Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase) - Rat Genome Database

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Gene: Ogt (O-linked N-acetylglucosamine (GlcNAc) transferase) Rattus norvegicus
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Symbol: Ogt
Name: O-linked N-acetylglucosamine (GlcNAc) transferase
RGD ID: 62060
Description: Exhibits several functions, including identical protein binding activity; monosaccharide binding activity; and protein N-acetylglucosaminyltransferase activity. Involved in several processes, including intracellular distribution of mitochondria; regulation of cellular protein localization; and regulation of protein phosphorylation. Localizes to several cellular components, including euchromatin; protein N-acetylglucosaminyltransferase complex; and zymogen granule. Biomarker of congestive heart failure. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 106. Orthologous to human OGT (O-linked N-acetylglucosamine (GlcNAc) transferase); PARTICIPATES IN DNA modification pathway; hexosamine biosynthetic pathway; O-linked glycan biosynthetic pathway; INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: O linked N-acetylglucosamine transferase; O-GlcNAc transferase subunit p110; O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit; UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,771,278 - 66,816,148 (+)NCBI
Rnor_6.0 EnsemblX71,528,988 - 71,585,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X71,540,870 - 71,585,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,721,369 - 89,766,218 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,794,801 - 89,838,207 (+)NCBI
CeleraX67,126,677 - 67,171,365 (+)NCBICelera
Cytogenetic MapXq22NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dinitrotoluene  (EXP)
2-amino-2-deoxy-D-glucopyranose  (ISO)
6-propyl-2-thiouracil  (EXP)
8-Br-cAMP  (ISO)
acetaminophen O-beta-D-glucosiduronic acid  (ISO)
aflatoxin B1  (ISO)
aldehydo-D-glucosamine  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (ISO)
bisphenol A  (EXP)
bortezomib  (ISO)
butyric acid  (ISO)
C60 fullerene  (EXP)
cadmium sulfate  (ISO)
carbon nanotube  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
crocidolite asbestos  (ISO)
CU-O LINKAGE  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dactolisib  (ISO)
DDT  (EXP,ISO)
diarsenic trioxide  (ISO)
dioxygen  (ISO)
doxorubicin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
ethanol  (ISO)
fenvalerate  (EXP)
folic acid  (ISO)
gamma-hexachlorocyclohexane  (EXP)
glucose  (ISO)
hemin  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (ISO)
lamivudine  (ISO)
lipopolysaccharide  (EXP,ISO)
menadione  (ISO)
methapyrilene  (EXP)
methoxychlor  (EXP)
methyl methanesulfonate  (ISO)
Methylazoxymethanol acetate  (EXP)
methylmercury chloride  (ISO)
miconazole  (ISO)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N-(6-acetamidohexyl)acetamide  (ISO)
nefazodone  (EXP)
nicotine  (ISO)
paracetamol  (ISO)
paracetamol sulfate  (ISO)
PCB138  (ISO)
phenobarbital  (ISO)
pirinixic acid  (EXP,ISO)
piroxicam  (ISO)
potassium chromate  (ISO)
progesterone  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium fluoride  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
vincristine  (ISO)
zidovudine  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA,ISO,ISS)
cellular response to glucose stimulus  (IMP)
cellular response to insulin stimulus  (IEP)
cellular response to lipopolysaccharide  (IMP)
cellular response to toxic substance  (IEP)
circadian regulation of gene expression  (IEA,ISO,ISS)
forebrain development  (IEP)
glucosamine metabolic process  (IDA,IMP)
histone H3-K4 trimethylation  (IEA,ISO,ISS)
histone H4-K16 acetylation  (IEA,ISO,ISS)
histone H4-K5 acetylation  (IEA,ISO,ISS)
histone H4-K8 acetylation  (IEA,ISO,ISS)
intracellular distribution of mitochondria  (IMP)
negative regulation of cell death  (IMP)
negative regulation of cellular response to hypoxia  (IMP)
negative regulation of peptidyl-serine phosphorylation  (IMP)
negative regulation of peptidyl-threonine phosphorylation  (IMP)
negative regulation of proteasomal ubiquitin-dependent protein catabolic process  (IEA,ISO)
negative regulation of protein phosphorylation  (IMP)
negative regulation of protein targeting to membrane  (IMP)
negative regulation of protein ubiquitination  (IEA,ISO,ISS)
phosphatidylinositol-mediated signaling  (IEA,ISO,ISS)
positive regulation of cell size  (IMP)
positive regulation of cold-induced thermogenesis  (ISO,ISS)
positive regulation of gene expression  (IMP)
positive regulation of histone H3-K27 methylation  (IEA,ISO,ISS)
positive regulation of protein localization to nucleus  (IMP)
positive regulation of protein phosphorylation  (IMP)
positive regulation of proteolysis  (IEA,ISO,ISS)
positive regulation of reactive oxygen species biosynthetic process  (IMP)
positive regulation of transcription by RNA polymerase II  (IEA,ISO,ISS)
protein O-linked glycosylation  (IBA,IDA,IEA,IMP,ISO)
protein phosphopantetheinylation  (IEA)
protein processing  (IEA,ISO,ISS)
regulation of gluconeogenesis  (IEA,ISO,ISS)
regulation of glycolytic process  (IEA,ISO,ISS)
regulation of insulin receptor signaling pathway  (IEA,ISO)
regulation of Rac protein signal transduction  (IEA,ISO)
regulation of transcription by RNA polymerase II  (ISO)
response to insulin  (IEA,ISO)
rhythmic process  (IEA)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
1. Akimoto Y, etal., Diabetes. 1999 Dec;48(12):2407-13.
2. Bouche C, etal., Endocr Rev. 2004 Oct;25(5):807-30.
3. Chen J, etal., FEBS Lett. 2015 Aug 19;589(18):2347-58. doi: 10.1016/j.febslet.2015.07.030. Epub 2015 Jul 29.
4. Copeland RJ, etal., Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E17-28. Epub 2008 Apr 29.
5. Dauphinee SM, etal., J Cell Biochem. 2005 Oct 15;96(3):579-88.
6. Delatte B, etal., EMBO J. 2014 Jun 2;33(11):1198-211. doi: 10.15252/embj.201488290. Epub 2014 May 13.
7. Ding F, etal., Amino Acids. 2013 Aug;45(2):339-49. doi: 10.1007/s00726-013-1504-2. Epub 2013 May 12.
8. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. GOA data from the GO Consortium
10. Goldberg H, etal., Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E713-26. doi: 10.1152/ajpendo.00108.2011. Epub 2011 Jun 28.
11. Haltiwanger RS, etal., J Biol Chem. 1992 May 5;267(13):9005-13.
12. Ho SR, etal., FEBS Lett. 2010 Jan 4;584(1):49-54. doi: 10.1016/j.febslet.2009.11.059. Epub .
13. Huang X, etal., J Biol Chem. 2013 Dec 20;288(51):36418-25. doi: 10.1074/jbc.M113.495713. Epub 2013 Nov 8.
14. Iyer SP, etal., J Biol Chem 2003 Feb 14;278(7):5399-409.
15. Konrad RJ, etal., Biochem Biophys Res Commun. 2002 Apr 26;293(1):207-12.
16. Kreppel LK and Hart GW, J Biol Chem. 1999 Nov 5;274(45):32015-22.
17. Kreppel LK, etal., J Biol Chem 1997 Apr 4;272(14):9308-15.
18. Lima VV, etal., Cardiovasc Res. 2011 Feb 15;89(3):614-22. doi: 10.1093/cvr/cvq338. Epub 2010 Oct 26.
19. Liu Y, etal., PLoS One. 2012;7(8):e43724. doi: 10.1371/journal.pone.0043724. Epub 2012 Aug 22.
20. Lunde IG, etal., Physiol Genomics. 2012 Feb 1;44(2):162-72. doi: 10.1152/physiolgenomics.00016.2011. Epub 2011 Nov 29.
21. Majumdar G, etal., Diabetes. 2004 Dec;53(12):3184-92.
22. Marz P, etal., J Biol Chem. 2006 Jul 21;281(29):20263-70. Epub 2006 May 18.
23. MGD data from the GO Consortium
24. NCBI rat LocusLink and RefSeq merged data July 26, 2002
25. Ngoh GA, etal., J Mol Cell Cardiol. 2008 Aug;45(2):313-25. doi: 10.1016/j.yjmcc.2008.04.009. Epub 2008 May 2.
26. Ohashi N, etal., Diabetes. 2017 Sep;66(9):2351-2362. doi: 10.2337/db16-1427. Epub 2017 Jun 21.
27. Pekkurnaz G, etal., Cell. 2014 Jul 3;158(1):54-68. doi: 10.1016/j.cell.2014.06.007.
28. Pipeline to import KEGG annotations from KEGG into RGD
29. RGD automated data pipeline
30. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
31. RGD automated import pipeline for gene-chemical interactions
32. Yang X, etal., Cell. 2002 Jul 12;110(1):69-80.
33. Zou L, etal., Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H515-23. doi: 10.1152/ajpheart.01025.2008. Epub 2008 Dec 19.
Additional References at PubMed
PMID:8889548   PMID:11700029   PMID:12060780   PMID:12724313   PMID:12911634   PMID:12947022   PMID:14675536   PMID:15247246   PMID:17208994   PMID:17670746   PMID:18029144   PMID:18288188  
PMID:20018852   PMID:20506529   PMID:20824293   PMID:21240259   PMID:21285374   PMID:21700703   PMID:22871113   PMID:22923583   PMID:23222540   PMID:23352454   PMID:23353889   PMID:23395176  
PMID:23777819   PMID:24474760   PMID:25416863   PMID:26678539   PMID:28584052   PMID:30053369   PMID:30699359  


Genomics

Comparative Map Data
Ogt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2X66,771,278 - 66,816,148 (+)NCBI
Rnor_6.0 EnsemblX71,528,988 - 71,585,908 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0X71,540,870 - 71,585,906 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X89,721,369 - 89,766,218 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1X89,794,801 - 89,838,207 (+)NCBI
CeleraX67,126,677 - 67,171,365 (+)NCBICelera
Cytogenetic MapXq22NCBI
OGT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX71,533,104 - 71,575,892 (+)EnsemblGRCh38hg38GRCh38
GRCh38X71,533,104 - 71,575,892 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X70,752,954 - 70,795,742 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36X70,669,658 - 70,712,465 (+)NCBINCBI36hg18NCBI36
Build 34X70,535,953 - 70,578,761NCBI
CeleraX71,105,953 - 71,148,788 (+)NCBI
Cytogenetic MapXq13.1NCBI
HuRefX64,568,037 - 64,610,949 (+)NCBIHuRef
CHM1_1X70,645,269 - 70,688,159 (+)NCBICHM1_1
Ogt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X100,683,617 - 100,727,957 (+)NCBIGRCm39mm39
GRCm39 EnsemblX100,683,666 - 100,727,957 (+)Ensembl
GRCm38X101,640,011 - 101,684,351 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX101,640,060 - 101,684,351 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X98,835,403 - 98,879,690 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X97,842,783 - 97,887,068 (+)NCBImm8
CeleraX88,557,707 - 88,602,477 (+)NCBICelera
Cytogenetic MapXDNCBI
Ogt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547511,062,076 - 11,114,169 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547511,062,258 - 11,112,252 (+)NCBIChiLan1.0ChiLan1.0
OGT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X70,852,687 - 70,894,921 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX70,852,687 - 70,894,921 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X60,798,219 - 60,840,948 (+)NCBIMhudiblu_PPA_v0panPan3
OGT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X55,821,227 - 55,857,597 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 EnsemblX55,821,234 - 55,855,502 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX46,648,032 - 46,684,418 (+)NCBI
ROS_Cfam_1.0X56,790,423 - 56,826,854 (+)NCBI
UMICH_Zoey_3.1X54,757,798 - 54,794,161 (+)NCBI
UNSW_CanFamBas_1.0X56,089,784 - 56,126,154 (+)NCBI
UU_Cfam_GSD_1.0X56,017,174 - 56,053,590 (+)NCBI
Ogt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X46,337,214 - 46,375,661 (-)NCBI
SpeTri2.0NW_00493676299,335 - 137,833 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OGT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX57,521,097 - 57,558,519 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X57,521,091 - 57,558,467 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X64,962,783 - 65,000,186 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OGT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X61,351,047 - 61,393,541 (+)NCBI
ChlSab1.1 EnsemblX61,351,054 - 61,394,305 (+)Ensembl
Ogt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249031,863,110 - 1,912,299 (+)NCBI

Position Markers
SHGC-16181  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X71,554,488 - 71,554,631NCBIRnor6.0
Rnor_5.0X72,403,823 - 72,403,966UniSTSRnor5.0
RGSC_v3.4X89,735,070 - 89,735,213UniSTSRGSC3.4
CeleraX67,140,233 - 67,140,376UniSTS
Cytogenetic MapXq31UniSTS
RH141352  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X71,575,803 - 71,576,005NCBIRnor6.0
Rnor_5.0X72,425,138 - 72,425,340UniSTSRnor5.0
RGSC_v3.4X89,756,321 - 89,756,523UniSTSRGSC3.4
CeleraX67,161,468 - 67,161,670UniSTS
Cytogenetic MapXq31UniSTS
RH135882  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_6.0X71,584,524 - 71,584,654NCBIRnor6.0
Rnor_5.0X72,433,859 - 72,433,989UniSTSRnor5.0
RGSC_v3.4X89,764,836 - 89,764,966UniSTSRGSC3.4
CeleraX67,169,983 - 67,170,113UniSTS
Cytogenetic MapXq31UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61430Cia18Collagen induced arthritis QTL 183.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X15688119127888215Rat
1598837Memor13Memory QTL 133.2exploratory behavior trait (VT:0010471)difference between time of physical contact/close proximity of test subject and social stimulus during sample phase and test phase (CMO:0002678)X44320616158345622Rat
738035Stresp1Stress response QTL 14.960.000011stress-related behavior trait (VT:0010451)defensive burying - copingX44557974120045269Rat
61431Cia19Collagen induced arthritis QTL 194.4joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)X70352120127888215Rat

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:556
Count of miRNA genes:271
Interacting mature miRNAs:359
Transcripts:ENSRNOT00000004692
Prediction methods:Miranda, Pita, Pita,Targetscan, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 38 11 8
Low 3
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000004692   ⟹   ENSRNOP00000004692
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,540,895 - 71,585,908 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000075963   ⟹   ENSRNOP00000068306
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,528,988 - 71,552,338 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000082967   ⟹   ENSRNOP00000072791
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 EnsemblX71,540,929 - 71,585,908 (+)Ensembl
RefSeq Acc Id: NM_017107   ⟹   NP_058803
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,771,349 - 66,816,148 (+)NCBI
Rnor_6.0X71,540,918 - 71,585,906 (+)NCBI
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBI
RGSC_v3.4X89,721,369 - 89,766,218 (+)RGD
CeleraX67,126,677 - 67,171,365 (+)RGD
Sequence:
RefSeq Acc Id: XM_006257056   ⟹   XP_006257118
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,771,375 - 66,816,148 (+)NCBI
Rnor_6.0X71,540,919 - 71,585,906 (+)NCBI
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257057   ⟹   XP_006257119
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2X66,771,278 - 66,814,087 (+)NCBI
Rnor_6.0X71,540,870 - 71,583,977 (+)NCBI
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006257058   ⟹   XP_006257120
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,540,919 - 71,583,977 (+)NCBI
Rnor_5.0X72,390,218 - 72,435,241 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_058803   ⟸   NM_017107
- UniProtKB: P56558 (UniProtKB/Swiss-Prot),   G3V6F4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257119   ⟸   XM_006257057
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K3V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257118   ⟸   XM_006257056
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K3V4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006257120   ⟸   XM_006257058
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSRNOP00000072791   ⟸   ENSRNOT00000082967
RefSeq Acc Id: ENSRNOP00000068306   ⟸   ENSRNOT00000075963
RefSeq Acc Id: ENSRNOP00000004692   ⟸   ENSRNOT00000004692
Protein Domains
TPR_REGION

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701881
Promoter ID:EPDNEW_R12403
Type:initiation region
Name:Ogt_1
Description:O-linked N-acetylglucosamine transferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0X71,540,951 - 71,541,011EPDNEW

Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:62060 AgrOrtholog
Ensembl Genes ENSRNOG00000003359 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000004692 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOP00000068306 UniProtKB/TrEMBL
  ENSRNOP00000072791 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000004692 ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOT00000075963 UniProtKB/TrEMBL
  ENSRNOT00000082967 UniProtKB/TrEMBL
Gene3D-CATH 1.25.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro OGT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  OGT/SEC/SPY_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-contain_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR-like_helical_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:26295 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 26295 ENTREZGENE
PANTHER PTHR44366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Glyco_transf_41 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ogt PhenoGen
PROSITE TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TPR_REGION UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48452 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A096MJY3_RAT UniProtKB/TrEMBL
  A0A0G2K3V4 ENTREZGENE, UniProtKB/TrEMBL
  G3V6F4 ENTREZGENE, UniProtKB/TrEMBL
  OGT1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-10-05 Ogt  O-linked N-acetylglucosamine (GlcNAc) transferase  Ogt  O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ogt  O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)    O linked N-acetylglucosamine transferase   Name updated 1299863 APPROVED
2002-06-10 Ogt  O linked N-acetylglucosamine transferase       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localized to the cytosol and nucleus 61681
gene_domains contains repeats of the tetratricopeptide repeat motif 61681