Lta4h (leukotriene A4 hydrolase) - Rat Genome Database

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Gene: Lta4h (leukotriene A4 hydrolase) Rattus norvegicus
Analyze
Symbol: Lta4h
Name: leukotriene A4 hydrolase
RGD ID: 1311333
Description: Enables leukotriene-A4 hydrolase activity. Involved in several processes, including leukotriene metabolic process; response to zinc ion; and type I pneumocyte differentiation. Located in cytoplasm and nucleus. Biomarker of adenocarcinoma; asthma; and squamous cell carcinoma. Orthologous to human LTA4H (leukotriene A4 hydrolase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: leukotriene A-4 hydrolase; LOC299732; LTA-4 hydrolase; tripeptide aminopeptidase LTA4H
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2727,969,796 - 28,001,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx729,960,190 - 29,991,962 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0732,122,406 - 32,154,178 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0731,897,354 - 31,929,083 (+)NCBIRnor_WKY
Rnor_6.0734,288,333 - 34,320,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,353,476 - 34,385,291 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,482,213 - 30,515,062 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,502,483 - 30,535,333 (+)NCBI
Celera725,071,700 - 25,102,147 (+)NCBICelera
Cytogenetic Map7q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-naphthyl isothiocyanate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
4,4'-diaminodiphenylmethane  (EXP,ISO)
5-aza-2'-deoxycytidine  (ISO)
acrolein  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azoxystrobin  (EXP)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
bisphenol A  (EXP,ISO)
Brodifacoum  (EXP)
buspirone  (EXP)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (EXP)
cisplatin  (ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (ISO)
cyclohexene  (ISO)
cyclosporin A  (ISO)
dexamethasone  (EXP)
diarsenic trioxide  (ISO)
dicrotophos  (ISO)
dioxygen  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
glyphosate  (EXP)
imidacloprid  (EXP)
ivermectin  (ISO)
leukotriene A4  (ISO)
leukotriene B4  (ISO)
menadione  (ISO)
methylmercury chloride  (ISO)
montelukast  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
phenylmercury acetate  (ISO)
picrotoxin  (EXP)
piperonyl butoxide  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propane-1-thiol  (ISO)
quinoline  (ISO)
SB 203580  (ISO)
SB 431542  (ISO)
silicon dioxide  (EXP)
Soman  (EXP)
sulforaphane  (ISO)
temozolomide  (ISO)
tetrachloromethane  (ISO)
tetrahydropalmatine  (ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
trovafloxacin  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vorinostat  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IDA)
cytosol  (IBA,ISO)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Nuclear localization of leukotriene A4 hydrolase in type II alveolar epithelial cells in normal and fibrotic lung. Brock TG, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L224-32. Epub 2005 Apr 1.
2. Leukotriene A4 hydrolase in rat and human esophageal adenocarcinomas and inhibitory effects of bestatin. Chen X, etal., J Natl Cancer Inst. 2003 Jul 16;95(14):1053-61.
3. Changes of 5-lipoxygenase pathway and proinflammatory mediators in cerebral cortex and lung tissue of sensitized rats. Deng YM, etal., Acta Pharmacol Sin. 2005 Mar;26(3):353-8.
4. Purification and characterisation of leukotriene A4 hydrolase from rat neutrophils. Evans JF, etal., Biochim Biophys Acta. 1985 May 29;840(1):43-50.
5. Prevention of upper aerodigestive tract cancer in zinc-deficient rodents: inefficacy of genetic or pharmacological disruption of COX-2. Fong LY, etal., Int J Cancer. 2008 Mar 1;122(5):978-89.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. Increased leukotriene A(4) hydrolase expression in the heart of angiotensin II-induced hypertensive rat. Ishizaka N, etal., FEBS Lett. 1999 Dec 10;463(1-2):155-9.
9. Human bronchial epithelial cells express an active and inducible biosynthetic pathway for leukotrienes B4 and C4. Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:1544505   PMID:9774412   PMID:11675384   PMID:12477932   PMID:15078870   PMID:18804029   PMID:19056867   PMID:22658674   PMID:23533145   PMID:24701582   PMID:30745237  


Genomics

Comparative Map Data
Lta4h
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2727,969,796 - 28,001,600 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx729,960,190 - 29,991,962 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0732,122,406 - 32,154,178 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0731,897,354 - 31,929,083 (+)NCBIRnor_WKY
Rnor_6.0734,288,333 - 34,320,243 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0734,353,476 - 34,385,291 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4730,482,213 - 30,515,062 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1730,502,483 - 30,535,333 (+)NCBI
Celera725,071,700 - 25,102,147 (+)NCBICelera
Cytogenetic Map7q13NCBI
LTA4H
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381296,000,753 - 96,043,520 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1296,000,753 - 96,043,520 (-)EnsemblGRCh38hg38GRCh38
GRCh371296,394,531 - 96,437,298 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361294,918,742 - 94,953,496 (-)NCBINCBI36Build 36hg18NCBI36
Build 341294,897,078 - 94,931,833NCBI
Celera1296,060,902 - 96,095,656 (-)NCBICelera
Cytogenetic Map12q23.1NCBI
HuRef1293,456,404 - 93,499,169 (-)NCBIHuRef
CHM1_11296,359,522 - 96,402,289 (-)NCBICHM1_1
T2T-CHM13v2.01295,974,750 - 96,017,515 (-)NCBIT2T-CHM13v2.0
Lta4h
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391093,289,258 - 93,320,758 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1093,289,273 - 93,320,737 (+)EnsemblGRCm39 Ensembl
GRCm381093,453,396 - 93,484,896 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1093,453,411 - 93,484,875 (+)EnsemblGRCm38mm10GRCm38
MGSCv371092,916,141 - 92,947,641 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361092,883,229 - 92,914,633 (+)NCBIMGSCv36mm8
Celera1095,436,799 - 95,470,679 (+)NCBICelera
Cytogenetic Map10C2NCBI
Lta4h
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540532,344,925 - 32,378,384 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540532,345,005 - 32,377,685 (-)NCBIChiLan1.0ChiLan1.0
LTA4H
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11296,978,203 - 97,012,427 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1296,978,203 - 97,012,427 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01293,589,758 - 93,624,529 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
LTA4H
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11535,795,934 - 35,830,681 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1535,795,979 - 35,830,844 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1536,182,408 - 36,217,145 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01536,460,885 - 36,495,697 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1536,460,861 - 36,495,858 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11535,733,722 - 35,768,521 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01535,828,282 - 35,863,043 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01536,091,485 - 36,126,289 (-)NCBIUU_Cfam_GSD_1.0
Lta4h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494524,115,386 - 24,153,026 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493650712,082,068 - 12,120,091 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493650712,082,373 - 12,120,078 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LTA4H
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl587,486,512 - 87,518,515 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1587,486,552 - 87,518,520 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2591,688,970 - 91,720,982 (+)NCBISscrofa10.2Sscrofa10.2susScr3
LTA4H
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11191,371,383 - 91,413,396 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1191,371,383 - 91,406,542 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666037153,722,667 - 153,757,250 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lta4h
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475011,274,664 - 11,314,581 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475011,274,506 - 11,314,683 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lta4h
160 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:15
Count of miRNA genes:14
Interacting mature miRNAs:15
Transcripts:ENSRNOT00000005930
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
10755438Coatc9Coat color QTL 90coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7352928048529280Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7532901950329019Rat
10755440Coatc10Coat color QTL 100coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)7749649952496499Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7757398552573985Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)7946224658265113Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)7946224698011544Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)7986646760460686Rat
738033Anxrr6Anxiety related response QTL 64.1exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)71557388960573889Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)71579556538073970Rat
2317059Aia15Adjuvant induced arthritis QTL 152.46joint integrity trait (VT:0010548)right rear ankle joint diameter (CMO:0002150)71700459862004598Rat
10755451Coatc11Coat color QTL 110coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)71794435762944357Rat
61369Mcs2Mammary carcinoma susceptibility QTL 23.38mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)71903280735526300Rat
1354637Scl30Serum cholesterol level QTL 303.7blood cholesterol amount (VT:0000180)blood total cholesterol level (CMO:0000051)71965431749753746Rat
1354644Spl4Serum phospholipid level QTL 44.9blood phospholipid amount (VT:0006084)blood phospholipid level (CMO:0001169)71965431749753746Rat
1354639Spl5Serum phospholipid level QTL 53.9blood LDL phospholipid amount (VT:0010505)blood low density lipoprotein phospholipid level (CMO:0001568)71965431752888450Rat
1300132Bp182Blood pressure QTL 1823.49arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)71965431784928080Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)72055570529891047Rat
7411569Bw137Body weight QTL 1370.001body mass (VT:0001259)body weight gain (CMO:0000420)72192119566921195Rat
1641885Alcrsp9Alcohol response QTL 9alcohol metabolism trait (VT:0015089)blood ethanol level (CMO:0000535)72409960669099606Rat
1549840Bss5Bone structure and strength QTL 59.8femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)72475184169751841Rat
70190Mcs6Mammary carcinoma susceptibility QTL 62.29mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)72673740163902784Rat

Markers in Region
BF395896  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2727,988,365 - 27,988,585 (+)MAPPERmRatBN7.2
Rnor_6.0734,306,915 - 34,307,134NCBIRnor6.0
Rnor_5.0734,371,970 - 34,372,189UniSTSRnor5.0
RGSC_v3.4730,501,835 - 30,502,054UniSTSRGSC3.4
Celera725,088,926 - 25,089,145UniSTS
RH 3.4 Map7189.3UniSTS
Cytogenetic Map7q13UniSTS
RH141007  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 38 57 41 19 41 4 7 74 35 41 11 4
Low 5 4 4 4
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000005930   ⟹   ENSRNOP00000005930
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl727,969,789 - 28,001,600 (+)Ensembl
Rnor_6.0 Ensembl734,288,365 - 34,320,235 (+)Ensembl
RefSeq Acc Id: NM_001030031   ⟹   NP_001025202
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2727,969,818 - 28,001,593 (+)NCBI
Rnor_6.0734,288,365 - 34,320,236 (+)NCBI
Rnor_5.0734,353,476 - 34,385,291 (+)NCBI
RGSC_v3.4730,482,213 - 30,515,062 (+)RGD
Celera725,071,700 - 25,102,147 (+)RGD
Sequence:
RefSeq Acc Id: XM_006241251   ⟹   XP_006241313
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2727,969,796 - 28,001,600 (+)NCBI
Rnor_6.0734,288,333 - 34,320,243 (+)NCBI
Rnor_5.0734,353,476 - 34,385,291 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs NP_001025202 (Get FASTA)   NCBI Sequence Viewer  
  XP_006241313 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99819 (Get FASTA)   NCBI Sequence Viewer  
  EDM16913 (Get FASTA)   NCBI Sequence Viewer  
  EDM16914 (Get FASTA)   NCBI Sequence Viewer  
  P30349 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001025202   ⟸   NM_001030031
- UniProtKB: Q499P2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006241313   ⟸   XM_006241251
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSRNOP00000005930   ⟸   ENSRNOT00000005930

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P30349-F1-model_v2 AlphaFold P30349 1-611 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695145
Promoter ID:EPDNEW_R5670
Type:initiation region
Name:Lta4h_1
Description:leukotriene A4 hydrolase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0734,288,399 - 34,288,459EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311333 AgrOrtholog
BioCyc Gene G2FUF-34393 BioCyc
BioCyc Pathway PWY66-375 [leukotriene biosynthesis] BioCyc
  PWY66-394 [aspirin triggered resolvin E biosynthesis] BioCyc
Ensembl Genes ENSRNOG00000004494 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000005930 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000005930 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.10.390.10 UniProtKB/Swiss-Prot
  1.25.40.320 UniProtKB/Swiss-Prot
  2.60.40.1730 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7930840 IMAGE-MGC_LOAD
InterPro Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  Aminopeptidase_N-like_N UniProtKB/Swiss-Prot
  ARM-type_fold UniProtKB/Swiss-Prot
  LTA4H UniProtKB/Swiss-Prot
  M1_LTA-4_hydro/amino_C_sf UniProtKB/Swiss-Prot
  M1_LTA4H UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_C UniProtKB/Swiss-Prot
  Peptidase_M1_dom UniProtKB/Swiss-Prot
  Peptidase_M4/M1_CTD_sf UniProtKB/Swiss-Prot
KEGG Report rno:299732 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124681 IMAGE-MGC_LOAD
NCBI Gene 299732 ENTREZGENE
PANTHER PTHR45726 UniProtKB/Swiss-Prot
Pfam Leuk-A4-hydro_C UniProtKB/Swiss-Prot
  Peptidase_M1 UniProtKB/Swiss-Prot
  Peptidase_M1_N UniProtKB/Swiss-Prot
PharmGKB LTA4H RGD
PhenoGen Lta4h PhenoGen
PRINTS ALADIPTASE UniProtKB/Swiss-Prot
PROSITE ZINC_PROTEASE UniProtKB/Swiss-Prot
SMART Leuk-A4-hydro_C UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48371 UniProtKB/Swiss-Prot
  SSF63737 UniProtKB/Swiss-Prot
TIGRFAMs leuko_A4_hydro UniProtKB/Swiss-Prot
UniProt LKHA4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q499P2 ENTREZGENE
UniProt Secondary Q499P2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-12-06 Lta4h  leukotriene A4 hydrolase  Lta4h_predicted  leukotriene A4 hydrolase (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Lta4h_predicted  leukotriene A4 hydrolase (predicted)      Symbol and Name status set to approved 70820 APPROVED