RGD Reference Report - Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma. - Rat Genome Database

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Clinicopathological significance of Fhit protein expression in stage I non-small cell lung carcinoma.

Authors: Tomizawa, Y  Nakajima, T  Kohno, T  Saito, R  Yamaguchi, N  Yokota, J 
Citation: Tomizawa Y, etal., Cancer Res. 1998 Dec 1;58(23):5478-83.
RGD ID: 13792770
Pubmed: PMID:9850082   (View Abstract at PubMed)

Abnormalities in structure and expression of the FHIT gene have been detected in a considerable fraction of primary lung tumors. Previous reports indicated that FHIT gene alterations can be simply detected by immunohistochemical methods. Therefore, we investigated the association of Fhit expression with clinicopathological features and allelic imbalance (AI) at the FHIT locus in 105 stage I non-small cell lung cancers (NSCLC) by the immunohistological method and PCR analysis. Thirty-six of 105 (34%) tumors showed marked reduction of Fhit immunoreactivity. Fhit expression was markedly reduced in most squamous cell carcinomas (24 of 28, 86%), whereas such a reduction was detected only in a small subset of adenocarcinomas (7 of 67, 10%; P < 0.001). A marked reduction of Fhit protein expression was observed more frequently in patients with a smoking history (32 of 80, 40%) than in patients without a smoking history (4 of 25, 16%; P = 0.013). These results indicate that FHIT gene alterations preferentially occur in squamous cell carcinomas and in smokers. Furthermore, a reduction of Fhit protein expression in tumor cells was associated with a poorer survival of patients with stage I NSCLC, irrespective of histological subtypes of tumors (P = 0.005; log-rank test). Fhit expression was reduced preferentially in tumors with AI at the FHIT locus; however, AI at the FHIT locus did not correlate with patients' survival (P = 0.262; log-rank test). These results suggested that Fhit protein expression could be a useful molecular marker for the prognosis of patients with surgically resected stage I NSCLC.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FHITHumanlung non-small cell carcinoma disease_progressionIEP  RGD 
FhitRatlung non-small cell carcinoma disease_progressionISOFHIT (Homo sapiens) RGD 
FhitMouselung non-small cell carcinoma disease_progressionISOFHIT (Homo sapiens) RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fhit  (fragile histidine triad diadenosine triphosphatase)

Genes (Mus musculus)
Fhit  (fragile histidine triad gene)

Genes (Homo sapiens)
FHIT  (fragile histidine triad diadenosine triphosphatase)


Additional Information