(-)-cotinine multiple interactions ISO RGD:1344220 6480464 [Tobacco Smoke Pollution results in increased abundance of Cotinine] which affects the methylation of FHIT gene CTD PMID:34009014 1,2-dichloroethane decreases expression ISO RGD:732571 6480464 ethylene dichloride results in decreased expression of FHIT mRNA CTD PMID:28189721 , PMID:28960355 1,2-dimethylhydrazine decreases expression ISO RGD:732571 6480464 1, 2-Dimethylhydrazine results in decreased expression of FHIT mRNA CTD PMID:22206623 1-nitropropane increases expression EXP 6480464 1-nitropropane results in increased expression of FHIT mRNA CTD PMID:17070881 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:1344220 6480464 Tetrachlorodibenzodioxin results in increased expression of FHIT mRNA CTD PMID:19684285 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO RGD:732571 6480464 Tetrachlorodibenzodioxin results in increased expression of FHIT mRNA CTD PMID:26290441 , PMID:26582802 2,3,7,8-tetrachlorodibenzodioxine affects expression ISO RGD:732571 6480464 Tetrachlorodibenzodioxin affects the expression of FHIT mRNA CTD PMID:26377647 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:1344220 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNA CTD PMID:19684285 2,4-diaminotoluene decreases expression EXP 6480464 2, 4-diaminotoluene results in decreased expression of FHIT mRNA CTD PMID:17070881 2,6-diaminotoluene decreases expression EXP 6480464 2, 6-diaminotoluene results in decreased expression of FHIT mRNA CTD PMID:17070881 2-acetamidofluorene decreases expression EXP 6480464 2-Acetylaminofluorene results in decreased expression of FHIT mRNA CTD PMID:17070881 2-nitro-p-phenylenediamine increases expression EXP 6480464 2-nitro-4-phenylenediamine results in increased expression of FHIT mRNA CTD PMID:17070881 2-nitropropane decreases expression EXP 6480464 2-nitropropane results in decreased expression of FHIT mRNA CTD PMID:17070881 2-nitrotoluene decreases expression ISO RGD:732571 6480464 2-nitrotoluene results in decreased expression of FHIT mRNA, 2-nitrotoluene results in decreased expression of FHIT protein CTD PMID:15618236 3-chloropropane-1,2-diol decreases expression ISO RGD:1344220 6480464 alpha-Chlorohydrin results in decreased expression of FHIT mRNA CTD PMID:35690182 3-methylcholanthrene multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein, [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter CTD PMID:20970405 3-methylcholanthrene decreases expression ISO RGD:1344220 6480464 Methylcholanthrene results in decreased expression of FHIT mRNA CTD PMID:22100608 4,4'-diaminodiphenylmethane increases expression ISO RGD:732571 6480464 4, 4'-diaminodiphenylmethane results in increased expression of FHIT mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol decreases expression ISO RGD:732571 6480464 bis(4-hydroxyphenyl)sulfone results in decreased expression of FHIT mRNA CTD PMID:33297965 4,4'-sulfonyldiphenol decreases methylation ISO RGD:1344220 6480464 bis(4-hydroxyphenyl)sulfone results in decreased methylation of FHIT gene CTD PMID:31601247 4-acetylaminofluorene decreases expression EXP 6480464 4-acetylaminofluorene results in decreased expression of FHIT mRNA CTD PMID:17070881 4-hydroxyphenyl retinamide decreases expression ISO RGD:732571 6480464 Fenretinide results in decreased expression of FHIT mRNA CTD PMID:28973697 4-nitro-1,2-phenylenediamine increases expression EXP 6480464 1, 2-diamino-4-nitrobenzene results in increased expression of FHIT mRNA CTD PMID:17070881 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of FHIT mRNA CTD PMID:15937960 5-aza-2'-deoxycytidine multiple interactions ISO RGD:1344220 6480464 [Decitabine affects the methylation of FHIT promoter] which affects the expression of FHIT mRNA more ... CTD PMID:17019711 , PMID:23618899 5-aza-2'-deoxycytidine decreases methylation EXP 6480464 Decitabine results in decreased methylation of FHIT promoter CTD PMID:15937960 5-aza-2'-deoxycytidine affects methylation ISO RGD:1344220 6480464 Decitabine affects the methylation of FHIT promoter CTD PMID:17019711 7,12-dimethyltetraphene decreases expression EXP 6480464 9 more ... CTD PMID:15937960 7,12-dimethyltetraphene increases methylation EXP 6480464 9 more ... CTD PMID:15937960 acrylamide affects expression EXP 6480464 Acrylamide affects the expression of FHIT mRNA CTD PMID:28959563 aflatoxin B1 affects expression ISO RGD:1344220 6480464 Aflatoxin B1 affects the expression of FHIT protein CTD PMID:20106945 aflatoxin B1 decreases methylation ISO RGD:1344220 6480464 Aflatoxin B1 results in decreased methylation of FHIT intron CTD PMID:30157460 aflatoxin B1 decreases expression ISO RGD:1344220 6480464 Aflatoxin B1 results in decreased expression of FHIT mRNA CTD PMID:21632981 more ... aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of FHIT mRNA CTD PMID:22545673 aflatoxin B1 decreases expression ISO RGD:732571 6480464 Aflatoxin B1 results in decreased expression of FHIT mRNA CTD PMID:19770486 Aflatoxin B2 alpha decreases methylation ISO RGD:1344220 6480464 aflatoxin B2 results in decreased methylation of FHIT intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:1344220 6480464 Tretinoin results in decreased expression of FHIT mRNA CTD PMID:23724009 aristolochic acid A decreases expression ISO RGD:1344220 6480464 aristolochic acid I results in decreased expression of FHIT mRNA CTD PMID:33212167 arsane affects methylation ISO RGD:1344220 6480464 Arsenic affects the methylation of FHIT gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:1344220 6480464 Arsenic affects the methylation of FHIT gene CTD PMID:25304211 benzo[a]pyrene decreases expression ISO RGD:732571 6480464 Benzo(a)pyrene results in decreased expression of FHIT mRNA CTD PMID:19770486 , PMID:21715664 benzo[a]pyrene increases expression ISO RGD:732571 6480464 Benzo(a)pyrene results in increased expression of FHIT mRNA CTD PMID:32417428 benzo[a]pyrene affects methylation ISO RGD:1344220 6480464 Benzo(a)pyrene affects the methylation of FHIT 5' UTR, Benzo(a)pyrene affects the methylation of FHIT intron CTD PMID:27901495 , PMID:30157460 benzo[a]pyrene increases methylation ISO RGD:1344220 6480464 Benzo(a)pyrene results in increased methylation of FHIT promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO RGD:1344220 6480464 Benzo(a)pyrene results in decreased expression of FHIT mRNA CTD PMID:20106945 more ... benzo[a]pyrene diol epoxide I decreases expression ISO RGD:1344220 6480464 7 more ... CTD PMID:26238291 benzo[e]pyrene affects methylation ISO RGD:1344220 6480464 benzo(e)pyrene affects the methylation of FHIT intron CTD PMID:30157460 Benzo[k]fluoranthene increases expression ISO RGD:732571 6480464 benzo(k)fluoranthene results in increased expression of FHIT mRNA CTD PMID:26377693 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of FHIT mRNA CTD PMID:25181051 bisphenol A increases methylation EXP 6480464 bisphenol A results in increased methylation of FHIT gene CTD PMID:28505145 butanal decreases expression ISO RGD:1344220 6480464 butyraldehyde results in decreased expression of FHIT mRNA CTD PMID:26079696 cadmium dichloride decreases methylation EXP 6480464 Cadmium Chloride results in decreased methylation of FHIT promoter CTD PMID:22457795 carbon nanotube decreases expression ISO RGD:732571 6480464 Nanotubes more ... CTD PMID:25554681 cisplatin decreases expression EXP 6480464 Cisplatin results in decreased expression of FHIT mRNA CTD PMID:22023808 cisplatin decreases expression ISO RGD:1344220 6480464 Cisplatin results in decreased expression of FHIT mRNA CTD PMID:27392435 cisplatin multiple interactions ISO RGD:1344220 6480464 [Cisplatin co-treated with jinfukang] results in decreased expression of FHIT mRNA CTD PMID:27392435 cisplatin decreases expression ISO RGD:732571 6480464 Cisplatin results in decreased expression of FHIT mRNA CTD PMID:25270620 clothianidin increases expression ISO RGD:1344220 6480464 clothianidin results in increased expression of FHIT mRNA CTD PMID:35690182 cycloheximide multiple interactions ISO RGD:1344220 6480464 [Tetrachlorodibenzodioxin co-treated with Cycloheximide] results in increased expression of FHIT mRNA CTD PMID:19684285 ethyl methanesulfonate decreases expression ISO RGD:1344220 6480464 Ethyl Methanesulfonate results in decreased expression of FHIT mRNA CTD PMID:23649840 graphite affects expression EXP 6480464 Graphite affects the expression of FHIT mRNA CTD PMID:29933104 hydralazine decreases methylation ISO RGD:1344220 6480464 Hydralazine results in decreased methylation of FHIT promoter CTD PMID:15862127 hydralazine increases expression ISO RGD:1344220 6480464 Hydralazine results in increased expression of FHIT mRNA CTD PMID:15862127 indole-3-methanol affects expression EXP 6480464 indole-3-carbinol affects the expression of FHIT mRNA CTD PMID:21396975 Lasiocarpine decreases expression ISO RGD:1344220 6480464 lasiocarpine results in decreased expression of FHIT mRNA CTD PMID:32234424 , PMID:35690182 MeIQx decreases expression ISO RGD:1344220 6480464 2-amino-3 more ... CTD PMID:22100608 menadione increases response to substance ISO RGD:1344220 6480464 FHIT protein results in increased susceptibility to Vitamin K 3 CTD PMID:19622739 methamphetamine affects response to substance ISO RGD:1344220 6480464 FHIT gene SNP affects the susceptibility to Methamphetamine CTD PMID:18316681 methapyrilene affects methylation ISO RGD:1344220 6480464 Methapyrilene affects the methylation of FHIT intron CTD PMID:30157460 methapyrilene increases expression ISO RGD:1344220 6480464 Methapyrilene results in increased expression of FHIT mRNA CTD PMID:35690182 methyl methanesulfonate decreases expression ISO RGD:1344220 6480464 Methyl Methanesulfonate results in decreased expression of FHIT mRNA CTD PMID:22100608 mitomycin C decreases expression ISO RGD:732571 6480464 Mitomycin results in decreased expression of FHIT mRNA CTD PMID:25270620 N-acetyl-L-cysteine multiple interactions EXP 6480464 Acetylcysteine inhibits the reaction [Tobacco Smoke Pollution results in decreased expression of FHIT protein] CTD PMID:16585223 N-methyl-N-nitrosourea increases methylation EXP 6480464 Methylnitrosourea results in increased methylation of FHIT intron, Methylnitrosourea results in increased methylation of FHIT promoter CTD PMID:15937960 N-methyl-N-nitrosourea decreases expression EXP 6480464 Methylnitrosourea results in decreased expression of FHIT mRNA, Methylnitrosourea results in decreased expression of FHIT protein CTD PMID:15937960 , PMID:17412507 N-nitrosodiethylamine multiple interactions EXP 6480464 [Diethylnitrosamine co-treated with Methylcholanthrene] results in decreased expression of FHIT protein, [Diethylnitrosamine co-treated with Methylcholanthrene] results in increased methylation of FHIT promoter CTD PMID:20970405 N-nitrosodiethylamine decreases expression EXP 6480464 Diethylnitrosamine results in decreased expression of FHIT protein CTD PMID:12112319 N-Nitrosopyrrolidine decreases expression ISO RGD:1344220 6480464 N-Nitrosopyrrolidine results in decreased expression of FHIT mRNA CTD PMID:32234424 , PMID:35690182 nickel dichloride decreases expression ISO RGD:732571 6480464 nickel chloride results in decreased expression of FHIT protein CTD PMID:14971660 nickel subsulfide decreases expression ISO RGD:732571 6480464 nickel subsulfide results in decreased expression of FHIT protein CTD PMID:14971660 O-methyleugenol decreases expression ISO RGD:732571 6480464 methyleugenol results in decreased expression of FHIT mRNA, methyleugenol results in decreased expression of FHIT protein CTD PMID:15618236 O-methyleugenol decreases expression ISO RGD:1344220 6480464 methyleugenol results in decreased expression of FHIT mRNA CTD PMID:32234424 , PMID:35690182 para-Nitrosodiphenylamine affects response to substance ISO RGD:1344220 6480464 FHIT gene SNP affects the susceptibility to 4-nitroso-N-phenylaniline CTD PMID:25622337 paracetamol affects expression ISO RGD:732571 6480464 Acetaminophen affects the expression of FHIT mRNA CTD PMID:17562736 paraquat decreases expression EXP 6480464 Paraquat results in decreased expression of FHIT mRNA CTD PMID:32680482 perfluorododecanoic acid increases expression EXP 6480464 perfluorododecanoic acid results in increased expression of FHIT protein CTD PMID:19854247 phenobarbital increases expression ISO RGD:732571 6480464 Phenobarbital results in increased expression of FHIT mRNA CTD PMID:19270015 phenobarbital affects expression ISO RGD:732571 6480464 Phenobarbital affects the expression of FHIT mRNA CTD PMID:23091169 PhIP decreases expression ISO RGD:1344220 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in decreased expression of FHIT mRNA CTD PMID:22100608 ponasterone A affects expression ISO RGD:1344220 6480464 ponasterone A affects the expression of FHIT protein CTD PMID:17019711 quercetin decreases expression ISO RGD:1344220 6480464 Quercetin results in decreased expression of FHIT mRNA CTD PMID:21632981 silicon dioxide decreases expression ISO RGD:1344220 6480464 Silicon Dioxide results in decreased expression of FHIT mRNA CTD PMID:25351596 sodium arsenite multiple interactions ISO RGD:1344220 6480464 decitabine inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein], U 0126 inhibits the reaction [sodium arsenite results in decreased expression of FHIT protein] CTD PMID:23618899 sodium arsenite decreases expression ISO RGD:1344220 6480464 sodium arsenite results in decreased expression of FHIT mRNA, sodium arsenite results in decreased expression of FHIT protein CTD PMID:23618899 sodium dichromate affects expression EXP 6480464 sodium bichromate affects the expression of FHIT mRNA CTD PMID:22110744 sodium dichromate decreases expression EXP 6480464 sodium bichromate results in decreased expression of FHIT mRNA CTD PMID:25993096 succimer multiple interactions ISO RGD:732571 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of FHIT mRNA CTD PMID:26378955 sunitinib increases expression ISO RGD:1344220 6480464 Sunitinib results in increased expression of FHIT mRNA CTD PMID:31533062 testosterone enanthate affects expression ISO RGD:1344220 6480464 testosterone enanthate affects the expression of FHIT mRNA CTD PMID:17440010 tetrachloromethane increases expression ISO RGD:732571 6480464 Carbon Tetrachloride results in increased expression of FHIT mRNA CTD PMID:27339419 titanium dioxide decreases expression ISO RGD:732571 6480464 titanium dioxide results in decreased expression of FHIT mRNA CTD PMID:23557971 trichostatin A multiple interactions ISO RGD:1344220 6480464 [decitabine co-treated with trichostatin A] affects the expression of FHIT protein CTD PMID:17019711 tris(2-butoxyethyl) phosphate affects expression ISO RGD:1344220 6480464 tris(2-butoxyethyl) phosphate affects the expression of FHIT mRNA CTD PMID:29024780 tunicamycin increases expression ISO RGD:1344220 6480464 Tunicamycin results in increased expression of FHIT mRNA CTD PMID:29453283 valproic acid affects expression ISO RGD:1344220 6480464 Valproic Acid affects the expression of FHIT mRNA CTD PMID:25979313 valproic acid increases expression ISO RGD:1344220 6480464 Valproic Acid results in increased expression of FHIT mRNA CTD PMID:28001369 vinyl carbamate decreases expression ISO RGD:732571 6480464 vinyl carbamate results in decreased expression of FHIT mRNA CTD PMID:17849452