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Gene: Fhit (fragile histidine triad diadenosine triphosphatase) Rattus norvegicus
Symbol: Fhit
Name: fragile histidine triad diadenosine triphosphatase
Description: Exhibits bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Localizes to cytosol; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase); PARTICIPATES IN non-small cell lung carcinoma pathway; purine metabolic pathway; small cell lung carcinoma pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.
Type: protein-coding
Also known as: AP3A hydrolase; AP3Aase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad; fragile histidine triad gene; fragile histidine triad protein
Homo sapiens (human) : FHIT (fragile histidine triad diadenosine triphosphatase)  HGNC  Alliance
Mus musculus (house mouse) : Fhit (fragile histidine triad gene)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fhit (fragile histidine triad diadenosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : FHIT (fragile histidine triad diadenosine triphosphatase)
Canis lupus familiaris (dog) : FHIT (fragile histidine triad diadenosine triphosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fhit (fragile histidine triad diadenosine triphosphatase)
Sus scrofa (pig) : FHIT (fragile histidine triad diadenosine triphosphatase)
Chlorocebus sabaeus (African green monkey) : FHIT (fragile histidine triad diadenosine triphosphatase)
Heterocephalus glaber (naked mole-rat) : Fhit (fragile histidine triad diadenosine triphosphatase)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
More on Fhit
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620448
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.