Gene: Ube2i (ubiquitin-conjugating enzyme E2I) Rattus norvegicus
Analyze
Symbol:
Ube2i
Name:
ubiquitin-conjugating enzyme E2I
Description:
Exhibits bHLH transcription factor binding activity; protein C-terminus binding activity; and ubiquitin-like protein transferase activity. Involved in cellular protein metabolic process; positive regulation of DNA-binding transcription factor activity; and regulation of signal transduction. Localizes to dendrite; nucleus; and synapse. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; sumoylation pathway; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; ammonium chloride.
Type:
protein-coding
RefSeq Status:
PROVISIONAL
Also known as:
MGC105476; RING-type E3 SUMO transferase UBC9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; UbcE2A; ubiquitin carrier protein 9; ubiquitin carrier protein I; Ubiquitin conjugating enzyme E2I; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-protein ligase I
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
UBE2I (ubiquitin conjugating enzyme E2 I) HGNC
Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):
Ube2i (ubiquitin-conjugating enzyme E2I) HGNC
Treefam, NCBI, OMA, HomoloGene, Inparanoid, Panther, PhylomeDB, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Ube2i (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):
UBE2I (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
UBE2I (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Ube2i (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
UBE2I (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Chlorocebus sabaeus (African green monkey):
UBE2I (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):
Ube2i (ubiquitin conjugating enzyme E2 I) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Alliance orthologs 3
Homo sapiens (human):
UBE2I (ubiquitin conjugating enzyme E2 I)
Alliance
DIOPT (PANTHER|HGNC|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
ube2ia (ubiquitin-conjugating enzyme E2Ia)
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Danio rerio (zebrafish):
ube2ib (ubiquitin-conjugating enzyme E2Ib)
Alliance
DIOPT (OMA|PhylomeDB|OrthoFinder|Hieranoid|TreeFam)
Caenorhabditis elegans (roundworm):
F29B9.5
Alliance
DIOPT (PANTHER|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid)
Saccharomyces cerevisiae (baker's yeast):
UBC9
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Drosophila melanogaster (fruit fly):
lwr
Alliance
DIOPT (PANTHER|Ensembl Compara|OMA|PhylomeDB|OrthoFinder|InParanoid|OrthoInspector|Hieranoid|TreeFam)
Latest Assembly:
Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl Rnor_6.0 10 14,618,615 - 14,639,274 (-) NCBI Rnor6.0 Rnor_6.0 rn6 Rnor6.0 Rnor_6.0 Ensembl 10 14,620,531 - 14,630,151 (-) Ensembl Rnor6.0 rn6 Rnor6.0 Rnor_5.0 10 14,436,200 - 14,456,889 (-) NCBI Rnor5.0 Rnor_5.0 rn5 Rnor5.0 RGSC_v3.4 10 14,509,948 - 14,524,551 (-) NCBI RGSC3.4 rn4 RGSC3.4 RGSC_v3.1 10 14,509,950 - 14,524,551 (-) NCBI Celera 10 13,951,568 - 13,966,171 (-) NCBI Celera Cytogenetic Map 10 q12 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Imported Annotations - ClinVar
idiopathic generalized epilepsy ISO RGD:734464 8554872 ClinVar Annotator: match by term: Idiopathic generalized epilepsy ClinVar PMID:28492532 tuberous sclerosis 2 ISO RGD:734464 8554872 ClinVar Annotator: match by term: Tuberous sclerosis 2 ClinVar PMID:16114042 more ... tuberous sclerosis 2 ISO RGD:734464 8554872 ClinVar Annotator: match by term: Tuberous sclerosis 2 ClinVar PMID:28492532 , PMID:29932062
Imported Annotations - CTD
Animal Mammary Neoplasms ISO RGD:734464 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 carcinoma ISO RGD:734464 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942 Mammary Neoplasms, Experimental ISO RGD:734464 11554173 CTD Direct Evidence: marker/mechanism CTD PMID:16316942
(+)-pilocarpine increases expression EXP 6480464 Pilocarpine results in increased expression of UBE2I mRNA CTD PMID:17971868 (S)-nicotine decreases expression ISO RGD:734464 6480464 Nicotine results in decreased expression of UBE2I mRNA CTD PMID:18247414 1,2-dichloroethane increases expression ISO RGD:11469 6480464 ethylene dichloride results in increased expression of UBE2I mRNA CTD PMID:28960355 17beta-estradiol multiple interactions ISO RGD:734464 6480464 Estradiol promotes the reaction [UBE2I protein binds to ESR1 protein] CTD PMID:15666801 1H-pyrazole increases expression ISO RGD:11469 6480464 pyrazole results in increased expression of UBE2I mRNA CTD PMID:17945193 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO RGD:11469 6480464 UBE2I promotes the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:23997114 2,4-dinitrotoluene affects expression EXP 6480464 2, 4-dinitrotoluene affects the expression of UBE2I mRNA CTD PMID:21346803 2-naphthylamine increases expression ISO RGD:734464 6480464 2-Naphthylamine results in increased expression of UBE2I mRNA CTD PMID:18247414 4-hydroxynon-2-enal increases expression ISO RGD:11469 6480464 4-hydroxy-2-nonenal results in increased expression of UBE2I mRNA CTD PMID:19191707 acrylamide decreases expression ISO RGD:11469 6480464 Acrylamide results in decreased expression of UBE2I mRNA CTD PMID:21319176 aflatoxin B1 increases expression ISO RGD:734464 6480464 Aflatoxin B1 results in increased expression of UBE2I mRNA CTD PMID:27153756 all-trans-retinoic acid increases expression ISO RGD:734464 6480464 Tretinoin results in increased expression of UBE2I mRNA CTD PMID:23724009 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of UBE2I mRNA CTD PMID:16483693 antirheumatic drug increases expression ISO RGD:734464 6480464 Antirheumatic Agents results in increased expression of UBE2I mRNA CTD PMID:24449571 arsane affects methylation ISO RGD:734464 6480464 Arsenic affects the methylation of UBE2I gene CTD PMID:25304211 arsenic atom affects methylation ISO RGD:734464 6480464 Arsenic affects the methylation of UBE2I gene CTD PMID:25304211 arsenous acid multiple interactions ISO RGD:734464 6480464 [Arsenic Trioxide promotes the reaction [UBE2I protein binds to PML protein]] which results in increased sumoylation of PML protein, Arsenic Trioxide promotes the reaction [UBE2I protein binds to PML protein] CTD PMID:20378816 benzo[a]pyrene increases expression ISO RGD:11469 6480464 Benzo(a)pyrene results in increased expression of UBE2I mRNA CTD PMID:19770486 , PMID:20504355 benzo[a]pyrene decreases expression ISO RGD:734464 6480464 Benzo(a)pyrene results in decreased expression of UBE2I mRNA CTD PMID:18247414 bilirubin IXalpha decreases expression ISO RGD:734464 6480464 Bilirubin results in decreased expression of UBE2I mRNA CTD PMID:20196124 bis(2-ethylhexyl) phthalate increases expression EXP 6480464 Diethylhexyl Phthalate results in increased expression of UBE2I mRNA CTD PMID:21318169 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of UBE2I mRNA CTD PMID:25181051 bisphenol A increases expression ISO RGD:734464 6480464 bisphenol A results in increased expression of UBE2I mRNA CTD PMID:30426790 calcium atom affects expression EXP 6480464 Calcium affects the expression of UBE2I mRNA CTD PMID:15913539 calcium(0) affects expression EXP 6480464 Calcium affects the expression of UBE2I mRNA CTD PMID:15913539 CARBENOXOLONE multiple interactions EXP 6480464 Carbenoxolone inhibits the reaction [Sodium Glutamate results in decreased expression of UBE2I protein] CTD PMID:31077719 carbon nanotube increases expression ISO RGD:11469 6480464 Nanotubes, Carbon analog results in increased expression of UBE2I mRNA, Nanotubes, Carbon results in increased expression of UBE2I mRNA CTD PMID:25554681 chlorpyrifos increases expression ISO RGD:11469 6480464 Chlorpyrifos results in increased expression of UBE2I mRNA CTD PMID:20350560 ciguatoxin CTX1B affects expression ISO RGD:11469 6480464 Ciguatoxins affects the expression of UBE2I mRNA CTD PMID:18353800 clofibrate increases expression EXP 6480464 Clofibrate results in increased expression of UBE2I mRNA CTD PMID:21318169 cocaine increases expression ISO RGD:734464 6480464 Cocaine results in increased expression of UBE2I mRNA CTD PMID:12629581 copper atom multiple interactions ISO RGD:734464 6480464 [Thiosemicarbazones binds to Copper] which results in decreased expression of UBE2I protein CTD PMID:20931265 copper(0) multiple interactions ISO RGD:734464 6480464 [Thiosemicarbazones binds to Copper] which results in decreased expression of UBE2I protein CTD PMID:20931265 D-gluconic acid multiple interactions EXP 6480464 [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of UBE2I mRNA CTD PMID:16556975 deoxycholic acid multiple interactions EXP 6480464 [gluconic acid co-treated with Deoxycholic Acid] results in increased expression of UBE2I mRNA CTD PMID:16556975 dexamethasone multiple interactions ISO RGD:11469 6480464 benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [Dexamethasone promotes the reaction [TSC22D3 protein binds to UBE2I protein]], Dexamethasone promotes the reaction [TSC22D3 protein binds to UBE2I protein] CTD PMID:20671745 diarsenic trioxide multiple interactions ISO RGD:734464 6480464 [Arsenic Trioxide promotes the reaction [UBE2I protein binds to PML protein]] which results in increased sumoylation of PML protein, Arsenic Trioxide promotes the reaction [UBE2I protein binds to PML protein] CTD PMID:20378816 dibutyl phthalate decreases expression ISO RGD:11469 6480464 Dibutyl Phthalate results in decreased expression of UBE2I mRNA CTD PMID:21266533 dorsomorphin multiple interactions ISO RGD:734464 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 doxorubicin increases expression ISO RGD:11469 6480464 Doxorubicin results in increased expression of UBE2I mRNA CTD PMID:25896364 doxorubicin decreases expression ISO RGD:734464 6480464 Doxorubicin results in decreased expression of UBE2I mRNA CTD PMID:29803840 emodin increases expression ISO RGD:11469 6480464 Emodin results in increased expression of UBE2I mRNA CTD PMID:21319176 endosulfan increases expression ISO RGD:734464 6480464 Endosulfan results in increased expression of UBE2I mRNA CTD PMID:30426790 ethanol affects splicing ISO RGD:11469 6480464 Ethanol affects the splicing of UBE2I mRNA CTD PMID:30319688 flavonoids decreases expression EXP 6480464 Flavonoids results in decreased expression of UBE2I mRNA CTD PMID:18035473 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of UBE2I mRNA CTD PMID:22061828 methotrexate decreases expression ISO RGD:734464 6480464 Methotrexate results in decreased expression of UBE2I mRNA CTD PMID:24449571 methylmercury chloride increases expression ISO RGD:11469 6480464 methylmercuric chloride results in increased expression of UBE2I mRNA CTD PMID:20061341 methylmercury chloride increases expression ISO RGD:734464 6480464 methylmercuric chloride results in increased expression of UBE2I mRNA CTD PMID:28001369 monosodium L-glutamate decreases expression EXP 6480464 Sodium Glutamate results in decreased expression of UBE2I protein CTD PMID:31077719 monosodium L-glutamate multiple interactions EXP 6480464 Carbenoxolone inhibits the reaction [Sodium Glutamate results in decreased expression of UBE2I protein] CTD PMID:31077719 nicotine decreases expression ISO RGD:734464 6480464 Nicotine results in decreased expression of UBE2I mRNA CTD PMID:18247414 nimesulide increases expression EXP 6480464 nimesulide results in increased expression of UBE2I mRNA CTD PMID:24136188 paracetamol affects expression ISO RGD:11469 6480464 Acetaminophen affects the expression of UBE2I mRNA CTD PMID:17562736 pentachlorophenol increases expression ISO RGD:11469 6480464 Pentachlorophenol results in increased expression of UBE2I mRNA CTD PMID:23892564 phenobarbital decreases expression ISO RGD:11469 6480464 Phenobarbital results in decreased expression of UBE2I mRNA CTD PMID:23091169 phenylmercury acetate decreases expression ISO RGD:734464 6480464 Phenylmercuric Acetate results in decreased expression of UBE2I mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:734464 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UBE2I mRNA CTD PMID:27188386 phlorizin decreases expression ISO RGD:11469 6480464 Phlorhizin results in decreased expression of UBE2I mRNA CTD PMID:22538082 pirinixic acid multiple interactions ISO RGD:734464 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of UBE2I mRNA CTD PMID:19710929 pirinixic acid increases expression ISO RGD:11469 6480464 pirinixic acid results in increased expression of UBE2I mRNA CTD PMID:23811191 propiconazole decreases expression ISO RGD:11469 6480464 propiconazole results in decreased expression of UBE2I mRNA CTD PMID:21278054 rifampicin multiple interactions EXP 6480464 UBE2I affects the reaction [Rifampin results in increased sumoylation of SNCA protein] CTD PMID:28132806 SB 431542 multiple interactions ISO RGD:734464 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 sodium arsenate increases expression ISO RGD:11469 6480464 sodium arsenate results in increased expression of UBE2I mRNA CTD PMID:21795629 succimer multiple interactions ISO RGD:11469 6480464 [Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of UBE2I mRNA CTD PMID:26378955 sunitinib decreases expression ISO RGD:734464 6480464 Sunitinib results in decreased expression of UBE2I mRNA CTD PMID:31533062 topotecan affects response to substance ISO RGD:734464 6480464 UBE2I protein affects the susceptibility to Topotecan CTD PMID:16217747 trichostatin A decreases expression ISO RGD:734464 6480464 trichostatin A results in decreased expression of UBE2I mRNA CTD PMID:26272509 trichostatin A multiple interactions ISO RGD:734464 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of UBE2I mRNA CTD PMID:27188386 trovafloxacin multiple interactions ISO RGD:11469 6480464 [trovafloxacin co-treated with lipopolysaccharide, E coli O55-B5] results in decreased expression of UBE2I mRNA CTD PMID:18930950 valproic acid increases methylation ISO RGD:734464 6480464 Valproic Acid results in increased methylation of UBE2I gene CTD PMID:29154799 valproic acid increases expression ISO RGD:734464 6480464 Valproic Acid results in increased expression of UBE2I mRNA CTD PMID:23179753 vincristine decreases expression ISO RGD:734464 6480464 Vincristine results in decreased expression of UBE2I mRNA CTD PMID:23649840 vorinostat decreases expression ISO RGD:734464 6480464 vorinostat results in decreased expression of UBE2I protein CTD PMID:20543569 zinc sulfate increases expression ISO RGD:734464 6480464 Zinc Sulfate results in increased expression of UBE2I mRNA CTD PMID:12756304
Biological Process cell division IEA UniProtKB-KW:KW-0132 1600115 GO_REF:0000043 UniProt GO_REF:0000043 chromosome segregation IEA UniProtKB-KW:KW-0159 1600115 GO_REF:0000043 UniProt GO_REF:0000043 negative regulation of transcription by RNA polymerase II ISO RGD:734464 1624291 (PMID:19955185) RGD PMID:19955185 negative regulation of transcription by RNA polymerase II ISO RGD:11469 1624291 (MGI:MGI:3604169, PMID:16127449) RGD MGI:MGI:3604169 , PMID:16127449 negative regulation of transcription, DNA-templated ISO RGD:734464 1624291 (PMID:16631117) RGD PMID:16631117 positive regulation of DNA-binding transcription factor activity IDA 2301354 glucocorticoid receptor, independent of sumoylation activity or presence of a GME RGD positive regulation of I-kappaB kinase/NF-kappaB signaling ISO RGD:11469 1624291 (MGI:MGI:894913, PMID:9223278) RGD MGI:MGI:894913 , PMID:9223278 positive regulation of intracellular steroid hormone receptor signaling pathway IDA 2301354 glucocorticoid receptor, independent of sumoylation activity or presence of a GME RGD positive regulation of SUMO transferase activity ISO RGD:734464 1624291 (PMID:19955185) RGD PMID:19955185 proteasome-mediated ubiquitin-dependent protein catabolic process IMP 730030 RGD protein sumoylation IDA 2301354 RGD protein sumoylation IBA CGD:CAL0000200419 more ... 13792537 PMID:21873635 GO_Central protein sumoylation ISO RGD:734464 1624291 (PMID:15660128), (PMID:19955185), (PMID:21968017), (PMID:26620705) RGD PMID:15660128 more ... protein sumoylation IEA UniPathway:UPA00886 1600115 GO_REF:0000041 UniProt GO_REF:0000041 protein ubiquitination IEA GO:0004842 1600115 GO_REF:0000108 GOC GO_REF:0000108 regulation of signaling receptor activity IDA 2301354 glucocorticoid receptor, independent of sumoylation activity or presence of a GME RGD ubiquitin-dependent protein catabolic process TAS 730030 RGD Cellular Component cytoplasm ISO RGD:734464 1624291 (PMID:9223278) RGD PMID:9223278 dendrite IDA 1642482 RGD fibrillar center IDA 2301351 RGD nuclear body IDA 2301350 RGD nuclear body ISO RGD:11469 1624291 (MGI:MGI:3820475, PMID:18681895) RGD MGI:MGI:3820475 , PMID:18681895 nuclear envelope IDA 9835353 RGD nucleus IDA 730030 RGD nucleus IBA FB:FBgn0010602 more ... 13792537 PMID:21873635 GO_Central nucleus ISO RGD:734464 1624291 (PMID:14752048), (PMID:16631117), (PMID:9223278) RGD PMID:14752048 more ... PML body ISO RGD:734464 1624291 (PMID:9885291) RGD PMID:9885291 sumoylated E2 ligase complex ISO RGD:734464 1624291 (PMID:15660128) RGD PMID:15660128 synapse IDA 1642482 RGD transferase complex ISO RGD:734464 1624291 (PMID:19955185) RGD PMID:19955185 Molecular Function ATP binding IEA UniProtKB-KW:KW-0067 1600115 GO_REF:0000043 UniProt GO_REF:0000043 bHLH transcription factor binding IPI RGD:1351290 730030 RGD enzyme binding ISO RGD:734464 1624291 UniProtKB:P35520 (PMID:17087506) RGD PMID:17087506 HLH domain binding ISO RGD:11469 1624291 UniProtKB:P15923-1 more ... RGD MGI:MGI:1099918 , PMID:9409784 protein binding IPI RGD:1603227 2301354 RGD protein binding ISO RGD:13867512 1624291 UniProtKB:P21530:PRO_0000038063 (PMID:20800867) RGD PMID:20800867 protein binding ISO RGD:734464 1624291 UniProtKB:G2XKQ0 more ... RGD PMID:10871618 more ... protein binding IPI UniProtKB:P42260 1642482 PMID:17486098 IntAct protein binding IPI RGD:1310380 9835353 RGD protein binding ISO RGD:11469 1624291 PR:O08900 more ... RGD MGI:MGI:1926539 more ... protein binding IPI UniProtKB:P63033 8554673 PMID:19498170 UniProt protein binding IPI RGD:736932 2301354 RGD protein binding IPI RGD:1304676 5508208 RGD protein C-terminus binding IPI RGD:2733 1642482 RGD RING-like zinc finger domain binding ISO RGD:734464 1624291 UniProtKB:Q969V5 (PMID:19407830) RGD PMID:19407830 small protein activating enzyme binding ISO RGD:734464 1624291 UniProtKB:Q9UBT2 (PMID:15660128) RGD PMID:15660128 SUMO conjugating enzyme activity ISO RGD:734464 1624291 (PMID:19955185) RGD PMID:19955185 SUMO conjugating enzyme activity IBA PANTHER:PTN000629675 more ... 13792537 PMID:21873635 GO_Central SUMO transferase activity IDA 2301354 RGD SUMO transferase activity ISO RGD:734464 1624291 (PMID:10562557), (PMID:10562558), (PMID:15539951) RGD PMID:10562557 more ... transcription cofactor binding ISO RGD:734464 1624291 UniProtKB:O14776 (PMID:20215116) RGD PMID:20215116 transcription factor binding ISO RGD:734464 1624291 UniProtKB:P58012 (PMID:19744555) RGD PMID:19744555 ubiquitin-protein transferase activity IDA 730030 RGD
Gene-Chemical Interaction Annotations
