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Gene: Il2 (interleukin 2) Rattus norvegicus
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Symbol: Il2
Name: interleukin 2
Description: Exhibits carbohydrate binding activity; glycosphingolipid binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of T cell activation; protein kinase C-activating G protein-coupled receptor signaling pathway; and regulation of protein phosphorylation. Localizes to the extracellular space. Used to study cystitis. Biomarker of allergic rhinitis and tongue squamous cell carcinoma. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autoimmune hypersensitivity disease (multiple); carcinoma (multiple); dermatitis (multiple); and neurodegenerative disease (multiple). Orthologous to human IL2 (interleukin 2); PARTICIPATES IN interleukin-12 signaling pathway; interleukin-2 signaling pathway; interleukin-23 signaling pathway; INTERACTS WITH (+)-pilocarpine; (R)-lipoic acid; 1,2-dichloroethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: IL-2; interleukin-2; T-cell growth factor; TCGF
Orthologs:
Homo sapiens (human) : IL2 (interleukin 2)  HGNC  Alliance
Mus musculus (house mouse) : Il2 (interleukin 2)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il2 (interleukin 2)
Pan paniscus (bonobo/pygmy chimpanzee) : IL2 (interleukin 2)
Canis lupus familiaris (dog) : IL2 (interleukin 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il2 (interleukin 2)
Sus scrofa (pig) : IL2 (interleukin 2)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.02123,847,150 - 123,851,854 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02143,460,866 - 143,465,570 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42123,655,005 - 123,659,709 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12123,599,966 - 123,604,671 (-)NCBI
Celera2114,959,889 - 114,964,593 (-)NCBICelera
Cytogenetic Map2q25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome

Strain Variation

Strain Sequence Variants (Rnor 5.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Il2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620047
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2019-04-23
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.