Car3 (carbonic anhydrase 3) - Rat Genome Database

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Gene: Car3 (carbonic anhydrase 3) Rattus norvegicus
Analyze
Symbol: Car3
Name: carbonic anhydrase 3
RGD ID: 2241
Description: Enables phosphatase activity. Involved in response to ethanol and response to oxidative stress. Predicted to be active in cytosol. Orthologous to human CA3 (carbonic anhydrase 3); INTERACTS WITH (S)-nicotine; 1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CA-III; Ca3; carbonate dehydratase III; carbonic anhydrase III
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,770,418 - 86,780,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,770,420 - 86,784,280 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,090,323 - 93,098,286 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,211,325 - 91,219,288 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,268,152 - 86,276,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,126,519 - 88,136,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02107,900,433 - 107,909,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,106,727 - 88,114,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,050,843 - 88,059,683 (-)NCBI
Celera282,369,065 - 82,377,024 (-)NCBICelera
Cytogenetic Map2q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(S)-nicotine  (EXP)
1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane  (EXP)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP)
1H-pyrazole  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP,ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
5-Hydroxythalidomide  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (ISO)
acetamide  (EXP)
acetazolamide  (ISO)
acrylamide  (ISO)
Actein  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
aldrin  (ISO)
all-trans-retinoic acid  (ISO)
alpha-hexachlorocyclohexane  (EXP)
amiodarone  (EXP)
ammonium chloride  (EXP)
Aroclor 1254  (EXP,ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzbromarone  (EXP)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[ghi]perylene  (ISO)
beta-D-glucosamine  (EXP)
beta-naphthoflavone  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
brinzolamide  (ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcium silicate  (ISO)
cannabidiol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
celecoxib  (ISO)
chlordecone  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (EXP)
clofibrate  (EXP)
clothianidin  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumarin  (EXP)
cyclosporin A  (ISO)
D-glucose  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
dibenzo[a,l]pyrene  (ISO)
dichlorine  (EXP)
diclofenac  (EXP,ISO)
diclofenamide  (ISO)
dimethylarsinic acid  (EXP,ISO)
diuron  (EXP)
doramapimod  (ISO)
dorsomorphin  (ISO)
dorzolamide hydrochloride  (ISO)
doxorubicin  (ISO)
elemental selenium  (EXP)
endosulfan  (EXP)
ethanol  (EXP)
ethoxzolamide  (ISO)
flavonoids  (EXP)
fonofos  (ISO)
fructose  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
glafenine  (EXP)
glucose  (ISO)
glyphosate  (ISO)
graphite  (ISO)
herbicide  (ISO)
hyaluronic acid  (EXP)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP)
hydrogencarbonate  (ISO)
hydroquinone  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
iodide salt  (EXP)
L-cysteine  (ISO)
L-ethionine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
mancozeb  (ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
metacetamol  (EXP)
methapyrilene  (EXP)
Methazolamide  (ISO)
methimazole  (EXP)
N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2-ylidene)acetamide  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nefazodone  (EXP)
nickel subsulfide  (EXP)
nicotine  (EXP)
nimesulide  (EXP)
nitrofen  (EXP)
O-methyleugenol  (ISO)
omeprazole  (EXP)
orphenadrine  (EXP)
oxaliplatin  (EXP)
oxycodone  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP)
parathion  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenethyl caffeate  (EXP)
phenobarbital  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
potassium bromate  (EXP)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
progesterone  (ISO)
prontosil  (ISO)
propiconazole  (ISO)
quercetin  (EXP)
rac-1,2-dichloropropane  (ISO)
resveratrol  (EXP,ISO)
rotenone  (EXP,ISO)
saccharin  (ISO)
SB 431542  (ISO)
selenium atom  (EXP)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium fluoride  (ISO)
streptozocin  (EXP)
sulforaphane  (ISO)
sulpiride  (ISO)
tamoxifen  (EXP,ISO)
terbufos  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topiramate  (ISO)
topotecan  (EXP)
trabectedin  (EXP)
triazines  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP)
Triptolide  (EXP)
triticonazole  (EXP)
valdecoxib  (EXP,ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
vorinostat  (ISO)
XL147  (ISO)
zonisamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA)
cytosol  (IBA,IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation. Cabiscol E and Levine RL, Proc Natl Acad Sci U S A. 1996 Apr 30;93(9):4170-4.
2. Androgen-linked control of carbonic anhydrase III expression occurs in rat perivenous hepatocytes; an immunocytochemical study. Carter N, etal., Ups J Med Sci 2001;106(1):67-76.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Region- and cell-specific differences in the distribution of carbonic anhydrases II, III, XII, and XIV in the adult rat epididymis. Hermo L, etal., J Histochem Cytochem. 2005 Jun;53(6):699-713. doi: 10.1369/jhc.4A6575.2005.
5. Suppression of carbonic anhydrase III in rat liver by a dioxin-related toxic compound, coplanar polychlorinated biphenyl, 3, 3',4,4',5-pentachlorobiphenyl. Ikeda M, etal., Arch Biochem Biophys 2000 Aug 1;380(1):159-64.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Characterisation of cDNA clones for rat muscle carbonic anhydrase III. Kelly CD, etal., Biosci Rep 1988 Oct;8(5):401-6.
8. Proteomics reveal a concerted upregulation of methionine metabolic pathway enzymes, and downregulation of carbonic anhydrase-III, in betaine supplemented ethanol-fed rats. Kharbanda KK, etal., Biochem Biophys Res Commun. 2009 Apr 17;381(4):523-7. doi: 10.1016/j.bbrc.2009.02.082. Epub 2009 Feb 23.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:1899179   PMID:8476041   PMID:9020864   PMID:11024467   PMID:12602780   PMID:15449734   PMID:15489334   PMID:15500001   PMID:15930751   PMID:15998239   PMID:18756007   PMID:20015077  
PMID:21551946   PMID:23012479   PMID:23083309   PMID:24789143   PMID:25684186   PMID:28983629   PMID:29559661   PMID:34387844   PMID:35108454  


Genomics

Comparative Map Data
Car3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2286,770,418 - 86,780,011 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl286,770,420 - 86,784,280 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx293,090,323 - 93,098,286 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0291,211,325 - 91,219,288 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0286,268,152 - 86,276,115 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0288,126,519 - 88,136,063 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02107,900,433 - 107,909,977 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4288,106,727 - 88,114,686 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1288,050,843 - 88,059,683 (-)NCBI
Celera282,369,065 - 82,377,024 (-)NCBICelera
Cytogenetic Map2q23NCBI
CA3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38885,438,859 - 85,449,040 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl885,373,436 - 85,449,040 (+)EnsemblGRCh38hg38GRCh38
GRCh37886,351,088 - 86,361,269 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36886,537,710 - 86,548,526 (+)NCBINCBI36Build 36hg18NCBI36
Build 34886,537,709 - 86,548,526NCBI
Celera882,356,136 - 82,366,348 (+)NCBICelera
Cytogenetic Map8q21.2NCBI
HuRef881,845,249 - 81,855,461 (+)NCBIHuRef
CHM1_1886,402,742 - 86,412,955 (+)NCBICHM1_1
T2T-CHM13v2.0885,877,589 - 85,887,769 (+)NCBIT2T-CHM13v2.0
Car3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39314,928,598 - 14,937,441 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl314,928,572 - 14,937,583 (+)EnsemblGRCm39 Ensembl
GRCm38314,863,538 - 14,872,381 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl314,863,512 - 14,872,523 (+)EnsemblGRCm38mm10GRCm38
MGSCv37314,863,538 - 14,872,381 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36314,840,282 - 14,849,125 (+)NCBIMGSCv36mm8
Celera314,876,182 - 14,885,071 (+)NCBICelera
Cytogenetic Map3A1NCBI
cM Map33.22NCBI
Ca3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554173,362,492 - 3,372,932 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554173,362,091 - 3,372,270 (+)NCBIChiLan1.0ChiLan1.0
CA3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1876,738,248 - 76,819,477 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0881,965,041 - 81,976,133 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1883,574,931 - 83,585,737 (+)NCBIpanpan1.1PanPan1.1panPan2
CA3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12931,935,192 - 31,945,585 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2931,935,172 - 31,980,579 (+)EnsemblCanFam3.1canFam3CanFam3.1
ROS_Cfam_1.02932,083,862 - 32,094,321 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2932,083,849 - 32,094,327 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12932,135,278 - 32,145,713 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02932,156,474 - 32,166,928 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02932,543,269 - 32,553,756 (+)NCBIUU_Cfam_GSD_1.0
Ca3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530347,444,945 - 47,454,991 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936544337,382 - 348,462 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936544337,437 - 347,760 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CA3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl451,227,485 - 51,237,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1451,227,485 - 51,237,861 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2456,190,405 - 56,200,779 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CA3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1880,805,296 - 80,816,127 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl880,805,134 - 80,816,190 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603960,283,705 - 60,322,506 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ca3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247446,199,382 - 6,212,163 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247446,202,151 - 6,211,662 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Car3
26 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:93
Count of miRNA genes:69
Interacting mature miRNAs:86
Transcripts:ENSRNOT00000014180
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
61371Edpm1Estrogen-dependent pituitary mass QTL 140.05pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)23513484188029593Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)240067944102785628Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)240067944102785628Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607157142209Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
2293676Bmd19Bone mineral density QTL 1910.70.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)243162366111362592Rat
2293682Bmd24Bone mineral density QTL 248.90.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)243162366111362592Rat
2293671Bss44Bone structure and strength QTL 4410.970.0001lumbar vertebra morphology trait (VT:0010494)lumbar vertebra cortical cross-sectional area (CMO:0001690)243162366148478373Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)259134147127460910Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)259324377103795077Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)259324377103795077Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)259324377141596857Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)259324719102755241Rat
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)259846005104846005Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)264366971109366971Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
7411551Bw131Body weight QTL 13129.60.001body mass (VT:0001259)body weight gain (CMO:0000420)267942638112942638Rat
1558653Prcr1Prostate cancer resistance QTL 15prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)272532993157142209Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)27478666494359546Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)27478666494359546Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)276539322102785628Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)276539322102785628Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)276539322150540526Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
2299162Iddm32Insulin dependent diabetes mellitus QTL 322.36blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)278665616143657569Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)280270434125270434Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)281018907126018907Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)282345893130923501Rat

Markers in Region
RH127589  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,770,483 - 86,770,666 (+)MAPPERmRatBN7.2
Rnor_6.0288,126,583 - 88,126,765NCBIRnor6.0
Rnor_5.02107,900,497 - 107,900,679UniSTSRnor5.0
RGSC_v3.4288,105,942 - 88,106,124UniSTSRGSC3.4
Celera282,368,280 - 82,368,462UniSTS
RH 3.4 Map2533.9UniSTS
Cytogenetic Map2q23UniSTS
RH129349  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,770,449 - 86,770,661 (+)MAPPERmRatBN7.2
Rnor_6.0288,126,549 - 88,126,760NCBIRnor6.0
Rnor_5.02107,900,463 - 107,900,674UniSTSRnor5.0
RGSC_v3.4288,105,908 - 88,106,119UniSTSRGSC3.4
Celera282,368,246 - 82,368,457UniSTS
RH 3.4 Map2533.1UniSTS
Cytogenetic Map2q23UniSTS
UniSTS:498421  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2286,780,677 - 86,780,760 (+)MAPPERmRatBN7.2
Rnor_6.0288,136,778 - 88,136,860NCBIRnor6.0
Rnor_5.02107,910,692 - 107,910,774UniSTSRnor5.0
RGSC_v3.4288,116,137 - 88,116,219UniSTSRGSC3.4
Celera282,378,475 - 82,378,557UniSTS
Cytogenetic Map2q23UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 6 5 5 7 8 2 7
Medium 3 17 31 16 14 16 1 3 5 28 16 9 1
Low 17 14 14 5 14 32 7 19 2
Below cutoff 9 6 6 6 25 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_019292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB030829 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB030830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB170009 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF037072 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC061980 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ210528 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ211459 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ214929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ215392 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ216182 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217272 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000067 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M22413 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000014180   ⟹   ENSRNOP00000014177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl286,770,420 - 86,779,274 (-)Ensembl
Rnor_6.0 Ensembl288,126,667 - 88,135,410 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000105296   ⟹   ENSRNOP00000083954
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl286,770,420 - 86,784,280 (-)Ensembl
RefSeq Acc Id: NM_019292   ⟹   NP_062165
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2286,771,269 - 86,779,227 (-)NCBI
Rnor_6.0288,127,368 - 88,135,327 (-)NCBI
Rnor_5.02107,900,433 - 107,909,977 (-)NCBI
RGSC_v3.4288,106,727 - 88,114,686 (-)RGD
Celera282,369,065 - 82,377,024 (-)RGD
Sequence:
RefSeq Acc Id: XM_006232116   ⟹   XP_006232178
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2286,770,418 - 86,780,011 (-)NCBI
Rnor_6.0288,126,519 - 88,136,063 (-)NCBI
Rnor_5.02107,900,433 - 107,909,977 (-)NCBI
Sequence:
RefSeq Acc Id: NP_062165   ⟸   NM_019292
- UniProtKB: O54961 (UniProtKB/Swiss-Prot),   Q9QV77 (UniProtKB/Swiss-Prot),   P14141 (UniProtKB/Swiss-Prot),   A6IH11 (UniProtKB/TrEMBL),   A0A8L2Q6S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006232178   ⟸   XM_006232116
- Peptide Label: isoform X1
- UniProtKB: O54961 (UniProtKB/Swiss-Prot),   Q9QV77 (UniProtKB/Swiss-Prot),   P14141 (UniProtKB/Swiss-Prot),   A6IH11 (UniProtKB/TrEMBL),   A0A8L2Q6S9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000014177   ⟸   ENSRNOT00000014180
RefSeq Acc Id: ENSRNOP00000083954   ⟸   ENSRNOT00000105296
Protein Domains
Alpha-carbonic anhydrase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P14141-F1-model_v2 AlphaFold P14141 1-260 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691220
Promoter ID:EPDNEW_R1745
Type:multiple initiation site
Name:Car3_1
Description:carbonic anhydrase 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0288,135,374 - 88,135,434EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2241 AgrOrtholog
BioCyc Gene G2FUF-53808 BioCyc
Ensembl Genes ENSRNOG00000010079 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055025940 UniProtKB/Swiss-Prot
  ENSRNOG00060002049 UniProtKB/Swiss-Prot
  ENSRNOG00065013129 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014180.7 UniProtKB/TrEMBL
  ENSRNOT00000105296 ENTREZGENE
  ENSRNOT00000105296.1 UniProtKB/Swiss-Prot
  ENSRNOT00055044797 UniProtKB/Swiss-Prot
  ENSRNOT00060003217 UniProtKB/Swiss-Prot
  ENSRNOT00065021532 UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.200.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5597975 IMAGE-MGC_LOAD
InterPro CA_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CA_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carbonic_anhydrase_a-class_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:54232 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72261 IMAGE-MGC_LOAD
NCBI Gene 54232 ENTREZGENE
PANTHER PTHR18952 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR18952:SF127 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CA3 RGD
PhenoGen Car3 PhenoGen
PROSITE ALPHA_CA_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ALPHA_CA_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000010079 RatGTEx
  ENSRNOG00055025940 RatGTEx
  ENSRNOG00060002049 RatGTEx
  ENSRNOG00065013129 RatGTEx
SMART Carb_anhydrase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF51069 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2Q6S9 ENTREZGENE, UniProtKB/TrEMBL
  A6IH11 ENTREZGENE, UniProtKB/TrEMBL
  CAH3_RAT UniProtKB/Swiss-Prot
  O54961 ENTREZGENE
  P14141 ENTREZGENE
  Q9QV77 ENTREZGENE
UniProt Secondary O54961 UniProtKB/Swiss-Prot
  Q9QV77 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-18 Car3  carbonic anhydrase 3  Ca3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2019-04-16 Ca3  carbonic anhydrase 3  Car3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Car3  carbonic anhydrase 3  Ca3  carbonic anhydrase 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ca3  carbonic anhydrase 3      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in liver 634676
gene_process may play a role in a defense system for oxidative stress 634677
gene_regulation expression is regulated by testosterone in the male 634676