Iqcf1 (IQ motif containing F1) - Rat Genome Database

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Gene: Iqcf1 (IQ motif containing F1) Rattus norvegicus
Analyze
Symbol: Iqcf1
Name: IQ motif containing F1
RGD ID: 1565640
Description: Predicted to enable calmodulin binding activity. Predicted to be involved in positive regulation of acrosome reaction and positive regulation of flagellated sperm motility involved in capacitation. Predicted to be active in acrosomal vesicle. Orthologous to human IQCF1 (IQ motif containing F1); INTERACTS WITH 3-chloropropane-1,2-diol; acetamiprid; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: IQ domain-containing protein F1; LOC503227; RGD1565640; similar to IQ motif containing F1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,008,081 - 116,011,950 (+)NCBIGRCr8
mRatBN7.28107,129,462 - 107,133,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,130,704 - 107,133,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,753,894 - 112,756,362 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,953,070 - 110,955,538 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,795,852 - 108,798,320 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,191,919 - 115,195,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,193,146 - 115,195,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,556,972 - 114,559,887 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,635,585 - 111,638,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8106,442,644 - 106,445,131 (+)NCBICelera
Cytogenetic Map8q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
acrosomal vesicle  (IBA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:25380116  


Genomics

Comparative Map Data
Iqcf1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr88116,008,081 - 116,011,950 (+)NCBIGRCr8
mRatBN7.28107,129,462 - 107,133,242 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl8107,130,704 - 107,133,249 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx8112,753,894 - 112,756,362 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.08110,953,070 - 110,955,538 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.08108,795,852 - 108,798,320 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.08115,191,919 - 115,195,599 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8115,193,146 - 115,195,668 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08114,556,972 - 114,559,887 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48111,635,585 - 111,638,080 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera8106,442,644 - 106,445,131 (+)NCBICelera
Cytogenetic Map8q32NCBI
IQCF1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38351,894,876 - 51,903,353 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl351,894,876 - 51,903,353 (-)EnsemblGRCh38hg38GRCh38
GRCh37351,928,892 - 51,937,369 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36351,903,932 - 51,912,391 (-)NCBINCBI36Build 36hg18NCBI36
Build 34351,903,932 - 51,912,391NCBI
Celera351,907,728 - 51,916,218 (-)NCBICelera
Cytogenetic Map3p21.2NCBI
HuRef351,992,583 - 52,001,072 (-)NCBIHuRef
CHM1_1351,881,593 - 51,890,082 (-)NCBICHM1_1
T2T-CHM13v2.0351,927,807 - 51,936,279 (-)NCBIT2T-CHM13v2.0
Iqcf1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399106,377,166 - 106,379,449 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl9106,377,166 - 106,379,453 (+)EnsemblGRCm39 Ensembl
GRCm389106,499,967 - 106,502,250 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9106,499,967 - 106,502,254 (+)EnsemblGRCm38mm10GRCm38
MGSCv379106,402,298 - 106,404,581 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv369106,358,083 - 106,360,352 (+)NCBIMGSCv36mm8
Celera9106,118,274 - 106,120,561 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map957.65NCBI
LOC102021703
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555323,559,990 - 3,561,238 (-)NCBIChiLan1.0ChiLan1.0
IQCF1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2251,890,290 - 51,927,780 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1351,882,930 - 51,905,753 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0351,836,683 - 51,847,503 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1353,068,288 - 53,076,768 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl353,068,302 - 53,076,490 (-)Ensemblpanpan1.1panPan2
IQCF1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12037,797,253 - 37,799,110 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2037,797,325 - 37,799,110 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2037,777,288 - 37,779,145 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02038,146,404 - 38,148,261 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2038,146,476 - 38,148,261 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12037,510,001 - 37,511,858 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02037,918,928 - 37,920,765 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02038,203,853 - 38,205,711 (+)NCBIUU_Cfam_GSD_1.0
LOC101959243
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560266,502,800 - 66,504,791 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049365293,263,311 - 3,266,991 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IQCF1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1334,057,164 - 34,060,951 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11334,057,694 - 34,059,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21337,254,232 - 37,255,986 (-)NCBISscrofa10.2Sscrofa10.2susScr3
IQCF1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12213,264,183 - 13,271,409 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2213,264,197 - 13,270,856 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666041153,634,100 - 153,670,754 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC101714413
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247305,706,146 - 5,706,571 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Iqcf1
34 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:27
Count of miRNA genes:26
Interacting mature miRNAs:27
Transcripts:ENSRNOT00000056391
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2303171Bp331Blood pressure QTL 3315.570.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)861290298119084929Rat
1549909Stresp11Stress response QTL 116.830.0019stress-related behavior trait (VT:0010451)number of approaches toward negative stimulus before onset of defensive burying response (CMO:0001960)873473045118473045Rat
631210Bw3Body weight QTL35.9mesenteric fat pad mass (VT:0010427)mesenteric fat pad weight to body weight ratio (CMO:0000654)869349194112783834Rat
1358903Bp252Blood pressure QTL 25270.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)840952565123900184Rat
9590292Uminl3Urine mineral level QTL 33.620.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)871888757116888757Rat
8694446Bw170Body weight QTL 17012.070.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)871888757116888757Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
631653Bp125Blood pressure QTL 1253.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)866142385111142385Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
738011Anxrr9Anxiety related response QTL 96.1exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)893535351123900184Rat
724539Cm19Cardiac mass QTL 192.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)8100149864120994388Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)846531639119088626Rat
738014Anxrr15Anxiety related response QTL 153.60.005locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)895718998123900184Rat
2300182Bmd56Bone mineral density QTL 565.4femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)895718998123900184Rat
2300181Bmd55Bone mineral density QTL 555.70.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)876468691121468691Rat
1300171Bp184Blood pressure QTL 1843.66arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)870513503118219066Rat
631217Activ1Activity QTL 115.9voluntary movement trait (VT:0003491)number of photobeam interruptions in an experimental apparatus (CMO:0001517)8102370617108923645Rat
1358893Bp263Blood pressure QTL 2635.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)893965141123900184Rat
2313400Anxrr25Anxiety related response QTL 25aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)889265192114019816Rat
8694200Abfw4Abdominal fat weight QTL 49.070.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)871888757116888757Rat
8694392Bw161Body weight QTL 1618.060.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)871888757116888757Rat
61437Cia6Collagen induced arthritis QTL 6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)882460758122812818Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 4 26 84 56 56 39 19 39 6 138 54 73 33 53 17

Sequence


Ensembl Acc Id: ENSRNOT00000056391   ⟹   ENSRNOP00000053229
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,130,745 - 107,133,240 (+)Ensembl
Rnor_6.0 Ensembl8115,193,146 - 115,195,668 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110544   ⟹   ENSRNOP00000085269
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl8107,130,704 - 107,133,249 (+)Ensembl
RefSeq Acc Id: NM_001109361   ⟹   NP_001102831
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,009,454 - 116,011,949 (+)NCBI
mRatBN7.28107,130,745 - 107,133,240 (+)NCBI
Rnor_6.08115,193,173 - 115,195,597 (+)NCBI
Rnor_5.08114,556,972 - 114,559,887 (+)NCBI
RGSC_v3.48111,635,585 - 111,638,080 (+)RGD
Celera8106,442,644 - 106,445,131 (+)RGD
Sequence:
RefSeq Acc Id: XM_006243838   ⟹   XP_006243900
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr88116,008,081 - 116,011,950 (+)NCBI
mRatBN7.28107,129,462 - 107,133,242 (+)NCBI
Rnor_6.08115,191,919 - 115,195,599 (+)NCBI
Rnor_5.08114,556,972 - 114,559,887 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001102831 (Get FASTA)   NCBI Sequence Viewer  
  XP_006243900 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL77288 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000053229.2
  ENSRNOP00000085269.1
RefSeq Acc Id: NP_001102831   ⟸   NM_001109361
- UniProtKB: D3ZLI2 (UniProtKB/TrEMBL),   A6I2T9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006243900   ⟸   XM_006243838
- Peptide Label: isoform X1
- UniProtKB: A0A8I5ZZQ9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000053229   ⟸   ENSRNOT00000056391
Ensembl Acc Id: ENSRNOP00000085269   ⟸   ENSRNOT00000110544

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZLI2-F1-model_v2 AlphaFold D3ZLI2 1-182 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13696255
Promoter ID:EPDNEW_R6780
Type:initiation region
Name:Iqcf1_1
Description:IQ motif containing F1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.08115,193,171 - 115,193,231EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1565640 AgrOrtholog
BioCyc Gene G2FUF-29232 BioCyc
Ensembl Genes ENSRNOG00000037289 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000056391.4 UniProtKB/TrEMBL
  ENSRNOT00000110544.1 UniProtKB/TrEMBL
Gene3D-CATH 1.20.5.190 UniProtKB/TrEMBL
InterPro IQ_CaM-bd_region UniProtKB/TrEMBL
  IQCF UniProtKB/TrEMBL
KEGG Report rno:503227 UniProtKB/TrEMBL
NCBI Gene 503227 ENTREZGENE
PANTHER IQ DOMAIN-CONTAINING PROTEIN F1 UniProtKB/TrEMBL
  PTHR21633 UniProtKB/TrEMBL
Pfam PF00612 UniProtKB/TrEMBL
PhenoGen Iqcf1 PhenoGen
PROSITE PS50096 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000037289 RatGTEx
SMART SM00015 UniProtKB/TrEMBL
UniProt A0A8I5ZZQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6I2T9 ENTREZGENE, UniProtKB/TrEMBL
  D3ZLI2 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Iqcf1  IQ motif containing F1  RGD1565640_predicted  similar to IQ motif containing F1 (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1565640_predicted  similar to IQ motif containing F1 (predicted)  LOC503227  similar to IQ motif containing F1  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC503227  similar to IQ motif containing F1      Symbol and Name status set to provisional 70820 PROVISIONAL