Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) - Rat Genome Database

Send us a Message



 Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap)  (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Pin1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) Rattus norvegicus
Analyze
Symbol: Pin1
Name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
RGD ID: 1310299
Description: Predicted to enable several functions, including GTPase activating protein binding activity; beta-catenin binding activity; and protein phosphorylated amino acid binding activity. Involved in positive regulation of cell growth involved in cardiac muscle cell development; positive regulation of protein modification process; and regulation of neuron apoptotic process. Predicted to be located in several cellular components, including ciliary basal body; midbody; and nucleoplasm. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic cytosol. Used to study asthma and secondary hyperparathyroidism. Orthologous to human PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1); PARTICIPATES IN altered p53 signaling pathway; p53 signaling pathway; platelet-derived growth factor signaling pathway; INTERACTS WITH 1,3-dinitrobenzene; 2,6-dinitrotoluene; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC298696; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,189,408 - 19,200,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,189,373 - 19,200,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,209,724 - 23,221,104 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0821,507,563 - 21,518,943 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0819,419,155 - 19,430,528 (+)NCBIRnor_WKY
Rnor_6.0821,669,236 - 21,680,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,669,236 - 21,680,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,725,297 - 21,736,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,669,537 - 19,681,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,668,944 - 19,681,740 (+)NCBI
Celera820,584,713 - 20,596,088 (+)NCBICelera
Cytogenetic Map8q13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
microtubule polymerization  (ISO)
negative regulation of amyloid-beta formation  (ISO)
negative regulation of cell motility  (ISO)
negative regulation of ERK1 and ERK2 cascade  (ISO)
negative regulation of neuron apoptotic process  (IMP)
negative regulation of protein binding  (ISO)
negative regulation of protein catabolic process  (ISO)
negative regulation of transforming growth factor beta receptor signaling pathway  (ISO)
neuron differentiation  (ISO)
positive regulation of canonical Wnt signaling pathway  (ISO)
positive regulation of cell growth involved in cardiac muscle cell development  (IMP)
positive regulation of GTPase activity  (ISO)
positive regulation of neuron apoptotic process  (IMP)
positive regulation of protein binding  (ISO)
positive regulation of protein dephosphorylation  (IMP)
positive regulation of protein phosphorylation  (IMP,ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of ubiquitin-protein transferase activity  (ISO)
protein peptidyl-prolyl isomerization  (ISO)
protein stabilization  (ISO)
regulation of cell population proliferation  (ISO)
regulation of cytokinesis  (ISO)
regulation of gene expression  (ISO)
regulation of pathway-restricted SMAD protein phosphorylation  (ISO)
regulation of protein localization to nucleus  (ISO)
regulation of protein phosphorylation  (ISO)
regulation of protein stability  (ISO)
regulation protein catabolic process at postsynapse  (ISO)
response to hypoxia  (ISO)
synapse organization  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Pin1 inhibition activates cyclin D and produces neurodegenerative pathology. Atabay KD and Karabay A, J Neurochem. 2012 Feb;120(3):430-9. doi: 10.1111/j.1471-4159.2011.07259.x. Epub 2011 May 5.
2. Pin1 mediates neural-specific activation of the mitochondrial apoptotic machinery. Becker EB and Bonni A, Neuron. 2006 Mar 2;49(5):655-62.
3. Transcriptional regulation by p53. Beckerman R and Prives C, Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a000935. doi: 10.1101/cshperspect.a000935. Epub 2010 Apr 28.
4. Nerve growth factor stimulates interaction of Cayman ataxia protein BNIP-H/Caytaxin with peptidyl-prolyl isomerase Pin1 in differentiating neurons. Buschdorf JP, etal., PLoS One. 2008 Jul 16;3(7):e2686. doi: 10.1371/journal.pone.0002686.
5. Pin1 deficiency causes endothelial dysfunction and hypertension. Chiasson VL, etal., Hypertension. 2011 Sep;58(3):431-8. doi: 10.1161/HYPERTENSIONAHA.111.172338. Epub 2011 Aug 1.
6. Pin1 modulates the type 1 immune response. Esnault S, etal., PLoS One. 2007 Feb 21;2(2):e226.
7. Mutant p53: one name, many proteins. Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
8. The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease. Galas MC, etal., J Biol Chem. 2006 Jul 14;281(28):19296-304. Epub 2006 May 3.
9. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
10. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
11. Pin1 allows for differential Tau dephosphorylation in neuronal cells. Hamdane M, etal., Mol Cell Neurosci. 2006 May-Jun;32(1-2):155-60. doi: 10.1016/j.mcn.2006.03.006. Epub 2006 May 11.
12. Role of Pin1 in neointima formation: down-regulation of Nrf2-dependent heme oxygenase-1 expression by Pin1. Kim SE, etal., Free Radic Biol Med. 2010 Jun 15;48(12):1644-53. doi: 10.1016/j.freeradbiomed.2010.03.013. Epub 2010 Mar 20.
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. The peptidyl-prolyl isomerase Pin1 determines parathyroid hormone mRNA levels and stability in rat models of secondary hyperparathyroidism. Nechama M, etal., J Clin Invest. 2009 Oct;119(10):3102-14. doi: 10.1172/JCI39522. Epub 2009 Sep 21.
15. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
16. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
17. Regulation of estrogen receptor alpha N-terminus conformation and function by peptidyl prolyl isomerase Pin1. Rajbhandari P, etal., Mol Cell Biol. 2012 Jan;32(2):445-57. doi: 10.1128/MCB.06073-11. Epub 2011 Nov 7.
18. GOA pipeline RGD automated data pipeline
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. Peptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteins. Rudrabhatla P, etal., J Neurosci. 2009 Nov 25;29(47):14869-80. doi: 10.1523/JNEUROSCI.4469-09.2009.
21. Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis. Shen ZJ, etal., J Clin Invest. 2008 Feb;118(2):479-90. doi: 10.1172/JCI32789.
22. Regulation of cardiac hypertrophic signaling by prolyl isomerase Pin1. Toko H, etal., Circ Res. 2013 Apr 26;112(9):1244-52. doi: 10.1161/CIRCRESAHA.113.301084. Epub 2013 Mar 13.
Additional References at PubMed
PMID:10037602   PMID:11533658   PMID:12477932   PMID:12810604   PMID:16554819   PMID:17548053   PMID:17626162   PMID:18635547   PMID:19122240   PMID:19638580   PMID:20179103   PMID:20956805  
PMID:22645310   PMID:23362255   PMID:23469846   PMID:24478626   PMID:24657892   PMID:24964035   PMID:25576397   PMID:26996940   PMID:28458925   PMID:29286102   PMID:34373763   PMID:35058248  
PMID:35227974   PMID:35416857  


Genomics

Comparative Map Data
Pin1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,189,408 - 19,200,785 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,189,373 - 19,200,785 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,209,724 - 23,221,104 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0821,507,563 - 21,518,943 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0819,419,155 - 19,430,528 (+)NCBIRnor_WKY
Rnor_6.0821,669,236 - 21,680,615 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,669,236 - 21,680,615 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,725,297 - 21,736,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,669,537 - 19,681,741 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1819,668,944 - 19,681,740 (+)NCBI
Celera820,584,713 - 20,596,088 (+)NCBICelera
Cytogenetic Map8q13NCBI
PIN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,835,318 - 9,849,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl199,835,257 - 9,849,689 (+)EnsemblGRCh38hg38GRCh38
GRCh37199,945,994 - 9,960,365 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,806,999 - 9,821,358 (+)NCBINCBI36Build 36hg18NCBI36
Build 34199,806,998 - 9,821,358NCBI
Celera199,841,421 - 9,855,782 (+)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef199,526,513 - 9,540,997 (+)NCBIHuRef
CHM1_1199,945,595 - 9,960,077 (+)NCBICHM1_1
T2T-CHM13v2.0199,961,482 - 9,975,854 (+)NCBIT2T-CHM13v2.0
Pin1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,563,335 - 20,575,008 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl920,563,391 - 20,577,880 (+)EnsemblGRCm39 Ensembl
GRCm38920,652,118 - 20,663,712 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,652,095 - 20,666,584 (+)EnsemblGRCm38mm10GRCm38
MGSCv37920,456,574 - 20,471,028 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,402,532 - 20,416,986 (+)NCBIMGSCv36mm8
Celera917,922,575 - 17,937,026 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.6NCBI
Pin1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,250,453 - 1,266,235 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,250,557 - 1,261,617 (+)NCBIChiLan1.0ChiLan1.0
PIN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan11913,756,211 - 13,770,837 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,389,829 - 9,404,099 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,053,733 - 10,067,343 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,053,254 - 10,066,853 (+)Ensemblpanpan1.1panPan2
PIN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12051,156,887 - 51,168,131 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2051,157,121 - 51,168,136 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2051,020,467 - 51,031,712 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,678,053 - 51,689,301 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,678,052 - 51,689,306 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,885,803 - 50,897,042 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02051,310,556 - 51,321,796 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,551,926 - 51,563,171 (-)NCBIUU_Cfam_GSD_1.0
Pin1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118210,033,412 - 210,045,166 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659309,506 - 321,334 (+)EnsemblSpeTri2.0
SpeTri2.0NW_004936659309,530 - 321,294 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,715,880 - 68,729,870 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,715,898 - 68,729,471 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2268,943,628 - 68,957,203 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PIN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.168,920,860 - 8,935,943 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl68,920,785 - 8,936,033 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607411,165,736 - 11,180,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pin1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,121,329 - 2,131,645 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,121,262 - 2,131,645 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Pin1
23 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:50
Interacting mature miRNAs:64
Transcripts:ENSRNOT00000027818
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
9590084Insglur5Insulin/glucose ratio QTL 518.540.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)8124597739Rat
2317882Alcrsp24Alcohol response QTL 243.20.05response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)8125902202Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)8209764047097640Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)8209764047097640Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)8209764047097640Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)8209764047097640Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)8470581049705810Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)8470581049705810Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)8470581049705810Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)8767057852670578Rat
1354595Despr4Despair related QTL 42.160.0036locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)8768895552688955Rat
1354627Despr14Despair related QTL 140.0056locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)8768895552688955Rat
1581557Eae16Experimental allergic encephalomyelitis QTL 163.8nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)88462195110921472Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)8873663553736635Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)8873663553736635Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)8971222053356647Rat
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)8971246341866876Rat
631650Stl6Serum triglyceride level QTL 640.0019blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)810378157112202585Rat
1558646Swd5Spike wave discharge measurement QTL 53.450.00036brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)81490675159906751Rat
61373Mcs4Mammary carcinoma susceptibility QTL 41.1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)81629044461290444Rat
631271Lecl1Lens clarity QTL 10.001lens clarity trait (VT:0001304)age of onset/diagnosis of cataract (CMO:0001584)81898416884531599Rat

Markers in Region
RH134222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,187,419 - 19,187,607 (+)MAPPERmRatBN7.2
Rnor_6.0821,667,248 - 21,667,435NCBIRnor6.0
Rnor_5.0821,723,309 - 21,723,496UniSTSRnor5.0
RGSC_v3.4819,667,549 - 19,667,736UniSTSRGSC3.4
Celera820,582,725 - 20,582,912UniSTS
Cytogenetic Map8q13UniSTS
RH134127  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21629,333,863 - 29,334,078 (+)MAPPERmRatBN7.2
mRatBN7.2819,200,556 - 19,200,775 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,387 - 21,680,605NCBIRnor6.0
Rnor_6.01632,656,297 - 32,656,511NCBIRnor6.0
Rnor_5.01632,490,170 - 32,490,384UniSTSRnor5.0
Rnor_5.0821,736,448 - 21,736,666UniSTSRnor5.0
RGSC_v3.41632,656,876 - 32,657,090UniSTSRGSC3.4
RGSC_v3.4819,681,513 - 19,681,731UniSTSRGSC3.4
Celera820,595,860 - 20,596,078UniSTS
Celera1629,327,779 - 29,327,993UniSTS
Cytogenetic Map16p12UniSTS
Cytogenetic Map8q13UniSTS
RH144258  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,984 - 19,201,192 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,815 - 21,681,022NCBIRnor6.0
Rnor_5.0821,736,876 - 21,737,083UniSTSRnor5.0
RGSC_v3.4819,681,941 - 19,682,148UniSTSRGSC3.4
Celera820,596,288 - 20,596,495UniSTS
Cytogenetic Map8q13UniSTS
AA962972  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,533 - 19,200,714 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,364 - 21,680,544NCBIRnor6.0
Rnor_5.0821,736,425 - 21,736,605UniSTSRnor5.0
RGSC_v3.4819,681,490 - 19,681,670UniSTSRGSC3.4
Celera820,595,837 - 20,596,017UniSTS
Cytogenetic Map8q13UniSTS
BI273895  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,345 - 19,200,555 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,176 - 21,680,385NCBIRnor6.0
Rnor_5.0821,736,237 - 21,736,446UniSTSRnor5.0
RGSC_v3.4819,681,302 - 19,681,511UniSTSRGSC3.4
Celera820,595,649 - 20,595,858UniSTS
Cytogenetic Map8q13UniSTS
RH125187  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2819,200,594 - 19,200,716 (+)MAPPERmRatBN7.2
Rnor_6.0821,680,425 - 21,680,546NCBIRnor6.0
Rnor_5.0821,736,486 - 21,736,607UniSTSRnor5.0
RGSC_v3.4819,681,551 - 19,681,672UniSTSRGSC3.4
Celera820,595,898 - 20,596,019UniSTS
Cytogenetic Map8q13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000027818   ⟹   ENSRNOP00000027819
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,192,419 - 19,200,785 (+)Ensembl
Rnor_6.0 Ensembl821,669,236 - 21,680,615 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000097790   ⟹   ENSRNOP00000090877
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,189,819 - 19,200,785 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000105043   ⟹   ENSRNOP00000094395
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,192,288 - 19,200,784 (+)Ensembl
RefSeq Acc Id: ENSRNOT00000117909   ⟹   ENSRNOP00000090826
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl819,189,373 - 19,193,895 (+)Ensembl
RefSeq Acc Id: NM_001106701   ⟹   NP_001100171
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2819,189,408 - 19,200,785 (+)NCBI
Rnor_6.0821,669,236 - 21,680,615 (+)NCBI
Rnor_5.0821,725,297 - 21,736,676 (+)NCBI
RGSC_v3.4819,669,537 - 19,681,741 (+)RGD
Celera820,584,713 - 20,596,088 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001100171 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAI58868 (Get FASTA)   NCBI Sequence Viewer  
  EDL78356 (Get FASTA)   NCBI Sequence Viewer  
  EDL78357 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: NP_001100171   ⟸   NM_001106701
- UniProtKB: B0BNL2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000027819   ⟸   ENSRNOT00000027818
RefSeq Acc Id: ENSRNOP00000094395   ⟸   ENSRNOT00000105043
RefSeq Acc Id: ENSRNOP00000090877   ⟸   ENSRNOT00000097790
RefSeq Acc Id: ENSRNOP00000090826   ⟸   ENSRNOT00000117909
Protein Domains
PpiC   WW

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-B0BNL2-F1-model_v2 AlphaFold B0BNL2 1-165 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695761
Promoter ID:EPDNEW_R6286
Type:multiple initiation site
Name:Pin1_1
Description:peptidylprolyl cis/trans isomerase, NIMA-interacting 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0821,669,220 - 21,669,280EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1310299 AgrOrtholog
BioCyc Gene G2FUF-31461 BioCyc
Ensembl Genes ENSRNOG00000020474 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSRNOP00000027819.5 UniProtKB/TrEMBL
  ENSRNOP00000090826.1 UniProtKB/TrEMBL
  ENSRNOP00000090877 ENTREZGENE
  ENSRNOP00000090877.1 UniProtKB/TrEMBL
  ENSRNOP00000094395.1 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000027818.6 UniProtKB/TrEMBL
  ENSRNOT00000097790 ENTREZGENE
  ENSRNOT00000097790.1 UniProtKB/TrEMBL
  ENSRNOT00000105043.1 UniProtKB/TrEMBL
  ENSRNOT00000117909.1 UniProtKB/TrEMBL
Gene3D-CATH 2.20.70.10 UniProtKB/TrEMBL
  3.10.50.40 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5623763 IMAGE-MGC_LOAD
InterPro PPIase_dom_sf UniProtKB/TrEMBL
  PPIase_PpiC UniProtKB/TrEMBL
  PPIase_PpiC_CS UniProtKB/TrEMBL
  WW_dom UniProtKB/TrEMBL
  WW_dom_sf UniProtKB/TrEMBL
KEGG Report rno:298696 UniProtKB/TrEMBL
MGC_CLONE MGC:188496 IMAGE-MGC_LOAD
NCBI Gene 298696 ENTREZGENE
PANTHER PEPTIDYL-PROLYL CIS-TRANS ISOMERASE UniProtKB/TrEMBL
  PEPTIDYL-PROLYL CIS-TRANS ISOMERASE-RELATED UniProtKB/TrEMBL
Pfam PF00397 UniProtKB/TrEMBL
  Rotamase UniProtKB/TrEMBL
PhenoGen Pin1 PhenoGen
PROSITE PPIC_PPIASE_1 UniProtKB/TrEMBL
  PPIC_PPIASE_2 UniProtKB/TrEMBL
  WW_DOMAIN_1 UniProtKB/TrEMBL
  WW_DOMAIN_2 UniProtKB/TrEMBL
SMART SM00456 UniProtKB/TrEMBL
Superfamily-SCOP FKBP-like UniProtKB/TrEMBL
  SSF51045 UniProtKB/TrEMBL
UniProt A0A8I6AB19_RAT UniProtKB/TrEMBL
  A0A8I6AJH7_RAT UniProtKB/TrEMBL
  A0A8I6GJ67_RAT UniProtKB/TrEMBL
  B0BNL2 ENTREZGENE, UniProtKB/TrEMBL
  F7EW79_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-09-09 Pin1  peptidylprolyl cis/trans isomerase, NIMA-interacting 1  Pin1  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Pin1  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1   Pin1_predicted  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Pin1_predicted  protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1 (predicted)      Symbol and Name status set to approved 70820 APPROVED