FHIT (fragile histidine triad diadenosine triphosphatase) - Rat Genome Database

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Gene: FHIT (fragile histidine triad diadenosine triphosphatase) Pan paniscus
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Symbol: FHIT
Name: fragile histidine triad diadenosine triphosphatase
RGD ID: 11668325
Description: ENCODES a protein that exhibits adenosine 5'-monophosphoramidase activity (ortholog); adenylylsulfatase activity (ortholog); adenylylsulfate-ammonia adenylyltransferase activity (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); intrinsic apoptotic signaling pathway by p53 class mediator (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (ortholog); cytosol (ortholog); fibrillar center (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: bis(5'-adenosyl)-triphosphatase; fragile histidine triad
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2259,695,617 - 61,199,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1361,069,947 - 62,568,700 (-)NCBIpanpan1.1PanPan1.1panPan2
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
FHIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2259,695,617 - 61,199,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1361,069,947 - 62,568,700 (-)NCBIpanpan1.1PanPan1.1panPan2
FHIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38359,747,277 - 61,251,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl359,747,277 - 61,251,459 (-)EnsemblGRCh38hg38GRCh38
GRCh37359,733,003 - 61,237,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36359,710,076 - 61,212,164 (-)NCBINCBI36Build 36hg18NCBI36
Build 34359,710,077 - 61,212,164NCBI
Celera359,748,610 - 61,250,104 (-)NCBICelera
Cytogenetic Map3p14.2NCBI
HuRef359,831,176 - 61,335,629 (-)NCBIHuRef
CHM1_1359,685,586 - 61,187,676 (-)NCBICHM1_1
T2T-CHM13v2.0359,787,636 - 61,294,609 (-)NCBIT2T-CHM13v2.0
Fhit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391411,307,718 - 12,919,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1411,307,738 - 12,919,681 (+)EnsemblGRCm39 Ensembl
GRCm38149,550,092 - 11,162,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl149,550,092 - 11,162,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv371410,382,608 - 11,994,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36148,343,886 - 9,955,286 (-)NCBIMGSCv36mm8
Celera145,162,596 - 6,766,296 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map145.61NCBI
Fhit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81516,365,401 - 17,872,901 (+)NCBIGRCr8
mRatBN7.21513,935,029 - 15,442,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1513,934,995 - 15,442,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1516,096,570 - 17,612,441 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01517,054,989 - 18,570,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01515,309,857 - 16,825,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
Fhit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955430221,518 - 508,094 (+)NCBIChiLan1.0ChiLan1.0
FHIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12029,735,380 - 31,113,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2030,591,449 - 31,357,367 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBIUU_Cfam_GSD_1.0
Fhit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118167,149,768 - 168,286,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936473676,237 - 1,424,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936473397,140 - 1,424,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1341,443,965 - 42,392,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11341,443,963 - 42,884,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21345,643,668 - 46,973,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12221,006,010 - 22,474,056 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041144,572,356 - 145,797,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248226,621,909 - 7,380,047 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248226,621,609 - 8,069,590 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


RefSeq Acc Id: XM_034956785   ⟹   XP_034812676
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,198,969 (-)NCBI
NHGRI_mPanPan1359,700,388 - 61,203,738 (-)NCBI
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBI
RefSeq Acc Id: XM_034956786   ⟹   XP_034812677
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,199,006 (-)NCBI
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBI
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBI
RefSeq Acc Id: XM_034956787   ⟹   XP_034812678
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,199,003 (-)NCBI
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBI
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBI
RefSeq Acc Id: XM_034956788   ⟹   XP_034812679
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,199,003 (-)NCBI
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBI
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBI
RefSeq Acc Id: XM_034956789   ⟹   XP_034812680
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,198,969 (-)NCBI
NHGRI_mPanPan1359,700,388 - 61,203,738 (-)NCBI
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBI
RefSeq Acc Id: XM_034956793   ⟹   XP_034812684
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 60,524,402 (-)NCBI
NHGRI_mPanPan1359,700,388 - 60,529,161 (-)NCBI
Mhudiblu_PPA_v0359,670,777 - 60,500,425 (-)NCBI
RefSeq Acc Id: XM_063602790   ⟹   XP_063458860
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,198,969 (-)NCBI
RefSeq Acc Id: XM_063602791   ⟹   XP_063458861
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,198,970 (-)NCBI
RefSeq Acc Id: XM_063602792   ⟹   XP_063458862
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,199,003 (-)NCBI
RefSeq Acc Id: XM_063602793   ⟹   XP_063458863
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
NHGRI_mPanPan1-v2259,695,617 - 61,198,974 (-)NCBI
RefSeq Acc Id: XP_034812677   ⟸   XM_034956786
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812680   ⟸   XM_034956789
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812678   ⟸   XM_034956787
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812676   ⟸   XM_034956785
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812679   ⟸   XM_034956788
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812684   ⟸   XM_034956793
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063458862   ⟸   XM_063602792
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063458863   ⟸   XM_063602793
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063458861   ⟸   XM_063602791
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063458860   ⟸   XM_063602790
- Peptide Label: isoform X1


Additional Information

Database Acc Id Source(s)
NCBI Gene FHIT ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-30 FHIT  fragile histidine triad diadenosine triphosphatase    fragile histidine triad  Symbol and/or name change 5135510 APPROVED