FHIT (fragile histidine triad diadenosine triphosphatase) - Rat Genome Database

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Gene: FHIT (fragile histidine triad diadenosine triphosphatase) Canis lupus familiaris
Analyze
Symbol: FHIT
Name: fragile histidine triad diadenosine triphosphatase
RGD ID: 12127929
Description: ENCODES a protein that exhibits bis(5'-adenosyl)-triphosphatase activity (ortholog); nickel cation binding (ortholog); INVOLVED IN diadenosine triphosphate catabolic process (ortholog); DNA replication (ortholog); ASSOCIATED WITH amenorrhea (ortholog); amphetamine abuse (ortholog); autistic disorder (ortholog); FOUND IN cytoplasm (inferred); cytosol (inferred); fibrillar center (inferred)
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bis(5'-adenosyl)-triphosphatase; fragile histidine triad
RGD Orthologs
Human
Mouse
Rat
Chinchilla
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12029,735,380 - 31,113,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2030,591,449 - 31,357,367 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBIUU_Cfam_GSD_1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IBA,IEA)
cytosol  (IEA)
fibrillar center  (IEA)
nucleus  (IBA,IEA)
plasma membrane  (IBA,IEA)

References
Additional References at PubMed
PMID:19498293   PMID:30032202  


Genomics

Comparative Map Data
FHIT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12029,735,380 - 31,113,859 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2030,591,449 - 31,357,367 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBIUU_Cfam_GSD_1.0
FHIT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38359,747,277 - 61,251,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl359,747,277 - 61,251,459 (-)EnsemblGRCh38hg38GRCh38
GRCh37359,733,003 - 61,237,126 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36359,710,076 - 61,212,164 (-)NCBINCBI36Build 36hg18NCBI36
Build 34359,710,077 - 61,212,164NCBI
Celera359,748,610 - 61,250,104 (-)NCBICelera
Cytogenetic Map3p14.2NCBI
HuRef359,831,176 - 61,335,629 (-)NCBIHuRef
CHM1_1359,685,586 - 61,187,676 (-)NCBICHM1_1
T2T-CHM13v2.0359,787,636 - 61,294,609 (-)NCBIT2T-CHM13v2.0
Fhit
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391411,307,718 - 12,919,681 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1411,307,738 - 12,919,681 (+)EnsemblGRCm39 Ensembl
GRCm38149,550,092 - 11,162,061 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl149,550,092 - 11,162,035 (-)EnsemblGRCm38mm10GRCm38
MGSCv371410,382,608 - 11,994,546 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36148,343,886 - 9,955,286 (-)NCBIMGSCv36mm8
Celera145,162,596 - 6,766,296 (-)NCBICelera
Cytogenetic Map14A1NCBI
cM Map145.61NCBI
Fhit
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81516,365,401 - 17,872,901 (+)NCBIGRCr8
mRatBN7.21513,935,029 - 15,442,620 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1513,934,995 - 15,442,340 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1516,096,570 - 17,612,441 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01517,054,989 - 18,570,873 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01515,309,857 - 16,825,743 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01515,697,292 - 16,862,873 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01519,698,557 - 20,157,380 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Rnor_5.01520,538,368 - 20,846,575 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41515,823,461 - 17,329,184 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11515,823,460 - 17,329,184 (+)NCBI
Celera1513,959,987 - 15,420,085 (+)NCBICelera
Cytogenetic Map15p15NCBI
Fhit
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_004955430221,518 - 508,094 (+)NCBIChiLan1.0ChiLan1.0
FHIT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2259,695,617 - 61,199,006 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1359,700,388 - 61,203,773 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0359,670,777 - 61,177,974 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1361,069,947 - 62,568,700 (-)NCBIpanpan1.1PanPan1.1panPan2
Fhit
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118167,149,768 - 168,286,240 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936473676,237 - 1,424,506 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936473397,140 - 1,424,805 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FHIT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1341,443,965 - 42,392,817 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11341,443,963 - 42,884,799 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21345,643,668 - 46,973,979 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FHIT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12221,006,010 - 22,474,056 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666041144,572,356 - 145,797,861 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fhit
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248226,621,909 - 7,380,047 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248226,621,609 - 8,069,590 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in FHIT
17682 total Variants

Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 11 12
Low 5 11 6 6 6 6 3 8 10 6
Below cutoff 3

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001142257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001308549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005632296 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005632301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014121714 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014121717 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_014121719 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406192 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406193 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406195 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406196 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406197 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406198 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406199 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_022406200 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426335 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426336 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426337 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426339 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426340 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038426341 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB469369 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB469370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000020 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSCAFT00000011527   ⟹   ENSCAFP00000010682
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl2030,356,572 - 31,113,859 (+)Ensembl
RefSeq Acc Id: ENSCAFT00845031646   ⟹   ENSCAFP00845024769
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0 Ensembl2030,591,449 - 31,357,367 (+)Ensembl
RefSeq Acc Id: NM_001142257   ⟹   NP_001135729
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12030,341,027 - 31,113,857 (+)NCBI
Dog10K_Boxer_Tasha2030,267,805 - 31,040,232 (+)NCBI
ROS_Cfam_1.02030,575,899 - 31,357,365 (+)NCBI
UMICH_Zoey_3.12030,060,502 - 30,839,134 (+)NCBI
UNSW_CanFamBas_1.02030,420,085 - 31,193,482 (+)NCBI
UU_Cfam_GSD_1.02030,586,849 - 31,358,781 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001308549   ⟹   NP_001295478
RefSeq Status: VALIDATED
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.12029,735,420 - 31,113,857 (+)NCBI
Dog10K_Boxer_Tasha2029,661,734 - 31,040,232 (+)NCBI
ROS_Cfam_1.02029,969,985 - 31,357,365 (+)NCBI
UMICH_Zoey_3.12029,454,740 - 30,839,134 (+)NCBI
UNSW_CanFamBas_1.02029,814,343 - 31,193,482 (+)NCBI
UU_Cfam_GSD_1.02029,913,532 - 31,358,781 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038426335   ⟹   XP_038282263
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02030,590,719 - 31,357,367 (+)NCBI
RefSeq Acc Id: XM_038426336   ⟹   XP_038282264
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02030,590,719 - 31,222,508 (+)NCBI
RefSeq Acc Id: XM_038426337   ⟹   XP_038282265
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02030,590,719 - 31,357,367 (+)NCBI
RefSeq Acc Id: XM_038426338   ⟹   XP_038282266
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBI
RefSeq Acc Id: XM_038426339   ⟹   XP_038282267
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBI
RefSeq Acc Id: XM_038426340   ⟹   XP_038282268
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBI
RefSeq Acc Id: XM_038426341   ⟹   XP_038282269
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.02029,969,947 - 31,357,367 (+)NCBI
RefSeq Acc Id: NP_001295478   ⟸   NM_001308549
- UniProtKB: B6F2G5 (UniProtKB/TrEMBL),   F1PWA0 (UniProtKB/TrEMBL),   A0A8C0QDA4 (UniProtKB/TrEMBL),   A0A8C0NUE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001135729   ⟸   NM_001142257
- UniProtKB: B6F2G5 (UniProtKB/TrEMBL),   F1PWA0 (UniProtKB/TrEMBL),   A0A8C0QDA4 (UniProtKB/TrEMBL),   A0A8C0NUE2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000010682   ⟸   ENSCAFT00000011527
RefSeq Acc Id: XP_038282267   ⟸   XM_038426339
- Peptide Label: isoform X4
- UniProtKB: F1PWA0 (UniProtKB/TrEMBL),   A0A8C0QDA4 (UniProtKB/TrEMBL),   B6F2G5 (UniProtKB/TrEMBL),   A0A8C0NUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282266   ⟸   XM_038426338
- Peptide Label: isoform X4
- UniProtKB: F1PWA0 (UniProtKB/TrEMBL),   A0A8C0QDA4 (UniProtKB/TrEMBL),   B6F2G5 (UniProtKB/TrEMBL),   A0A8C0NUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282268   ⟸   XM_038426340
- Peptide Label: isoform X4
- UniProtKB: F1PWA0 (UniProtKB/TrEMBL),   A0A8C0QDA4 (UniProtKB/TrEMBL),   B6F2G5 (UniProtKB/TrEMBL),   A0A8C0NUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282269   ⟸   XM_038426341
- Peptide Label: isoform X4
- UniProtKB: F1PWA0 (UniProtKB/TrEMBL),   A0A8C0QDA4 (UniProtKB/TrEMBL),   B6F2G5 (UniProtKB/TrEMBL),   A0A8C0NUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282263   ⟸   XM_038426335
- Peptide Label: isoform X1
- UniProtKB: A0A8C0NUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282265   ⟸   XM_038426337
- Peptide Label: isoform X3
- UniProtKB: A0A8C0NUE2 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038282264   ⟸   XM_038426336
- Peptide Label: isoform X2
RefSeq Acc Id: ENSCAFP00845024769   ⟸   ENSCAFT00845031646
Protein Domains
HIT


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007194 Ensembl, UniProtKB/TrEMBL
  ENSCAFG00030018443 UniProtKB/TrEMBL
  ENSCAFG00040007499 UniProtKB/TrEMBL
  ENSCAFG00845017871 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011527.6 UniProtKB/TrEMBL
  ENSCAFT00030033976.1 UniProtKB/TrEMBL
  ENSCAFT00040013966.1 UniProtKB/TrEMBL
  ENSCAFT00845031646 ENTREZGENE
  ENSCAFT00845031646.1 UniProtKB/TrEMBL
Gene3D-CATH 3.30.428.10 UniProtKB/TrEMBL
InterPro FHIT UniProtKB/TrEMBL
  Histidine_triad_CS UniProtKB/TrEMBL
  HIT-like UniProtKB/TrEMBL
  HIT-like_sf UniProtKB/TrEMBL
KEGG Report cfa:100215999 UniProtKB/TrEMBL
NCBI Gene FHIT ENTREZGENE
PANTHER BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/TrEMBL
  BIS(5'-ADENOSYL)-TRIPHOSPHATASE UniProtKB/TrEMBL
Pfam HIT UniProtKB/TrEMBL
PROSITE HIT_1 UniProtKB/TrEMBL
  HIT_2 UniProtKB/TrEMBL
Superfamily-SCOP SSF54197 UniProtKB/TrEMBL
UniProt A0A8C0NUE2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C0QDA4 ENTREZGENE, UniProtKB/TrEMBL
  B6F2G5 ENTREZGENE, UniProtKB/TrEMBL
  F1PWA0 ENTREZGENE
UniProt Secondary F1PWA0 UniProtKB/TrEMBL
VGNC ID VGNC:40870 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-08-06 FHIT  fragile histidine triad diadenosine triphosphatase  FHIT  fragile histidine triad  Symbol and/or name change 5135510 APPROVED