Fhit (fragile histidine triad diadenosine triphosphatase) - Rat Genome Database

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Gene: Fhit (fragile histidine triad diadenosine triphosphatase) Rattus norvegicus
Analyze
Symbol: Fhit
Name: fragile histidine triad diadenosine triphosphatase
RGD ID: 620448
Description: Enables bis(5'-adenosyl)-triphosphatase activity and nickel cation binding activity. Involved in diadenosine triphosphate catabolic process. Predicted to be located in cytosol and fibrillar center. Predicted to be active in cytoplasm; nucleus; and plasma membrane. Used to study hepatocellular carcinoma. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase); PARTICIPATES IN non-small cell lung carcinoma pathway; purine metabolic pathway; small cell lung carcinoma pathway; INTERACTS WITH 1-nitropropane; 2,4-diaminotoluene; 2,6-diaminotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: adenosine 5'-monophosphoramidase FHIT; adenylylsulfatase; adenylylsulfate-ammonia adenylyltransferase; AP3A hydrolase; AP3Aase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; fragile histidine triad; fragile histidine triad gene; fragile histidine triad protein; LOC102552150; uncharacterized LOC102552150
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81516,365,401 - 17,872,901 (+)NCBIGRCr8
mRatBN7.21513,935,029 - 15,442,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1513,934,995 - 15,442,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1516,096,570 - 17,612,441 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01517,054,989 - 18,570,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01515,309,857 - 16,825,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-nitropropane  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-diaminotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitropropane  (EXP)
2-nitrotoluene  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (EXP,ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-acetylaminofluorene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
5-aza-2'-deoxycytidine  (EXP,ISO)
7,12-dimethyltetraphene  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
bisphenol A  (EXP)
butanal  (ISO)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
cycloheximide  (ISO)
Dibutyl phosphate  (ISO)
ethyl methanesulfonate  (ISO)
graphite  (EXP)
hydralazine  (ISO)
indole-3-methanol  (EXP)
inulin  (ISO)
Lasiocarpine  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (ISO)
nickel subsulfide  (ISO)
O-methyleugenol  (ISO)
para-Nitrosodiphenylamine  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
ponasterone A  (ISO)
quercetin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
succimer  (ISO)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinyl carbamate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,ISO)
cytosol  (IEA,ISO)
fibrillar center  (IEA,ISO)
mitochondrion  (IEA)
nucleus  (IBA)
plasma membrane  (IBA,IEA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Biochemical and immunochemical characterisation of human diadenosine triphosphatase provides evidence for its identification with the tumour suppressor Fhit protein. Asensio AC, etal., Biochimie. 2006 May;88(5):461-71. Epub 2005 Nov 15.
2. Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer. Burke L, etal., Cancer Res. 1998 Jun 15;58(12):2533-6.
3. Evaluation of FHIT gene alterations in ovarian cancer. Buttitta F, etal., Br J Cancer. 1998 Apr;77(7):1048-51.
4. Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer. Choi CH, etal., Cancer Lett. 2007 Sep 18;255(1):26-33. Epub 2007 Apr 30.
5. HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA. Chu TY, etal., Int J Cancer. 1998 Jan 19;75(2):199-204.
6. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Chu YX, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Mar;37(2):218-20.
7. FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension. Dannewitz Prosseda S, etal., Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC.
8. CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. Dhillon VS, etal., Mol Cancer. 2004 Dec 1;3:33.
9. Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia. Eyzaguirre E and Gatalica Z, Mod Pathol. 2002 Oct;15(10):1068-72.
10. Different immunohistochemical patterns of Fhit protein expression in renal neoplasms. Eyzaguirre EJ, etal., Mod Pathol. 1999 Oct;12(10):979-83.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
13. Distribution of Fhit protein in rat tissues and its intracellular localization. Golebiowski F, etal., Mol Cell Biochem 2001 Oct;226(1-2):49-55.
14. CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. Gutierrez MI, etal., Mod Pathol. 2004 Oct;17(10):1268-74.
15. The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer. Holschneider CH, etal., Clin Cancer Res. 2005 Aug 15;11(16):5756-63.
16. Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer. Huiping C, etal., Eur J Cancer. 2000 Aug;36(12):1552-7.
17. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
18. Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT. Larson GP, etal., Cancer Res. 2005 Feb 1;65(3):805-14.
19. Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. Levin AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1294-7.
20. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Lubet RA, etal., Carcinogenesis. 2005 Mar;26(3):571-8. Epub 2004 Dec 9.
21. Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Maruyama R, etal., Cancer Res. 2001 Dec 15;61(24):8659-63.
22. Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. Maruyama R, etal., Clin Cancer Res. 2002 Feb;8(2):514-9.
23. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
24. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
26. A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. Poland KS, etal., Genes Chromosomes Cancer. 2007 Sep;46(9):805-12.
27. GOA pipeline RGD automated data pipeline
28. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
29. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
30. Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas. Segawa T, etal., Clin Cancer Res. 2000 Jun;6(6):2341-8.
31. Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays. Skotheim RI, etal., Neoplasia. 2003 Sep-Oct;5(5):397-404.
32. The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions. Terry G, etal., Br J Cancer. 2007 Jan 15;96(1):110-7. Epub 2006 Dec 12.
33. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Tomizawa Y, etal., Cancer Res. 1998 Dec 1;58(23):5478-83.
34. Alterations of the Fhit gene in hepatocellular carcinomas induced by N-nitrosodiethylamine in rats. Tsujiuchi T, etal., Mol Carcinog 2002 May;34(1):19-24.
35. Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer. Yang Q, etal., Clin Cancer Res. 2002 Sep;8(9):2890-3.
Additional References at PubMed
PMID:8794732   PMID:9261067   PMID:9323207   PMID:9576908   PMID:9699672   PMID:12619037   PMID:15007172   PMID:15254237   PMID:15313915   PMID:15937960   PMID:16189514   PMID:17974098  
PMID:18077326   PMID:23376485   PMID:24722188   PMID:25416956   PMID:27107012   PMID:31515488   PMID:36637791  


Genomics

Comparative Map Data
Fhit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81516,365,401 - 17,872,901 (+)NCBIGRCr8
mRatBN7.21513,935,029 - 15,442,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1513,934,995 - 15,442,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1516,096,570 - 17,612,441 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01517,054,989 - 18,570,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01515,309,857 - 16,825,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
FHIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38359,747,277 - 61,251,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl359,747,277 - 61,251,459 (-)EnsemblGRCh38hg38GRCh38
GRCh37359,733,003 - 61,237,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36359,710,076 - 61,212,164 (-)NCBINCBI36Build 36hg18NCBI36
Build 34359,710,077 - 61,212,164NCBI
Celera359,748,610 - 61,250,104 (-)NCBICelera
Cytogenetic Map3p14.2NCBI
HuRef359,831,176 - 61,335,629 (-)NCBIHuRef
CHM1_1359,685,586 - 61,187,676 (-)NCBICHM1_1
T2T-CHM13v2.0359,787,636 - 61,294,609 (-)NCBIT2T-CHM13v2.0
Fhit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391411,307,718 - 12,919,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1411,307,738 - 12,919,681 (+)EnsemblGRCm39 Ensembl
GRCm38149,550,092 - 11,162,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl149,550,092 - 11,162,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv371410,382,608 - 11,994,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36148,343,886 - 9,955,286 (-)NCBIMGSCv36mm8
Celera145,162,596 - 6,766,296 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map145.61NCBI
Fhit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955430221,518 - 508,094 (+)NCBIChiLan1.0ChiLan1.0
FHIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2259,695,617 - 61,199,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1361,069,947 - 62,568,700 (-)NCBIpanpan1.1PanPan1.1panPan2
FHIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12029,735,380 - 31,113,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2030,591,449 - 31,357,367 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBIUU_Cfam_GSD_1.0
Fhit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118167,149,768 - 168,286,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936473676,237 - 1,424,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936473397,140 - 1,424,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1341,443,965 - 42,392,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11341,443,963 - 42,884,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21345,643,668 - 46,973,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12221,006,010 - 22,474,056 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041144,572,356 - 145,797,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248226,621,909 - 7,380,047 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248226,621,609 - 8,069,590 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fhit
9977 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:31
Count of miRNA genes:31
Interacting mature miRNAs:31
Transcripts:ENSRNOT00000009393
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1641913Colcr2Colorectal carcinoma resistance QTL 26.570.0197intestine integrity trait (VT:0010554)poorly differentiated malignant colorectal tumor number (CMO:0002076)15226636822711984Rat
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
5684946Bss98Bone structure and strength QTL 983.90.0026tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)15105825014481294Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

Markers in Region
D15Mit2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,481,165 - 14,481,294 (+)MAPPERmRatBN7.2
Rnor_6.01515,828,242 - 15,828,368NCBIRnor6.0
Rnor_5.01519,829,554 - 19,829,680UniSTSRnor5.0
RGSC_v3.41516,365,832 - 16,365,960RGDRGSC3.4
RGSC_v3.41516,365,833 - 16,365,959UniSTSRGSC3.4
RGSC_v3.11516,365,684 - 16,366,009RGD
Celera1514,471,849 - 14,471,971UniSTS
RH 3.4 Map15110.5UniSTS
RH 3.4 Map15110.5RGD
RH 2.0 Map1544.5RGD
Cytogenetic Map15p15-p14UniSTS
D15Rat168  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,537,515 - 14,537,769 (+)MAPPERmRatBN7.2
Rnor_6.01515,883,929 - 15,884,182NCBIRnor6.0
Rnor_5.01519,885,936 - 19,886,189UniSTSRnor5.0
RGSC_v3.41516,422,679 - 16,422,931RGDRGSC3.4
RGSC_v3.41516,422,678 - 16,422,931UniSTSRGSC3.4
RGSC_v3.11516,422,679 - 16,422,931RGD
Celera1514,526,769 - 14,527,022UniSTS
SHRSP x BN Map159.5698RGD
SHRSP x BN Map159.5698UniSTS
Cytogenetic Map15p15-p14UniSTS
AU047515  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,751,328 - 14,751,483 (+)MAPPERmRatBN7.2
Rnor_6.01516,041,584 - 16,041,738NCBIRnor6.0
Rnor_5.01520,041,705 - 20,041,859UniSTSRnor5.0
Celera1514,740,372 - 14,740,526UniSTS
Cytogenetic Map15p15-p14UniSTS
RH144127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,442,358 - 15,442,459 (+)MAPPERmRatBN7.2
Rnor_6.01516,862,892 - 16,862,992NCBIRnor6.0
Rnor_5.01520,846,594 - 20,846,694UniSTSRnor5.0
RGSC_v3.41517,329,203 - 17,329,303UniSTSRGSC3.4
Celera1515,420,104 - 15,420,204UniSTS
RH 3.4 Map15110.3UniSTS
Cytogenetic Map15p15-p14UniSTS
RH144674  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,005,237 - 14,005,392 (+)MAPPERmRatBN7.2
Rnor_6.01514,088,056 - 14,088,210NCBIRnor6.0
Rnor_5.01518,101,436 - 18,101,590UniSTSRnor5.0
RGSC_v3.41515,873,922 - 15,874,076UniSTSRGSC3.4
Celera1513,996,896 - 13,997,050UniSTS
RH 3.4 Map15110.0UniSTS
Cytogenetic Map15p15-p14UniSTS
AU048334  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,655,606 - 14,655,802 (+)MAPPERmRatBN7.2
Rnor_6.01516,169,762 - 16,169,957NCBIRnor6.0
Rnor_5.01520,167,240 - 20,167,435UniSTSRnor5.0
RGSC_v3.41516,542,377 - 16,542,572UniSTSRGSC3.4
Celera1514,643,887 - 14,644,082UniSTS
Cytogenetic Map15p15-p14UniSTS
AU047671  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,244,001 - 15,244,128 (+)MAPPERmRatBN7.2
Rnor_6.01516,659,942 - 16,660,068NCBIRnor6.0
Rnor_5.01520,650,789 - 20,650,915UniSTSRnor5.0
RGSC_v3.41517,126,464 - 17,126,590UniSTSRGSC3.4
Celera1515,222,110 - 15,222,236UniSTS
Cytogenetic Map15p15-p14UniSTS
AU046903  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,117,351 - 15,117,479 (+)MAPPERmRatBN7.2
Rnor_6.01516,533,619 - 16,533,746NCBIRnor6.0
Rnor_5.01520,524,591 - 20,524,718UniSTSRnor5.0
RGSC_v3.41516,995,894 - 16,996,021UniSTSRGSC3.4
Celera1515,097,717 - 15,097,844UniSTS
Cytogenetic Map15p15-p14UniSTS
AU046643  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21515,117,330 - 15,117,465 (+)MAPPERmRatBN7.2
Rnor_6.01516,533,598 - 16,533,732NCBIRnor6.0
Rnor_5.01520,524,570 - 20,524,704UniSTSRnor5.0
RGSC_v3.41516,995,873 - 16,996,007UniSTSRGSC3.4
Celera1515,097,696 - 15,097,830UniSTS
Cytogenetic Map15p15-p14UniSTS
BE119151  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21514,338,256 - 14,338,413 (+)MAPPERmRatBN7.2
Rnor_6.01515,685,559 - 15,685,715NCBIRnor6.0
Rnor_5.01519,686,824 - 19,686,980UniSTSRnor5.0
RGSC_v3.41516,219,420 - 16,219,576UniSTSRGSC3.4
Celera1514,328,293 - 14,328,449UniSTS
RH 3.4 Map15110.7UniSTS
Cytogenetic Map15p15-p14UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001431357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431361 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431363 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001431365 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021774 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197206 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197207 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NR_197208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093631 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039093632 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274600 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274601 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274602 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274603 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274604 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063274605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF170064 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000015 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000097146   ⟹   ENSRNOP00000088307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1514,595,743 - 15,421,227 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109492   ⟹   ENSRNOP00000080145
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1513,934,995 - 15,442,340 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109627   ⟹   ENSRNOP00000079130
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1515,130,515 - 15,414,200 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000110619   ⟹   ENSRNOP00000091108
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1514,595,743 - 15,414,200 (+)Ensembl
RefSeq Acc Id: NM_021774   ⟹   NP_068542
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81516,398,252 - 17,872,621 (+)NCBI
mRatBN7.21513,967,882 - 15,442,340 (+)NCBI
Rnor_6.01515,697,292 - 16,862,873 (+)NCBI
Rnor_5.01519,698,557 - 20,157,380 (+)NCBI
Rnor_5.01520,538,368 - 20,846,575 (+)NCBI
RGSC_v3.41515,823,461 - 17,329,184 (+)RGD
Celera1513,959,987 - 15,420,085 (+)RGD
Sequence:
RefSeq Acc Id: XM_039093631   ⟹   XP_038949559
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81517,019,382 - 17,872,901 (+)NCBI
mRatBN7.21514,588,869 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_039093632   ⟹   XP_038949560
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81516,365,401 - 17,872,901 (+)NCBI
mRatBN7.21513,935,036 - 15,442,620 (+)NCBI
RefSeq Acc Id: XM_063274600   ⟹   XP_063130670
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81517,026,046 - 17,872,901 (+)NCBI
RefSeq Acc Id: XM_063274601   ⟹   XP_063130671
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81516,365,401 - 17,872,901 (+)NCBI
RefSeq Acc Id: XM_063274602   ⟹   XP_063130672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81516,365,401 - 17,872,901 (+)NCBI
RefSeq Acc Id: XM_063274603   ⟹   XP_063130673
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81516,365,401 - 17,872,901 (+)NCBI
RefSeq Acc Id: XM_063274604   ⟹   XP_063130674
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81517,019,245 - 17,872,901 (+)NCBI
RefSeq Acc Id: XM_063274605   ⟹   XP_063130675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81517,548,529 - 17,872,901 (+)NCBI
RefSeq Acc Id: NP_068542   ⟸   NM_021774
- Sequence:
RefSeq Acc Id: XP_038949560   ⟸   XM_039093632
- Peptide Label: isoform X2
- UniProtKB: A0A8I5ZQ19 (UniProtKB/TrEMBL),   A6K0A2 (UniProtKB/TrEMBL),   A0A8I6A955 (UniProtKB/TrEMBL),   A0A8I6AAY9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038949559   ⟸   XM_039093631
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A955 (UniProtKB/TrEMBL),   A0A8I6AAY9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000080145   ⟸   ENSRNOT00000109492
Ensembl Acc Id: ENSRNOP00000091108   ⟸   ENSRNOT00000110619
Ensembl Acc Id: ENSRNOP00000079130   ⟸   ENSRNOT00000109627
Ensembl Acc Id: ENSRNOP00000088307   ⟸   ENSRNOT00000097146
RefSeq Acc Id: XP_063130673   ⟸   XM_063274603
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A955 (UniProtKB/TrEMBL),   A0A8I6AAY9 (UniProtKB/TrEMBL),   A0A8I5ZQ19 (UniProtKB/TrEMBL),   A6K0A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130672   ⟸   XM_063274602
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A955 (UniProtKB/TrEMBL),   A0A8I6AAY9 (UniProtKB/TrEMBL),   A0A8I5ZQ19 (UniProtKB/TrEMBL),   A6K0A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130671   ⟸   XM_063274601
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A955 (UniProtKB/TrEMBL),   A0A8I6AAY9 (UniProtKB/TrEMBL),   A0A8I5ZQ19 (UniProtKB/TrEMBL),   A6K0A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130674   ⟸   XM_063274604
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063130670   ⟸   XM_063274600
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A955 (UniProtKB/TrEMBL),   A0A8I6AAY9 (UniProtKB/TrEMBL),   A0A8I5ZQ19 (UniProtKB/TrEMBL),   A6K0A2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063130675   ⟸   XM_063274605
- Peptide Label: isoform X4
Protein Domains
HIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JIX3-F1-model_v2 AlphaFold Q9JIX3 1-150 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:620448 AgrOrtholog
BioCyc Gene G2FUF-14338 BioCyc
Ensembl Genes ENSRNOG00000064939 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097146.1 UniProtKB/TrEMBL
  ENSRNOT00000109492.1 UniProtKB/TrEMBL
  ENSRNOT00000109627.1 UniProtKB/TrEMBL
  ENSRNOT00000110619.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FHIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histidine_triad_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:60398 UniProtKB/Swiss-Prot
NCBI Gene 60398 ENTREZGENE
PANTHER BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/Swiss-Prot
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/Swiss-Prot
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/TrEMBL
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/TrEMBL
Pfam HIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fhit PhenoGen
PROSITE HIT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000064939 RatGTEx
Superfamily-SCOP SSF54197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I5ZMT4_RAT UniProtKB/TrEMBL
  A0A8I5ZQ19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A955 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AAY9 ENTREZGENE, UniProtKB/TrEMBL
  A6K0A2 ENTREZGENE, UniProtKB/TrEMBL
  FHIT_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Fhit  fragile histidine triad diadenosine triphosphatase  LOC102552150  uncharacterized LOC102552150  Data merged from RGD:7646175 737654 PROVISIONAL
2019-05-09 Fhit  fragile histidine triad diadenosine triphosphatase  Fhit  fragile histidine triad  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102552150  uncharacterized LOC102552150      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-16 Fhit  fragile histidine triad  Fhit  fragile histidine triad gene  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fhit  fragile histidine triad gene    fragile histidine triad protein  Name updated 1299863 APPROVED
2002-08-07 Fhit  fragile histidine triad protein      Symbol and Name status set to provisional 70820 PROVISIONAL