Lta4h (leukotriene A4 hydrolase) - Rat Genome Database

Name: Lta4h
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Lta4h (leukotriene A4 hydrolase) Rattus norvegicus

Analyze

Symbol:

Lta4h

Name:

leukotriene A4 hydrolase

RGD ID:

1311333

Description:

Exhibits leukotriene-A4 hydrolase activity. Involved in several processes, including leukotriene metabolic process; response to zinc ion; and type I pneumocyte differentiation. Localizes to cytoplasm and nucleus. Biomarker of adenocarcinoma; asthma; and squamous cell carcinoma. Orthologous to human LTA4H (leukotriene A4 hydrolase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 1-naphthyl isothiocyanate; 2,6-dinitrotoluene; 4,4'-diaminodiphenylmethane.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Also known as:

leukotriene A-4 hydrolase; LOC299732; LTA-4 hydrolase; tripeptide aminopeptidase LTA4H

RGD Orthologs

Human

Mouse

Chinchilla

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	LTA4H (leukotriene A4 hydrolase)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Lta4h (leukotriene A4 hydrolase)	HGNC	Treefam, EggNOG, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):	Lta4h (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	LTA4H (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LTA4H (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Lta4h (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	LTA4H (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):	LTA4H (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Lta4h (leukotriene A4 hydrolase)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	LTA4H (leukotriene A4 hydrolase)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Mus musculus (house mouse):	Lta4h (leukotriene A4 hydrolase)	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Danio rerio (zebrafish):	lta4h (leukotriene A4 hydrolase)	Alliance	DIOPT (PhylomeDB\|TreeFam)
Drosophila melanogaster (fruit fly):	CG10602	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Saccharomyces cerevisiae (baker's yeast):	LAP2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|TreeFam)
Caenorhabditis elegans (roundworm):	ltah-1.1	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Caenorhabditis elegans (roundworm):	ltah-1.2	Alliance	DIOPT (Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)

Latest Assembly:

Rnor_6.0 - RGSC Genome Assembly v6.0

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	27,969,796 - 28,001,600 (+)	NCBI
Rnor_6.0 Ensembl	7	34,288,365 - 34,320,235 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	34,288,333 - 34,320,243 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	34,353,476 - 34,385,291 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	30,482,213 - 30,515,062 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	30,502,483 - 30,535,333 (+)	NCBI
Celera	7	25,071,700 - 25,102,147 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (IEP)

asthma (IEP)

atherosclerosis (ISO)

COVID-19 (ISO)

Experimental Liver Cirrhosis (ISO)

otitis media (ISO)

squamous cell carcinoma (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1-naphthyl isothiocyanate (EXP)

17beta-hydroxy-17-methylestra-4,9,11-trien-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,6-dinitrotoluene (EXP)

4,4'-diaminodiphenylmethane (EXP,ISO)

5-aza-2'-deoxycytidine (ISO)

acrolein (ISO)

alpha-pinene (ISO)

ammonium chloride (EXP)

amphetamine (EXP)

antirheumatic drug (ISO)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (EXP,ISO)

Brodifacoum (EXP)

buspirone (EXP)

cadmium dichloride (ISO)

carbamazepine (ISO)

chloropicrin (ISO)

cisplatin (ISO)

clofibrate (ISO)

clofibric acid (EXP)

copper(II) sulfate (ISO)

cyclohexene (ISO)

cyclosporin A (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

dicrotophos (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

leukotriene A4 (ISO)

leukotriene B4 (ISO)

menadione (ISO)

methylmercury chloride (ISO)

montelukast (ISO)

N-nitrosodiethylamine (EXP)

N-nitrosodimethylamine (EXP)

nefazodone (EXP)

nickel atom (ISO)

nimesulide (EXP)

ozone (EXP,ISO)

paracetamol (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenylmercury acetate (ISO)

picrotoxin (EXP)

piperonyl butoxide (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (EXP)

propane-1-thiol (ISO)

quinoline (ISO)

SB 203580 (ISO)

SB 431542 (ISO)

silicon dioxide (EXP)

Soman (EXP)

sulforaphane (ISO)

tetrachloromethane (ISO)

tetrahydropalmatine (ISO)

thimerosal (ISO)

titanium dioxide (ISO)

trichostatin A (ISO)

trovafloxacin (EXP)

valproic acid (ISO)

vinclozolin (EXP)

vorinostat (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular protein metabolic process (ISO)

leukotriene biosynthetic process (IBA,ISO,ISS)

leukotriene metabolic process (IDA)

peptide catabolic process (IBA,ISO,ISS)

proteolysis (IEA)

response to peptide hormone (IEP)

response to zinc ion (IEP)

type I pneumocyte differentiation (IEP)

Cellular Component

cytoplasm (IDA)

cytosol (IBA,ISO)

nucleoplasm (ISO)

nucleus (IBA,IDA)

Molecular Function

aminopeptidase activity (IBA,ISO,ISS)

epoxide hydrolase activity (IBA,ISO,ISS)

leukotriene-A4 hydrolase activity (IBA,IDA,ISO)

metalloaminopeptidase activity (ISO)

protein binding (ISO)

tripeptide aminopeptidase activity (IEA)

zinc ion binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

acetylsalicylic acid pharmacodynamics pathway (ISO)

antipyrine drug pathway (ISO)

arachidonic acid metabolic pathway (IEA,ISO)

celecoxib pharmacodynamics pathway (ISO)

diclofenac pharmacodynamics pathway (ISO)

diflunisal pharmacodynamics pathway (ISO)

etodolac pharmacodynamics pathway (ISO)

fenoprofen pharmacodynamics pathway (ISO)

flurbiprofen pharmacodynamics pathway (ISO)

ibuprofen pharmacodynamics pathway (ISO)

indometacin pharmacodynamics pathway (ISO)

ketoprofen pharmacodynamics pathway (ISO)

ketorolac pharmacodynamics pathway (ISO)

leukotriene C4 synthase deficiency pathway (ISO)

leukotriene metabolic pathway (ISO)

lipoxygenase mediated pathway of arachidonic acid metabolism (ISO)

lornoxicam pharmacodynamics pathway (ISO)

magnesium salicylate pharmacodynamics pathway (ISO)

mefenamic acid pharmacodynamics pathway (ISO)

meloxicam pharmacodynamics pathway (ISO)

nabumetone pharmacodynamics pathway (ISO)

naproxen pharmacodynamics pathway (ISO)

paracetamol drug pathway (ISO)

piroxicam pharmacodynamics pathway (ISO)

salicylic acid pharmacodynamics pathway (ISO)

sodium salicylate pharmacodynamics pathway (ISO)

sulindac pharmacodynamics pathway (ISO)

tenoxicam pharmacodynamics pathway (ISO)

tiaprofenic acid pharmacodynamics pathway (ISO)

tolmetin pharmacodynamics pathway (ISO)

valdecoxib pharmacodynamics pathway (ISO)

References

References - curated


1.	Brock TG, etal., Am J Physiol Lung Cell Mol Physiol. 2005 Aug;289(2):L224-32. Epub 2005 Apr 1.
2.	Chen X, etal., J Natl Cancer Inst. 2003 Jul 16;95(14):1053-61.
3.	Deng YM, etal., Acta Pharmacol Sin. 2005 Mar;26(3):353-8.
4.	Evans JF, etal., Biochim Biophys Acta. 1985 May 29;840(1):43-50.
5.	Fong LY, etal., Int J Cancer. 2008 Mar 1;122(5):978-89.
6.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7.	GOA data from the GO Consortium
8.	Ishizaka N, etal., FEBS Lett. 1999 Dec 10;463(1-2):155-9.
9.	Jame AJ, etal., Clin Exp Allergy. 2007 Jun;37(6):880-92.
10.	Pipeline to import KEGG annotations from KEGG into RGD
11.	Pipeline to import SMPDB annotations from SMPDB into RGD
12.	RGD automated data pipeline
13.	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:1544505	PMID:9774412	PMID:11675384	PMID:12477932	PMID:15078870	PMID:18804029	PMID:19056867	PMID:22658674	PMID:23533145	PMID:24701582	PMID:30745237

Genomics

Comparative Map Data

Lta4h
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	7	27,969,796 - 28,001,600 (+)	NCBI
Rnor_6.0 Ensembl	7	34,288,365 - 34,320,235 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	7	34,288,333 - 34,320,243 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	7	34,353,476 - 34,385,291 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	7	30,482,213 - 30,515,062 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	7	30,502,483 - 30,535,333 (+)	NCBI
Celera	7	25,071,700 - 25,102,147 (+)	NCBI		Celera
Cytogenetic Map	7	q13	NCBI

LTA4H
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	12	96,000,753 - 96,043,520 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	12	96,000,753 - 96,043,520 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	12	96,394,531 - 96,437,298 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	94,918,742 - 94,953,496 (-)	NCBI	NCBI36		hg18	NCBI36
Build 34	12	94,897,078 - 94,931,833	NCBI
Celera	12	96,060,902 - 96,095,656 (-)	NCBI
Cytogenetic Map	12	q23.1	NCBI
HuRef	12	93,456,404 - 93,499,169 (-)	NCBI		HuRef
CHM1_1	12	96,359,522 - 96,402,289 (-)	NCBI		CHM1_1

Lta4h
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	93,289,258 - 93,320,758 (+)	NCBI	GRCm39		mm39
GRCm39 Ensembl	10	93,289,273 - 93,320,737 (+)	Ensembl
GRCm38	10	93,453,396 - 93,484,896 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	93,453,411 - 93,484,875 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	92,916,141 - 92,947,641 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	10	92,883,229 - 92,914,633 (+)	NCBI			mm8
Celera	10	95,436,799 - 95,470,679 (+)	NCBI		Celera
Cytogenetic Map	10	C2	NCBI

Lta4h
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955405	32,344,925 - 32,378,384 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955405	32,345,005 - 32,377,685 (-)	NCBI	ChiLan1.0	ChiLan1.0

LTA4H
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	12	96,978,203 - 97,012,427 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	96,978,203 - 97,012,427 (-)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	12	93,589,758 - 93,624,529 (-)	NCBI	Mhudiblu_PPA_v0		panPan3

LTA4H
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1 Ensembl	15	35,795,979 - 35,830,844 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
CanFam3.1	15	35,795,934 - 35,830,681 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Lta4h
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936507	12,082,373 - 12,120,078 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

LTA4H
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	87,486,512 - 87,518,515 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	87,486,552 - 87,518,520 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	91,688,970 - 91,720,982 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LTA4H
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	91,371,383 - 91,413,396 (-)	NCBI
ChlSab1.1 Ensembl	11	91,371,383 - 91,406,542 (-)	Ensembl

Lta4h
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624750	11,274,506 - 11,314,683 (+)	NCBI

Position Markers

BF395896

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	7	34,306,915 - 34,307,134	NCBI	Rnor6.0
Rnor_5.0	7	34,371,970 - 34,372,189	UniSTS	Rnor5.0
RGSC_v3.4	7	30,501,835 - 30,502,054	UniSTS	RGSC3.4
Celera	7	25,088,926 - 25,089,145	UniSTS
RH 3.4 Map	7	189.3	UniSTS
Cytogenetic Map	7	q13	UniSTS

RH141007

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	q13	UniSTS

QTLs in Region (Rnor_6.0)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
9590142	Scort5	Serum corticosterone level QTL 5	24.4	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	7	1	34828535	Rat
7411566	Bw136	Body weight QTL 136	10.4	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	1	34828535	Rat
724560	Plsm3	Polydactyly-luxate syndrome (PLS) morphotypes QTL 3		0.0003	tibia length (VT:0004357)	tibia length (CMO:0000450)	7	1	37009673	Rat
2317047	Wbc4	White blood cell count QTL 4		0.01	leukocyte quantity (VT:0000217)	white blood cell count (CMO:0000027)	7	1	38119654	Rat
634336	Anxrr17	Anxiety related response QTL 17	3.66		locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	7	2920071	124838025	Rat
61410	Bw19	Body weight QTL 19	6.2	0.001	body mass (VT:0001259)	body weight (CMO:0000012)	7	5911477	50911477	Rat
631503	Bp102	Blood pressure QTL 102	1.9		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	5951969	50951969	Rat
10755438	Coatc9	Coat color QTL 9		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	9758045	54758045	Rat
9590102	Sffal5	Serum free fatty acids level QTL 5	8.62	0.001	blood free fatty acid amount (VT:0001553)	plasma free fatty acids level (CMO:0000546)	7	11647102	56647102	Rat
2298547	Neuinf5	Neuroinflammation QTL 5	3.7		nervous system integrity trait (VT:0010566)	spinal cord Cd74 protein level (CMO:0002131)	7	12328467	67193263	Rat
1643004	Pain2	Pain QTL 2	1		mechanical nociception trait (VT:0002734)	self mutilation severity score (CMO:0002145)	7	12328467	106995532	Rat
1578652	Bmd15	Bone mineral density QTL 15	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	7	12687850	67801690	Rat
10755440	Coatc10	Coat color QTL 10		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	13952179	58952179	Rat
10059592	Kidm45	Kidney mass QTL 45	3.95	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	7	14445685	59445685	Rat
1582260	Bw72	Body weight QTL 72	3.2	0.0043	body mass (VT:0001259)	body weight (CMO:0000012)	7	20215583	44668493	Rat
1582261	Bw69	Body weight QTL 69	3.2	0.0048	body mass (VT:0001259)	body weight (CMO:0000012)	7	20215583	44668493	Rat
1582262	Bw75	Body weight QTL 75	3	0.0038	body mass (VT:0001259)	body weight (CMO:0000012)	7	20215583	44668493	Rat
738033	Anxrr6	Anxiety related response QTL 6	4.1		exploratory behavior trait (VT:0010471)	percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)	7	22168412	67168412	Rat
10755451	Coatc11	Coat color QTL 11		0	coat/hair pigmentation trait (VT:0010463)	pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)	7	24731465	69731465	Rat
61369	Mcs2	Mammary carcinoma susceptibility QTL 2	3.38		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	24738680	40433335	Rat
1354644	Spl4	Serum phospholipid level QTL 4	4.9		blood phospholipid amount (VT:0006084)	blood phospholipid level (CMO:0001169)	7	25365633	57064364	Rat
1354637	Scl30	Serum cholesterol level QTL 30	3.7		blood cholesterol amount (VT:0000180)	blood total cholesterol level (CMO:0000051)	7	25365633	57064364	Rat
1354639	Spl5	Serum phospholipid level QTL 5	3.9		blood LDL phospholipid amount (VT:0010505)	blood low density lipoprotein phospholipid level (CMO:0001568)	7	25365633	60317612	Rat
1300132	Bp182	Blood pressure QTL 182	3.49		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	25365633	93155402	Rat
2290372	Gluco33	Glucose level QTL 33	2.71		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	26508887	36346595	Rat
7411569	Bw137	Body weight QTL 137		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	7	28204653	73204653	Rat
1641885	Alcrsp9	Alcohol response QTL 9			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	7	31381529	76381529	Rat
1549840	Bss5	Bone structure and strength QTL 5	9.8		femur strength trait (VT:0010010)	femur midshaft polar moment of inertia (CMO:0001669)	7	32035053	77035053	Rat
61439	Cia8	Collagen induced arthritis QTL 8	5.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	7	32572942	77572942	Rat
70190	Mcs6	Mammary carcinoma susceptibility QTL 6	2.29		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	7	33044449	71352127	Rat

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	15
Count of miRNA genes:	14
Interacting mature miRNAs:	15
Transcripts:	ENSRNOT00000005930
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	3	38	57	41	19	41	4	7	74	35	41	11	4
Low		5					4	4					4
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001030031	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006241251	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	BC099819	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473960	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JACYVU010000185	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000005930 ⟹ ENSRNOP00000005930

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	7	34,288,365 - 34,320,235 (+)	Ensembl

RefSeq Acc Id:

NM_001030031 ⟹ NP_001025202

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	27,969,818 - 28,001,593 (+)	NCBI
Rnor_6.0	7	34,288,365 - 34,320,236 (+)	NCBI
Rnor_5.0	7	34,353,476 - 34,385,291 (+)	NCBI
RGSC_v3.4	7	30,482,213 - 30,515,062 (+)	RGD
Celera	7	25,071,700 - 25,102,147 (+)	RGD

Sequence:

show sequence

CCTCTATGCTTCCCTCCTTTCTCAGGCTTGCGGTGAAAGTCTGGCGGTAGAGTGTCTGGGTGCT
GGTTGACGTGCGGCGGATCTCCCACAACCATGCCTGAGGTCGCGGATACTTGTTCCTTGGCTTC
TCCAGCCTCGGTCTGCCGAACCCAGCACCTCCATCTTCGCTGCAGCGTCGACTTCGCTCGCCGG
GCACTGACCGGGACCGCCGCGCTCACGGTCCAGTCACAGGAGGATAATCTGCGCAGCCTGACTT
TGGATACAAAAGACCTTACGATAGAAAAAGTGGTGATCAACGGACAAGAAGTCAAATACACTCT
TGGAGAAAGCCAGGGTTACAAAGGATCGCCGATGGAAATCTCCCTTCCCATCGCTCTGAGCAAA
AATCAAGAGGTCGTTATAGAGATTTCCTTCGAGACATCTCCCAAGTCCTCGGCCCTTCAGTGGC
TCACTCCCGAGCAGACTTCAGGAAAGCAGCATCCATACCTCTTCAGTCAGTGCCAGGCCATCCA
CTGCAGGGCAATCCTCCCTTGCCAAGACACTCCTTCTGTGAAGTTAACCTACACCGCAGAGGTA
TCTGTCCCCAAAGAACTGGTGGCTCTCATGAGTGCCATCCGTGATGGAGAAGCCCCTGACCCAG
AAGACCCCAGCAGGAAGATATACAGATTTAACCAGAGGGTTCCCATACCGTGCTACCTGATTGC
TTTAGTCGTTGGCGCTTTAGAAAGCAGGCAAATTGGCCCAAGAACTCTGGTGTGGTCTGAGAAA
GAGCAGGTGGAGAAGTCTGCTTATGAATTCTCTGAGACTGAATCCATGCTTAAAATTGCAGAAG
ATCTGGGGGGACCCTATGTTTGGGGACAGTACGACCTGTTGGTCCTGCCCCCATCCTTCCCGTA
CGGAGGCATGGAGAATCCTTGTCTCACATTCGTAACCCCTACTCTATTGGCAGGTGACAAGTCA
CTCTCTAATGTTATTGCACACGAAATATCGCATAGCTGGACAGGGAACCTAGTGACTAACAAGA
CTTGGGATCACTTCTGGTTAAACGAAGGACATACCGTCTATTTAGAGCGCCACATTTGTGGGCG
GTTGTTTGGGGAAAAATTCAGACATTTCCACGCTTTAGGAGGATGGGGAGAGCTACAGAACACG
ATAAAGACTTTCGGGGAGTCCCATCCCTTCACCAAGCTCGTGGTCGATCTGAAGGACGTAGACC
CCGATGTGGCCTACTCCTCCATTCCCTACGAGAAGGGCTTCGCCTTGCTCTTCTACCTGGAACA
ACTTCTTGGGGGACCGGAGGTGTTTCTAGGATTCCTAAAGGCTTATGTGGAGAAGTTTTCCTAC
CAGAGCGTAACCACTGATGACTGGAAGAGTTTCCTGTATGCTCACTTTAAAGATAAGGTGGATC
TTCTCAATCAAGTTGATTGGAATGCCTGGCTCTATGCTCCTGGCCTGCCTCCTGTCAAACCCAA
TTACGATGTGACTCTCACGAATGCCTGCATCGCCTTAAGTCAAAGATGGGTCACTGCCAAAGAG
GAAGATTTAAATTCATTCAGCATCGAAGACCTGAAGGACCTCTCGTCCCATCAGCTGAATGAGT
TCCTGGCACAGGTGCTTCAGAAGGCACCTCTTCCCTTGGGGCACATAAAGCGAATGCAAGAGGT
GTACAACTTCAATGCCATTAACAATTCTGAAATACGATTCAGATGGTTACGGCTCTGCATTCAA
TCGAAGTGGGAAGAAGCAATTCCTTTGGCCCTAAAGATGGCAACTGAACAAGGAAGGATGAAAT
TTACACGACCTCTATTCAAGGACCTCGCTGCCTTCGACAAATCCCACGATCAAGCTGTCCGCAC
CTACCAGGAACATAAAGCCTGTATGCATCCCGTGACCGCCATGCTGGTGGGGAAAGATCTGAAA
GTGGATTAAGGAACTGAGTGTTGCTGATTTCAGAAAATTCCTTTTTTTTAAGAAAAAAAATCGA
ACCTATTAAGAAATACAAAATTTTAGCTCTCGTTGTAAAAAAAAAAAAAAAAAAAAAAAAAAAA
AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006241251 ⟹ XP_006241313

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	7	27,969,796 - 28,001,600 (+)	NCBI
Rnor_6.0	7	34,288,333 - 34,320,243 (+)	NCBI
Rnor_5.0	7	34,353,476 - 34,385,291 (+)	NCBI

Sequence:

show sequence

CTCCCTTTCCCGGGGTGCACCGCGCCGTCTACCCTCTATGCTTCCCTCCTTTCTCAGGCTTGCG
GTGAAAGTCTGGCGGTAGAGTGTCTGGGTGCTGGTTGACGTGCGGCGGATCTCCCACAACCATG
CCTGAGGTCGCGGATACTTGTTCCTTGGCTTCTCCAGCCTCGGTCTGCCGAACCCAGCACCTCC
ATCTTCGCTGCAGCGTCGACTTCGCTCGCCGGGCACTGACCGGGACCGCCGCGCTCACGGTCCA
GTCACAGGAGGATAATCTGCGCAGCCTGACTTTGGATACAAAAGACCTTACGATAGAAAAAGTG
GTGATCAACGGACAAGAAGTCAAATACACTCTTGGAGAAAGCCAGGGTTACAAAGGATCGCCGA
TGGAAATCTCCCTTCCCATCGCTCTGAGCAAAAATCAAGAGGTCGTTATAGAGATTTCCTTCGA
GACATCTCCCAAGTCCTCGGCCCTTCAGTGGCTCACTCCCGAGCAGACTTCAGGAAAGCAGCAT
CCATACCTCTTCAGTCAGTGCCAGGCCATCCACTGCAGGGCAATCCTCCCTTGCCAAGACACTC
CTTCTGTGAAGTTAACCTACACCGCAGAGGTATCTGTCCCCAAAGAACTGGTGGCTCTCATGAG
TGCCATCCGTGATGGAGAAGCCCCTGACCCAGAAGACCCCAGCAGGAAGATATACAGATTTAAC
CAGAGGGTTCCCATACCGTGCTACCTGATTGCTTTAGTCGTTGGCGCTTTAGAAAGCAGGCAAA
TTGGCCCAAGAACTCTGGTGTGGTCTGAGAAAGAGCAGGTGGAGAAGTCTGCTTATGAATTCTC
TGAGACTGAATCCATGCTTAAAATTGCAGAAGATCTGGGGGGACCCTATGTTTGGGGACAGTAC
GACCTGTTGGTCCTGCCCCCATCCTTCCCGTACGGAGGCATGGAGAATCCTTGTCTCACATTCG
TAACCCCTACTCTATTGGCAGGTGACAAGTCACTCTCTAATGTTATTGCACACGAAATATCGCA
TAGCTGGACAGGGAACCTAGTGACTAACAAGACTTGGGATCACTTCTGGTTAAACGAAGGACAT
ACCGTCTATTTAGAGCGCCACATTTGTGGGCGGTTGTTTGGGGAAAAATTCAGACATTTCCACG
CTTTAGGAGGATGGGGAGAGCTACAGAACACGATAAAGACTTTCGGGGAGTCCCATCCCTTCAC
CAAGCTCGTGGTCGATCTGAAGGACGTAGACCCCGATGTGGCCTACTCCTCCATTCCCTACGAG
AAGGGCTTCGCCTTGCTCTTCTACCTGGAACAACTTCTTGGGGGACCGGAGGTGTTTCTAGGAT
TCCTAAAGGCTTATGTGGAGAAGTTTTCCTACCAGAGCGTAACCACTGATGACTGGAAGAGTTT
CCTGTATGCTCACTTTAAAGATAAGGTGGATCTTCTCAATCAAGTTGATTGGAATGCCTGGCTC
TATGCTCCTGGCCTGCCTCCTGTCAAACCCAATTACGATGTGACTCTCACGAATGCCTGCATCG
CCTTAAGTCAAAGATGGGTCACTGCCAAAGAGGAAGATTTAAATTCATTCAGCATCGAAGACCT
GAAGGACCTCTCGTCCCATCAGCTGAATGAGTTCCTGGCACAGGTGCTTCAGAAGATGGTTACG
GCTCTGCATTCAATCGAAGTGGGAAGAAGCAATTCCTTTGGCCCTAAAGATGGCAACTGAACAA
GGAAGGATGAAATTTACACGACCTCTATTCAAGGACCTCGCTGCCTTCGACAAATCCCACGATC
AAGCTGTCCGCACCTACCAGGAACATAAAGCCTGTATGCATCCCGTGACCGCCATGCTGGTGGG
GAAAGATCTGAAAGTGGATTAAGGAACTGAGTGTTGCTGATTTCAGAAAATTCCTTTTTTTAAG
AAAAAAAATCGAACCTATTAAGAAATACAAAATTTTAGCTCTCGTTGTATTTTAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001025202	(Get FASTA)	NCBI Sequence Viewer
	XP_006241313	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH99819	(Get FASTA)	NCBI Sequence Viewer
	EDM16913	(Get FASTA)	NCBI Sequence Viewer
	EDM16914	(Get FASTA)	NCBI Sequence Viewer
	P30349	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

NP_001025202 ⟸ NM_001030031

- UniProtKB:

Q499P2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MPEVADTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQSQEDNLRSLTLDTKDLTIEK
VVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKQ
HPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRF
NQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQ
YDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEG
HTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPY
EKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLLNQVDWNAW
LYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVLQKAP
LPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLA
AFDKSHDQAVRTYQEHKACMHPVTAMLVGKDLKVD

hide sequence

RefSeq Acc Id:

XP_006241313 ⟸ XM_006241251

- Peptide Label:

isoform X1

- Sequence:

show sequence

MPEVADTCSLASPASVCRTQHLHLRCSVDFARRALTGTAALTVQSQEDNLRSLTLDTKDLTIEK
VVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEVVIEISFETSPKSSALQWLTPEQTSGKQ
HPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRF
NQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQ
YDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEG
HTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPY
EKGFALLFYLEQLLGGPEVFLGFLKAYVEKFSYQSVTTDDWKSFLYAHFKDKVDLLNQVDWNAW
LYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLNSFSIEDLKDLSSHQLNEFLAQVLQKMV
TALHSIEVGRSNSFGPKDGN

hide sequence

RefSeq Acc Id:

ENSRNOP00000005930 ⟸ ENSRNOT00000005930

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695145

Promoter ID:

EPDNEW_R5670

Type:

initiation region

Name:

Lta4h_1

Description:

leukotriene A4 hydrolase

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	34,288,399 - 34,288,459	EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)

ACI/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

ACI/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

ACI/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

BBDP/Wor (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

BN/SsN (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Buf/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

COP/CrCrl (MCW & UW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob) University of Wisconsin (Dr. James Shull)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Charles River Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)

F344/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

F344/NRrrc (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

FHH/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHH/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

FHL/EurMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

FHL/EurMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

GH/OmrMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

GK/Ox (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LE/Stm (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/Crl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LEW/NCrlBR (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LH/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LL/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

LN/MavRrrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

M520/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

MHS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MNS/Gib (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

MR/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

SBH/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBH/Ygl sequenced by MCW

SBH/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SBN/Ygl (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	SBN/Ygl sequenced by MCW

SBN/Ygl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHR/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SHRSP/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SR/JrHsd (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Harlan Laboratories
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SR/JrHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/Jr (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

SS/JrHsdMcwi (MCW)

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Sequenced By:	Medical College of Wisconsin (Dr. Howard Jacob)
Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA v0.7.7 and GATK v3.2-2
Breeder:	Medical College of Wisconsin
Description:	Provided by the Medical College of Wisconsin (Dr. Howard Jacob)

SS/JrHsdMcwi (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WAG/Rij (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/Gcrc (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

WKY/NCrl (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WKY/NHsd (RGD)

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Platform:	Illumina HiSeq 2000
Secondary Analysis:	BWA mem 0.7.15, GATK v.3.6-0
Description:	Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD

WN/N (MCW)

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Sequenced By:	Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen) Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform:	SOLiD 4 and 5500
Secondary Analysis:	liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder:	National Institutes of Health
Description:	Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:1311333	AgrOrtholog
Ensembl Genes	ENSRNOG00000004494	Ensembl, ENTREZGENE
Ensembl Protein	ENSRNOP00000005930	ENTREZGENE
Ensembl Transcript	ENSRNOT00000005930	ENTREZGENE
Gene3D-CATH	1.10.390.10	UniProtKB/Swiss-Prot
	1.25.40.320	UniProtKB/Swiss-Prot
	2.60.40.1730	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:7930840	IMAGE-MGC_LOAD
InterPro	Aminopeptidase_N-like_N	UniProtKB/Swiss-Prot
	ARM-type_fold	UniProtKB/Swiss-Prot
	LTA4H	UniProtKB/Swiss-Prot
	M1_LTA-4_hydro/amino_C_sf	UniProtKB/Swiss-Prot
	M1_LTA4H	UniProtKB/Swiss-Prot
	Peptidase_M1	UniProtKB/Swiss-Prot
	Peptidase_M1_C	UniProtKB/Swiss-Prot
	Peptidase_M1_dom	UniProtKB/Swiss-Prot
	Peptidase_M4/M1_CTD_sf	UniProtKB/Swiss-Prot
KEGG Report	rno:299732	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:124681	IMAGE-MGC_LOAD
NCBI Gene	299732	ENTREZGENE
PANTHER	PTHR45726	UniProtKB/Swiss-Prot
Pfam	Leuk-A4-hydro_C	UniProtKB/Swiss-Prot
	Peptidase_M1	UniProtKB/Swiss-Prot
PharmGKB	LTA4H	RGD
PhenoGen	Lta4h	PhenoGen
PRINTS	ALADIPTASE	UniProtKB/Swiss-Prot
PROSITE	ZINC_PROTEASE	UniProtKB/Swiss-Prot
SMART	Leuk-A4-hydro_C	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF48371	UniProtKB/Swiss-Prot
	SSF63737	UniProtKB/Swiss-Prot
TIGRFAMs	leuko_A4_hydro	UniProtKB/Swiss-Prot
UniProt	LKHA4_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q499P2	ENTREZGENE
UniProt Secondary	Q499P2	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-12-06	Lta4h	leukotriene A4 hydrolase	Lta4h_predicted	leukotriene A4 hydrolase (predicted)	Symbol and Name updated	1559027	APPROVED
2005-01-12	Lta4h_predicted	leukotriene A4 hydrolase (predicted)			Symbol and Name status set to approved	70820	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

RGD Manual Annotations

Imported Annotations - SMPDB

Imported Annotations - KEGG (archival)