Cryab (crystallin, alpha B) - Rat Genome Database
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Gene: Cryab (crystallin, alpha B) Rattus norvegicus
Analyze
Symbol: Cryab
Name: crystallin, alpha B
RGD ID: 2414
Description: Exhibits microtubule binding activity. Involved in several processes, including negative regulation of reactive oxygen species metabolic process; response to estradiol; and stress-activated MAPK cascade. Localizes to several cellular components, including cytoskeleton; myofibril; and perikaryon. Biomarker of cataract and macular degeneration. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (+)-schisandrin B; 1,2-dimethylhydrazine; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AACRYA; alpha B-crystallin; alpha(B)-crystallin; alpha-crystallin B chain; crystallin alpha polypeptide 2; crystallin, alpha polypeptide 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2851,093,441 - 51,099,161 (+)NCBI
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Celera850,642,744 - 50,646,745 (+)NCBICelera
Cytogenetic Map8q23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1-naphthyl isothiocyanate  (EXP)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
4-nitroquinoline N-oxide  (ISO)
5-azacytidine  (EXP)
6-propyl-2-thiouracil  (EXP)
7H-xanthine  (EXP)
9H-xanthine  (EXP)
acetamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
amphibole asbestos  (ISO)
arecoline  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (ISO)
Aurin  (ISO)
azetidinecarboxylic acid  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bortezomib  (EXP,ISO)
bucladesine  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
captan  (ISO)
casticin  (ISO)
celastrol  (ISO)
celecoxib  (EXP)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
cocaine  (EXP,ISO)
colforsin daropate hydrochloride  (EXP)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (EXP)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
curcumin  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cytarabine  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (EXP)
Diisodecyl phthalate  (ISO)
dimethylarsinous acid  (ISO)
disulfiram  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elesclomol  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
ethanol  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glutathione  (EXP)
Hexachloro-1,3-butadiene  (EXP)
indole-3-methanol  (EXP)
indometacin  (EXP)
iopamidol  (ISO)
isoprenaline  (EXP)
ketamine  (EXP)
L-ascorbic acid  (EXP)
lead diacetate  (ISO)
lead nitrate  (EXP)
lead(0)  (ISO)
lead(2+)  (ISO)
lipopolysaccharide  (ISO)
lithium atom  (EXP)
lithium hydride  (EXP)
manganese(II) chloride  (EXP)
masoprocol  (EXP)
melittin  (EXP)
mercury atom  (ISO)
mercury(0)  (ISO)
methamphetamine  (EXP)
methanol  (EXP)
methyl methanesulfonate  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
methylseleninic acid  (ISO)
mifepristone  (EXP)
morphine  (EXP,ISO)
N-acetyl-L-cysteine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosodimethylamine  (EXP)
nickel dichloride  (EXP)
nicotine  (ISO)
ochratoxin A  (EXP)
orphenadrine  (EXP)
ozone  (EXP)
paracetamol  (ISO)
PCB138  (ISO)
PhIP  (EXP)
pioglitazone  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP)
progesterone  (EXP,ISO)
prostaglandin A1  (EXP)
prostaglandin A2  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP)
prostaglandin J2  (EXP)
resveratrol  (ISO)
SB 431542  (ISO)
SCH 23390  (EXP)
scopolamine  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (EXP,ISO)
sodium nitrate  (ISO)
sodium tungstate  (ISO)
Soman  (EXP)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiostrepton  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
triadimefon  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
troglitazone  (ISO)
ursodeoxycholic acid  (EXP)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
zinc atom  (EXP)
zinc pyrithione  (ISO)
zinc(0)  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Abraham EC, etal., Mol Cell Biochem. 2008 Mar;310(1-2):235-9. Epub 2007 Dec 25.
2. Aggeli IK, etal., Cell Signal. 2008 Jul;20(7):1292-302. Epub 2008 Mar 4.
3. Bhat SP and Nagineni CN, Biochem Biophys Res Commun 1989 Jan 16;158(1):319-25.
4. Doran P, etal., Eur J Cell Biol. 2007 Oct;86(10):629-40. Epub 2007 Aug 29.
5. Fujita Y, etal., J Cell Sci. 2004 Apr 1;117(Pt 9):1719-26. Epub 2004 Mar 9.
6. Gangalum RK, etal., J Biol Chem. 2004 Oct 15;279(42):43374-7. Epub 2004 Aug 31.
7. GOA data from the GO Consortium
8. Golenhofen N, etal., J Mol Cell Cardiol 2002 Mar;34(3):309-19.
9. Hsu JT, etal., Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2982-7. Epub 2007 Feb 9.
10. Iwaki A, etal., J Biol Chem 1990 Dec 25;265(36):22197-203.
11. Kumar MS, etal., FEBS Lett. 2009 Jan 5;583(1):175-9. doi: 10.1016/j.febslet.2008.11.047. Epub 2008 Dec 9.
12. Kumarapeli AR, etal., Circ Res. 2008 Dec 5;103(12):1473-82. Epub 2008 Oct 30.
13. Liu B, etal., Biochem Biophys Res Commun. 2004 Aug 13;321(1):254-8.
14. Lutsch G, etal., Circulation. 1997 Nov 18;96(10):3466-76.
15. MGD data from the GO Consortium
16. Muraleva NA, etal., Cell Cycle. 2014;13(22):3499-505. doi: 10.4161/15384101.2014.958393.
17. NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. OMIM Disease Annotation Pipeline
19. Online Mendelian Inheritance in Man, OMIM (TM).
20. Pipeline to import KEGG annotations from KEGG into RGD
21. RGD automated data pipeline
22. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
23. RGD automated import pipeline for gene-chemical interactions
24. Rumyantseva YV, etal., Biochemistry (Mosc). 2008 Nov;73(11):1176-82.
25. Schmidt T, etal., Histochem Cell Biol. 2012 Sep;138(3):407-18. doi: 10.1007/s00418-012-0964-x. Epub 2012 May 23.
26. Sugiyama Y, etal., J Biol Chem. 2000 Jan 14;275(2):1095-104.
Additional References at PubMed
PMID:1764082   PMID:1765091   PMID:1783614   PMID:8282729   PMID:8639509   PMID:10751411   PMID:11687538   PMID:12235146   PMID:12546709   PMID:12601044   PMID:14575708   PMID:14627610  
PMID:14752512   PMID:15308659   PMID:15856211   PMID:16303126   PMID:16439475   PMID:16675842   PMID:16680485   PMID:17092938   PMID:17196975   PMID:17438522   PMID:17634366   PMID:17893660  
PMID:18191123   PMID:18330356   PMID:18566458   PMID:19056867   PMID:19340546   PMID:19379782   PMID:19464326   PMID:19558454   PMID:19646995   PMID:19651604   PMID:20587334   PMID:20723582  
PMID:20802487   PMID:21311744   PMID:21423662   PMID:21464278   PMID:21617129   PMID:21777656   PMID:21975426   PMID:22143763   PMID:22153508   PMID:23071119   PMID:23106396   PMID:23153557  
PMID:23188086   PMID:23212619   PMID:23264262   PMID:23376485   PMID:23386121   PMID:23508955   PMID:23533145   PMID:23542032   PMID:23543138   PMID:23546289   PMID:23559016   PMID:24103517  
PMID:24183572   PMID:24464634   PMID:24466295   PMID:25319025   PMID:25596465   PMID:26465331   PMID:26475352   PMID:26708692   PMID:27085702   PMID:27226619   PMID:27264546   PMID:27851782  
PMID:28425051   PMID:28502773   PMID:29542021   PMID:30246229   PMID:30463298   PMID:31970633   PMID:32016842  


Genomics

Comparative Map Data
Cryab
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2851,093,441 - 51,099,161 (+)NCBI
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0855,178,543 - 55,182,546 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0853,776,100 - 53,779,780 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,107,824 - 54,111,502 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1854,126,302 - 54,130,559 (+)NCBI
Celera850,642,744 - 50,646,745 (+)NCBICelera
Cytogenetic Map8q23NCBI
CRYAB
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl11111,908,564 - 111,923,722 (-)EnsemblGRCh38hg38GRCh38
GRCh3811111,908,564 - 111,923,740 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3711111,779,288 - 111,794,464 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh3711111,779,350 - 111,782,473 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611111,284,560 - 111,287,683 (-)NCBINCBI36hg18NCBI36
Build 3411111,284,559 - 111,287,683NCBI
Celera11108,932,558 - 108,935,681 (-)NCBI
Cytogenetic Map11q23.1NCBI
HuRef11107,703,256 - 107,706,379 (-)NCBIHuRef
CHM1_111111,662,424 - 111,667,017 (-)NCBICHM1_1
Cryab
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,657,251 - 50,667,936 (+)NCBIGRCm39mm39
GRCm38950,745,951 - 50,756,636 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,751,325 - 50,756,636 (+)EnsemblGRCm38mm10GRCm38
MGSCv37950,560,863 - 50,564,738 (+)NCBIGRCm37mm9NCBIm37
MGSCv36950,504,988 - 50,508,863 (+)NCBImm8
Celera948,039,922 - 48,043,797 (+)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Cryab
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,625,363 - 13,640,426 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,626,018 - 13,629,495 (-)NCBIChiLan1.0ChiLan1.0
CRYAB
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.111110,639,442 - 110,644,245 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,639,442 - 110,644,272 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v011106,795,406 - 106,800,019 (-)NCBIMhudiblu_PPA_v0panPan3
CRYAB
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl521,179,936 - 21,360,132 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1521,181,836 - 21,185,164 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cryab
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366122,532,851 - 2,536,473 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRYAB
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,638,502 - 39,643,530 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,638,505 - 39,643,530 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,428,979 - 44,433,758 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRYAB
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11103,258,715 - 103,263,274 (-)NCBI
ChlSab1.1 Ensembl1103,257,347 - 103,261,990 (-)Ensembl
Cryab
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247847,074,590 - 7,093,471 (-)NCBI

Position Markers
RH143847  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0855,176,840 - 55,176,979NCBIRnor6.0
Rnor_5.0853,774,076 - 53,774,215UniSTSRnor5.0
RGSC_v3.4854,105,800 - 54,105,939UniSTSRGSC3.4
Celera850,641,041 - 50,641,180UniSTS
Cytogenetic Map8q23UniSTS
PMC123035P1  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0855,177,932 - 55,178,902NCBIRnor6.0
Rnor_5.0853,775,168 - 53,776,138UniSTSRnor5.0
RGSC_v3.4854,106,892 - 54,107,862UniSTSRGSC3.4
Celera850,642,133 - 50,643,103UniSTS
Cytogenetic Map8q23UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)89531047119211942Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)81038843955388439Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)81038843955388439Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810938911120496129Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81137326757541668Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81144825156448251Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81144825156448251Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81766655562666555Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)82071759265717592Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)82146491991140553Rat
731182Uae24Urinary albumin excretion QTL 246.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)821813070100873963Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)82784149672841496Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)82986798359908353Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)829867983106526740Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)829867983106526740Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)829867983106526740Rat
2303564Gluco43Glucose level QTL 433blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83014480075144800Rat
2303572Insul13Insulin level QTL 132blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)83014480075144800Rat
1331804Cm30Cardiac mass QTL 303.77443heart mass (VT:0007028)heart wet weight (CMO:0000069)83091811258858224Rat
1300146Rf17Renal function QTL 172.9renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)83091811275918112Rat
8662823Vetf5Vascular elastic tissue fragility QTL 51.9artery integrity trait (VT:0010639)patent ductus arteriosus score (CMO:0002566)830918112107206309Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83220198175971421Rat
1549908Neudeg1Neurodegradation QTL 15.50nervous system integrity trait (VT:0010566)logarithm of the ratio of the lesioned side motor neuron count to contralateral side motor neuron count (CMO:0001986)832888352101374135Rat
1331744Bp217Blood pressure QTL 2173.398arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866062857995Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
61353Bp35Blood pressure QTL 350.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)83355866065717592Rat
1359033Bp273Blood pressure QTL 273arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83355866065717592Rat
11556286Cm81Cardiac mass QTL 810.01heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)83355866065717592Rat
2313046Bss78Bone structure and strength QTL 783.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)83355866089058369Rat
2313057Bss76Bone structure and strength QTL 7630.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)83355866089058369Rat
2313067Bss77Bone structure and strength QTL 773.10.0001tibia size trait (VT:0100001)tibia midshaft endosteal cross-sectional area (CMO:0001716)83355866089058369Rat
2313088Bss75Bone structure and strength QTL 753.10.0001body length (VT:0001256)body length, nose to rump (CMO:0000079)83355866089058369Rat
1578765Klgr1Kidney lesion grade QTL 13.30.0001kidney morphology trait (VT:0002135)organ lesion measurement (CMO:0000677)833558660109028082Rat
1578769Uae31Urinary albumin excretion QTL 313.30.001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)833558660109028082Rat
1578755Pur5Proteinuria QTL 53.30.0001total urine protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)833558660109028082Rat
2316950Scl66Serum cholesterol level QTL 664.1blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)833558764113580387Rat
1298065Scl16Serum cholesterol level QTL 163.8blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)83504141480041414Rat
1582222Epfw2Epididymal fat weight QTL 23.20.0005epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)83592559480925594Rat
1331838Niddm61Non-insulin dependent diabetes mellitus QTL 613.530.0004blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)839230130106506973Rat
61358Bp39Blood pressure QTL 392arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)83992790184927901Rat
61464Niddm11Non-insulin dependent diabetes mellitus QTL 113.10.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)83995802284958022Rat
737824Hcar10Hepatocarcinoma resistance QTL 102.9liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)84421919789542960Rat
1358906Bp253Blood pressure QTL 25340.0004arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)844219197100873963Rat
1554321Bmd3Bone mineral density QTL 37.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)844458129118087517Rat
1331769Rf39Renal function QTL 393.871urine output (VT:0003620)timed urine volume (CMO:0000260)84571234480003418Rat
1298079Activ2Activity QTL 29.50.000001voluntary movement trait (VT:0003491)rearing measurement (CMO:0001515)84571234490712344Rat
631216Stl9Serum triglyceride level QTL 94.710.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)84571247575971259Rat
70161Bp62Blood pressure QTL 622.90.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)84658843796998640Rat
12879882Am8Aortic mass QTL 80.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)847200750106394378Rat
12879878Bw183Body weight QTL 1830.001body mass (VT:0001259)body weight (CMO:0000012)847200750106394378Rat
12879879Cm99Cardiac mass QTL 990.001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)847200750106394378Rat
12879880Cm100Cardiac mass QTL 1000.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)847200750106394378Rat
12879881Cm101Cardiac mass QTL 1010.001heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)847200750106394378Rat
12879883Kidm65Kidney mass QTL 650.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)847200750106394378Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)850529480128036471Rat
70197BpQTLcluster8Blood pressure QTL cluster 83.482arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)850529480128036471Rat
1331837Bw23Body weight QTL 234.190.00007body mass (VT:0001259)body weight (CMO:0000012)850529563106506973Rat
2313086Bss60Bone structure and strength QTL 604.10.0001tibia length (VT:0004357)tibia length (CMO:0000450)85406504489058369Rat
4889938Bss89Bone structure and strength QTL 893.8tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)85406504489058369Rat
5684973Bss100Bone structure and strength QTL 1004.7tibia area (VT:1000281)tibia area measurement (CMO:0001382)85406504489058369Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:94
Count of miRNA genes:85
Interacting mature miRNAs:90
Transcripts:ENSRNOT00000059127
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High 25 1 2 1
Medium 3 18 4 2 9 2 7 9 24 29 23 11 7
Low 53 39 10 39 46 6 18
Below cutoff 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_012935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039080879 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC132668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473975 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK357656 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217150 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ217655 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221154 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ221373 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222356 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ222897 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ223053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ224782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228448 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M24092 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M55534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S74229 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77138 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S77142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U04320 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000059127   ⟹   ENSRNOP00000055901
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl855,178,289 - 55,182,545 (+)Ensembl
RefSeq Acc Id: NM_012935   ⟹   NP_037067
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2851,095,158 - 51,099,161 (+)NCBI
Rnor_6.0855,178,543 - 55,182,546 (+)NCBI
Rnor_5.0853,776,100 - 53,779,780 (+)NCBI
RGSC_v3.4854,107,824 - 54,111,502 (+)RGD
Celera850,642,744 - 50,646,745 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039080878   ⟹   XP_038936806
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2851,095,199 - 51,099,161 (+)NCBI
RefSeq Acc Id: XM_039080879   ⟹   XP_038936807
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2851,093,441 - 51,099,161 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_037067   ⟸   NM_012935
- UniProtKB: P23928 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000055901   ⟸   ENSRNOT00000059127
RefSeq Acc Id: XP_038936807   ⟸   XM_039080879
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038936806   ⟸   XM_039080878
- Peptide Label: isoform X1
Protein Domains
sHSP

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695953
Promoter ID:EPDNEW_R6477
Type:initiation region
Name:Cryab_1
Description:crystallin, alpha B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0855,178,828 - 55,178,888EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2414 AgrOrtholog
Ensembl Genes ENSRNOG00000010524 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000055901 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000059127 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.790 UniProtKB/Swiss-Prot
InterPro A-crystallin/Hsp20_dom UniProtKB/Swiss-Prot
  ACD_alphaB-crystallin UniProtKB/Swiss-Prot
  Alpha-crystallin/HSP UniProtKB/Swiss-Prot
  Alpha-crystallin_N UniProtKB/Swiss-Prot
  HSP20-like_chaperone UniProtKB/Swiss-Prot
KEGG Report rno:25420 UniProtKB/Swiss-Prot
NCBI Gene 25420 ENTREZGENE
PANTHER PTHR45640 UniProtKB/Swiss-Prot
Pfam Crystallin UniProtKB/Swiss-Prot
  HSP20 UniProtKB/Swiss-Prot
PhenoGen Cryab PhenoGen
PIRSF Sm_HSP_B1 UniProtKB/Swiss-Prot
PRINTS ACRYSTALLIN UniProtKB/Swiss-Prot
PROSITE SHSP UniProtKB/Swiss-Prot
Superfamily-SCOP SSF49764 UniProtKB/Swiss-Prot
UniProt CRYAB_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q6LDR2 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-11-06 Cryab  crystallin, alpha B    Crystallin, alpha polypeptide 2  Name updated 625702 APPROVED
2002-06-10 Cryab  Crystallin, alpha polypeptide 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization translocated to the N(2)-line area of myofibrillar I-bands of cardiomyocytes during ischemia 704398