Fhit (fragile histidine triad diadenosine triphosphatase) - Rat Genome Database

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Gene: Fhit (fragile histidine triad diadenosine triphosphatase) Rattus norvegicus
Analyze
Symbol: Fhit
Name: fragile histidine triad diadenosine triphosphatase
RGD ID: 620448
Description: Enables bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Located in cytosol; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase); PARTICIPATES IN non-small cell lung carcinoma pathway; purine metabolic pathway; small cell lung carcinoma pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: AP3A hydrolase; AP3Aase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad; fragile histidine triad gene; fragile histidine triad protein; LOC102552150; uncharacterized LOC102552150
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21513,935,029 - 15,442,620 (+)NCBI
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropropane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-nitrotoluene  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aflatoxin B2  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP)
carbon nanotube  (ISO)
cisplatin  (EXP,ISO)
cycloheximide  (ISO)
ethyl methanesulfonate  (ISO)
graphite  (EXP)
hydralazine  (ISO)
indole-3-methanol  (EXP)
Lasiocarpine  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
O-methyleugenol  (ISO)
para-Nitrosodiphenylamine  (ISO)
paracetamol  (ISO)
perfluorododecanoic acid  (EXP)
phenobarbital  (ISO)
PhIP  (ISO)
ponasterone A  (ISO)
quercetin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinyl carbamate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IDA,ISO)
fibrillar center  (ISO)
nucleus  (IBA,IDA)
plasma membrane  (IBA,IDA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Asensio AC, etal., Biochimie. 2006 May;88(5):461-71. Epub 2005 Nov 15.
2. Burke L, etal., Cancer Res. 1998 Jun 15;58(12):2533-6.
3. Buttitta F, etal., Br J Cancer. 1998 Apr;77(7):1048-51.
4. Choi CH, etal., Cancer Lett. 2007 Sep 18;255(1):26-33. Epub 2007 Apr 30.
5. Chu TY, etal., Int J Cancer. 1998 Jan 19;75(2):199-204.
6. Chu YX, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Mar;37(2):218-20.
7. Dhillon VS, etal., Mol Cancer. 2004 Dec 1;3:33.
8. Eyzaguirre E and Gatalica Z, Mod Pathol. 2002 Oct;15(10):1068-72.
9. Eyzaguirre EJ, etal., Mod Pathol. 1999 Oct;12(10):979-83.
10. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
11. GOA data from the GO Consortium
12. Golebiowski F, etal., Mol Cell Biochem 2001 Oct;226(1-2):49-55.
13. Gutierrez MI, etal., Mod Pathol. 2004 Oct;17(10):1268-74.
14. Holschneider CH, etal., Clin Cancer Res. 2005 Aug 15;11(16):5756-63.
15. Huiping C, etal., Eur J Cancer. 2000 Aug;36(12):1552-7.
16. KEGG
17. Larson GP, etal., Cancer Res. 2005 Feb 1;65(3):805-14.
18. Levin AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1294-7.
19. Lubet RA, etal., Carcinogenesis. 2005 Mar;26(3):571-8. Epub 2004 Dec 9.
20. Maruyama R, etal., Cancer Res. 2001 Dec 15;61(24):8659-63.
21. Maruyama R, etal., Clin Cancer Res. 2002 Feb;8(2):514-9.
22. MGD data from the GO Consortium
23. NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Pipeline to import KEGG annotations from KEGG into RGD
25. Poland KS, etal., Genes Chromosomes Cancer. 2007 Sep;46(9):805-12.
26. RGD automated data pipeline
27. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. RGD automated import pipeline for gene-chemical interactions
29. Segawa T, etal., Clin Cancer Res. 2000 Jun;6(6):2341-8.
30. Skotheim RI, etal., Neoplasia. 2003 Sep-Oct;5(5):397-404.
31. Terry G, etal., Br J Cancer. 2007 Jan 15;96(1):110-7. Epub 2006 Dec 12.
32. Tomizawa Y, etal., Cancer Res. 1998 Dec 1;58(23):5478-83.
33. Tsujiuchi T, etal., Mol Carcinog 2002 May;34(1):19-24.
34. Yang Q, etal., Clin Cancer Res. 2002 Sep;8(9):2890-3.
Additional References at PubMed
PMID:8794732   PMID:9261067   PMID:9323207   PMID:9576908   PMID:9699672   PMID:12619037   PMID:15007172   PMID:15254237   PMID:15313915   PMID:15937960   PMID:16189514   PMID:17974098  
PMID:18077326   PMID:23376485   PMID:24722188   PMID:25416956   PMID:27107012   PMID:31515488  


Genomics

Comparative Map Data
Fhit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21513,935,029 - 15,442,620 (+)NCBI
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
FHIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl359,747,277 - 61,251,459 (-)EnsemblGRCh38hg38GRCh38
GRCh38359,747,277 - 61,251,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37359,733,003 - 61,237,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36359,710,076 - 61,212,164 (-)NCBINCBI36hg18NCBI36
Build 34359,710,077 - 61,212,164NCBI
Celera359,748,610 - 61,250,104 (-)NCBI
Cytogenetic Map3p14.2NCBI
HuRef359,831,176 - 61,335,629 (-)NCBIHuRef
CHM1_1359,685,586 - 61,187,676 (-)NCBICHM1_1
Fhit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391411,307,679 - 12,919,681 (+)NCBIGRCm39mm39
GRCm39 Ensembl1411,307,738 - 12,919,681 (+)Ensembl
GRCm38149,550,092 - 11,162,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl149,550,092 - 11,162,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv371410,382,608 - 11,994,546 (-)NCBIGRCm37mm9NCBIm37
MGSCv36148,343,886 - 9,955,286 (-)NCBImm8
Celera145,162,596 - 6,766,296 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map145.61NCBI
Fhit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955430221,518 - 508,094 (+)NCBIChiLan1.0ChiLan1.0
FHIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1361,069,947 - 62,568,700 (-)NCBIpanpan1.1PanPan1.1panPan2
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBIMhudiblu_PPA_v0panPan3
FHIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12029,735,380 - 31,113,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBI
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBI
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBI
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBI
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBI
Fhit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118167,149,768 - 168,286,240 (+)NCBI
SpeTri2.0NW_004936473397,140 - 1,424,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1341,443,965 - 42,228,680 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11341,443,963 - 42,884,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21345,643,668 - 46,973,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12221,006,010 - 22,474,056 (-)NCBI
Vero_WHO_p1.0NW_023666041144,572,356 - 145,797,861 (+)NCBI
Fhit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248226,621,609 - 8,069,590 (-)NCBI

Position Markers
D15Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,481,165 - 14,481,294 (+)MAPPER
Rnor_6.01515,828,242 - 15,828,368NCBIRnor6.0
Rnor_5.01519,829,554 - 19,829,680UniSTSRnor5.0
RGSC_v3.41516,365,832 - 16,365,960RGDRGSC3.4
RGSC_v3.41516,365,833 - 16,365,959UniSTSRGSC3.4
RGSC_v3.11516,365,684 - 16,366,009RGD
Celera1514,471,849 - 14,471,971UniSTS
RH 3.4 Map15110.5UniSTS
RH 3.4 Map15110.5RGD
RH 2.0 Map1544.5RGD
Cytogenetic Map15p15-p14UniSTS
D15Rat168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,537,515 - 14,537,769 (+)MAPPER
Rnor_6.01515,883,929 - 15,884,182NCBIRnor6.0
Rnor_5.01519,885,936 - 19,886,189UniSTSRnor5.0
RGSC_v3.41516,422,679 - 16,422,931RGDRGSC3.4
RGSC_v3.41516,422,678 - 16,422,931UniSTSRGSC3.4
RGSC_v3.11516,422,679 - 16,422,931RGD
Celera1514,526,769 - 14,527,022UniSTS
SHRSP x BN Map159.5698RGD
SHRSP x BN Map159.5698UniSTS
Cytogenetic Map15p15-p14UniSTS
AU047515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,751,328 - 14,751,483 (+)MAPPER
Rnor_6.01516,041,584 - 16,041,738NCBIRnor6.0
Rnor_5.01520,041,705 - 20,041,859UniSTSRnor5.0
Celera1514,740,372 - 14,740,526UniSTS
Cytogenetic Map15p15-p14UniSTS
RH144127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,442,358 - 15,442,459 (+)MAPPER
Rnor_6.01516,862,892 - 16,862,992NCBIRnor6.0
Rnor_5.01520,846,594 - 20,846,694UniSTSRnor5.0
RGSC_v3.41517,329,203 - 17,329,303UniSTSRGSC3.4
Celera1515,420,104 - 15,420,204UniSTS
RH 3.4 Map15110.3UniSTS
Cytogenetic Map15p15-p14UniSTS
RH144674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,005,237 - 14,005,392 (+)MAPPER
Rnor_6.01514,088,056 - 14,088,210NCBIRnor6.0
Rnor_5.01518,101,436 - 18,101,590UniSTSRnor5.0
RGSC_v3.41515,873,922 - 15,874,076UniSTSRGSC3.4
Celera1513,996,896 - 13,997,050UniSTS
RH 3.4 Map15110.0UniSTS
Cytogenetic Map15p15-p14UniSTS
AU048334  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,655,606 - 14,655,802 (+)MAPPER
Rnor_6.01516,169,762 - 16,169,957NCBIRnor6.0
Rnor_5.01520,167,240 - 20,167,435UniSTSRnor5.0
RGSC_v3.41516,542,377 - 16,542,572UniSTSRGSC3.4
Celera1514,643,887 - 14,644,082UniSTS
Cytogenetic Map15p15-p14UniSTS
AU047671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,244,001 - 15,244,128 (+)MAPPER
Rnor_6.01516,659,942 - 16,660,068NCBIRnor6.0
Rnor_5.01520,650,789 - 20,650,915UniSTSRnor5.0
RGSC_v3.41517,126,464 - 17,126,590UniSTSRGSC3.4
Celera1515,222,110 - 15,222,236UniSTS
Cytogenetic Map15p15-p14UniSTS
AU046903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,117,351 - 15,117,479 (+)MAPPER
Rnor_6.01516,533,619 - 16,533,746NCBIRnor6.0
Rnor_5.01520,524,591 - 20,524,718UniSTSRnor5.0
RGSC_v3.41516,995,894 - 16,996,021UniSTSRGSC3.4
Celera1515,097,717 - 15,097,844UniSTS
Cytogenetic Map15p15-p14UniSTS
AU046643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,117,330 - 15,117,465 (+)MAPPER
Rnor_6.01516,533,598 - 16,533,732NCBIRnor6.0
Rnor_5.01520,524,570 - 20,524,704UniSTSRnor5.0
RGSC_v3.41516,995,873 - 16,996,007UniSTSRGSC3.4
Celera1515,097,696 - 15,097,830UniSTS
Cytogenetic Map15p15-p14UniSTS
BE119151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,338,256 - 14,338,413 (+)MAPPER
Rnor_6.01515,685,559 - 15,685,715NCBIRnor6.0
Rnor_5.01519,686,824 - 19,686,980UniSTSRnor5.0
RGSC_v3.41516,219,420 - 16,219,576UniSTSRGSC3.4
Celera1514,328,293 - 14,328,449UniSTS
RH 3.4 Map15110.7UniSTS
Cytogenetic Map15p15-p14UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15130597196Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15137708474Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15137708474Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15137708474Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15142844179Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15143521446Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15162301382Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15110589015828368Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)colorectal tumor number (CMO:0001794)15232787726288802Rat
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15232787726288802Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15232787753535766Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)15388113148881131Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151071919155719191Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151549236072568189Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151582824233657761Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000009393
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: NM_021774   ⟹   NP_068542
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21513,967,882 - 15,442,340 (+)NCBI
Rnor_6.01515,697,292 - 16,862,873 (+)NCBI
Rnor_5.01519,698,557 - 20,157,380 (+)NCBI
Rnor_5.01520,538,368 - 20,846,575 (+)NCBI
RGSC_v3.41515,823,461 - 17,329,184 (+)RGD
Celera1513,959,987 - 15,420,085 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093625   ⟹   XP_038949553
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21514,588,748 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093626   ⟹   XP_038949554
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21514,588,350 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093627   ⟹   XP_038949555
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21513,935,030 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093628   ⟹   XP_038949556
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21513,935,029 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093629   ⟹   XP_038949557
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21513,935,030 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093630   ⟹   XP_038949558
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21514,595,386 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093631   ⟹   XP_038949559
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21514,588,869 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093632   ⟹   XP_038949560
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21513,935,036 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093633   ⟹   XP_038949561
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21514,934,248 - 15,442,620 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_068542   ⟸   NM_021774
- UniProtKB: Q9JIX3 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_038949556   ⟸   XM_039093628
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949557   ⟸   XM_039093629
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949555   ⟸   XM_039093627
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949560   ⟸   XM_039093632
- Peptide Label: isoform X5
RefSeq Acc Id: XP_038949554   ⟸   XM_039093626
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038949553   ⟸   XM_039093625
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038949559   ⟸   XM_039093631
- Peptide Label: isoform X4
RefSeq Acc Id: XP_038949558   ⟸   XM_039093630
- Peptide Label: isoform X3
RefSeq Acc Id: XP_038949561   ⟸   XM_039093633
- Peptide Label: isoform X6
Protein Domains
HIT


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620448 AgrOrtholog
Gene3D-CATH 3.30.428.10 UniProtKB/Swiss-Prot
InterPro FHIT UniProtKB/Swiss-Prot
  Histidine_triad_CS UniProtKB/Swiss-Prot
  Histidine_triad_HIT UniProtKB/Swiss-Prot
  HIT-like UniProtKB/Swiss-Prot
  HIT-like_sf UniProtKB/Swiss-Prot
KEGG Report rno:60398 UniProtKB/Swiss-Prot
NCBI Gene 60398 ENTREZGENE
Pfam HIT UniProtKB/Swiss-Prot
PhenoGen Fhit PhenoGen
PROSITE HIT_1 UniProtKB/Swiss-Prot
  HIT_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54197 UniProtKB/Swiss-Prot
UniProt FHIT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fhit  fragile histidine triad diadenosine triphosphatase  LOC102552150  uncharacterized LOC102552150  Data Merged 737654 PROVISIONAL
2019-05-09 Fhit  fragile histidine triad diadenosine triphosphatase  Fhit  fragile histidine triad  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102552150  uncharacterized LOC102552150      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-16 Fhit  fragile histidine triad  Fhit  fragile histidine triad gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fhit  fragile histidine triad gene    fragile histidine triad protein  Name updated 1299863 APPROVED
2002-08-07 Fhit  fragile histidine triad protein      Symbol and Name status set to provisional 70820 PROVISIONAL