Fhit (fragile histidine triad gene) - Rat Genome Database

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Gene: Fhit (fragile histidine triad gene) Mus musculus
Analyze
Symbol: Fhit
Name: fragile histidine triad gene
RGD ID: 732571
MGI Page MGI
Description: Predicted to enable several functions, including adenosine 5'-monophosphoramidase activity; adenylylsulfate-ammonia adenylyltransferase activity; and hydrolase activity, acting on acid anhydrides. Acts upstream of or within DNA replication. Located in cytoplasm. Is expressed in brain; genitourinary system; liver; mammary gland; and spleen. Used to study Muir-Torre syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human FHIT (fragile histidine triad diadenosine triphosphatase).
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: adenosine 5'-monophosphoramidase FHIT; adenylylsulfatase; adenylylsulfate-ammonia adenylyltransferase; AP3A hydrolase; AP3Aase; AW045638; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; diadenosine triphosphate hydrolase; dinucleosidetriphosphatase; Fra1; Fra14A2; fragile histidine triad protein
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391411,307,718 - 12,919,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1411,307,738 - 12,919,681 (+)EnsemblGRCm39 Ensembl
GRCm38149,550,092 - 11,162,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl149,550,092 - 11,162,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv371410,382,608 - 11,994,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36148,343,886 - 9,955,286 (-)NCBIMGSCv36mm8
Celera145,162,596 - 6,766,296 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map145.61NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-cotinine  (ISO)
(1->4)-beta-D-glucan  (EXP)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1-nitropropane  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,6-diaminotoluene  (ISO)
2-acetamidofluorene  (ISO)
2-nitro-p-phenylenediamine  (ISO)
2-nitropropane  (ISO)
2-nitrotoluene  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-acetylaminofluorene  (ISO)
4-hydroxyphenyl retinamide  (EXP)
4-nitro-1,2-phenylenediamine  (ISO)
5-aza-2'-deoxycytidine  (ISO)
7,12-dimethyltetraphene  (ISO)
acrylamide  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[e]pyrene  (ISO)
Benzo[k]fluoranthene  (EXP)
bisphenol A  (ISO)
butanal  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (EXP)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
cycloheximide  (ISO)
ethyl methanesulfonate  (ISO)
graphite  (ISO)
hydralazine  (ISO)
indole-3-methanol  (ISO)
inulin  (EXP)
Lasiocarpine  (ISO)
MeIQx  (ISO)
menadione  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (EXP)
N-acetyl-L-cysteine  (ISO)
N-methyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel dichloride  (EXP)
nickel subsulfide  (EXP)
O-methyleugenol  (EXP,ISO)
para-Nitrosodiphenylamine  (ISO)
paracetamol  (EXP)
paraquat  (ISO)
perfluorododecanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
phenobarbital  (EXP)
PhIP  (ISO)
ponasterone A  (ISO)
quercetin  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
succimer  (EXP)
sunitinib  (ISO)
testosterone enanthate  (ISO)
tetrachloromethane  (EXP)
titanium dioxide  (EXP)
trichostatin A  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinyl carbamate  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IDA,ISO)
cytosol  (ISO)
fibrillar center  (ISO)
mitochondrion  (IEA)
nucleus  (IBA)
plasma membrane  (IBA,ISO)

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Allelic deletion analysis of the FHIT gene predicts poor survival in non-small cell lung cancer. Burke L, etal., Cancer Res. 1998 Jun 15;58(12):2533-6.
2. Evaluation of FHIT gene alterations in ovarian cancer. Buttitta F, etal., Br J Cancer. 1998 Apr;77(7):1048-51.
3. Hypermethylation and loss of heterozygosity of tumor suppressor genes on chromosome 3p in cervical cancer. Choi CH, etal., Cancer Lett. 2007 Sep 18;255(1):26-33. Epub 2007 Apr 30.
4. HPV-associated cervical cancers show frequent allelic loss at 3p14 but no apparent aberration of FHIT mRNA. Chu TY, etal., Int J Cancer. 1998 Jan 19;75(2):199-204.
5. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition Chu YX, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2006 Mar;37(2):218-20.
6. FHIT, a Novel Modifier Gene in Pulmonary Arterial Hypertension. Dannewitz Prosseda S, etal., Am J Respir Crit Care Med. 2019 Jan 1;199(1):83-98. doi: 10.1164/rccm.201712-2553OC.
7. Early-onset ataxia with ocular motor apraxia and hypoalbuminemia is caused by mutations in a new HIT superfamily gene. Date H, etal., Nat Genet 2001 Oct;29(2):184-8.
8. CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. Dhillon VS, etal., Mol Cancer. 2004 Dec 1;3:33.
9. Loss of Fhit expression in testicular germ cell tumors and intratubular germ cell neoplasia. Eyzaguirre E and Gatalica Z, Mod Pathol. 2002 Oct;15(10):1068-72.
10. Different immunohistochemical patterns of Fhit protein expression in renal neoplasms. Eyzaguirre EJ, etal., Mod Pathol. 1999 Oct;12(10):979-83.
11. CpG island methylation in Schistosoma- and non-Schistosoma-associated bladder cancer. Gutierrez MI, etal., Mod Pathol. 2004 Oct;17(10):1268-74.
12. The fragile histidine triad gene: a molecular link between cigarette smoking and cervical cancer. Holschneider CH, etal., Clin Cancer Res. 2005 Aug 15;11(16):5756-63.
13. Analysis of the fragile histidine triad (FHIT) gene in lobular breast cancer. Huiping C, etal., Eur J Cancer. 2000 Aug;36(12):1552-7.
14. Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT. Larson GP, etal., Cancer Res. 2005 Feb 1;65(3):805-14.
15. Association between germline variation in the FHIT gene and prostate cancer in Caucasians and African Americans. Levin AM, etal., Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1294-7.
16. 4-Hydroxybutyl(butyl)nitrosamine-induced urinary bladder cancers in mice: characterization of FHIT and survivin expression and chemopreventive effects of indomethacin. Lubet RA, etal., Carcinogenesis. 2005 Mar;26(3):571-8. Epub 2004 Dec 9.
17. Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features. Maruyama R, etal., Cancer Res. 2001 Dec 15;61(24):8659-63.
18. Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features. Maruyama R, etal., Clin Cancer Res. 2002 Feb;8(2):514-9.
19. MGDs mouse GO annotations MGD data from the GO Consortium
20. MGD IEA MGD IEA
21. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
22. A constitutional balanced t(3;8)(p14;q24.1) translocation results in disruption of the TRC8 gene and predisposition to clear cell renal cell carcinoma. Poland KS, etal., Genes Chromosomes Cancer. 2007 Sep;46(9):805-12.
23. Mouse MP Annotation Import Pipeline RGD automated import pipeline
24. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
25. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
26. Clinicopathological significance of fragile histidine triad transcription protein expression in endometrial carcinomas. Segawa T, etal., Clin Cancer Res. 2000 Jun;6(6):2341-8.
27. Candidate genes for testicular cancer evaluated by in situ protein expression analyses on tissue microarrays. Skotheim RI, etal., Neoplasia. 2003 Sep-Oct;5(5):397-404.
28. The expression of FHIT, PCNA and EGFR in benign and malignant breast lesions. Terry G, etal., Br J Cancer. 2007 Jan 15;96(1):110-7. Epub 2006 Dec 12.
29. Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. Tomizawa Y, etal., Cancer Res. 1998 Dec 1;58(23):5478-83.
30. Two-hit inactivation of FHIT by loss of heterozygosity and hypermethylation in breast cancer. Yang Q, etal., Clin Cancer Res. 2002 Sep;8(9):2890-3.
Additional References at PubMed
PMID:8598045   PMID:8794732   PMID:8889548   PMID:9671749   PMID:9699672   PMID:9699673   PMID:10758156   PMID:11248081   PMID:11320209   PMID:11517343   PMID:12477932   PMID:12748294  
PMID:14610273   PMID:14630947   PMID:14681479   PMID:15254237   PMID:15389587   PMID:15467769   PMID:15489334   PMID:15569992   PMID:15741177   PMID:15798093   PMID:16061637   PMID:16085127  
PMID:16141072   PMID:16204026   PMID:16602821   PMID:16672365   PMID:16864578   PMID:17145874   PMID:17283132   PMID:18000371   PMID:18162546   PMID:18483248   PMID:19479888   PMID:21097531  
PMID:21873635   PMID:22451343   PMID:23102829   PMID:23209436   PMID:23929738   PMID:24223161   PMID:24244712   PMID:24556720   PMID:26782170   PMID:27513973   PMID:32325033  


Genomics

Comparative Map Data
Fhit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391411,307,718 - 12,919,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1411,307,738 - 12,919,681 (+)EnsemblGRCm39 Ensembl
GRCm38149,550,092 - 11,162,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl149,550,092 - 11,162,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv371410,382,608 - 11,994,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36148,343,886 - 9,955,286 (-)NCBIMGSCv36mm8
Celera145,162,596 - 6,766,296 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map145.61NCBI
FHIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38359,747,277 - 61,251,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl359,747,277 - 61,251,459 (-)EnsemblGRCh38hg38GRCh38
GRCh37359,733,003 - 61,237,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36359,710,076 - 61,212,164 (-)NCBINCBI36Build 36hg18NCBI36
Build 34359,710,077 - 61,212,164NCBI
Celera359,748,610 - 61,250,104 (-)NCBICelera
Cytogenetic Map3p14.2NCBI
HuRef359,831,176 - 61,335,629 (-)NCBIHuRef
CHM1_1359,685,586 - 61,187,676 (-)NCBICHM1_1
T2T-CHM13v2.0359,787,636 - 61,294,609 (-)NCBIT2T-CHM13v2.0
Fhit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81516,365,401 - 17,872,901 (+)NCBIGRCr8
mRatBN7.21513,935,029 - 15,442,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1513,934,995 - 15,442,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1516,096,570 - 17,612,441 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01517,054,989 - 18,570,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01515,309,857 - 16,825,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
Fhit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955430221,518 - 508,094 (+)NCBIChiLan1.0ChiLan1.0
FHIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2259,695,617 - 61,199,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1361,069,947 - 62,568,700 (-)NCBIpanpan1.1PanPan1.1panPan2
FHIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12029,735,380 - 31,113,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2030,591,449 - 31,357,367 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBIUU_Cfam_GSD_1.0
Fhit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118167,149,768 - 168,286,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936473676,237 - 1,424,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936473397,140 - 1,424,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1341,443,965 - 42,392,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11341,443,963 - 42,884,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21345,643,668 - 46,973,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12221,006,010 - 22,474,056 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041144,572,356 - 145,797,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248226,621,909 - 7,380,047 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248226,621,609 - 8,069,590 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fhit
56957 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:790
Count of miRNA genes:385
Interacting mature miRNAs:422
Transcripts:ENSMUST00000160340, ENSMUST00000160956, ENSMUST00000161179, ENSMUST00000161302, ENSMUST00000161895, ENSMUST00000162278, ENSMUST00000162817, ENSMUST00000179394
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10412071Ssen3_msuseptibility to Sendai virus 3 (mouse)Not determined14126987934Mouse
11532711Sluc40_msusceptibility to lung cancer 40 (mouse)14127379943Mouse
13824988Phsq1_mpercent hyperactivated sperm QTL 1 (mouse)14305000119469772Mouse
1301991Wta3_mweight adult 3 (mouse)Not determined14388747337887650Mouse
4141550Dbm3_mdiabetes modifier 3 (mouse)Not determined514347339143596Mouse
4141265Appd2_mAPP associated premature death 2 (mouse)Not determined14594555230114862Mouse
4141864Mrdq4_mmodifier of retinal degeneration QTL 4 (mouse)Not determined992324548765082Mouse
1300779Dyscalc4_mdystrophic cardiac calcinosis 4 (mouse)Not determined141221287146213007Mouse

Markers in Region
16.MMHAP12FRF7.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38149,780,635 - 9,780,796UniSTSGRCm38
MGSCv371410,613,149 - 10,613,310UniSTSGRCm37
Celera145,387,198 - 5,387,359UniSTS
Cytogenetic Map14A2UniSTS
cM Map141.75UniSTS
Whitehead_YAC14 UniSTS
D14Mit229  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38149,961,277 - 9,961,394UniSTSGRCm38
MGSCv371410,793,791 - 10,793,908UniSTSGRCm37
Celera145,568,187 - 5,568,304UniSTS
Cytogenetic Map14A2UniSTS
cM Map141.75UniSTS
cM Map14 UniSTS
Whitehead Genetic142.2UniSTS
Whitehead_YAC14 UniSTS
D14Mit132  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381410,497,633 - 10,497,764UniSTSGRCm38
MGSCv371411,330,147 - 11,330,278UniSTSGRCm37
Celera143,001,693 - 3,001,824UniSTS
Cytogenetic Map14A2UniSTS
cM Map141.75UniSTS
Whitehead Genetic140.0UniSTS
Whitehead/MRC_RH1491.33UniSTS
AF047699  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38149,550,270 - 9,550,388UniSTSGRCm38
MGSCv371410,382,784 - 10,382,902UniSTSGRCm37
Celera145,162,772 - 5,162,890UniSTS
Cytogenetic Map14A2UniSTS
cM Map141.75UniSTS
Whitehead/MRC_RH1486.1UniSTS
Whitehead/MRC_RH1469.72UniSTS
AI591601  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38149,886,403 - 9,886,515UniSTSGRCm38
MGSCv371410,718,917 - 10,719,029UniSTSGRCm37
Celera145,493,181 - 5,493,293UniSTS
Cytogenetic Map14A2UniSTS
Cytogenetic Map3F1UniSTS
Cytogenetic Map14A1UniSTS
cM Map141.75UniSTS
Whitehead/MRC_RH1490.28UniSTS
UniSTS:224436  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381411,132,008 - 11,132,187UniSTSGRCm38
MGSCv371411,964,522 - 11,964,701UniSTSGRCm37
Celera146,736,563 - 6,736,742UniSTS
Cytogenetic Map14A2UniSTS
cM Map141.75UniSTS
UniSTS:225186  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381410,439,685 - 10,439,837UniSTSGRCm38
MGSCv371411,272,199 - 11,272,351UniSTSGRCm37
Celera146,046,125 - 6,046,277UniSTS
Cytogenetic Map14A2UniSTS
Cytogenetic Map8B1.3UniSTS
cM Map141.75UniSTS
PMC18303P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38149,861,912 - 9,862,277UniSTSGRCm38
MGSCv371410,694,426 - 10,694,791UniSTSGRCm37
Celera145,468,690 - 5,469,055UniSTS
Cytogenetic Map14A2UniSTS
cM Map141.75UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001308285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308286 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360141 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001424437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_010210 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006517924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158462 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158463 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036158464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AA797426 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC102431 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC105071 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154360 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC154776 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC158979 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC159306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF047699 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF055573 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH006186 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010679 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010680 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH013372 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI597104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL589696 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW045638 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AW047533 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC012662 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466579 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ053929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ056464 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CJ058331 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CO040033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT485999 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000160340   ⟹   ENSMUSP00000124017
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1411,307,738 - 12,919,673 (+)Ensembl
GRCm38.p6 Ensembl149,550,100 - 11,162,035 (-)Ensembl
RefSeq Acc Id: ENSMUST00000160956   ⟹   ENSMUSP00000123820
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1411,307,738 - 12,599,666 (+)Ensembl
GRCm38.p6 Ensembl149,870,107 - 11,162,035 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161179
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1411,344,594 - 12,706,093 (+)Ensembl
GRCm38.p6 Ensembl149,763,680 - 11,125,179 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161302   ⟹   ENSMUSP00000123874
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1412,016,315 - 12,919,681 (+)Ensembl
GRCm38.p6 Ensembl149,550,092 - 10,453,458 (-)Ensembl
RefSeq Acc Id: ENSMUST00000161895   ⟹   ENSMUSP00000124957
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1411,344,182 - 12,896,285 (+)Ensembl
GRCm38.p6 Ensembl149,573,488 - 11,125,591 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162278   ⟹   ENSMUSP00000124073
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1411,307,741 - 12,919,673 (+)Ensembl
GRCm38.p6 Ensembl149,550,100 - 11,162,032 (-)Ensembl
RefSeq Acc Id: ENSMUST00000162817   ⟹   ENSMUSP00000124500
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1411,344,211 - 12,705,986 (+)Ensembl
GRCm38.p6 Ensembl149,763,787 - 11,125,562 (-)Ensembl
RefSeq Acc Id: ENSMUST00000179394   ⟹   ENSMUSP00000136011
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1412,048,176 - 12,919,380 (+)Ensembl
GRCm38.p6 Ensembl149,550,393 - 10,421,597 (-)Ensembl
RefSeq Acc Id: NM_001308285   ⟹   NP_001295214
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,736 - 12,919,679 (+)NCBI
GRCm38149,550,094 - 11,162,035 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001308286   ⟹   NP_001295215
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391412,016,320 - 12,919,679 (+)NCBI
GRCm38149,550,094 - 10,453,458 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360141   ⟹   NP_001347070
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,736 - 12,919,679 (+)NCBI
GRCm38149,550,094 - 11,162,035 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001424436   ⟹   NP_001411365
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,736 - 12,919,679 (+)NCBI
RefSeq Acc Id: NM_001424437   ⟹   NP_001411366
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,736 - 12,919,679 (+)NCBI
RefSeq Acc Id: NM_010210   ⟹   NP_034340
RefSeq Status: REVIEWED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,736 - 12,919,679 (+)NCBI
GRCm38149,550,094 - 11,162,035 (-)NCBI
MGSCv371410,382,608 - 11,994,546 (-)RGD
Celera145,162,596 - 6,766,296 (-)RGD
cM Map14 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006517924   ⟹   XP_006517987
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,344,599 - 12,919,681 (+)NCBI
GRCm38149,550,092 - 11,125,174 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036158462   ⟹   XP_036014355
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,718,072 - 12,919,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158463   ⟹   XP_036014356
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,718 - 12,919,681 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036158464   ⟹   XP_036014357
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391411,307,718 - 12,919,681 (+)NCBI
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_034340   ⟸   NM_010210
- Peptide Label: isoform 2
- UniProtKB: Q6URW5 (UniProtKB/Swiss-Prot),   Q91VL1 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot),   E9PVU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006517987   ⟸   XM_006517924
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: NP_001295214   ⟸   NM_001308285
- Peptide Label: isoform 1
- UniProtKB: E9PZ91 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001295215   ⟸   NM_001308286
- Peptide Label: isoform 2
- UniProtKB: Q6URW5 (UniProtKB/Swiss-Prot),   Q91VL1 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot),   E9PVU9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001347070   ⟸   NM_001360141
- Peptide Label: isoform 2
- UniProtKB: Q6URW5 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot),   Q91VL1 (UniProtKB/Swiss-Prot),   E9PVU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: ENSMUSP00000136011   ⟸   ENSMUST00000179394
RefSeq Acc Id: ENSMUSP00000124017   ⟸   ENSMUST00000160340
RefSeq Acc Id: ENSMUSP00000123820   ⟸   ENSMUST00000160956
RefSeq Acc Id: ENSMUSP00000124500   ⟸   ENSMUST00000162817
RefSeq Acc Id: ENSMUSP00000124073   ⟸   ENSMUST00000162278
RefSeq Acc Id: ENSMUSP00000123874   ⟸   ENSMUST00000161302
RefSeq Acc Id: ENSMUSP00000124957   ⟸   ENSMUST00000161895
RefSeq Acc Id: XP_036014356   ⟸   XM_036158463
- Peptide Label: isoform X3
- UniProtKB: Q6URW5 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot),   Q91VL1 (UniProtKB/Swiss-Prot),   E9PVU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014357   ⟸   XM_036158464
- Peptide Label: isoform X3
- UniProtKB: Q6URW5 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot),   Q91VL1 (UniProtKB/Swiss-Prot),   E9PVU9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036014355   ⟸   XM_036158462
- Peptide Label: isoform X1
- UniProtKB: E9PZ91 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001411365   ⟸   NM_001424436
- Peptide Label: isoform 2
- UniProtKB: Q6URW5 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot),   Q91VL1 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: NP_001411366   ⟸   NM_001424437
- Peptide Label: isoform 2
- UniProtKB: Q91VL1 (UniProtKB/Swiss-Prot),   Q6URW5 (UniProtKB/Swiss-Prot),   O89106 (UniProtKB/Swiss-Prot)
Protein Domains
HIT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O89106-F1-model_v2 AlphaFold O89106 1-150 view protein structure

Promoters
RGD ID:8681498
Promoter ID:EPDNEW_M18780
Type:multiple initiation site
Name:Fhit_1
Description:Mus musculus fragile histidine triad gene , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18782  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381410,453,453 - 10,453,513EPDNEW
RGD ID:8681502
Promoter ID:EPDNEW_M18782
Type:multiple initiation site
Name:Fhit_2
Description:Mus musculus fragile histidine triad gene , transcript variant2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M18780  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381411,162,035 - 11,162,095EPDNEW
RGD ID:6824940
Promoter ID:MM_KWN:15664
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_4Hour
Transcripts:UC007SFJ.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361411,285,691 - 11,286,191 (-)MPROMDB
RGD ID:6824937
Promoter ID:MM_KWN:15668
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Liver,   Lung,   MEF_B6,   Spleen
Transcripts:NM_010210
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361411,994,324 - 11,994,824 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1277947 AgrOrtholog
Ensembl Genes ENSMUSG00000060579 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000160340 ENTREZGENE
  ENSMUST00000160340.8 UniProtKB/TrEMBL
  ENSMUST00000160956.2 UniProtKB/TrEMBL
  ENSMUST00000161302 ENTREZGENE
  ENSMUST00000161302.8 UniProtKB/Swiss-Prot
  ENSMUST00000161895 ENTREZGENE
  ENSMUST00000161895.8 UniProtKB/TrEMBL
  ENSMUST00000162278 ENTREZGENE
  ENSMUST00000162278.8 UniProtKB/Swiss-Prot
  ENSMUST00000162817.3 UniProtKB/TrEMBL
  ENSMUST00000179394.8 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.428.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FHIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Histidine_triad_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14198 UniProtKB/Swiss-Prot
MGD MGI:1277947 ENTREZGENE
NCBI Gene 14198 ENTREZGENE
PANTHER BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/Swiss-Prot
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/Swiss-Prot
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/TrEMBL
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/TrEMBL
Pfam HIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Fhit PhenoGen
PROSITE HIT_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HIT_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt E9PVU9 ENTREZGENE, UniProtKB/TrEMBL
  E9PZ91 ENTREZGENE, UniProtKB/TrEMBL
  E9Q3M6_MOUSE UniProtKB/TrEMBL
  F6SV10_MOUSE UniProtKB/TrEMBL
  FHIT_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q6URW5 ENTREZGENE
  Q91VL1 ENTREZGENE
UniProt Secondary Q6URW5 UniProtKB/Swiss-Prot
  Q91VL1 UniProtKB/Swiss-Prot