RGD Reference Report - Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT. - Rat Genome Database

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Genetic linkage of prostate cancer risk to the chromosome 3 region bearing FHIT.

Authors: Larson, GP  Ding, Y  Cheng, LS  Lundberg, C  Gagalang, V  Rivas, G  Geller, L  Weitzel, J  MacDonald, D  Archambeau, J  Slater, J  Neuberg, D  Daly, MB  Angel, I  Benson AB, 3RD  Smith, K  Kirkwood, JM  O'Dwyer, PJ  Raskay, B  Sutphen, R  Drew, R  Stewart, JA  Werndli, J  Johnson, D  Ruckdeschel, JC  Elston, RC  Krontiris, TG 
Citation: Larson GP, etal., Cancer Res. 2005 Feb 1;65(3):805-14.
RGD ID: 2289878
Pubmed: PMID:15705877   (View Abstract at PubMed)

We conducted linkage analysis of 80 candidate genes in 201 brother pairs affected with prostatic adenocarcinoma. Markers representing two adjacent candidate genes on chromosome 3p, CDC25A and FHIT, showed suggestive evidence for linkage with single-point identity-by-descent allele-sharing statistics. Fine-structure multipoint linkage analysis yielded a maximum LOD score of 3.17 (P = 0.00007) at D3S1234 within FHIT intron 5. For a subgroup of 38 families in which three or more affected brothers were reported, the LOD score was 3.83 (P = 0.00001). Further analysis reported herein suggested a recessive mode of inheritance. Association testing of 16 single nucleotide polymorphisms (SNP) spanning a 381-kb interval surrounding D3S1234 in 202 cases of European descent with 143 matched, unrelated controls revealed significant evidence for association between case status and the A allele of single nucleotide polymorphism rs760317, located within intron 5 of FHIT (Pearson's chi(2) = 8.54, df = 1, P = 0.0035). Our results strongly suggest involvement of germline variations of FHIT in prostate cancer risk.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FHITHumanprostate cancer  IAGP DNA:SNP:intron:increased risk in carriers of minor allele of SNP rs760317RGD 
FhitRatprostate cancer  ISOFHIT (Homo sapiens) RGD 
FhitMouseprostate cancer  ISOFHIT (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fhit  (fragile histidine triad diadenosine triphosphatase)

Genes (Mus musculus)
Fhit  (fragile histidine triad gene)

Genes (Homo sapiens)
FHIT  (fragile histidine triad diadenosine triphosphatase)


Additional Information