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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 620448
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Fhit
Name: fragile histidine triad diadenosine triphosphatase
Acc ID: CHEBI:50102
Term: N-methyl-N-nitrosourea
Definition: A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.
Chemical ID: MESH:D008770
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Fhitdecreases expressionEXP 6480464CTDMethylnitrosourea results in decreased expression of FHIT mRNA; Methylnitrosourea results in decreased expression of FHIT proteinPMID:15937960 PMID:17412507
Fhitincreases methylationEXP 6480464CTDMethylnitrosourea results in increased methylation of FHIT intron; Methylnitrosourea results in increased methylation of FHIT promoterPMID:15937960
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