Cartpt (CART prepropeptide) - Rat Genome Database

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Gene: Cartpt (CART prepropeptide) Rattus norvegicus
Symbol: Cartpt
Name: CART prepropeptide
RGD ID: 2272
Description: Predicted to enable neuropeptide hormone activity. Involved in several processes, including adult feeding behavior; circadian regulation of gene expression; and regulation of peptide hormone secretion. Located in extracellular space. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in obesity. Orthologous to human CARTPT (CART prepropeptide); INTERACTS WITH (3,4-dihydroxyphenyl)acetic acid; (S)-nicotine; 17beta-estradiol.
Type: protein-coding
Previously known as: Cart; cocaine and amphetamine regulated transcript; cocaine- and amphetamine-regulated transcript protein
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2231,255,098 - 31,257,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,333,324 - 38,335,346 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,427,667 - 36,429,691 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,220,463 - 31,222,481 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,125,249 - 30,127,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,285,118 - 49,287,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,889,817 - 30,891,837 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,810,185 - 30,812,206 (-)NCBI
Celera227,276,402 - 27,278,422 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(3,4-dihydroxyphenyl)acetic acid  (EXP)
(S)-nicotine  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2-naphthylamine  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
alpha-melanocyte stimulating hormone  (EXP)
AM-251  (EXP)
ammonium chloride  (EXP)
amphetamine  (EXP)
arachidonyl-2'-chloroethylamide  (EXP)
arsenite(3-)  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (EXP,ISO)
Butylparaben  (EXP)
C60 fullerene  (EXP)
carbonyl sulfide  (EXP)
CGP 52608  (ISO)
chlorpyrifos  (EXP,ISO)
clozapine  (EXP)
cocaine  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
corticosterone  (EXP)
dichlorine  (EXP)
diprotium oxide  (EXP)
entinostat  (ISO)
enzacamene  (EXP)
ethanol  (ISO)
fluoxetine  (EXP)
fonofos  (ISO)
fructose  (EXP)
Glutathione ethyl ester  (EXP)
glycidol  (EXP)
hydrogen sulfide  (ISO)
icariin  (ISO)
KT 5720  (EXP)
linuron  (EXP)
lipopolysaccharide  (EXP)
malathion  (ISO)
methylmercury chloride  (ISO)
morphine  (ISO)
nicotine  (EXP,ISO)
nitroprusside  (EXP)
ozone  (EXP)
paracetamol  (EXP)
parathion  (ISO)
PCB138  (ISO)
pirinixic acid  (EXP,ISO)
rimonabant  (ISO)
rotenone  (EXP)
scopolamine  (EXP)
Soman  (EXP)
streptozocin  (EXP)
terbufos  (ISO)
triphenyl phosphate  (ISO)
water  (EXP)


References - curated
# Reference Title Reference Citation
1. Early and transient ontogenetic expression of the cocaine- and amphetamine-regulated transcript peptide in the rat mesencephalon: correlation with tyrosine hydroxylase expression. Brischoux F, etal., J Neurobiol 2002 Sep 5;52(3):221-9.
2. Mutational screening of the CART gene in obese children: identifying a mutation (Leu34Phe) associated with reduced resting energy expenditure and cosegregating with obesity phenotype in a large family. del Giudice EM, etal., Diabetes. 2001 Sep;50(9):2157-60.
3. PCR differential display identifies a rat brain mRNA that is transcriptionally regulated by cocaine and amphetamine. Douglass J, etal., J Neurosci 1995 Mar;15(3 Pt 2):2471-81.
4. Sequence variants in the human cocaine and amphetamine-regulated transcript (CART) gene in subjects with early onset obesity. Echwald SM, etal., Obes Res. 1999 Nov;7(6):532-6.
5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
6. Colocalization of CART peptide with prodynorphin and dopamine D1 receptors in the rat nucleus accumbens. Hubert GW and Kuhar MJ, Neuropeptides. 2006 Dec;40(6):409-15. Epub 2006 Oct 24.
7. Hypothalamic CART is a new anorectic peptide regulated by leptin. Kristensen P, etal., Nature. 1998 May 7;393(6680):72-6.
8. Cocaine- and amphetamine-regulated transcript (CART) peptide activates the extracellular signal-regulated kinase (ERK) pathway in AtT20 cells via putative G-protein coupled receptors. Lakatos A, etal., Neurosci Lett. 2005 Aug 12-19;384(1-2):198-202.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
11. Cocaine-amphetamine-regulated transcript (CART) acts in the central nervous system to inhibit gastric acid secretion via brain corticotropin-releasing factor system. Okumura T, etal., Endocrinology 2000 Aug;141(8):2854-60.
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. Testosterone (T)-induced changes in arcuate nucleus cocaine-amphetamine-regulated transcript and NPY mRNA are attenuated in old compared to young male brown Norway rats: contribution of T to age-related changes in cocaine-amphetamine-regulated transcript and NPY gene expression. Sohn EH, etal., Endocrinology 2002 Mar;143(3):954-63.
16. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
17. CART peptide diurnal rhythm in brain and effect of fasting. Vicentic A, etal., Brain Res. 2005 Jan 25;1032(1-2):111-5.
18. A polymorphism in the gene encoding CART is not associated with obesity in Pima Indians. Walder K, etal., Int J Obes Relat Metab Disord. 2000 Apr;24(4):520-1.
19. CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats. Wierup N, etal., Diabetes. 2006 Feb;55(2):305-11.
Additional References at PubMed
PMID:9654146   PMID:11711504   PMID:11841916   PMID:12147208   PMID:12147209   PMID:12468444   PMID:12490674   PMID:12559087   PMID:12588509   PMID:12591118   PMID:12732339   PMID:12933358  
PMID:14691017   PMID:14698680   PMID:14700744   PMID:14730586   PMID:14764627   PMID:15155577   PMID:15271883   PMID:15380921   PMID:15572204   PMID:15652661   PMID:15720470   PMID:15724149  
PMID:15874973   PMID:15890775   PMID:15908130   PMID:15978559   PMID:16154276   PMID:16339196   PMID:16374620   PMID:16614075   PMID:16644010   PMID:16684132   PMID:16879170   PMID:16971488  
PMID:17023531   PMID:17105939   PMID:17434149   PMID:17616293   PMID:17634068   PMID:17669377   PMID:17880396   PMID:18078990   PMID:18384674   PMID:18472225   PMID:18554810   PMID:18624928  
PMID:18645412   PMID:18719668   PMID:18823957   PMID:19005467   PMID:19046951   PMID:19070636   PMID:19254763   PMID:19258027   PMID:19426783   PMID:19490082   PMID:19533109   PMID:19632277  
PMID:19704931   PMID:19755135   PMID:19825396   PMID:19854189   PMID:20116848   PMID:20528087   PMID:20595030   PMID:20626417   PMID:20810898   PMID:20883668   PMID:20886038   PMID:21167239  
PMID:21407156   PMID:21452228   PMID:21539900   PMID:21589937   PMID:21624661   PMID:21821286   PMID:21903152   PMID:22137563   PMID:22887004   PMID:22960117   PMID:23155622   PMID:23206801  
PMID:23211962   PMID:23250745   PMID:23318496   PMID:23538212   PMID:23545074   PMID:23736294   PMID:23770418   PMID:23907376   PMID:24549602   PMID:24630272   PMID:24647922   PMID:24939825  
PMID:24989426   PMID:25151991   PMID:25256086   PMID:25552080   PMID:25825358   PMID:26008155   PMID:26150151   PMID:26771081   PMID:26955782   PMID:27258934   PMID:27349817   PMID:27822503  
PMID:27823935   PMID:28237718   PMID:28300671   PMID:28984394   PMID:30610873   PMID:31830460   PMID:33098940   PMID:34043767   PMID:36539163   PMID:37859350  


Comparative Map Data
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
mRatBN7.2231,255,098 - 31,257,452 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx238,333,324 - 38,335,346 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0236,427,667 - 36,429,691 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0231,220,463 - 31,222,481 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0230,125,249 - 30,127,408 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0249,285,118 - 49,287,405 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4230,889,817 - 30,891,837 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1230,810,185 - 30,812,206 (-)NCBI
Celera227,276,402 - 27,278,422 (-)NCBICelera
Cytogenetic Map2q12NCBI
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38571,719,275 - 71,721,045 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl571,719,275 - 71,721,048 (+)EnsemblGRCh38hg38GRCh38
GRCh37571,015,102 - 71,016,872 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36571,050,750 - 71,052,628 (+)NCBINCBI36Build 36hg18NCBI36
Celera566,910,678 - 66,912,563 (+)NCBICelera
Cytogenetic Map5q13.2NCBI
HuRef566,220,931 - 66,222,816 (+)NCBIHuRef
CHM1_1570,447,686 - 70,449,571 (+)NCBICHM1_1
T2T-CHM13v2.0572,200,597 - 72,202,367 (+)NCBIT2T-CHM13v2.0
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3913100,034,991 - 100,037,191 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl13100,034,997 - 100,037,599 (-)EnsemblGRCm39 Ensembl
GRCm381399,898,483 - 99,910,179 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1399,898,489 - 99,901,091 (-)EnsemblGRCm38mm10GRCm38
MGSCv3713100,668,439 - 100,670,638 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3613100,998,914 - 101,000,892 (-)NCBIMGSCv36mm8
Celera13103,550,272 - 103,552,922 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1352.9NCBI
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
ChiLan1.0 EnsemblNW_004955575551,991 - 555,149 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955575551,991 - 555,118 (+)NCBIChiLan1.0ChiLan1.0
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
NHGRI_mPanPan1541,746,812 - 41,748,989 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0543,591,683 - 43,593,586 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1544,236,114 - 44,238,229 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl544,236,114 - 44,238,229 (-)Ensemblpanpan1.1panPan2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
CanFam3.1254,865,043 - 54,867,410 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl254,865,298 - 54,867,158 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha251,831,747 - 51,833,904 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0255,380,658 - 55,382,812 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl255,380,662 - 55,382,560 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1252,441,398 - 52,443,555 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0253,208,304 - 53,210,460 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0254,099,675 - 54,101,833 (+)NCBIUU_Cfam_GSD_1.0
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
HiC_Itri_2NW_024407213186,139,406 - 186,141,636 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365494,717,771 - 4,719,395 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365494,717,337 - 4,719,523 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
Sscrofa11.1 Ensembl1648,043,492 - 48,045,592 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11648,043,558 - 48,045,592 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21651,989,808 - 51,991,843 (+)NCBISscrofa10.2Sscrofa10.2susScr3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
ChlSab1.1466,058,755 - 66,060,635 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl466,058,769 - 66,061,112 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604914,805,312 - 14,807,192 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
HetGla_female_1.0 EnsemblNW_004624905751,223 - 752,845 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624905751,032 - 753,012 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Variants in Cartpt
16 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:173
Count of miRNA genes:134
Interacting mature miRNAs:143
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat
10402051Gdil2Gastrointestinal dilation QTL 2enteric ganglion morphology trait (VT:0001045)length of intestine affected by colonic aganglionosis to total length of colon ratio (CMO:0001836)22490385374786777Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)225413423143657569Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423157142209Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)225413423157142209Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)225413652157142078Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22691781781754745Rat
1354617Bp240Blood pressure QTL 2404arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)22691781781754745Rat
1354603Bp243Blood pressure QTL 2433.9arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)226917817127469484Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)226917817136917119Rat
1331764Bp205Blood pressure QTL 2053.476arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)22699957143154682Rat
1643006Pain1Pain QTL 13.630.005mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)22699957148268661Rat
9590095Sffal3Serum free fatty acids level QTL 36.780.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)22715716072157160Rat
1300160Hrtrt3Heart rate QTL 33.62heart pumping trait (VT:2000009)absolute change in heart rate (CMO:0000534)22997159351729300Rat
10755434Coatc7Coat color QTL 70.04794coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)23064806575648065Rat


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
Medium 1 20
Low 2 7 8 50 9 3
Below cutoff 8 11 4 9 4 1 1 4 4 11 6 1


RefSeq Acc Id: ENSRNOT00000023869   ⟹   ENSRNOP00000023869
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl231,255,098 - 31,290,713 (-)Ensembl
Rnor_6.0 Ensembl230,125,249 - 30,127,269 (-)Ensembl
RefSeq Acc Id: NM_017110   ⟹   NP_058806
Rat AssemblyChrPosition (strand)Source
mRatBN7.2231,255,098 - 31,257,120 (-)NCBI
Rnor_6.0230,125,249 - 30,127,269 (-)NCBI
Rnor_5.0249,285,118 - 49,287,405 (-)NCBI
RGSC_v3.4230,889,817 - 30,891,837 (-)RGD
Celera227,276,402 - 27,278,422 (-)RGD
RefSeq Acc Id: XM_006231843   ⟹   XP_006231905
Rat AssemblyChrPosition (strand)Source
mRatBN7.2231,255,099 - 31,257,452 (-)NCBI
Rnor_6.0230,125,252 - 30,127,408 (-)NCBI
Rnor_5.0249,285,118 - 49,287,405 (-)NCBI
RefSeq Acc Id: NP_058806   ⟸   NM_017110
- Peptide Label: precursor
- UniProtKB: P49192 (UniProtKB/Swiss-Prot),   A6I575 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231905   ⟸   XM_006231843
- Peptide Label: isoform X1
- UniProtKB: P49192 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000023869   ⟸   ENSRNOT00000023869

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P49192-F1-model_v2 AlphaFold P49192 1-129 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13691099
Promoter ID:EPDNEW_R1624
Type:single initiation site
Description:CART prepropeptide
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database,
Experiment Methods:Single-end sequencing.
Rat AssemblyChrPosition (strand)Source
Rnor_6.0230,127,269 - 30,127,329EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2272 AgrOrtholog
BioCyc Gene G2FUF-54681 BioCyc
Ensembl Genes ENSRNOG00000017712 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000023869 ENTREZGENE
  ENSRNOT00000023869.3 UniProtKB/Swiss-Prot
Gene3D-CATH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CART UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CART_C_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:29131 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR16655 UniProtKB/Swiss-Prot
Pfam CART UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cartpt PhenoGen
RatGTEx ENSRNOG00000017712 RatGTEx
Superfamily-SCOP Satiety factor CART (cocaine and amphetamine regulated transcript) UniProtKB/TrEMBL, UniProtKB/Swiss-Prot
TIGR TC234475

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-05-15 Cartpt  CART prepropeptide  Cart  cocaine and amphetamine regulated transcript  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Cart  cocaine and amphetamine regulated transcript      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in mesencephalon of central nervous system 634696
gene_process may have a role in the development of specific regions of the rat brain 634696
gene_regulation expression may be regulated by testosterone 1299848