Ube2i (ubiquitin-conjugating enzyme E2I) - Rat Genome Database

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Gene: Ube2i (ubiquitin-conjugating enzyme E2I) Rattus norvegicus
Analyze
Symbol: Ube2i
Name: ubiquitin-conjugating enzyme E2I
RGD ID: 3926
Description: Exhibits bHLH transcription factor binding activity; protein C-terminus binding activity; and ubiquitin-like protein transferase activity. Involved in cellular protein metabolic process; positive regulation of DNA-binding transcription factor activity; and regulation of signal transduction. Localizes to dendrite; nucleus; and synapse. Orthologous to human UBE2I (ubiquitin conjugating enzyme E2 I); PARTICIPATES IN altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; sumoylation pathway; INTERACTS WITH (+)-pilocarpine; 2,4-dinitrotoluene; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: MGC105476; RING-type E3 SUMO transferase UBC9; SUMO-conjugating enzyme UBC9; SUMO-protein ligase; UbcE2A; ubiquitin carrier protein 9; ubiquitin carrier protein I; Ubiquitin conjugating enzyme E2I; Ubiquitin conjugating enzyme E2I (homologous to yeast UBC9); ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast); ubiquitin-conjugating enzyme UbcE2A; ubiquitin-protein ligase I
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,277,749 - 14,294,681 (-)NCBI
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01014,618,615 - 14,639,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01014,436,200 - 14,456,889 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,509,948 - 14,524,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,509,950 - 14,524,551 (-)NCBI
Celera1013,951,568 - 13,966,171 (-)NCBICelera
Cytogenetic Map10q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (EXP)
(S)-nicotine  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,4-dinitrotoluene  (EXP)
2-naphthylamine  (ISO)
4-hydroxynon-2-enal  (ISO)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenous acid  (ISO)
benzo[a]pyrene  (ISO)
bilirubin IXalpha  (ISO)
bis(2-ethylhexyl) phthalate  (EXP)
bisphenol A  (EXP,ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
CARBENOXOLONE  (EXP)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
ciguatoxin CTX1B  (ISO)
clofibrate  (EXP)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
D-gluconic acid  (EXP)
deoxycholic acid  (EXP)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dorsomorphin  (ISO)
doxorubicin  (ISO)
emodin  (ISO)
endosulfan  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
folic acid  (ISO)
genistein  (ISO)
gentamycin  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mevinphos  (EXP)
monosodium L-glutamate  (EXP)
nicotine  (ISO)
nimesulide  (EXP)
paracetamol  (ISO)
pentachlorophenol  (ISO)
phenobarbital  (ISO)
phenylmercury acetate  (ISO)
phlorizin  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
rifampicin  (EXP)
SB 431542  (ISO)
sodium arsenate  (ISO)
succimer  (ISO)
sunitinib  (ISO)
topotecan  (ISO)
trichostatin A  (ISO)
trovafloxacin  (ISO)
valproic acid  (ISO)
vincristine  (ISO)
vorinostat  (ISO)
zinc sulfate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Additional References at PubMed
PMID:9223278   PMID:9409784   PMID:9885291   PMID:10562557   PMID:10562558   PMID:12477932   PMID:14739995   PMID:14752048   PMID:15489334   PMID:15539428   PMID:15539951   PMID:15611122  
PMID:15660128   PMID:15802564   PMID:16127449   PMID:16631117   PMID:17087506   PMID:17911097   PMID:18555800   PMID:18681895   PMID:19039338   PMID:19407830   PMID:19744555   PMID:19955185  
PMID:20167237   PMID:20209145   PMID:21518833   PMID:21616059   PMID:21630459   PMID:21968017   PMID:22082260   PMID:22658674   PMID:26620705   PMID:30772377  


Genomics

Candidate Gene Status
Ube2i is a candidate Gene for QTL Bmd4
Comparative Map Data
Ube2i
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21014,277,749 - 14,294,681 (-)NCBI
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01014,618,615 - 14,639,274 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01014,436,200 - 14,456,889 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41014,509,948 - 14,524,551 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11014,509,950 - 14,524,551 (-)NCBI
Celera1013,951,568 - 13,966,171 (-)NCBICelera
Cytogenetic Map10q12NCBI
UBE2I
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl161,308,880 - 1,327,018 (+)EnsemblGRCh38hg38GRCh38
GRCh38161,309,152 - 1,327,017 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37161,359,153 - 1,377,018 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36161,299,181 - 1,315,391 (+)NCBINCBI36hg18NCBI36
Build 34161,299,180 - 1,315,391NCBI
Celera161,573,488 - 1,589,693 (+)NCBI
Cytogenetic Map16p13.3NCBI
HuRef161,287,961 - 1,305,367 (+)NCBIHuRef
CHM1_1161,359,074 - 1,376,964 (+)NCBICHM1_1
Ube2i
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391725,479,484 - 25,494,965 (-)NCBIGRCm39mm39
GRCm39 Ensembl1725,480,890 - 25,493,596 (-)Ensembl
GRCm381725,260,510 - 25,275,799 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1725,261,916 - 25,274,622 (-)EnsemblGRCm38mm10GRCm38
MGSCv371725,397,456 - 25,411,255 (-)NCBIGRCm37mm9NCBIm37
MGSCv361724,988,111 - 25,001,891 (-)NCBImm8
Celera1725,787,805 - 25,801,616 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
Ube2i
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544215,901,980 - 15,913,037 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495544215,902,026 - 15,913,033 (-)NCBIChiLan1.0ChiLan1.0
UBE2I
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1161,365,291 - 1,382,575 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl161,367,288 - 1,382,575 (+)Ensemblpanpan1.1panPan2
UBE2I
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1639,440,123 - 39,453,688 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl639,440,314 - 39,817,588 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha640,707,767 - 40,719,921 (-)NCBI
ROS_Cfam_1.0639,786,145 - 39,798,312 (-)NCBI
UMICH_Zoey_3.1639,462,778 - 39,474,925 (-)NCBI
UNSW_CanFamBas_1.0639,435,400 - 39,447,553 (-)NCBI
UU_Cfam_GSD_1.0639,913,736 - 39,925,904 (-)NCBI
Ube2i
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024409344104,133,975 - 104,147,758 (+)NCBI
SpeTri2.0NW_0049366942,561,701 - 2,571,284 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
UBE2I
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1340,556,556 - 40,586,382 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2341,899,856 - 41,966,997 (+)NCBISscrofa10.2Sscrofa10.2susScr3
UBE2I
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.151,203,513 - 1,216,662 (+)NCBI
Ube2i
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249132,025,241 - 2,041,394 (+)NCBI

Position Markers
RH127604  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21069,702,700 - 69,702,904 (+)MAPPER
mRatBN7.21014,279,208 - 14,279,412 (-)MAPPER
mRatBN7.21014,279,208 - 14,279,412 (+)MAPPER
mRatBN7.21069,702,700 - 69,702,904 (-)MAPPER
Rnor_6.01072,148,529 - 72,148,732NCBIRnor6.0
Rnor_6.01014,620,070 - 14,620,273NCBIRnor6.0
Rnor_5.01014,437,660 - 14,437,863UniSTSRnor5.0
Rnor_5.01072,055,388 - 72,055,591UniSTSRnor5.0
RGSC_v3.41014,510,002 - 14,510,205UniSTSRGSC3.4
RGSC_v3.41073,106,012 - 73,106,215UniSTSRGSC3.4
Celera1068,630,602 - 68,630,805UniSTS
Celera1013,951,622 - 13,951,825UniSTS
Cytogenetic Map10q26UniSTS
Cytogenetic Map10q12UniSTS
BE107288  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21014,284,780 - 14,284,934 (+)MAPPER
Rnor_6.01014,625,642 - 14,625,795NCBIRnor6.0
Rnor_5.01014,443,232 - 14,443,385UniSTSRnor5.0
RGSC_v3.41014,515,574 - 14,515,727UniSTSRGSC3.4
Celera1013,957,194 - 13,957,347UniSTS
RH 3.4 Map10170.6UniSTS
Cytogenetic Map10q12UniSTS


QTLs in Region (Rnor_6.0)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7387235Uae41Urinary albumin excretion QTL 415.260.1874urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)10129592136Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135538813Rat
634327Hc4Hypercalciuria QTL 42.4urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)10138594330Rat
7411611Foco17Food consumption QTL 1718.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)10142669970Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)10144902893Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1076442166221621Rat
1576304Schws7Schwannoma susceptibility QTL 70.0115nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)10483563820170031Rat
631828Alc5Alcohol consumption QTL 52.4consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719917555534Rat
737820Alc9Alcohol consumption QTL 92.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)10521719919591669Rat
2313064Bmd71Bone mineral density QTL 710.90.0001tibia mineral mass (VT:1000283)cortical volumetric bone mineral density (CMO:0001730)10546011921524070Rat
2313066Bss63Bone structure and strength QTL 631.40.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)10546011921524070Rat
2313081Bss64Bone structure and strength QTL 641.30.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)10546011921524070Rat
2313095Bss62Bone structure and strength QTL 621.50.0001tibia size trait (VT:0100001)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2313104Bss61Bone structure and strength QTL 610.90.0001tibia area (VT:1000281)tibia midshaft cross-sectional area (CMO:0001717)10546011921524070Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10587753664401490Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10622909575983805Rat
631660Hcar1Hepatocarcinoma resistance QTL 13.40.0001liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)10622928936185929Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10642907599492409Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10752145052521450Rat
2303118Mamtr7Mammary tumor resistance QTL 70.003mammary gland integrity trait (VT:0010552)mammary tumor growth rate (CMO:0000344)109841807108540162Rat
9590310Scort19Serum corticosterone level QTL 196.30.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9590268Scort13Serum corticosterone level QTL 133.260.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)101263951357639513Rat
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101263951357639513Rat

miRNA Target Status

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir199a2rno-miR-199a-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI20965886

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:151
Interacting mature miRNAs:175
Transcripts:ENSRNOT00000024406
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 43 57 41 19 41 8 11 74 35 41 11 8
Low
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000024406   ⟹   ENSRNOP00000024406
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1014,620,531 - 14,630,151 (-)Ensembl
RefSeq Acc Id: NM_013050   ⟹   NP_037182
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,279,155 - 14,293,759 (-)NCBI
Rnor_6.01014,620,016 - 14,634,619 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
RGSC_v3.41014,509,948 - 14,524,551 (-)RGD
Celera1013,951,568 - 13,966,171 (-)RGD
Sequence:
RefSeq Acc Id: XM_006245918   ⟹   XP_006245980
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01014,618,615 - 14,639,274 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245919   ⟹   XP_006245981
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,277,749 - 14,293,627 (-)NCBI
Rnor_6.01014,618,615 - 14,634,501 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006245920   ⟹   XP_006245982
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,277,749 - 14,294,681 (-)NCBI
Rnor_6.01014,618,615 - 14,635,541 (-)NCBI
Rnor_5.01014,436,200 - 14,456,889 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008767549   ⟹   XP_008765771
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,277,749 - 14,294,678 (-)NCBI
Rnor_6.01014,618,615 - 14,635,539 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017597044   ⟹   XP_017452533
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.21014,277,749 - 14,294,214 (-)NCBI
Rnor_6.01014,618,615 - 14,635,243 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_037182   ⟸   NM_013050
- UniProtKB: P63281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245980   ⟸   XM_006245918
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_006245982   ⟸   XM_006245920
- Peptide Label: isoform X1
- UniProtKB: P63281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006245981   ⟸   XM_006245919
- Peptide Label: isoform X1
- UniProtKB: P63281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_008765771   ⟸   XM_008767549
- Peptide Label: isoform X1
- UniProtKB: P63281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_017452533   ⟸   XM_017597044
- Peptide Label: isoform X1
- UniProtKB: P63281 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000024406   ⟸   ENSRNOT00000024406
Protein Domains
UBC core

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Strain Variation

Strain Sequence Variants (Rnor 6.0)
ACI/EurMcwi (MCW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
ACI/EurMcwi (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
ACI/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
BBDP/Wor (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
BN/SsN (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
Buf/N (MCW)
Visual CSV TAB Printer
Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
COP/CrCrl (MCW & UW)
Visual CSV TAB Printer
Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
University of Wisconsin (Dr. James Shull)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Charles River Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob) and UW Madison (Dr. James Shull)
F344/NCrl (RGD)
Visual CSV TAB Printer
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
F344/NRrrc (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
FHH/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHH/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
FHL/EurMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
FHL/EurMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
GH/OmrMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
GK/Ox (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LE/Stm (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/Crl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LEW/NCrlBR (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LH/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LL/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
LN/MavRrrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
M520/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
MHS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MNS/Gib (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
MR/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
SBH/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBH/Ygl sequenced by MCW
SBH/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SBN/Ygl (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: SBN/Ygl sequenced by MCW
SBN/Ygl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHR/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SHRSP/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SR/JrHsd (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Harlan Laboratories
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SR/JrHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/Jr (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
SS/JrHsdMcwi (MCW)
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Sequenced By: Medical College of Wisconsin (Dr. Howard Jacob)
Platform: Illumina HiSeq 2000
Secondary Analysis: BWA v0.7.7 and GATK v3.2-2
Breeder: Medical College of Wisconsin
Description: Provided by the Medical College of Wisconsin (Dr. Howard Jacob)
SS/JrHsdMcwi (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WAG/Rij (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/Gcrc (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin
WKY/NCrl (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WKY/NHsd (RGD)
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Platform: Illumina HiSeq 2000
Secondary Analysis: BWA mem 0.7.15, GATK v.3.6-0
Description: Sequences from Atanur et al and Hermsen et al realigned to the Rnor 6.0 assembly and reanalyzed by RGD
WN/N (MCW)
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Sequenced By: Royal Netherland Academy of Arts and Sciences (Dr. Edwin Cuppen)
Max Delbruck Center for Molecular Medicine (Dr. Norbert Huebner)
Platform: SOLiD 4 and 5500
Secondary Analysis: liftOver (Batch Coordinate Conversion)--genome.ucsc.edu
Breeder: National Institutes of Health
Description: Founder strain for the heterogeneous stock (HS) rat population; SNPs from the RGSC 3.4 assembly were "lifted over" from RGSC 3.4 to Rnor 5.0 and from Rnor 5.0 to Rnor 6.0; Provided by Medical College of Wisconsin

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3926 AgrOrtholog
Ensembl Genes ENSRNOG00000017907 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSRNOP00000024406 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024406 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 3.10.110.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7305067 IMAGE-MGC_LOAD
  IMAGE:7310403 IMAGE-MGC_LOAD
InterPro UBQ-conjugat_E2 UniProtKB/Swiss-Prot
  UBQ-conjugating_AS UniProtKB/Swiss-Prot
  UBQ-conjugating_enzyme/RWD UniProtKB/Swiss-Prot
KEGG Report rno:25573 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105476 IMAGE-MGC_LOAD
  MGC:105477 IMAGE-MGC_LOAD
NCBI Gene 25573 ENTREZGENE
Pfam UQ_con UniProtKB/Swiss-Prot
PhenoGen Ube2i PhenoGen
PROSITE UBIQUITIN_CONJUGAT_1 UniProtKB/Swiss-Prot
  UBIQUITIN_CONJUGAT_2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF54495 UniProtKB/Swiss-Prot
TIGR TC228339
UniProt P63281 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary P50550 UniProtKB/Swiss-Prot
  Q15698 UniProtKB/Swiss-Prot
  Q86VB3 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2011-08-01 Ube2i  ubiquitin-conjugating enzyme E2I  Ube2i  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-05-25 Ube2i  ubiquitin-conjugating enzyme E2I (UBC9 homolog, yeast)  Ube2i  ubiquitin-conjugating enzyme E2I  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Ube2i  Ubiquitin conjugating enzyme E2I      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction protein binds helix-loop-helix protein E47 specificaly at a 54 aa region (477-530) 730030