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Gene: FHIT (fragile histidine triad diadenosine triphosphatase) Homo sapiens
Symbol: FHIT
Name: fragile histidine triad diadenosine triphosphatase
Description: Exhibits bis(5'-adenosyl)-triphosphatase activity; identical protein binding activity; and ubiquitin protein ligase binding activity. Involved in intrinsic apoptotic signaling pathway by p53 class mediator; negative regulation of proteasomal ubiquitin-dependent protein catabolic process; and purine nucleotide metabolic process. Localizes to cytosol; fibrillar center; and plasma membrane. Implicated in carcinoma (multiple); invasive ductal carcinoma; reproductive organ cancer (multiple); and urinary bladder cancer. Biomarker of lung non-small cell carcinoma; renal cell carcinoma; and seminoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AP3A hydrolase; AP3Aase; bis(5'-adenosyl)-triphosphatase; diadenosine 5',5'''-P1,P3-triphosphate hydrolase; dinucleosidetriphosphatase; FRA3B; fragile histidine triad; fragile histidine triad protein; fragile site, aphidicolin type, common, fra(3)(p14.2); tumor suppressor protein
Mus musculus (house mouse) : Fhit (fragile histidine triad gene)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fhit (fragile histidine triad diadenosine triphosphatase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fhit (fragile histidine triad diadenosine triphosphatase)
Pan paniscus (bonobo/pygmy chimpanzee) : FHIT (fragile histidine triad diadenosine triphosphatase)
Canis lupus familiaris (dog) : FHIT (fragile histidine triad diadenosine triphosphatase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fhit (fragile histidine triad diadenosine triphosphatase)
Sus scrofa (pig) : FHIT (fragile histidine triad diadenosine triphosphatase)
Chlorocebus sabaeus (African green monkey) : FHIT (fragile histidine triad diadenosine triphosphatase)
Heterocephalus glaber (naked mole-rat) : Fhit (fragile histidine triad diadenosine triphosphatase)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl359,747,277 - 61,251,459 (-)EnsemblGRCh38hg38GRCh38
GRCh38359,747,277 - 61,251,461 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37359,735,036 - 61,237,133 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36359,710,076 - 61,212,164 (-)NCBINCBI36hg18NCBI36
Build 34359,710,077 - 61,212,164NCBI
Celera359,748,610 - 61,250,104 (-)NCBI
Cytogenetic Map3p14.2NCBI
HuRef359,831,176 - 61,335,629 (-)NCBIHuRef
CHM1_1359,683,554 - 61,187,678 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on FHIT
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1344220
Created: 2005-03-08
Species: Homo sapiens
Last Modified: 2020-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.