Slc25a48 (solute carrier family 25, member 48) - Rat Genome Database

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Gene: Slc25a48 (solute carrier family 25, member 48) Rattus norvegicus
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Symbol: Slc25a48
Name: solute carrier family 25, member 48
RGD ID: 1563703
Description: Predicted to enable transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in mitochondrial inner membrane. Predicted to be active in mitochondrion. Orthologous to human SLC25A48 (solute carrier family 25 member 48); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC361206; RGD1563703; similar to hypothetical protein E230025K15; solute carrier family 25 member 48
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,113,134 - 8,172,376 (-)NCBIGRCr8
mRatBN7.2178,119,964 - 8,161,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,121,175 - 8,160,748 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0178,567,014 - 8,608,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,570,472 - 8,607,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,741,365 - 10,782,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera178,212,422 - 8,242,778 (-)NCBICelera
Cytogenetic Map17p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:18614015  


Genomics

Comparative Map Data
Slc25a48
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,113,134 - 8,172,376 (-)NCBIGRCr8
mRatBN7.2178,119,964 - 8,161,293 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl178,121,175 - 8,160,748 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0178,567,014 - 8,608,213 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl178,570,472 - 8,607,494 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01710,741,365 - 10,782,545 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera178,212,422 - 8,242,778 (-)NCBICelera
Cytogenetic Map17p14NCBI
SLC25A48
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385135,579,172 - 135,888,637 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5135,476,913 - 135,889,770 (+)EnsemblGRCh38hg38GRCh38
GRCh375134,914,862 - 135,224,326 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365135,198,264 - 135,236,335 (+)NCBINCBI36Build 36hg18NCBI36
Celera5131,295,101 - 131,349,055 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5130,358,467 - 130,412,795 (+)NCBIHuRef
CHM1_15134,602,986 - 134,656,957 (+)NCBICHM1_1
T2T-CHM13v2.05136,106,315 - 136,411,134 (+)NCBIT2T-CHM13v2.0
Slc25a48
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391356,585,774 - 56,620,180 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1356,586,168 - 56,622,052 (+)EnsemblGRCm39 Ensembl
GRCm381356,437,960 - 56,472,367 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1356,438,355 - 56,474,239 (+)EnsemblGRCm38mm10GRCm38
MGSCv371356,539,716 - 56,573,724 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361356,447,977 - 56,481,943 (+)NCBIMGSCv36mm8
Celera1357,498,851 - 57,536,050 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1330.06NCBI
Slc25a48
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540830,901,124 - 30,940,383 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540830,775,521 - 30,940,335 (+)NCBIChiLan1.0ChiLan1.0
SLC25A48
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24131,123,332 - 131,177,313 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15129,262,892 - 129,316,873 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05131,227,723 - 131,281,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15137,108,442 - 137,421,754 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5137,367,729 - 137,421,754 (+)Ensemblpanpan1.1panPan2
SLC25A48
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11123,754,223 - 23,808,172 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1123,761,858 - 23,852,384 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1122,509,857 - 22,562,237 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01124,578,420 - 24,630,593 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1124,578,231 - 24,669,380 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11123,265,817 - 23,306,502 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01123,131,538 - 23,183,916 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01123,781,666 - 23,834,067 (+)NCBIUU_Cfam_GSD_1.0
Slc25a48
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213123,899,751 - 123,940,624 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365972,925,021 - 2,962,437 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365972,924,814 - 2,965,529 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC25A48
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2137,986,828 - 138,035,578 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12137,979,811 - 138,035,582 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22143,578,973 - 143,634,938 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC25A48
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12338,580,380 - 38,633,232 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603439,275,845 - 39,326,687 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc25a48
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473311,237,609 - 11,280,774 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473311,240,090 - 11,280,573 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc25a48
554 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:59
Count of miRNA genes:52
Interacting mature miRNAs:56
Transcripts:ENSRNOT00000016138
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354581Bp247Blood pressure QTL 2474.5arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)17169599340Rat
1354613Kidm14Kidney mass QTL 146.2kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)17429913035837242Rat
631499Stl1Serum triglyceride level QTL 13.6blood triglyceride amount (VT:0002644)blood triglyceride level (CMO:0000118)17327139827389946Rat
2293664Bmd28Bone mineral density QTL 285.10.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)17435448727028127Rat
1300123Bp194Blood pressure QTL 1942.82arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)17211514934551001Rat
2324619Coatc4Coat color QTL 40.001coat/hair pigmentation trait (VT:0010463)pigmented dorsal coat/hair area to total dorsal coat/hair area ratio (CMO:0001811)17429913021293263Rat
2303627Vencon8Ventilatory control QTL 80.001respiration trait (VT:0001943)tidal volume (CMO:0000222)17452803849528038Rat
70184BpQTLcluster14Blood pressure QTL cluster 143.38arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)17131990913Rat
1581553Pur14Proteinuria QTL 145.30.0001urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)17797996816317111Rat
631207Niddm41Non-insulin dependent diabetes mellitus QTL 41blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)17137830672Rat
1354651Lmblg2Limb length QTL 26tibia length (VT:0004357)tibia length (CMO:0000450)17429913069599340Rat
1354596Bw32Body weight QTL 324.5body mass (VT:0001259)body weight (CMO:0000012)17429913060781592Rat
10401807Kidm52Kidney mass QTL 52kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)17131701463Rat
10054088Scort28Serum corticosterone level QTL 282.040.0102blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17452803849528038Rat
1354662Rf49Renal function QTL 492.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)17169599340Rat
1354630Cm34Cardiac mass QTL 348.7heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)17429913069599340Rat
2293648Bmd31Bone mineral density QTL 314.50.0001femur size trait (VT:1000369)femoral neck cortical cross-sectional area (CMO:0001702)17435448727028127Rat
1354658Spl8Serum phospholipid level QTL 83.8blood VLDL phospholipid amount (VT:0010507)blood very low density lipoprotein phospholipid level (CMO:0001571)17160781592Rat
1641902Colcr7Colorectal carcinoma resistance QTL 73.350.0044intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)17211514921881669Rat
1354638Insul1Insulin level QTL 14.8blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)17429913069599340Rat
9590316Scort21Serum corticosterone level QTL 214.750.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)17122871563Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 6 21 113 91 90 59 25 59 6 179 65 93 41 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000016138   ⟹   ENSRNOP00000016138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl178,121,175 - 8,160,748 (-)Ensembl
Rnor_6.0 Ensembl178,570,472 - 8,607,494 (-)Ensembl
RefSeq Acc Id: XM_039096450   ⟹   XP_038952378
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,127,863 - 8,166,799 (-)NCBI
mRatBN7.2178,122,607 - 8,161,291 (-)NCBI
RefSeq Acc Id: XR_010059371
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,113,134 - 8,172,376 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001419223 (Get FASTA)   NCBI Sequence Viewer  
  XP_038952378 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL93939 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000016138.6
Ensembl Acc Id: ENSRNOP00000016138   ⟸   ENSRNOT00000016138
RefSeq Acc Id: XP_038952378   ⟸   XM_039096450
- UniProtKB: D4A961 (UniProtKB/TrEMBL),   A6KAN1 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D4A961-F1-model_v2 AlphaFold D4A961 1-306 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1563703 AgrOrtholog
BioCyc Gene G2FUF-10263 BioCyc
Ensembl Genes ENSRNOG00000012040 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000016138.7 UniProtKB/TrEMBL
Gene3D-CATH 1.50.40.10 UniProtKB/TrEMBL
InterPro Mit_carrier UniProtKB/TrEMBL
  Mitochondrial_Carrier UniProtKB/TrEMBL
  Mitochondrial_sb/sol_carrier UniProtKB/TrEMBL
  Mt_carrier_dom UniProtKB/TrEMBL
NCBI Gene 361206 ENTREZGENE
PANTHER MITOCHONDRIAL BASIC AMINO ACIDS TRANSPORTER-RELATED UniProtKB/TrEMBL
  SOLUTE CARRIER FAMILY 25 MEMBER 48 UniProtKB/TrEMBL
Pfam Mito_carr UniProtKB/TrEMBL
PhenoGen Slc25a48 PhenoGen
PRINTS MITOCARRIER UniProtKB/TrEMBL
PROSITE SOLCAR UniProtKB/TrEMBL
RatGTEx ENSRNOG00000012040 RatGTEx
Superfamily-SCOP Mitoch_carrier UniProtKB/TrEMBL
UniProt A6KAN1 ENTREZGENE, UniProtKB/TrEMBL
  D4A961 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-05-26 Slc25a48  solute carrier family 25, member 48  RGD1563703  similar to hypothetical protein E230025K15  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 RGD1563703  similar to hypothetical protein E230025K15   RGD1563703_predicted  similar to hypothetical protein E230025K15 (predicted)  'predicted' is removed 2292626 APPROVED
2006-03-07 RGD1563703_predicted  similar to hypothetical protein E230025K15 (predicted)  LOC361206  similar to hypothetical protein E230025K15  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC361206  similar to hypothetical protein E230025K15      Symbol and Name status set to provisional 70820 PROVISIONAL