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Gene: UBE2I (ubiquitin conjugating enzyme E2 I) Pan paniscus

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Symbol:

UBE2I

Name:

ubiquitin conjugating enzyme E2 I

RGD ID:

12025556

Description:

ENCODES a protein that exhibits bHLH transcription factor binding (ortholog); ionotropic glutamate receptor binding (ortholog); SUMO transferase activity (ortholog); INVOLVED IN nuclear export (ortholog); positive regulation of DNA-binding transcription factor activity (ortholog); positive regulation of intracellular steroid hormone receptor signaling pathway (ortholog); PARTICIPATES IN aldosterone signaling pathway; altered ubiquitin/proteasome degradation pathway; Alzheimer's disease pathway; ASSOCIATED WITH Animal Mammary Neoplasms (ortholog); carcinoma (ortholog); dilated cardiomyopathy (ortholog); FOUND IN dendrite (ortholog); fibrillar center (ortholog); nuclear body (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

SUMO-conjugating enzyme UBC9

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly

Position:

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	1,572,047 - 1,588,221 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	5,358,365 - 5,374,530 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	1,365,291 - 1,382,575 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	1,367,288 - 1,382,575 (+)	Ensembl	panpan1.1		panPan2

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	dilated cardiomyopathy		ISO	UBE2I (Homo sapiens)	9068941	mRNA:increased expression:left ventricle	RGD	PMID:23360823 and REF_RGD_ID:13831294
UBE2I	Bonobo	Experimental Mammary Neoplasms		ISO	UBE2I (Homo sapiens)	9068941	MCF-7 human breast cancer cell tumors grown in nude mice	RGD	PMID:15735760 and REF_RGD_ID:2301345
UBE2I	Bonobo	ovarian cancer		ISO	UBE2I (Homo sapiens)	9068941	mRNA:increased expression:tumor:relative to normal ovarian epithelium from the same patient (p<0.01)	RGD	PMID:15735760 and REF_RGD_ID:2301345
UBE2I	Bonobo	urinary bladder cancer		ISO	UBE2I (Homo sapiens)	9068941	radiation-induced dysplasia and carcinoma in situ and protein:increased expression:bladder urothelium:increased in Chernobyl victims vs controls from uncontaminated areas of the Ukraine (p<0.001)	RGD	PMID:16407042 and REF_RGD_ID:2301343

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	epilepsy		ISO	UBE2I (Homo sapiens)	8554872	ClinVar Annotator: match by term: Epilepsy	ClinVar	PMID:28492532
UBE2I	Bonobo	Idiopathic Generalized Epilepsy		ISO	UBE2I (Homo sapiens)	8554872	ClinVar Annotator: match by term: Idiopathic generalized epilepsy	ClinVar	PMID:28492532
UBE2I	Bonobo	short-rib thoracic dysplasia 9 with or without polydactyly		ISO	UBE2I (Homo sapiens)	8554872	ClinVar Annotator: match by term: Saldino-Mainzer syndrome	ClinVar	PMID:19370764 more ...
UBE2I	Bonobo	tuberous sclerosis 2		ISO	UBE2I (Homo sapiens)	8554872	ClinVar Annotator: match by term: Tuberous sclerosis 2	ClinVar	PMID:16114042 more ...

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	Animal Mammary Neoplasms		ISO	UBE2I (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:16316942
UBE2I	Bonobo	carcinoma		ISO	UBE2I (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:16316942
UBE2I	Bonobo	Experimental Mammary Neoplasms		ISO	UBE2I (Homo sapiens)	9068941	CTD Direct Evidence: marker/mechanism	CTD	PMID:16316942

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	modulation of chemical synaptic transmission	involved_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	negative regulation of DNA-templated transcription	involved_in	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	negative regulation of transcription by RNA polymerase II	involved_in	IEA	UniProtKB:P63279 more ...	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	nuclear export	involved_in	ISO	Ube2i (Mus musculus)	9068941	PMID:27160050	ComplexPortal	PMID:27160050
UBE2I	Bonobo	nuclear export	involved_in	ISO	UBE2I (Homo sapiens)	9068941	PMID:27160050	ComplexPortal	PMID:27160050
UBE2I	Bonobo	positive regulation of canonical NF-kappaB signal transduction	acts_upstream_of_or_within	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	positive regulation of cell migration	involved_in	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	positive regulation of DNA-binding transcription factor activity		ISO	Ube2i (Rattus norvegicus)	9068941	glucocorticoid receptor and independent of sumoylation activity or presence of a GME	RGD	PMID:11812797 and REF_RGD_ID:2301354
UBE2I	Bonobo	positive regulation of intracellular steroid hormone receptor signaling pathway		ISO	Ube2i (Rattus norvegicus)	9068941	glucocorticoid receptor and independent of sumoylation activity or presence of a GME	RGD	PMID:11812797 and REF_RGD_ID:2301354
UBE2I	Bonobo	proteasome-mediated ubiquitin-dependent protein catabolic process		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:9013644 and REF_RGD_ID:730030
UBE2I	Bonobo	protein modification by small protein conjugation	involved_in	IEA	ARBA:ARBA00026720	150520179		UniProt	GO_REF:0000117
UBE2I	Bonobo	protein sumoylation		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:11812797 and REF_RGD_ID:2301354
UBE2I	Bonobo	protein sumoylation	involved_in	IEA	UniProtKB:P63279 more ...	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	regulation of signaling receptor activity		ISO	Ube2i (Rattus norvegicus)	9068941	glucocorticoid receptor and independent of sumoylation activity or presence of a GME	RGD	PMID:11812797 and REF_RGD_ID:2301354

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	cytoplasm	located_in	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	dendrite		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:17486098 and REF_RGD_ID:1642482
UBE2I	Bonobo	fibrillar center		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:17587596 and REF_RGD_ID:2301351
UBE2I	Bonobo	glutamatergic synapse	is_active_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	nuclear body		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:17549507 and REF_RGD_ID:2301350
UBE2I	Bonobo	nuclear body	located_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	nuclear envelope		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:9497385 and REF_RGD_ID:9835353
UBE2I	Bonobo	nucleoplasm	is_active_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	nucleus	located_in	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	PML body	located_in	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	postsynaptic cytosol	is_active_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	presynaptic cytosol	is_active_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	Schaffer collateral - CA1 synapse	is_active_in	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	SUMO ligase complex	part_of	IEA	UniProtKB:P63279 more ...	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	transferase complex	part_of	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	ATP binding	enables	IEA	UniProtKB-KW:KW-0067	150520179		UniProt	GO_REF:0000043
UBE2I	Bonobo	ATP binding	enables	IEA	UniRule:UR000141827	150520179		UniProt	GO_REF:0000104
UBE2I	Bonobo	bHLH transcription factor binding		ISO	TCF3 (Homo sapiens)	9068941		RGD	PMID:9013644 and REF_RGD_ID:730030
UBE2I	Bonobo	enzyme binding	enables	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	HLH domain binding	enables	IEA	UniProtKB:P63280 and ensembl:ENSMUSP00000134261	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	ionotropic glutamate receptor binding		ISO	Grik2 (Rattus norvegicus)	9068941	protein C-terminus binding	RGD	PMID:17486098 and REF_RGD_ID:1642482
UBE2I	Bonobo	nucleotide binding	enables	IEA	UniProtKB-KW:KW-0547	150520179		UniProt	GO_REF:0000043
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P23396	9068941	PMID:21968017	UniProt	PMID:21968017
UBE2I	Bonobo	protein binding	enables	ISO	PR:O08900	9068941	PMID:15767674	MGI	PMID:15767674
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q505F1	9068941	PMID:17187077	IntAct	PMID:17187077
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q7TN99	9068941	PMID:26074071	UniProt	PMID:26074071
UBE2I	Bonobo	protein binding	enables	ISO	PR:Q9QYB2	9068941	PMID:11025202	MGI	PMID:11025202
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P21530-PRO_0000038063	9068941	PMID:20800867	AgBase	PMID:20800867
UBE2I	Bonobo	protein binding	enables	ISO	PR:Q149T7	9068941	PMID:12633878	MGI	PMID:12633878
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P29991-PRO_0000037946	9068941	PMID:21911577	IntAct	PMID:21911577
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P54253	9068941	PMID:16713569	IntAct	PMID:16713569
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9Y3V2	9068941	PMID:23469069	UniProt	PMID:23469069
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P07686 more ...	9068941	PMID:32814053	IntAct	PMID:32814053
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:G2XKQ0 more ...	9068941	PMID:25416956	IntAct	PMID:25416956
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P63165 more ...	9068941	PMID:31515488	IntAct	PMID:31515488
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P19419 more ...	9068941	PMID:23395904	IntAct	PMID:23395904
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P46060	9068941	PMID:22194619	IntAct	PMID:22194619
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P22314 more ...	9068941	PMID:17956732	IntAct	PMID:17956732
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q12800 and UniProtKB:Q96IK5	9068941	PMID:27107012	IntAct	PMID:27107012
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P19419 and UniProtKB:P46060	9068941	PMID:17036045	IntAct	PMID:17036045
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q08379	9068941	PMID:29568061	IntAct	PMID:29568061
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P05549 more ...	9068941	PMID:12072434	UniProt	PMID:12072434
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O75928 more ...	9068941	PMID:16189514	IntAct	PMID:16189514
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P63165	9068941	PMID:18264111 more ...	IntAct	PMID:18264111 more ...
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q13485	9068941	PMID:15231748 and PMID:29892012	IntAct	PMID:15231748 and PMID:29892012
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:G2XKQ0	9068941	PMID:27211601	UniProt	PMID:27211601
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9UBT2	9068941	PMID:17643372	IntAct	PMID:17643372
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P61956 and UniProtKB:P63165	9068941	PMID:17491593	IntAct	PMID:17491593
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9UER7	9068941	PMID:11112409	IntAct	PMID:11112409
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P46060 more ...	9068941	PMID:26496610	IntAct	PMID:26496610
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O75928 more ...	9068941	PMID:19549727	IntAct	PMID:19549727
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O75928 more ...	9068941	PMID:21988832	IntAct	PMID:21988832
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q7Z333	9068941	PMID:24105744 and PMID:24244371	UniProt	PMID:24105744 and PMID:24244371
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P46060 and UniProtKB:P63165	9068941	PMID:16732283	IntAct	PMID:16732283
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P05549 and UniProtKB:Q92754	9068941	PMID:12072434 and PMID:24835590	IntAct	PMID:12072434 and PMID:24835590
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9H444	9068941	PMID:16730941	IntAct	PMID:16730941
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9Y4E5	9068941	PMID:21516116	IntAct	PMID:21516116
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O75928 more ...	9068941	PMID:20936779	IntAct	PMID:20936779
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P59595	9068941	PMID:16998888 and PMID:17037517	IntAct	PMID:16998888 and PMID:17037517
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P29590-4	9068941	PMID:9885291	UniProt	PMID:9885291
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O94829	9068941	PMID:21139563 and PMID:23435562	IntAct	PMID:21139563 and PMID:23435562
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P56524	9068941	PMID:16166628	IntAct	PMID:16166628
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P26358	9068941	PMID:19450230	UniProt	PMID:19450230
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q07869	9068941	PMID:19955185	BHF-UCL	PMID:19955185
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9Y265	9068941	PMID:18087039	IntAct	PMID:18087039
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P03230	9068941	PMID:21795333	IntAct	PMID:21795333
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9NS56	9068941	PMID:14516784	UniProt	PMID:14516784
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P56693	9068941	PMID:16494873	IntAct	PMID:16494873
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O96006	9068941	PMID:27068747	UniProt	PMID:27068747
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O00429	9068941	PMID:19638400	UniProt	PMID:19638400
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O14503	9068941	PMID:11278694	IntAct	PMID:11278694
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q13330	9068941	PMID:21965678	UniProt	PMID:21965678
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P42260	9068941	PMID:17486098	IntAct	PMID:17486098 and REF_RGD_ID:1642482
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O88508	9068941	PMID:14752048	UniProt	PMID:14752048
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:O00148 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P08152	9068941	PMID:21836637	IntAct	PMID:21836637
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q8N4C6	9068941	PMID:16154161	HGNC-UCL	PMID:16154161
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P49792	9068941	PMID:35271311	IntAct	PMID:35271311
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P46060 more ...	9068941	PMID:28514442 and PMID:33961781	IntAct	PMID:28514442 and PMID:33961781
UBE2I	Bonobo	protein binding		ISO	Tollip (Rattus norvegicus)	9068941		RGD	PMID:19198660 and REF_RGD_ID:5508208
UBE2I	Bonobo	protein binding		ISO	GMEB1 (Homo sapiens)	9068941		RGD	PMID:11812797 and REF_RGD_ID:2301354
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P63033	9068941	PMID:19498170	UniProt	PMID:19498170 and REF_RGD_ID:8554673
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P04637	9068941	PMID:18624398 and PMID:31467278	IntAct	PMID:18624398 and PMID:31467278
UBE2I	Bonobo	protein binding		ISO	Rangap1 (Rattus norvegicus)	9068941		RGD	PMID:9497385 and REF_RGD_ID:9835353
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P03116	9068941	PMID:10871618	IntAct	PMID:10871618
UBE2I	Bonobo	protein binding	enables	ISO	PR:Q9Z1E3	9068941	PMID:9223278	MGI	PMID:9223278
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q06945	9068941	PMID:16631117	BHF-UCL	PMID:16631117
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q96IK5 more ...	9068941	PMID:32296183	IntAct	PMID:32296183
UBE2I	Bonobo	protein binding		ISO	GMEB2 (Homo sapiens)	9068941		RGD	PMID:11812797 and REF_RGD_ID:2301354
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q9UBC3	9068941	PMID:11735126	IntAct	PMID:11735126
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:P23497-2	9068941	PMID:11313457	BHF-UCL	PMID:11313457
UBE2I	Bonobo	protein binding	enables	ISO	UniProtKB:Q99497	9068941	PMID:15983381	ParkinsonsUK-UCL	PMID:15983381
UBE2I	Bonobo	RING-like zinc finger domain binding	enables	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	small protein activating enzyme binding	enables	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	SUMO conjugating enzyme activity	enables	IEA	UniProtKB:P63279 more ...	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	SUMO transferase activity		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:11812797 and REF_RGD_ID:2301354
UBE2I	Bonobo	SUMO transferase activity	enables	ISO	UBE2I (Homo sapiens)	9068941	PMID:11877416 more ...	Reactome	PMID:11877416 more ...
UBE2I	Bonobo	transcription coregulator binding	enables	IEA	UniProtKB:P63279 and ensembl:ENSP00000380649	150520179		Ensembl	GO_REF:0000107
UBE2I	Bonobo	transferase activity	enables	IEA	UniProtKB-KW:KW-0808	150520179		UniProt	GO_REF:0000043
UBE2I	Bonobo	ubiquitin-like protein transferase activity	enables	IEA	ARBA:ARBA00027363	150520179		UniProt	GO_REF:0000117
UBE2I	Bonobo	ubiquitin-protein transferase activity		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:9013644 and REF_RGD_ID:730030

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
UBE2I	Bonobo	aldosterone signaling pathway		ISO	UBE2I (Homo sapiens)	9068941		RGD	PMID:21784126 and REF_RGD_ID:7421504
UBE2I	Bonobo	altered ubiquitin/proteasome degradation pathway		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:11020223 and REF_RGD_ID:1302873
UBE2I	Bonobo	Alzheimer's disease pathway		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:11020223 and REF_RGD_ID:1302873
UBE2I	Bonobo	sumoylation pathway		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:17486098 and REF_RGD_ID:1642482
UBE2I	Bonobo	ubiquitin/proteasome degradation pathway		ISO	Ube2i (Rattus norvegicus)	9068941		RGD	PMID:9013644 and REF_RGD_ID:730030

PMID:30032202

UBE2I
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	1,572,047 - 1,588,221 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	5,358,365 - 5,374,530 (+)	NCBI		NHGRI_mPanPan1
PanPan1.1	16	1,365,291 - 1,382,575 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	16	1,367,288 - 1,382,575 (+)	Ensembl	panpan1.1		panPan2

UBE2I
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	1,309,152 - 1,327,017 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	1,291,444 - 1,327,018 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	16	1,359,153 - 1,377,018 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	1,299,181 - 1,315,391 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	16	1,299,180 - 1,315,391	NCBI
Celera	16	1,573,488 - 1,589,693 (+)	NCBI		Celera
Cytogenetic Map	16	p13.3	NCBI
HuRef	16	1,287,961 - 1,305,367 (+)	NCBI		HuRef
CHM1_1	16	1,359,074 - 1,376,964 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	16	1,325,332 - 1,343,194 (+)	NCBI		T2T-CHM13v2.0

Ube2i
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	17	25,479,484 - 25,494,965 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	17	25,479,482 - 25,493,856 (-)	Ensembl		GRCm39 Ensembl
GRCm38	17	25,260,510 - 25,275,799 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	17	25,261,916 - 25,274,622 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	17	25,397,456 - 25,411,255 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	17	24,988,111 - 25,001,891 (-)	NCBI		MGSCv36	mm8
Celera	17	25,787,805 - 25,801,616 (-)	NCBI		Celera
Cytogenetic Map	17	A3.3	NCBI
cM Map	17	12.53	NCBI

Ube2i
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	10	14,782,245 - 14,802,911 (-)	NCBI		GRCr8
mRatBN7.2	10	14,277,749 - 14,294,681 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	69,701,618 - 69,702,443 (+)	Ensembl		mRatBN7.2 Ensembl
mRatBN7.2 Ensembl	10	14,277,749 - 14,295,136 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	19,019,943 - 19,034,557 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	18,508,805 - 18,523,419 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	14,008,012 - 14,022,626 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	14,618,615 - 14,639,274 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	14,620,531 - 14,630,151 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	14,436,200 - 14,456,889 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	14,509,948 - 14,524,551 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	14,509,950 - 14,524,551 (-)	NCBI
Celera	10	13,951,568 - 13,966,171 (-)	NCBI		Celera
Cytogenetic Map	10	q12	NCBI

Ube2i
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955442	15,901,980 - 15,913,037 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955442	15,902,026 - 15,913,033 (-)	NCBI	ChiLan1.0	ChiLan1.0

UBE2I
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	6	39,440,123 - 39,453,688 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	6	39,440,314 - 39,817,588 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	6	40,707,767 - 40,719,921 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	6	39,786,145 - 39,798,312 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	6	39,462,778 - 39,474,925 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	6	39,435,400 - 39,447,553 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	6	39,913,736 - 39,925,904 (-)	NCBI		UU_Cfam_GSD_1.0

Ube2i
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409344	104,133,975 - 104,147,758 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936694	2,561,681 - 2,576,647 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936694	2,561,701 - 2,571,284 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

UBE2I
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	3	40,556,556 - 40,586,382 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	3	41,899,856 - 41,966,997 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

UBE2I
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	1,203,513 - 1,216,662 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	1,200,018 - 1,216,741 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666068	29,867,995 - 29,884,946 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ube2i
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624913	2,025,528 - 2,041,690 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624913	2,025,241 - 2,041,394 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.


RefSeq Transcripts	XM_003807624	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_003807627	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959767	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959768	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008959770	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034951632	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034951634	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034951635	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034951636	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_034951638	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_055100103	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JARIFH020000018	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSPPAT00000013071 ⟹ ENSPPAP00000002754

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
PanPan1.1 Ensembl	16	1,367,288 - 1,382,575 (+)	Ensembl

RefSeq Acc Id:

XM_034951632 ⟹ XP_034807523

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	1,572,517 - 1,587,594 (+)	NCBI
NHGRI_mPanPan1	16	5,358,827 - 5,373,915 (+)	NCBI

RefSeq Acc Id:

XM_034951634 ⟹ XP_034807525

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	1,572,047 - 1,587,594 (+)	NCBI
NHGRI_mPanPan1	16	5,358,365 - 5,373,915 (+)	NCBI

RefSeq Acc Id:

XM_034951635 ⟹ XP_034807526

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	1,572,203 - 1,587,594 (+)	NCBI
NHGRI_mPanPan1	16	5,358,509 - 5,373,915 (+)	NCBI

RefSeq Acc Id:

XM_034951636 ⟹ XP_034807527

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	1,572,517 - 1,588,221 (+)	NCBI
NHGRI_mPanPan1	16	5,358,822 - 5,374,530 (+)	NCBI

RefSeq Acc Id:

XM_034951638 ⟹ XP_034807529

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	1,572,061 - 1,588,221 (+)	NCBI
NHGRI_mPanPan1	16	5,358,366 - 5,374,530 (+)	NCBI

RefSeq Acc Id:

XM_055100103 ⟹ XP_054956078

Type:

CODING

Position:

Bonobo Assembly	Chr	Position (strand)	Source
NHGRI_mPanPan1-v2	18	1,575,355 - 1,587,594 (+)	NCBI
NHGRI_mPanPan1	16	5,361,560 - 5,373,915 (+)	NCBI


Protein RefSeqs	XP_034807523	(Get FASTA)	NCBI Sequence Viewer
	XP_034807525	(Get FASTA)	NCBI Sequence Viewer
	XP_034807526	(Get FASTA)	NCBI Sequence Viewer
	XP_034807527	(Get FASTA)	NCBI Sequence Viewer
	XP_034807529	(Get FASTA)	NCBI Sequence Viewer
	XP_054956078	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSPPAP00000002754.1

Ensembl Acc Id:

ENSPPAP00000002754 ⟸ ENSPPAT00000013071

RefSeq Acc Id:	XP_034807529 ⟸ XM_034951638
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZJA0 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_034807525 ⟸ XM_034951634
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_034807526 ⟸ XM_034951635
- Peptide Label:	isoform X1

RefSeq Acc Id:	XP_034807527 ⟸ XM_034951636
- Peptide Label:	isoform X2
- UniProtKB:	A0A2R8ZJA0 (UniProtKB/TrEMBL)

Protein Domains

UBC core

Database	Acc Id	Source(s)
Ensembl Genes	ENSPPAG00000011896	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSPPAT00000013071.1	UniProtKB/TrEMBL
Gene3D-CATH	3.10.110.10	UniProtKB/TrEMBL
InterPro	Ub_conjugating_enzyme	UniProtKB/TrEMBL
	UBQ-conjugat_E2	UniProtKB/TrEMBL
	UBQ-conjugating_AS	UniProtKB/TrEMBL
	UBQ-conjugating_enzyme/RWD	UniProtKB/TrEMBL
NCBI Gene	UBE2I	ENTREZGENE
PANTHER	UBIQUITIN-CONJUGATING ENZYME E2	UniProtKB/TrEMBL
Pfam	UQ_con	UniProtKB/TrEMBL
PROSITE	UBC_1	UniProtKB/TrEMBL
	UBC_2	UniProtKB/TrEMBL
SMART	UBCc	UniProtKB/TrEMBL
Superfamily-SCOP	SSF54495	UniProtKB/TrEMBL
UniProt	A0A2R8ZJA0	ENTREZGENE, UniProtKB/TrEMBL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailable


InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailable


Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable

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