Fam151b (family with sequence similarity 151, member B) - Rat Genome Database

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Gene: Fam151b (family with sequence similarity 151, member B) Rattus norvegicus
Analyze
Symbol: Fam151b
Name: family with sequence similarity 151, member B
RGD ID: 1561110
Description: Predicted to be involved in photoreceptor cell development. Orthologous to human FAM151B (family with sequence similarity 151 member B); INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 6-propyl-2-thiouracil; amitrole.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: hypothetical protein LOC499507; LOC499507; RGD1561110; similar to hypothetical protein 2BE2121 - Chinese hamster (fragment); uncharacterized protein LOC499507
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,409,382 - 25,446,225 (-)NCBIGRCr8
mRatBN7.2223,674,317 - 23,710,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,674,318 - 23,710,403 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,704,165 - 30,740,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,804,521 - 28,840,701 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,632,479 - 23,668,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,023,038 - 22,059,166 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,023,052 - 22,059,149 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,226,509 - 41,262,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,686,502 - 22,722,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera219,764,151 - 19,800,235 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932  


Genomics

Comparative Map Data
Fam151b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8225,409,382 - 25,446,225 (-)NCBIGRCr8
mRatBN7.2223,674,317 - 23,710,420 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,674,318 - 23,710,403 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,704,165 - 30,740,348 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,804,521 - 28,840,701 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,632,479 - 23,668,849 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0222,023,038 - 22,059,166 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl222,023,052 - 22,059,149 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0241,226,509 - 41,262,343 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,686,502 - 22,722,586 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera219,764,151 - 19,800,235 (-)NCBICelera
Cytogenetic Map2q12NCBI
FAM151B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,488,100 - 80,542,563 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,487,969 - 80,542,563 (+)EnsemblGRCh38hg38GRCh38
GRCh37579,783,919 - 79,838,382 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36579,819,556 - 79,873,962 (+)NCBINCBI36Build 36hg18NCBI36
Celera575,685,113 - 75,739,510 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef574,991,977 - 75,046,540 (+)NCBIHuRef
CHM1_1579,216,891 - 79,271,486 (+)NCBICHM1_1
T2T-CHM13v2.0580,972,095 - 81,026,566 (+)NCBIT2T-CHM13v2.0
Fam151b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,586,128 - 92,620,539 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,586,133 - 92,620,523 (-)EnsemblGRCm39 Ensembl
GRCm381392,449,620 - 92,484,031 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1392,449,625 - 92,484,015 (-)EnsemblGRCm38mm10GRCm38
MGSCv371393,219,575 - 93,253,986 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361393,550,377 - 93,584,828 (-)NCBIMGSCv36mm8
Celera1396,055,148 - 96,092,361 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.7NCBI
Fam151b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541829,325,203 - 29,347,148 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541829,328,292 - 29,349,940 (-)NCBIChiLan1.0ChiLan1.0
FAM151B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,761,409 - 34,820,494 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,915,376 - 32,974,019 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,775,157 - 34,829,828 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1535,049,564 - 35,103,071 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl535,049,564 - 35,103,071 (-)Ensemblpanpan1.1panPan2
FAM151B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,614,337 - 26,646,997 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,615,693 - 26,647,372 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,855,081 - 27,887,728 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0326,535,246 - 26,567,908 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl326,535,085 - 26,567,899 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1326,475,202 - 26,507,817 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0326,450,225 - 26,482,502 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,729,883 - 26,762,576 (-)NCBIUU_Cfam_GSD_1.0
FAM151B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,118,920 - 89,144,264 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,109,259 - 89,144,270 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2290,957,798 - 90,992,174 (+)NCBISscrofa10.2Sscrofa10.2susScr3
FAM151B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1474,652,807 - 74,702,552 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl474,652,817 - 74,702,107 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,514,793 - 23,564,431 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fam151b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247431,388,750 - 1,405,429 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247431,389,721 - 1,405,429 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Fam151b
292 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:195
Count of miRNA genes:137
Interacting mature miRNAs:145
Transcripts:ENSRNOT00000031909
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
7387318Stl32Serum triglyceride level QTL 323.20.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)22238462767384627Rat
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)218960362228801039Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat

Markers in Region
RH128352  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2223,674,479 - 23,674,674 (+)MAPPERmRatBN7.2
Rnor_6.0222,023,201 - 22,023,395NCBIRnor6.0
Rnor_5.0241,226,672 - 41,226,866UniSTSRnor5.0
RGSC_v3.4222,686,665 - 22,686,859UniSTSRGSC3.4
Celera219,764,314 - 19,764,508UniSTS
Cytogenetic Map2q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000031909   ⟹   ENSRNOP00000032254
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,674,318 - 23,710,403 (-)Ensembl
Rnor_6.0 Ensembl222,023,052 - 22,059,149 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000114357   ⟹   ENSRNOP00000091224
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,674,318 - 23,700,524 (-)Ensembl
RefSeq Acc Id: NM_001134748   ⟹   NP_001128220
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,382 - 25,445,466 (-)NCBI
mRatBN7.2223,674,317 - 23,710,403 (-)NCBI
Rnor_6.0222,023,038 - 22,059,122 (-)NCBI
Rnor_5.0241,226,509 - 41,262,343 (-)NCBI
RGSC_v3.4222,686,502 - 22,722,586 (-)RGD
Celera219,764,151 - 19,800,235 (-)RGD
Sequence:
RefSeq Acc Id: XM_039102823   ⟹   XP_038958751
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,436,353 (-)NCBI
mRatBN7.2223,674,328 - 23,710,420 (-)NCBI
RefSeq Acc Id: XM_063282336   ⟹   XP_063138406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,446,225 (-)NCBI
RefSeq Acc Id: XM_063282337   ⟹   XP_063138407
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,446,225 (-)NCBI
RefSeq Acc Id: XM_063282338   ⟹   XP_063138408
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,446,225 (-)NCBI
RefSeq Acc Id: XM_063282339   ⟹   XP_063138409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,436,357 (-)NCBI
RefSeq Acc Id: XM_063282340   ⟹   XP_063138410
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,446,225 (-)NCBI
RefSeq Acc Id: XM_063282342   ⟹   XP_063138412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8225,409,393 - 25,446,225 (-)NCBI
RefSeq Acc Id: NP_001128220   ⟸   NM_001134748
- UniProtKB: B2RZ92 (UniProtKB/TrEMBL),   A6I4R1 (UniProtKB/TrEMBL),   A0A8I6AFQ9 (UniProtKB/TrEMBL),   F7EMX6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032254   ⟸   ENSRNOT00000031909
RefSeq Acc Id: XP_038958751   ⟸   XM_039102823
- Peptide Label: isoform X1
- UniProtKB: A0A8I6AFQ9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000091224   ⟸   ENSRNOT00000114357
RefSeq Acc Id: XP_063138412   ⟸   XM_063282342
- Peptide Label: isoform X7
RefSeq Acc Id: XP_063138406   ⟸   XM_063282336
- Peptide Label: isoform X2
- UniProtKB: A0A8I6AFQ9 (UniProtKB/TrEMBL),   A6I4R0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138407   ⟸   XM_063282337
- Peptide Label: isoform X3
- UniProtKB: A0A8I6AFQ9 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063138410   ⟸   XM_063282340
- Peptide Label: isoform X6
RefSeq Acc Id: XP_063138408   ⟸   XM_063282338
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063138409   ⟸   XM_063282339
- Peptide Label: isoform X5

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B2RZ92-F1-model_v2 AlphaFold B2RZ92 1-276 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691059
Promoter ID:EPDNEW_R1583
Type:initiation region
Name:Fam151b_1
Description:family with sequence similarity 151, member B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0222,059,096 - 22,059,156EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1561110 AgrOrtholog
BioCyc Gene G2FUF-54866 BioCyc
Ensembl Genes ENSRNOG00000024136 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000031909.6 UniProtKB/TrEMBL
  ENSRNOT00000114357.1 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:9032304 IMAGE-MGC_LOAD
InterPro DUF2181 UniProtKB/TrEMBL
KEGG Report rno:499507 UniProtKB/TrEMBL
MGC_CLONE MGC:189401 IMAGE-MGC_LOAD
NCBI Gene 499507 ENTREZGENE
PANTHER PROTEIN FAM151B UniProtKB/TrEMBL
  PTHR21184 UniProtKB/TrEMBL
Pfam DUF2181 UniProtKB/TrEMBL
PhenoGen Fam151b PhenoGen
RatGTEx ENSRNOG00000024136 RatGTEx
UniProt A0A8I6AFQ9 ENTREZGENE, UniProtKB/TrEMBL
  A6I4R0 ENTREZGENE, UniProtKB/TrEMBL
  A6I4R1 ENTREZGENE, UniProtKB/TrEMBL
  B2RZ92 ENTREZGENE
  F7EMX6 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B2RZ92 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-07 Fam151b  family with sequence similarity 151, member B  RGD1561110_predicted  similar to hypothetical protein 2BE2121 - Chinese hamster (fragment) (predicted)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-07 RGD1561110_predicted  similar to hypothetical protein 2BE2121 - Chinese hamster (fragment) (predicted)  LOC499507  similar to hypothetical protein 2BE2121 - Chinese hamster (fragment)  Symbol and Name status set to approved 1299863 APPROVED
2006-02-09 LOC499507  similar to hypothetical protein 2BE2121 - Chinese hamster (fragment)      Symbol and Name status set to provisional 70820 PROVISIONAL