
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,291,342 (-)NCBI
RefSeq Acc Id: XM_063286163   ⟹   XP_063142233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,255,216 (-)NCBI
RefSeq Acc Id: XM_063286164   ⟹   XP_063142234
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84172,119,948 - 172,291,670 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: ENSRNOP00000009328   ⟸   ENSRNOT00000009328
RefSeq Acc Id: NP_001363864   ⟸   NM_001376935
- UniProtKB: F1M3L7 (UniProtKB/Swiss-Prot),   A0A8L2Q453 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142234   ⟸   XM_063286164
- Peptide Label: isoform X1
- UniProtKB: F1M3L7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063142232   ⟸   XM_063286162
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142228   ⟸   XM_063286158
- Peptide Label: isoform X1
- UniProtKB: F1M3L7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063142230   ⟸   XM_063286160
- Peptide Label: isoform X1
- UniProtKB: F1M3L7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063142233   ⟸   XM_063286163
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063142229   ⟸   XM_063286159
- Peptide Label: isoform X1
- UniProtKB: F1M3L7 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_063142231   ⟸   XM_063286161
- Peptide Label: isoform X1
- UniProtKB: F1M3L7 (UniProtKB/Swiss-Prot)
Protein Domains
PTB   SH3

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-F1M3L7-F1-model_v2 AlphaFold F1M3L7 1-822 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310590 AgrOrtholog
BioCyc Gene G2FUF-42570 BioCyc
Ensembl Genes ENSRNOG00000007047 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009328 ENTREZGENE
  ENSRNOT00000009328.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.150.50 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 Domains UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro EPS8-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EPS8_PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Eps8_SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTB/PI_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM/pointed_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 312812 ENTREZGENE
PANTHER PTHR12287 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR12287:SF21 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SAM_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Eps8 PhenoGen
PROSITE SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007047 RatGTEx
SMART PTB UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SH3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF50044 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q453 ENTREZGENE, UniProtKB/TrEMBL
  EPS8_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2024-01-08 Eps8  EGFR pathway substrate 8, signaling adaptor  Eps8  epidermal growth factor receptor pathway substrate 8  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Eps8  epidermal growth factor receptor pathway substrate 8   Eps8_predicted  epidermal growth factor receptor pathway substrate 8 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Eps8_predicted  epidermal growth factor receptor pathway substrate 8 (predicted)      Symbol and Name status set to approved 70820 APPROVED