Mettl3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit) - Rat Genome Database

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Gene: Mettl3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit) Rattus norvegicus
Analyze
Symbol: Mettl3
Name: methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit
RGD ID: 1311750
Description: Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; mRNA m(6)A methyltransferase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC361035; methyltransferase-like 3; N6-adenosine-methyltransferase 70 kDa subunit; N6-adenosine-methyltransferase catalytic subunit
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,476,659 - 27,491,134 (-)NCBIGRCr8
mRatBN7.21525,002,505 - 25,014,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1525,003,172 - 25,014,041 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,775,831 - 27,786,629 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,729,960 - 28,740,788 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,982,911 - 26,993,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,710,299 - 28,721,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,710,300 - 28,721,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,520,500 - 32,531,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,743,959 - 27,754,787 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,759,659 - 27,770,487 (-)NCBI
Celera1525,307,322 - 25,318,150 (-)NCBICelera
Cytogenetic Map15p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-demecolcine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1,4-benzoquinone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4,6-trichlorophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-methylcholine  (ISO)
6-propyl-2-thiouracil  (EXP)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
casticin  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
clofibrate  (ISO)
cobalt atom  (ISO)
colistin  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (ISO)
disodium cromoglycate  (ISO)
doxorubicin  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
gentamycin  (EXP)
hydralazine  (ISO)
isoflurane  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead(0)  (EXP,ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N(6)-methyladenosine  (EXP,ISO)
N-acetyl-L-cysteine  (ISO)
nicotine  (ISO)
ozone  (ISO)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
sevoflurane  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
stattic  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
testosterone  (ISO)
tetrachloromethane  (EXP,ISO)
thallium(I) acetate  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
urethane  (ISO)
valproic acid  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9409616   PMID:12477932   PMID:22575960   PMID:24209618   PMID:24284625   PMID:24316715   PMID:24394384   PMID:24407421   PMID:24981863   PMID:25456834   PMID:25569111   PMID:25719671  
PMID:25799998   PMID:26321680   PMID:26458103   PMID:26593424   PMID:27281194   PMID:27373337   PMID:27602518   PMID:27627798   PMID:28297716   PMID:28637692   PMID:28792938   PMID:28809392  
PMID:28914256   PMID:28965759   PMID:29348140   PMID:29506078   PMID:29507755   PMID:29547716   PMID:30559377   PMID:30696066   PMID:32954854   PMID:33197240   PMID:33741419   PMID:33992834  
PMID:35040253   PMID:35066738   PMID:35470497   PMID:35717715   PMID:35985997   PMID:36269280   PMID:36443649   PMID:36656457   PMID:36747144   PMID:36782035   PMID:37030526   PMID:37041485  
PMID:37105375   PMID:37245538   PMID:37249328   PMID:37455557   PMID:37482304   PMID:37898386   PMID:37964653   PMID:38349604   PMID:38462207   PMID:39075530  


Genomics

Comparative Map Data
Mettl3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81527,476,659 - 27,491,134 (-)NCBIGRCr8
mRatBN7.21525,002,505 - 25,014,097 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1525,003,172 - 25,014,041 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1527,775,831 - 27,786,629 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01528,729,960 - 28,740,788 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01526,982,911 - 26,993,739 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01528,710,299 - 28,721,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1528,710,300 - 28,721,127 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01532,520,500 - 32,531,328 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41527,743,959 - 27,754,787 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11527,759,659 - 27,770,487 (-)NCBI
Celera1525,307,322 - 25,318,150 (-)NCBICelera
Cytogenetic Map15p14NCBI
METTL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381421,498,138 - 21,511,340 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1421,498,133 - 21,511,342 (-)EnsemblGRCh38hg38GRCh38
GRCh371421,966,282 - 21,979,482 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361421,036,122 - 21,049,297 (-)NCBINCBI36Build 36hg18NCBI36
Build 341421,036,128 - 21,049,291NCBI
Celera141,829,623 - 1,842,799 (-)NCBICelera
Cytogenetic Map14q11.2NCBI
HuRef142,084,139 - 2,097,311 (-)NCBIHuRef
CHM1_11421,967,747 - 21,980,923 (-)NCBICHM1_1
T2T-CHM13v2.01415,695,502 - 15,708,704 (-)NCBIT2T-CHM13v2.0
Mettl3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391452,532,298 - 52,548,555 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1452,532,298 - 52,542,585 (-)EnsemblGRCm39 Ensembl
GRCm381452,294,841 - 52,308,741 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1452,294,841 - 52,305,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv371452,914,516 - 52,924,799 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361451,216,792 - 51,227,075 (-)NCBIMGSCv36mm8
Celera1449,276,812 - 49,287,103 (-)NCBICelera
Cytogenetic Map14C2NCBI
cM Map1426.88NCBI
Mettl3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555502,211,270 - 2,227,715 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555502,211,270 - 2,227,715 (-)NCBIChiLan1.0ChiLan1.0
METTL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21522,953,632 - 22,968,331 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11422,170,121 - 22,184,812 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0142,315,868 - 2,329,460 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11420,392,665 - 20,405,906 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1420,392,665 - 20,405,906 (-)Ensemblpanpan1.1panPan2
METTL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11518,528,755 - 18,546,303 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1518,528,772 - 18,546,531 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1519,013,198 - 19,030,699 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01518,787,670 - 18,805,206 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1518,787,058 - 18,805,159 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11518,469,711 - 18,487,143 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01518,525,791 - 18,543,324 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01518,654,667 - 18,672,174 (-)NCBIUU_Cfam_GSD_1.0
Mettl3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864032,737,455 - 32,751,969 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936880644,079 - 661,544 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936880646,835 - 661,312 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
METTL3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl777,662,058 - 77,695,934 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1777,661,945 - 77,679,459 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2783,003,445 - 83,020,958 (+)NCBISscrofa10.2Sscrofa10.2susScr3
METTL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12921,967,309 - 21,981,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2921,963,982 - 21,981,579 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605924,449,037 - 24,463,081 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mettl3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248257,513,481 - 7,527,695 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248257,513,481 - 7,527,716 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Mettl3
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:156
Count of miRNA genes:133
Interacting mature miRNAs:138
Transcripts:ENSRNOT00000017720
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631273Lecl2Lens clarity QTL 20.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)151059608955596089Rat
2300167Bmd63Bone mineral density QTL 635.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1331729Rf42Renal function QTL 423.071kidney blood vessel physiology trait (VT:0100012)absolute change in renal blood flow rate (CMO:0001168)151736289773690657Rat
1641887Alcrsp14Alcohol response QTL 14response to alcohol trait (VT:0010489)brain neurotensin receptor 1 density (CMO:0002068)15142356671Rat
731170Pur3Proteinuria QTL 32.30.0005urine protein amount (VT:0005160)urine protein excretion rate (CMO:0000759)15141686771Rat
738017Hcas7Hepatocarcinoma susceptibility QTL 72.91liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)15226636846921453Rat
10054130Srcrt8Stress Responsive Cort QTL 82.180.0085blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)152211793367117933Rat
2300173Bmd62Bone mineral density QTL 6212.80.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)151111114256111142Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)152280624098288169Rat
9589149Insul29Insulin level QTL 299.060.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)15134723002Rat
2324620Coatc3Coat color QTL 3coat/hair pigmentation trait (VT:0010463)pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)151985656646187442Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)152280624098288169Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151672552880672115Rat
10401805Kidm51Kidney mass QTL 51kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1530632945306329Rat
1582251Gluco24Glucose level QTL 243.20.0008blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)15553075650530756Rat
1354657Despr13Despair related QTL 130.0022locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)15129912054Rat
2317750Glom26Glomerulus QTL 264.3urine protein amount (VT:0005160)urine protein level (CMO:0000591)151249614165205939Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)15155302115Rat
631550Bw7Body weight QTL 73.6body mass (VT:0001259)body weight (CMO:0000012)151985656634924750Rat
8552920Pigfal8Plasma insulin-like growth factor 1 level QTL 83blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)15134723002Rat
2293688Bss29Bone structure and strength QTL 295.310.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)151111114256111142Rat
5685002Bss103Bone structure and strength QTL 1032.8tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)151448116528469888Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)152280624098288169Rat
8694361Abfw6Abdominal fat weight QTL 610.20.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)15134723002Rat

Markers in Region
D15Got203  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21525,014,800 - 25,015,016 (+)MAPPERmRatBN7.2
Rnor_6.01528,721,928 - 28,722,143NCBIRnor6.0
Rnor_5.01532,532,129 - 32,532,344UniSTSRnor5.0
RGSC_v3.41527,755,588 - 27,755,803UniSTSRGSC3.4
Celera1525,318,951 - 25,319,166UniSTS
Cytogenetic Map15p14UniSTS
RH133738  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21525,003,212 - 25,003,362 (+)MAPPERmRatBN7.2
Rnor_6.01528,710,340 - 28,710,489NCBIRnor6.0
Rnor_5.01532,520,541 - 32,520,690UniSTSRnor5.0
RGSC_v3.41527,744,000 - 27,744,149UniSTSRGSC3.4
Celera1525,307,363 - 25,307,512UniSTS
Cytogenetic Map15p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000017720   ⟹   ENSRNOP00000017720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1525,003,172 - 25,014,041 (-)Ensembl
Rnor_6.0 Ensembl1528,710,300 - 28,721,127 (-)Ensembl
RefSeq Acc Id: NM_001024794   ⟹   NP_001019965
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,476,659 - 27,487,487 (-)NCBI
mRatBN7.21525,003,172 - 25,014,000 (-)NCBI
Rnor_6.01528,710,299 - 28,721,127 (-)NCBI
Rnor_5.01532,520,500 - 32,531,328 (-)NCBI
RGSC_v3.41527,743,959 - 27,754,787 (-)RGD
Celera1525,307,322 - 25,318,150 (-)RGD
Sequence:
RefSeq Acc Id: XM_008770555   ⟹   XP_008768777
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,476,659 - 27,491,134 (-)NCBI
mRatBN7.21525,002,505 - 25,014,097 (-)NCBI
Rnor_6.01528,710,428 - 28,721,491 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039093481   ⟹   XP_038949409
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81527,476,659 - 27,482,376 (-)NCBI
mRatBN7.21525,003,172 - 25,014,054 (-)NCBI
Protein Sequences
Protein RefSeqs NP_001019965 (Get FASTA)   NCBI Sequence Viewer  
  XP_008768777 (Get FASTA)   NCBI Sequence Viewer  
  XP_038949409 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH97400 (Get FASTA)   NCBI Sequence Viewer  
  EDL88478 (Get FASTA)   NCBI Sequence Viewer  
  EDL88479 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000017720.5
RefSeq Acc Id: NP_001019965   ⟸   NM_001024794
- UniProtKB: Q4V8G6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008768777   ⟸   XM_008770555
- Peptide Label: isoform X1
- UniProtKB: F7FFC6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000017720   ⟸   ENSRNOT00000017720
RefSeq Acc Id: XP_038949409   ⟸   XM_039093481
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q4V8G6-F1-model_v2 AlphaFold Q4V8G6 1-580 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699640
Promoter ID:EPDNEW_R10164
Type:multiple initiation site
Name:Mettl3_1
Description:methyltransferase-like 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01528,721,173 - 28,721,233EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1311750 AgrOrtholog
BioCyc Gene G2FUF-13974 BioCyc
Ensembl Genes ENSRNOG00000013111 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000017720.8 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.150 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7453630 IMAGE-MGC_LOAD
InterPro MT-A70 UniProtKB/TrEMBL
  MT-A70 UniProtKB/TrEMBL
  SAM-dependent_MTases-like UniProtKB/TrEMBL
KEGG Report rno:361035 UniProtKB/TrEMBL
MGC_CLONE MGC:114445 IMAGE-MGC_LOAD
NCBI Gene 361035 ENTREZGENE
PANTHER N6-ADENOSINE-METHYLTRANSFERASE UniProtKB/TrEMBL
  N6-ADENOSINE-METHYLTRANSFERASE CATALYTIC SUBUNIT UniProtKB/TrEMBL
Pfam MT-A70 UniProtKB/TrEMBL
PhenoGen Mettl3 PhenoGen
PROSITE MT_A70 UniProtKB/TrEMBL
  SAM_MT62 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000013111 RatGTEx
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A6KEH4_RAT UniProtKB/TrEMBL
  F7FFC6 ENTREZGENE, UniProtKB/TrEMBL
  Q4V8G6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-06-17 Mettl3  methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit  Mettl3  methyltransferase-like 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 Mettl3  methyltransferase-like 3  Mettl3_predicted  methyltransferase-like 3 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-12 Mettl3_predicted  methyltransferase-like 3 (predicted)      Symbol and Name status set to approved 70820 APPROVED